ライフサイエンスコーパス: highly pathogenic

1 se in alpha2,6 binding affinity, and was not highly pathogenic.

2 lished in other host niches, however, GBS is highly pathogenic.

3 he window for treating lethal infection with highly pathogenic A(H5N1) influenza virus in mice.

4 mmunity and improve outcomes associated with highly pathogenic A(H5N1).

5 he fifth-wave outbreak in China, including a highly pathogenic A(H7N9) human isolate.

6 tudes and a single host, while ranavirus was highly pathogenic across multiple hosts, life-stages and

7 ytes (hFRG mice) and rhesus macaques using a highly pathogenic African YFV strain.

8 e hypothesise that the parallel emergence of highly-pathogenic AIV may be facilitated by permissive o

9 ains of AI viruses (AIVs)-when compared with highly pathogenic AIVs (HPAIVs)-are not even well-descri

10 Highly-pathogenic AIVs evolve independently from low-pat

11 Chikungunya virus (CHIKV) is a highly pathogenic alphavirus representative, and its non

12 ed genetic mutations and emergence of a both highly pathogenic and antibiotic-resistant strain with a

13 ous clone, which contains the VNDT motif, is highly pathogenic and causes lethality in a mouse model.

14 The emergent Nipah virus (NiV) is a highly pathogenic and deadly zoonotic paramyxovirus.

15 wever, the biosafety level 4 NiV and HeV are highly pathogenic and have a wide mammalian host range.

16 an viruses (EBOV and SUDV, respectively) are highly pathogenic and have both caused recurring, large

17 ying novel strategies to effectively address highly pathogenic and lethal infections stemming from ba

18 artland virus in the United States, that are highly pathogenic, and UUKV will now serve as a comparat

19 differential host innate immune responses to highly pathogenic arenavirus infections.IMPORTANCE Arena

20 genic NW arenaviruses, in contrast to the OW highly pathogenic arenavirus LASV, readily elicited an I

21 ilable to combat infection by Lassa virus, a highly pathogenic arenavirus, is toxic and prone to trea

22 the distinct innate immune response to these highly pathogenic arenaviruses and open new directions f

23 nterplays between the host immune system and highly pathogenic arenaviruses as well as distinct mecha

24 In conclusion, strain M23ND has become highly pathogenic as the result of a combination of mult

25 me-series structure of outbreak severity for highly pathogenic avain influenza (H5N1) in Egypt.

26 We previously showed that only a subset of highly pathogenic avian (HPAI) H5N1 influenza virus stra

27 ection compared them to infections caused by highly pathogenic avian (HPAI) H5N1 viruses.

28 ch transgenic mice were largely resistant to highly pathogenic avian H5 and H7 influenza A viruses, b

29 use annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7

30 Although the epidemiology differs from human highly pathogenic avian H5N1 influenza virus infections,

31 Highly pathogenic avian H5N1 influenza viruses have spor

32 Highly pathogenic avian H5N1 influenza viruses sometimes

33 Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans

34 the antibodies cross-inhibited the N1 NAs of highly pathogenic avian H5N1 influenza viruses.

35 Infections with highly pathogenic avian H5N1 virus and, more recently, a

36 e, we report that the PA proteins of several highly pathogenic avian H5N1 viruses have attenuating pr

37 Our results demonstrate that a highly pathogenic avian H7 virus can become capable of a

38 ies models to incidence data of outbreaks of highly pathogenic avian influenza (H5N1) in Egypt, avail

39 from a pandemic influenza (pdmH1N1) virus or highly pathogenic avian influenza (H5N1) virus elicits r

40 of alternative clade 2.3.4.4 CVVs.IMPORTANCE Highly pathogenic avian influenza (HPAI) A(H5) viruses h

41 th ciliated and nonciliated cells, whereas a highly pathogenic avian influenza (HPAI) A(H5N1) virus p

42 Emerging outbreaks of newly found, highly pathogenic avian influenza (HPAI) A(H5N8) viruses

43 ber of human infections and the emergence of highly pathogenic avian influenza (HPAI) A(H7N9) strains

44 The H5N8 highly pathogenic avian influenza (HPAI) clade 2.3.4.4 v

45 In 2015, highly pathogenic avian influenza (HPAI) H5 viruses have

46 Highly pathogenic avian influenza (HPAI) H5 viruses, of

47 Interestingly, a human isolate of the highly pathogenic avian influenza (HPAI) H5N1 virus succ

48 The highly pathogenic avian influenza (HPAI) H5N1 viruses co

49 nicity of H5N1 viruses in mammals.IMPORTANCE Highly pathogenic avian influenza (HPAI) H5N1 viruses co

50 kbones of the 2009 pandemic H1N1 (pH1N1) and highly pathogenic avian influenza (HPAI) H5N1 viruses.

51 The unprecedented 2015 outbreaks of highly pathogenic avian influenza (HPAI) H5N2 in the U.S

52 Emergence of a highly pathogenic avian influenza (HPAI) H5N8 virus in A

53 A novel highly pathogenic avian influenza (HPAI) H5N8 virus, fir

54 and a backyard farm infected during the 2013 highly pathogenic avian influenza (HPAI) H7N7 epidemic i

55 With the emergence of highly pathogenic avian influenza (HPAI) H7N9 and H5N1 s

56 Novel highly pathogenic avian influenza (HPAI) H7N9 viruses of

57 Highly Pathogenic Avian Influenza (HPAI) has recently (2

58 Highly pathogenic avian influenza (HPAI) is a devastatin

59 and between-host evolutionary dynamics of a highly pathogenic avian influenza (HPAI) strain during a

60 e 2009 pandemic influenza virus A/H1N1/2009, highly pathogenic avian influenza (HPAI) virus A/H5N1, a

61 An H7N8 highly pathogenic avian influenza (HPAI) virus and an H7

62 Outbreaks of highly pathogenic avian influenza (HPAI) virus subtype H

63 .IMPORTANCE The outbreak of clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus that occu

64 dented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus.

65 cause morbidity and mortality annually, and highly pathogenic avian influenza (HPAI) viruses along w

66 In early 2016, the presence of H7N8 highly pathogenic avian influenza (HPAI) viruses and clo

67 Highly pathogenic avian influenza (HPAI) viruses are enz

68 Highly pathogenic avian influenza (HPAI) viruses of the

69 Highly pathogenic avian influenza (HPAI) viruses of the

70 th the intercontinental spread of H5 subtype highly pathogenic avian influenza (HPAI) viruses of the

71 The spread of H5 subtype highly pathogenic avian influenza (HPAI) viruses of the

72 increase fitness in poultry.IMPORTANCE H5Nx highly pathogenic avian influenza (HPAI) viruses of the

73 Infections with H7 highly pathogenic avian influenza (HPAI) viruses remain

74 m wild birds have the potential to mutate to highly pathogenic avian influenza (HPAI) viruses, but su

75 eographic distribution, and the emergence of highly pathogenic avian influenza (HPAI) viruses.

76 ant reservoirs and long-distance carriers of highly pathogenic avian influenza (HPAI).

77 Human infections with highly pathogenic avian influenza A (H5N1) virus are fre

78 9 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce

79 Whole-genome sequences of representative highly pathogenic avian influenza A(H5) viruses from Vie

80 Highly pathogenic avian influenza A(H5N1) causes severe

81 ciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infectio

82 Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the

83 te viruses of distinct phenotypes.IMPORTANCE Highly pathogenic avian influenza A(H5N1) viruses have c

84 Highly pathogenic avian influenza A(H5N8) viruses first

85 in 2005, 200 human infections with clade 2.1 highly pathogenic avian influenza A/H5N1 virus have been

86 We apply this new method to the analysis of highly pathogenic avian influenza H5N1 clade data in the

87 The emergence of highly pathogenic avian influenza H5N1 viruses has raise

88 Clade 2.2.2.1 highly pathogenic avian influenza H5N1 viruses were isol

89 A-X deficient 2009 pandemic H1N1 (pH1N1) and highly pathogenic avian influenza H5N1 viruses.

90 ckbone of the 2009 H1N1 pandemic (pH1N1) and highly pathogenic avian influenza H5N1 viruses.

91 Since May 2014, highly pathogenic avian influenza H5N6 virus has been re

92 Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.

93 An outbreak of highly pathogenic avian influenza H7N7 virus in Italy du

94 economic factors on the seasonality of H5N1 Highly Pathogenic Avian Influenza in the domestic poultr

95 s in Washington yielded 10 (6.7%) additional highly pathogenic avian influenza isolates (H5N8 = 3 and

96 date there is no rapid method to screen for highly pathogenic avian influenza strains that may be in

97 The highly pathogenic avian influenza subtype H5N1 (HPAI H5N

98 an intensive study was initiated to conduct highly pathogenic avian influenza surveillance in wild b

99 viral spread after intranasal infection with highly pathogenic avian influenza virus (H5N1 [A/Viet Na

100 ing site that has experienced several recent highly pathogenic avian influenza virus (HPAIV) epizooti

101 ines.IMPORTANCE The sustained circulation of highly pathogenic avian influenza virus (HPAIV) H5N1 A/g

102 The highly pathogenic avian influenza virus (HPAIV) H5N1 A/g

103 onsistently been shown to be associated with highly pathogenic avian influenza virus (HPAIV) H5N1 out

104 ears as one of the major policies to control highly pathogenic avian influenza virus (HPAIV) infectio

105 The expression of the H5 HA of an H5N1 highly pathogenic avian influenza virus (HPAIV), A/Vietn

106 A novel highly pathogenic avian influenza virus belonging to the

107 ants of recombinant HA (short and long) from highly pathogenic avian influenza virus H5N1 and the ant

108 Highly pathogenic avian influenza virus infection is cha

109 In November 2014, a Eurasian strain H5N8 highly pathogenic avian influenza virus was detected in

110 hunter-harvested wild birds were sampled and highly pathogenic avian influenza virus was detected in

111 rium on gain-of-function (GOF) research with highly pathogenic avian influenza virus, severe acute re

112 elate with the severity of both seasonal and highly pathogenic avian influenza virus.

113 HA) can be activated by furin, a hallmark of highly pathogenic avian influenza virus.

114 otential role for DCs in the pathogenesis of highly pathogenic avian influenza virus.

115 Highly pathogenic avian influenza viruses (HPAIV) induce

116 We found that the H5Nx highly pathogenic avian influenza viruses exhibited high

117 are the precursors of numerous outbreaks of highly pathogenic avian influenza viruses in commercial

118 s of particular concern in Bangladesh, where highly pathogenic avian influenza viruses of the A(H5N1)

119 Since 1997, highly pathogenic avian influenza viruses of the H5N1 su

120 Highly pathogenic avian influenza viruses of the H5N1 su

121 ibed for mammalian influenza viruses and for highly pathogenic avian influenza viruses that circulate

122 The pH of HA activation of highly pathogenic avian influenza viruses was greater th

123 to prevent and treat human disease caused by highly pathogenic avian influenza viruses.

124 upon infection with most strains, including highly pathogenic avian influenza.

125 This defect shortens lifespan on highly pathogenic bacteria but extends lifespan and heal

126 n in vivo murine model of infection with the highly pathogenic bacterium Burkholderia pseudomallei, i

127 Burkholderia pseudomallei, a highly pathogenic bacterium that causes melioidosis, is

128 Although MojV is genetically related to highly pathogenic bat-borne henipaviruses, the absence o

129 d DI genomes to inhibit Nipah virus (NiV), a highly pathogenic biosafety level 4 paramyxovirus.

130 s superior to imipenem and meropenem against highly pathogenic carbapenem-resistant strains, such as

131 rus family includes several members that are highly pathogenic, causing acute viral hemorrhagic fever

132 y spreading from zoonotic sources and can be highly pathogenic, causing serious morbidity and mortali

133 and has been implicated in the emergence of highly pathogenic CDV and host switching.

134 lines may have facilitated selection of this highly pathogenic clone.

135 n V. cholerae evolution and the emergence of highly pathogenic clones, such as the variant strains as

136 Staphylococcus aureus, especially highly pathogenic community-acquired methicillin-resista

137 y syndrome coronavirus (MERS-CoV), two other highly pathogenic coronavirus spillovers, which collecti

138 e coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the hum

139 t 1 decade after the appearance of the first highly pathogenic coronavirus, severe acute respiratory

140 Highly pathogenic coronaviruses are rare and appear to e

141 nt history is punctuated by the emergence of highly pathogenic coronaviruses such as SARS- and MERS-C

142 ere is currently no approved therapeutic for highly pathogenic coronaviruses, even as MERS-CoV is spr

143 the use of recombinant IFNs in two related, highly pathogenic coronaviruses, SARS-CoV and MERS-CoV,

144 te evaluation of inhibitors directed against highly pathogenic coronaviruses.

145 Understanding the pathogenesis of this highly pathogenic CoV is crucial for developing successf

146 host factors that regulate susceptibility to highly pathogenic CoVs.

147 African swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a mark

148 HIV) entry were challenged with SHIV89.6P, a highly pathogenic dual-tropic chimeric SIV-HIV viral str

149 The highly pathogenic Ebola virus (EBOV) has a nonsegmented

150 iviral therapeutics and vaccines against the highly pathogenic Ebola virus (EBOV), the cellular mecha

151 filoviruses has historically focused on the highly pathogenic ebola- and marburgviruses.

152 ingent lethal aerosol challenge of mice with highly pathogenic EEEV.

153 lts do not support the previous concept that highly pathogenic EEHV1A crossed from African to Asian e

154 The protease is further hijacked by highly pathogenic emerging viruses for the processing of

155 therapies and safer vaccines to combat these highly pathogenic emerging viruses.

156 Viruses in the genus Henipavirus encompass 2 highly pathogenic emerging zoonotic pathogens, Hendra vi

157 Given that HTTexon1 encodes the highly pathogenic exon 1 HTT protein, it is essential th

158 yadenylated mRNA (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein.

159 lated transcript (Httexon1) that encodes the highly pathogenic exon 1 HTT protein.

160 Marburg virus (MARV) is a highly pathogenic filovirus that is classified in a genu

161 avivirus vaccine development, especially for highly pathogenic flaviviruses.

162 resistant influenza viruses and in view of a highly pathogenic flu pandemic, it is important to devel

163 ntly discovered emerging herpesvirus that is highly pathogenic for koi and common carp.

164 ersists in wild bird populations yet remains highly pathogenic for poultry.

165 at B. salamandrivorans is restricted to, but highly pathogenic for, salamanders and newts (Urodela).

166 ansition from the low pathogenic form to the highly pathogenic form occurred within the first infecte

167 ian influenza viruses (LPAIVs) can mutate to highly pathogenic forms and are therefore subject to str

168 Furthermore, highly pathogenic GBS strains have acquired unique facto

169 genic ASFV isolate, OUR T88/3 (OURT), or the highly pathogenic Georgia 2007/1 (GRG).

170 1pdm09, H3N2, and type B viruses, as well as highly pathogenic H5 and H7 viruses.

171 penia is a hallmark of severe infection with highly pathogenic H5N1 and the newly emerged H7N9 influe

172 Early diagnosis of the highly pathogenic H5N1 avian influenza virus (AIV) is si

173 ng a pandemic H1N1 influenza virus strain, a highly pathogenic H5N1 avian influenza virus strain, and

174 ins in vitro, including pandemic H1N1 virus, highly pathogenic H5N1 avian influenza virus, and the re

175 Highly pathogenic H5N1 avian influenza viruses are assoc

176 Highly pathogenic H5N1 avian influenza viruses are assoc

177 Many amino acid substitutions in highly pathogenic H5N1 avian influenza viruses have been

178 Highly pathogenic H5N1 avian influenza viruses have caus

179 Highly pathogenic H5N1 avian influenza viruses must acqu

180 ruses are harmless for humans, some (such as highly pathogenic H5N1 avian influenza viruses) are capa

181 agent or prophylactic with activity against highly pathogenic H5N1 avian influenza viruses.

182 Highly pathogenic H5N1 influenza A viruses continue to c

183 Although the number of human infections with highly pathogenic H5N1 influenza viruses continues to ri

184 rast to other avian IAVs, recent isolates of highly pathogenic H5N1 influenza viruses had a high prop

185 ns known to increase the transmissibility of highly pathogenic H5N1 influenza viruses.

186 in thus plays a role in the pathogenicity of highly pathogenic H5N1 influenza viruses.

187 ylactically before intranasal inoculation of highly pathogenic H5N1 virus (A/Indonesia/05/2005) and w

188 ickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively.

189 ficant contributors to progeny production of highly pathogenic H5N1 viruses.

190 s frequently truncated in recent isolates of highly pathogenic H5N1 viruses.

191 However, unlike highly pathogenic H7 viruses, the disease-causing potent

192 Adaptation of low-pathogenic H7N7 to highly pathogenic H7N7 in Europe in 2015 raised further

193 H7N9, seasonal H3N2, pandemic-2009 H1N1, and highly pathogenic H7N7 influenza A viruses.

194 These results suggest that the highly pathogenic H7N9 virus has pandemic potential and

195 The highly pathogenic H7N9 viruses replicated efficiently in

196 V) and Lassa virus (LASV), two unrelated but highly pathogenic hemorrhagic fever viruses that have ca

197 We report here that the highly pathogenic HIV R3A efficiently activated pDCs to

198 nons, as well as that from recently isolated highly pathogenic HIV-1 group N, do not discriminate bet

199 Risk factors for human infection with highly pathogenic (HP) and low-pathogenic (LP) avian inf

200 exemplified by the apparent disappearance of highly pathogenic (HP) H5N1, H5N2, and H5N8 (H5Nx) virus

201 protein, which were previously found in the highly pathogenic (HP) human influenza A (H7N9) [IAV(H7N

202 iratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human coronavirus causing severe disea

203 iratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human CoV that emerged in Saudi Arabia

204 espiratory syndrome CoV (SARS-CoV) represent highly pathogenic human CoVs that share a property to in

205 identifying potential vaccine candidates for highly pathogenic human CoVs, including the use of atten

206 Highly pathogenic human respiratory coronaviruses cause

207 Bats are the reservoir host for many highly pathogenic human viruses, including henipaviruses

208 of these genes in lung tissue in response to highly pathogenic IAV infection by 400-fold, 30-fold, 30

209 so significant safety concerns for work with highly pathogenic IAV strains in the laboratory.

210 safety of vaccine studies and of research on highly pathogenic IAV.

211 nd does not transmit in mallards but remains highly pathogenic in chickens.

212 enia syndrome virus and Heartland virus, are highly pathogenic in humans.

213 We found that glycosylated viruses were highly pathogenic in Ifnar1(-/-) mice.

214 H5N1 viruses possessing these mutations are highly pathogenic in mice).

215 r to that of A/Anhui/1/2013 (H7N9), which is highly pathogenic in mice.

216 and reemerging viruses, several of which are highly pathogenic in other mammals but cause no clinical

217 receptors CCR6 and CXCR3, are proposed to be highly pathogenic in several autoimmune disorders due in

218 The ST16 clone was highly pathogenic in the larvae model.

219 ST16 clone was highly pathogenic in the larvae model.

220 nteract with cartilage in vivo and are often highly pathogenic in the mouse.

221 genic CD103(-) DCs that overexpress Opn were highly pathogenic in vivo.

222 e, that were challenged with lethal doses of highly pathogenic influenza A H5N1 or H1N1 viruses.

223 Thus, we sought to determine if a highly pathogenic influenza A H7N1 (A/H7N1) virus with n

224 Highly pathogenic influenza viruses of the H5N1 subtype

225 compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that

226 s obtained from macaques infected with three highly pathogenic lines of Lassa virus (LASV), the causa

227 chicken embryonated fibroblasts (CEFs) with highly pathogenic MDV-RB1B increases the cellular choles

228 l activity of Ceftriaxone/Cefotaxime against highly pathogenic MRSA infection.

229 However, the host innate immune responses to highly pathogenic New World (NW) arenaviruses are not we

230 en that replication and dissemination of the highly pathogenic Nipah virus (NiV) include exposure to

231 the accuracy of prediction and identified 18 highly pathogenic non-synonymous SNPs (nsSNPs) out of 60

232 ion protects mice against infection with the highly pathogenic North American strain of EEEV.

233 In contrast, infections with the highly pathogenic NW arenavirus JUNV are associated with

234 MACV, another highly pathogenic NW arenavirus, also activated IFN resp

235 we report that Machupo virus (MACV), another highly pathogenic NW arenavirus, also induces an IFN res

236 We have previously shown that the highly pathogenic NW arenavirus, Junin virus (JUNV), ind

237 The highly pathogenic Old World (OW) arenavirus Lassa fever

238 stis, the bacterium that causes plague, is a highly pathogenic organism.

239 , were evaluated for their ability to render highly pathogenic organisms nonviable and safe for handl

240 pment of next-generation, safer vaccines for highly pathogenic orthopoxviruses.

241 Infections of humans with the highly pathogenic OW LASV are accompanied by potent supp

242 diagnostic indicators of virulence linked to highly pathogenic pandemic influenza viruses without amp

243 otein associated with increased virulence in highly pathogenic pandemic influenza viruses.

244 Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes frequent out

245 ected ferrets from lethal challenge with the highly pathogenic parental virus.

246 eplication of EEEV and may contribute to its highly pathogenic phenotype.IMPORTANCE Eastern equine en

247 mutations in AIV genomes associated with the highly-pathogenic phenotype.

248 In this study, we demonstrated that highly pathogenic PRRSV (HP-PRRSV) infection specificall

249 The highly pathogenic R3A efficiently activated pDCs to indu

250 enza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, parti

251 The rapid emergence of a highly pathogenic, readily transmissible coronavirus has

252 iratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidit

253 iratory syndrome coronavirus (MERS-CoV) is a highly pathogenic respiratory virus that emerged from zo

254 iratory syndrome coronavirus (MERS-CoV) is a highly pathogenic respiratory virus that emerged from zo

255 onavirus (MERS-CoV) emerged in 2012 and is a highly pathogenic respiratory virus.

256 implicated in lung disease induced by other highly pathogenic respiratory viruses.IMPORTANCE PF has

257 The life cycles of many highly pathogenic RNA viruses like influenza A virus (IA

258 matory cytokine response, and the outcome of highly pathogenic S. suis infection in a mouse model.

259 ly was serotype specific and associated with highly pathogenic serotypes (O157 and top non-O157 Shiga

260 lar pocket also appears to be present in the highly pathogenic severe acute respiratory syndrome coro

261 Highly pathogenic severe acute respiratory syndrome coro

262 The highly pathogenic severe acute respiratory syndrome coro

263 ted low-dose intravaginal challenge with the highly pathogenic SIVmac251, we show that although these

264 milar to that of GP from Zaire ebolavirus, a highly pathogenic species, in terms of both the activati

265 ease complement deposition on the relatively highly pathogenic strain MNZ41.

266 minants for growth in vitro and in vivo of a highly pathogenic strain of C. jejuni.

267 The major findings of this report are that a highly pathogenic strain of H7N1 avian influenza virus c

268 Outbreaks of highly pathogenic strains of avian influenza viruses (AI

269 Infection with highly pathogenic Streptococcus suis can cause septic sh

270 ese findings demonstrate that AEA suppresses highly pathogenic T cell subsets through CB1-mediated ma

271 tion of insulin epitope results in escape of highly pathogenic T cells.

272 licated in such infections, but since 2003 a highly pathogenic, tetracycline-resistant C. jejuni clon

273 is a stealthy intracellular pathogen that is highly pathogenic to a range of mammals, including human

274 Although these viruses are highly pathogenic to humans, our study highlights distin

275 that although all viruses studied herein are highly pathogenic to humans, the host IFN responses towa

276 are reservoirs of emerging viruses that are highly pathogenic to other mammals, including humans.

277 viruses, including several viruses that are highly pathogenic to other mammals.

278 al) is an emerging invasive pathogen that is highly pathogenic to salamander species.

279 ses are insect-specific DNA viruses that are highly pathogenic to their insect hosts.

280 Although highly pathogenic to their spillover hosts, bats harbor

281 A novel and a highly pathogenic TPMT variant not detectable through st

282 obal public health threat as a result of its highly pathogenic variants, large zoonotic reservoir, an

283 undergo natural selection and may represent highly pathogenic variants.

284 V), a member of the Filoviridae family, is a highly pathogenic virus that causes severe hemorrhagic f

285 oronavirus (SADS-CoV) is a newly discovered, highly pathogenic virus that likely evolved from closely

286 or high-containment conditions to study this highly pathogenic virus.

287 on T-cell responses and vaccination against highly pathogenic viruses are not well understood.

288 irology as tools for studying the biology of highly pathogenic viruses in a lower biosafety environme

289 ction.IMPORTANCE EBOV belongs to a family of highly pathogenic viruses that cause severe hemorrhagic

290 The arenavirus family consists of several highly pathogenic viruses, including the Old World (OW)

291 The role of biosensors in containing highly pathogenic viruses, saving lives and economy is e

292 NA vaccination studies against NiV and other highly pathogenic viruses.

293 e potential therapeutics against emerging or highly pathogenic viruses.

294 ch was to modify the hemagglutinin gene of a highly pathogenic wild-type (wt) clade 2.2.1.1 virus, A/

295 NoV is highly pathogenic with an estimated median viral infecti

296 Ebola virus (EBOV) is highly pathogenic, with a predisposition to cause outbre

297 from a rapid-progressor PTM was consistently highly pathogenic, with high acute and chronic viral rep

298 us with a 5'-monophosphorylated genome, is a highly pathogenic zoonotic agent with significant public

299 Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fat

300 MARV, members of the family Filoviridae, are highly pathogenic zoonotic viruses that cause severe dis