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1 livery systems that are both efficacious and highly selective.
2 hat this therapeutic strategy will likely be highly selective.
3 cally define that the Vip1 gene product is a highly selective 1-kinase and 1-pyrophosphatase enzyme w
5 -StackPhos complex efficiently catalyzes the highly selective 6-endo-dig cyclization, completely reve
7 multisite nerve bundle stimulation to induce highly-selective activations of limb muscles, which coul
9 fly" sensing platforms in bioassays, using a highly selective affinity peptide probe for "OFF-ON" det
10 SSTI, we found that GPER activation with the highly selective agonist G-1 limits S. aureus SSTI and H
12 fast response time (<15s), simple, low cost, highly selective along with abilities towards online mon
13 lity of TYK2 JH2 domain binders to provide a highly selective alternative to conventional TYK2 orthos
14 and CERS are shown to be cost-effective and highly selective analytical tools in the biosciences and
16 principle for a novel strategy in developing highly selective and broad-spectrum antiviral molecules
17 act, currently available PXR ligands are not highly selective and can exhibit toxicity and/or potenti
20 ne triacetate is employed in a key step as a highly selective and efficient iodinating reagent for a
22 rom the blood, including early isolates, are highly selective and enter cells through some primate CD
28 ence of two classes of cells: those encoding highly selective and invariant representations of abstra
30 contact, so direct electrical detection is a highly selective and label-free single-molecule detectio
31 y due to the broader challenge of developing highly selective and live-cell compatible affinity probe
32 h a rational design approach we discovered a highly selective and potent BTK kinase inhibitor (CHMFL-
34 l cation currents were blocked by Pico145, a highly selective and potent TRPC1/4/5 channel blocker an
37 hores, ionophores, and ion-exchangers enable highly selective and rapid fluorescence detection of phy
38 dy therefore is a step forward in developing highly selective and sensitive electrokinetic assays for
42 a dual-responsive optical marker to develop highly selective and sensitive probe as visible (sol-to-
45 programmed in our precursors' design rely on highly selective and sequential activations of carbon-br
47 The aim of this study was the development of highly selective and specific PSMA probes with enhanced
48 h Swi6 shows that the Chp2-Mit1 interface is highly selective and thereby provides the molecular basi
50 al calcium uniporter complex in metazoans, a highly selective and tightly controlled Ca(2+) channel o
53 migatus In this work, we developed a robust, highly selective, and broad-range allele-specific TaqMan
54 ea viscosa that constitutes a submicromolar, highly selective, and cell-active modulator of ERAP1.
56 Structure-based design yielded the potent, highly selective, and orally bioavailable small-molecule
59 cyclo[1.1.1]pentane-1,3-dicarboxylic acid is highly selective, and up to four chlorine atoms can be i
62 eptors) orthosteric binding sites, obtaining highly selective antagonists is a challenging but critic
64 etection of amyloid-beta (Abeta) peptides by highly selective aptamers immobilized onto the SiO(2) su
65 des, the modular glucosides are derived from highly selective assembly of moieties from nucleoside, a
66 ion for how virus antigenic evolution can be highly selective at the global level but nearly neutral
68 oorthogonal click chemistry ensures fast and highly selective attachment onto a variety of biomolecul
70 ucleotide polymorphism (SNP) detection using highly selective BiDz sensors targeting loci associated
73 od tissue diffusion, low immunogenicity, and highly selective binding to their target cell-surface re
79 on BTK inhibitor, with zanubrutinib, a novel highly selective BTK inhibitor, in patients with WM.
82 e show that CASTOR from Lotus japonicus is a highly selective Ca(2+) channel whose activation require
83 re-operated Ca(2+) entry (SOCE) channels are highly selective Ca(2+) channels activated by the endopl
86 lavin-dependent 'ene'-reductases (EREDs) are highly selective catalysts for the asymmetric reduction
87 e nanotubes (BNNT) were recently reported as highly selective catalysts for the oxidative dehydrogena
88 on nitride, have recently been identified as highly selective catalysts for the oxidative dehydrogena
89 g materials have recently been identified as highly selective catalysts for the oxidative dehydrogena
90 structure-aided merging to synthesize novel, highly selective CatS inhibitors with picomolar enzymati
92 ith the identification of (R)-55 (GSK232), a highly selective, cellularly penetrant CECR2 inhibitor w
93 group of peptide-based, long-acting, stable, highly selective cholecystokinin 1 receptor (CCK-1R) ago
96 provides a unique strategy for efficient and highly selective CO(2) reduction by water to high-value
100 ning paradigm, we have identified JNJ0966, a highly selective compound that inhibited activation of M
102 has evolved as an attractive way to engineer highly selective compounds for targeted G-protein couple
103 N-aryl tetramic acid which is advanced via a highly selective conjugate addition/intramolecular Fried
105 nbiased screening to identify new classes of highly selective covalent inhibitors for diverse molecul
109 label-free strategy for quick, sensitive and highly selective detection of Gram-positive bacteria.
110 rbitrary waveform generation, we demonstrate highly selective detection of picosecond signals overlap
111 paper, we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhib
114 he potential utility of VK4-116, a novel and highly selective dopamine D3 receptor (D3R) antagonist,
115 Here we report the development of SR-4835, a highly selective dual inhibitor of CDK12 and CDK13, whic
116 mechanisms), mutations in fusA1 can lead to highly selective dysregulation of virulence gene express
119 plex genetic regulation of immune cells with highly selective effects on autoimmune disease risk at t
123 predictions of selectivity provide the first highly selective entry into KDO equatorial glycosides su
126 estral promiscuous RNA repair enzymes to the highly selective enzymes needed for their essential func
128 effects on attentional control signals were highly selective even for different subclasses of narrow
130 Targeted nucleic acid analysis requires the highly selective extraction of desired DNA fragments in
131 s in mtDNA in a rapid, highly sensitive, and highly selective fashion is important for the real-time
132 ation and polymerization of vinylarenes in a highly selective fashion, depending on the Lewis base ca
133 ty, and solubility leading ultimately to the highly selective first-in-class clinical candidate robli
135 Here, we show that tautomycetin (TTN) is highly selective for a single PPP, protein phosphatase 1
137 mulation studies confirm that the channel is highly selective for anions and that such anion selectiv
138 hat GFAP-CreERT2 expression in these mice is highly selective for astrocytes, and we are able to sign
140 a wide range of a(Cl) (0.1 mM to 100 mM), is highly selective for Cl(-) over other biological anions
141 able D3R affinity (Ki = 12-25.6 nM) and were highly selective for D3R vs D3R (ranging from 264- to 90
145 ide-1 (GLP-1R) are normally considered to be highly selective for glucagon and GLP-1, respectively.
148 ive imaging radiotracer, (18)F-fluoride, was highly selective for hydroxyapatite deposition in athero
154 t of the nanomolar agonists were found to be highly selective for PPAR-delta and are structurally dif
156 SPIN1, displayed high binding affinity, was highly selective for SPIN1 over other epigenetic readers
160 icles show that these main-group cations are highly selective for the fluoride anion, which is transp
161 -substituted cyclobutanones was proven to be highly selective for the formation of cis alcohol (>90%)
162 fonamide) showed an IC(50) of 0.02 muM being highly selective for the parasites over THP-1 cells with
163 ntravenous (IV) anesthetic molecules that is highly selective for the slow type of gamma-aminobutyric
165 task, disparity-selective neurons in V2 were highly selective for the task, and their activity correl
166 ture unique catalytic behavior, allowing the highly selective formation of the desired mono-alpha-ary
167 showcases the tunability of hemoproteins for highly selective functionalization of cyclic targets and
168 pyridine derivatives to provide a library of highly selective functionalized products in good to exce
169 ined results allowed the identification of a highly selective G-quadruplex ligand that, when studied
174 th its protein targets (low in alpha) and is highly selective (high in beta) in forming the probe-pro
177 ynthetic macrocycles for structure-specific, highly selective, host-guest complexation has experience
178 fect transistor (EG-FET) transducer leads to highly selective HSA determination in the femtomolar con
181 n could potentially serve as a promising and highly selective immunosuppressive drug target in autoim
184 y after the onset of a sound and then become highly selective in the following sustained response epo
188 We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that
189 cell line, suggesting that it may provide a highly selective inhibitor of MEK1/2 for use as a cancer
190 les of GSK789, a potent, cell-permeable, and highly selective inhibitor of the first bromodomains of
192 profile of GSK046, also known as iBET-BD2, a highly selective inhibitor of the second bromodomains of
193 a peptide-derived, potent, bioavailable and highly selective inhibitor, which is widely used for stu
194 del to aid in the design of a novel class of highly selective inhibitors acting against such specific
195 rcinoma progression and the potential use of highly selective inhibitors of HDAC11 in combating lung
198 FG-1) represent an opportunity for designing highly selective inhibitors with unexpected binding mode
200 e mitochondrial calcium uniporter (MCU) is a highly selective ion channel that transports Ca(2+) into
206 Herein we describe the development of a highly selective kinetic resolution of cyclobutanones vi
209 conformations and can guide the discovery of highly selective ligands for the IRE1alpha kinase site t
210 EGF overexpression culminating in extensive, highly selective loss of DG GCs (thereby also reinforcin
211 ote the development of robust, efficient and highly selective LRSPR based biosensors with SiO(2) as t
212 ble kinase inhibitors are modified to design highly selective, lysine-targeted covalent inhibitors.
220 modes, which are essential for the design of highly selective melatonin tool compounds and therapeuti
225 etween mGlu(1) and M(4) and demonstrate that highly selective mGlu(1) PAMs may provide a novel strate
226 we have developed oxaziridine chemistry for highly selective modification of methionine called redox
227 important structural factors underlying this highly selective molecular recognition, we have used sol
231 y as a novel scaffold for the development of highly selective mTOR inhibitors for cancer treatment.
232 ional analysis of VirChR1 shows that it is a highly selective, Na(+)/K(+)-conducting channel and, in
233 g groups with minimal wavelength overlap and highly selective natural and unnatural amino acid recogn
234 eroid-resistant asthma were examined using a highly selective NLRP3 inhibitor, MCC950; the specific c
235 assay of 265,211 compounds and isolated six highly selective NPYLR7 agonists that inhibit mosquito a
236 is shown to be susceptible to a subsequent, highly selective nucleophilic displacement reaction.
240 lability led to the discovery of the potent, highly selective, orally available ATR inhibitor BAY 189
241 tent irreversible inhibitor of LOXL2 that is highly selective over LOX and other amine oxidases.
244 rapeutic potential of combining niraparib, a highly selective PARP1/2 inhibitor, with anti-PD-1 immun
246 7 (DNS-8254), was identified as a potent and highly selective PDE2a enzyme inhibitor with favorable r
247 he mPTP in failing human myocardium, and the highly selective pharmacological blockade of either iPLA
250 (INCB050465), a next-generation, potent, and highly selective phosphatidylinositol 3-kinase delta (PI
251 group-directed Vorbruggen glycosylation, and highly selective phosphoramidation to furnish the API.
254 (I) mediated aerobic oxidation of betulin, a highly selective PIFA mediated dehydrogenation of an oxi
255 (BQCA) and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) o
263 or the incorporation of chemical groups with highly selective reactivity into small molecules or prot
265 we outline the selection and refinement of a highly selective recombinant antibody for specific adduc
266 uantification of proteins in biomatrices, by highly selective removal of matrix peptides and componen
268 )-selective electrodes thus prepared exhibit highly selective responses with the theoretically expect
269 nisms of resistance to these next-generation highly selective RET inhibitors is an area of active res
270 lation by a tRNA-cleaving toxin that enlists highly selective ribosome stalling to recalibrate the tr
274 e interaction), between F(-) and MOF host, a highly selective, sensitive, and reliable fluoride senso
276 tiple-mechanism washing and elution achieved highly selective separation despite the low plate number
277 en generate acidified leachates that require highly selective separation methods to recover the REEs
278 n, and radiation dosimetry in humans for the highly selective sigma-1 receptor PET agent (18)F-6-(3-f
280 main of RIPK1 has enabled the development of highly selective small-molecule inhibitors of its kinase
281 cations of a cyclic octapeptide as the first highly selective small-molecule ligand for alphavbeta8.
283 oting TIC formation and highlights pdTp as a highly selective SND1 inhibitor as a candidate therapeut
287 2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective, subnanomolar-affinity PET tracer for i
289 orted the discovery of takinib, a potent and highly selective TAK1 inhibitor that has only marginal a
290 les and the identification of the potent and highly selective TBK1/IKKepsilon inhibitor BAY-985.
293 RP channels that is permeable to cations and highly selective to Ca(2+) ; it shows constitutive activ
295 In fluorescence channel, 1 was found to be highly selective to H2S in 50% aqueous buffer (pH 7).
296 everal potent inhibitors; however, so far no highly selective type-II inhibitors have been reported.
297 5 nM) and A3AR antagonist (Ki = 0.31 nM) and highly selective versus A2A; 11 and 26 were most potent
299 ible TR modulators, and the receptors appear highly selective with respect to the ligand structural d
300 plications on strategies for obtaining thin, highly selective zeolite membranes from 2D zeolites in a