ライフサイエンスコーパス: histatin

1 ine-rich proteins, cystatins, statherin, and histatins.

2 s characteristic of PRP-1, PRP-2, PIF-s, and histatins.

3 basic proline-rich proteins, statherin, and histatins.

4 es containing amylase, PRPs, statherins, and histatins.

5 P) patients, the antimicrobial peptide (AMP) histatin 1 (HTN1) was found to be the most differentiall

6 These studies indicated that histatin 1 selectively bound to Cysl and Cys2, whereas s

7 ound to Cysl and Cys2, whereas statherin and histatin 1, 3, and 5 selectively bound to Cys8a.

8 lysozyme, proline-rich proteins, statherin, histatin 1, and mucous glycoprotein 1 were observed.

9 zymatic cleavage sites as K(13) and K(17) in histatin 1, R(22), Y(24), and R(25) in histatin 3, and Y

10 acidic proline-rich proteins, statherin, and histatin 1.

11 beta, secretory IgA, and lower lysozyme, and histatins 1 and 5 were found in patients with cirrhosis,

12 Mathematical models predict that histatins 1, 3, and 5 levels in whole saliva stabilize a

13 M, representing 59, 27, and 11% of glandular histatins 1, 3, and 5 levels, respectively.

14 Pure synthetic histatins 1, 3, and 5 were incubated with whole saliva s

15 The effects of zoledronic acid (1-100 uM), Histatin-1 (10 uM), or their combination was evaluated i

16 The aims of this study were to determine if histatin-1 (H1) is present in normal human tears and whe

17 itulated in endothelial cells (EA.hy926), as Histatin-1 counteracted cytotoxic and antimigratory effe

18 We conclude that Histatin-1 counteracts the cytotoxic and antimigratory e

19 This study aims to unveil the role of Histatin-1 in osteoblastic and vascular cell lineages ch

20 Importantly, Histatin-1 restored both cell viability and migration in

21 The salivary peptide Histatin-1 was recently shown to promote oral wound heal

22 observations highlight the potential use of Histatin-1, in the design of novel therapies aiming to p

23 re on the order of histatin-5 > histatin-3 > histatin-1.

24 ntage, we genetically engineered variants of histatin 3 with one, two, three, or four copies of the f

25 7) in histatin 1, R(22), Y(24), and R(25) in histatin 3, and Y(10), K(11), R(12), K(13), H(15), E(16)

26 fficiency, were on the order of histatin-5 > histatin-3 > histatin-1.

27 partners for the antifungal cationic peptide Histatin 5 (Hst 5) in vivo.

28 Salivary histatin 5 (Hst 5) is a cationic salivary protein with h

29 Human salivary histatin 5 (Hst 5) is a nonimmune salivary protein with

30 Histatin 5 (Hst 5) is a salivary gland-secreted cationic

31 Histatin 5 (Hst 5) is a small cationic human salivary pe

32 Salivary protein histatin 5 (Hst 5) is fungicidal toward Candida albicans

33 ther pathogenic fungi by the catonic protein Histatin 5 (Hst 5) is loss of cytoplasmic small molecule

34 Salivary histatin 5 (Hst 5) kills the fungal pathogen C. albicans

35 Salivary histatin 5 (Hst 5), a potent toxin for the human fungal

36 Histatin 5 (Hst5) is a 24-amino acid (aa) member of the

37 The inhibitory activity of histatin 5 against host and bacterial proteases at physi

38 esidues 9 to 22 showed identical activity to histatin 5 against MMP-9.

39 in these functional characteristics between histatin 5 and dh-5 on the one hand and dhvar1, dhvar4,

40 In contrast, histatin 5 and dh-5 showed fewer or none of these featur

41 dritic cells both demonstrated that 20.0 muM histatin 5 attenuated (p < 0.05) 0.02 muM HagB-induced C

42 ctural modeling studies all demonstrated two histatin 5 binding sites on HagB.

43 In this study, we hypothesized that histatin 5 binds to Porphyromonas gingivalis hemagglutin

44 Histatin 5 bound to immobilized HagB in a surface plasmo

45 more resistant to the antimicrobial peptide histatin 5 but showed essentially normal responses to th

46 hese data indicate that the salivary protein histatin 5 exerts its antifungal function through a mech

47 Fluorimetric measurements showed that histatin 5 induced the formation of reactive oxygen spec

48 Histatin 5 inhibited respiration of isolated C. albicans

49 al proteases, a detailed characterization of histatin 5 inhibition of gingipains from Porphyromonas g

50 e potential mechanistic relationship between histatin 5 interference with the respiratory apparatus a

51 Histatin 5 is a 24-residue peptide from human saliva wit

52 nhibition of the Arg-gingipain revealed that histatin 5 is a competitive inhibitor, affecting only th

53 Thus histatin 5 is capable of attenuating chemokine responses

54 n that the human salivary antifungal peptide histatin 5 is taken up by Candida albicans cells and ass

55 To evaluate the effect of histatin 5 on bacterial proteases, a detailed characteri

56 ing residues 1 to 14 and residues 4 to 15 of histatin 5 showed much lower inhibitory activities (IC50

57 d specifically designed synthetic analogs of histatin 5 to elucidate the role of peptide amphipathici

58 We recently demonstrated that histatin 5 translocates across the yeast membrane and ta

59 Using biotinylated gelatin as a substrate, histatin 5 was found to inhibit the activity of the host

60 ree peptides containing different regions of histatin 5 were synthesized and tested as inhibitors of

61 This study evaluated the potential of histatin 5, a 24-residue histidine-rich salivary antimic

62 re dh-5, comprising the functional domain of histatin 5, and dhvar1 and dhvar4, both designed to maxi

63 Unlike the antifungal peptide histatin 5, it did not require energy-dependent transpor

64 lity of highly protease-susceptible proteins-histatin 5, statherin, and PRP1-was assessed.

65 peptin, antipain, and EDTA could not prevent histatin 5, statherin, or PRP1 degradation in whole sali

66 In contrast to histatin 5, the conventional inhibitors of the respirato

67 nonrespiring yeast cells are insensitive to histatin 5, the potential mechanistic relationship betwe

68 2), K(13), H(15), E(16), K(17), and H(18) in histatin 5.

69 l domain localized in the C-terminal part of histatin 5.

70 proteolytic efficiency, were on the order of histatin-5 > histatin-3 > histatin-1.

71 Human salivary histatin-5 (Hsn-5), a 24-amino acid polypeptide, is a po

72 Histatin-5 (Hst-5) is an antimicrobial, salivary protein

73 r candidacidal activity by using recombinant histatin-5 and its variants produced in Escherichia coli

74 The conformational preferences of histatin-5 and variants were determined by circular dich

75 such as Lys-13 and Arg-22 in the sequence of histatin-5 are, indeed, important for candidacidal activ

76 gnificantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is cru

77 ignificantly less effective than recombinant histatin-5 in killing Candida albicans, suggesting that

78 ns with affinity tags at the N-terminus, and histatin-5, a peptide with multiple histidine residues.

79 Here, we use model peptides of Histatin-5, a salivary peptide with Cu-potentiated antif

80 wever, are comparable to that of recombinant histatin-5, indicating that Arg-12, Lys-17, His-19, and

81 nce for a comprehensive mechanistic model of histatin-5-provoked yeast cell death in which oxygen rad

82 radykinin, neurokinin A, Met-Lys-bradykinin, histatin 8, and a myosin light chain fragment.

83 cytokines/secretory immunoglobulin A (IgA), histatins and lysozyme in a subsequent group.

84 tance to the antifungal activity of salivary histatins and mucins.

85 The candidacidal activity of histatins appears to be a distinctive multistep mechanis

86 Salivary histatins are a family of small histidine-rich peptides

87 line-rich proteins, statherin, and the major histatins are capable of undergoing crosslink reactions

88 Histatins are human salivary gland peptides with anti-mi

89 Salivary histatins are potent in vitro antifungal proteins and ha

90 Histatins are small molecular weight proteins produced b

91 roline-rich proteins (PRPs), statherins, and histatins but not MG1, sIgA, secretory component, or cys

92 tatherin, and some of the lysines present in histatins, could participate in the crosslink reaction.

93 olyphenols to hydroxyapatite, while enriched histatins did not increase binding.

94 ndem repeats, relatively young proteins like histatins do not contain such repeated domains.

95 oring of the appearance and disappearance of histatin fragments yielded the identification of the fir

96 aromyces cerevisiae that mediates binding of histatin (Hst) 5.

97 Salivary histatins (Hsts) are antifungal peptides with promise as

98 Salivary histatins (Hsts) are potent in vitro antifungal agents a

99 ts to a new potential biological function of histatin in the oral cavity.

100 novel fragments of proline-rich proteins and histatins in abundance.

101 ylase, proline-rich proteins, statherin, and histatins in salivary secretions, and the aim of this st

102 rly perfect correlation was observed between histatin-induced inhibition of respiration and cell kill

103 ,6,6-tetramethylpiperidine-N-oxyl, abolished histatin-induced ROS formation in isolated mitochondria.

104 n components of saliva, including cystatins, histatins, lysozyme, and isoforms and/or fragments of al

105 Components identified in pellicle included histatins, lysozyme, statherin, cytokeratins, and calgra

106 Human salivary histatins possess fungicidal and bactericidal activities

107 e rate and mode of degradation of individual histatin proteins in whole saliva to establish the impac

108 consistent with the presence of lysozyme and histatins, respectively, which may represent the major c

109 Also the previous suggestion that the histatin/statherin gene family, located in this region,

110 The purified recombinant histatins were examined for their candidacidal activity

111 a, Cys8b, Cys8c) of MUC5B with statherin and histatins were investigated.

112 s showed that amylase, PRPs, statherins, and histatins were released.

113 line-rich proteins, statherin, and the major histatins, whereas a glutamine-containing dansylated pep

114 uates the structure-function relationship of histatins with regard to their candidacidal activity by