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1 nced the autophosphorylation activity of the histidine kinase.
2 suggest the phosphodonor is instead the EspA histidine kinase.
3 for analysing ligand regulation of a sensor histidine kinase.
4 are sometimes fused into a so-called hybrid histidine kinase.
5 eraction between transmembrane receptors and histidine kinase.
6 n) is phosphorylated by the WalK(Spn) (VicK) histidine kinase.
7 Trimers activate and control the histidine kinase.
8 ly functioning via interaction with the AgrC histidine kinase.
9 different from those observed in prokaryotic histidine kinases.
10 ing methyl-accepting chemotaxis proteins and histidine kinases.
11 lar architecture of KinB is similar to other histidine kinases.
12 um between the inactive and active states of histidine kinases.
13 r specificity in vitro relative to canonical histidine kinases.
14 with a two-state model for ligand control of histidine kinases.
15 0.10 min(-1)] and typical of those of other histidine kinases.
16 le is known about the signals sensed by WalK histidine kinases.
17 lation via a phosphorelay involving multiple histidine kinases.
18 ns of response regulators with their cognate histidine kinases.
19 SR pathways mediated by multiple HWE/HisKA_2 histidine kinases.
20 been identified that directly interact with histidine kinases.
21 gh it has slower kinetics than other similar histidine kinases.
22 ce with the GHKL domain of bacterial sensory histidine kinases.
25 modular proteins consisting of rhodopsin, a histidine kinase, a response regulator, and in some case
26 orelay based on genetic analysis of receptor histidine kinase activity and mutants involving the type
28 alyses of gene expression support a role for histidine kinase activity in eliciting the ethylene resp
30 reversal frequencies, an in vivo measure of histidine kinase activity in the phototaxis system, indi
31 yte phytochromes also retain light-regulated histidine kinase activity lost in the streptophyte phyto
33 1) and ETHYLENE RESPONSE SENSOR1 (ERS1) have histidine kinase activity, unlike the subfamily 2 member
35 a transmembrane region; a cytoplasmic HAMP (histidine kinase, adenylyl cyclases, methyl-accepting ch
36 ely 55 amino acid motifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting c
37 MP domains mediate input-output signaling in histidine kinases, adenylyl cyclases, methyl-accepting c
38 model for PAS (Per-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemo
41 s by sensing the accumulation of AIP via the histidine kinase AgrC and the response regulator AgrA.
42 he histidine phosphotransferase AHP2 and the histidine kinases AHK2 and AHK3, previously reported to
43 the extracellular domain of the Arabidopsis histidine kinase (AHKs) receptors induces autophosphoryl
45 requires the CYTOKININ INDEPENDENT 1 (CKI1) histidine kinase, an activator of the cytokinin signalin
46 cally composed of a membrane-spanning sensor histidine kinase and a cytoplasmic response regulator.
47 signal transduction pathways consisting of a histidine kinase and a response regulator are used by pr
48 tion pathway is conserved in Shewanella, and histidine kinase and flagella-mediated motility are esse
49 idization probes were designed to target the histidine kinase and glyceraldehyde-3-phosphate dehydrog
52 scribed with scnK and scnR, which encode the histidine kinase and response regulator, respectively, o
53 cifically designed to predict pairing of the histidine kinase and response-regulator proteins forming
55 e signal transduction system consisting of a histidine kinase and two response regulators, named here
57 g network that involves integration from two histidine kinases and branching to three response regula
59 ting to summarize an emerging picture of how histidine kinases and cognate response regulators achiev
62 wo-component systems (TCS) comprising sensor histidine kinases and response regulator proteins are am
64 first assess the algorithm's performance on histidine kinases and response regulators from bacterial
66 TCS both modulate phosphorelays comprised of histidine kinases and response regulators, some of which
67 nal transduction systems consist of pairs of histidine kinases and response regulators, which mediate
70 ound a core phosphotransfer reaction between histidine kinases and their output response regulator pr
71 of the algZ [fimS] gene, encoding a putative histidine kinase), and PAO1 DeltaalgR for swarming motil
73 axis, transmembrane chemoreceptors, the CheA histidine kinase, and the CheW coupling protein assemble
75 ncoding the NarL response regulator and NarS histidine kinase are hypothesized to constitute a two-co
76 phosphotransfer activities of a conventional histidine kinase are split onto two distinct proteins th
77 osphorelay in which phosphoryl groups from a histidine kinase are successively transferred via relay
79 avin-binding LOV (light, oxygen, or voltage) histidine kinases are competent to perceive cytoplasmic
83 a to favorable environments by controlling a histidine kinase as a function of chemoreceptor ligand o
84 n addition, we identified His390 of the LytS histidine kinase as the site of autophosphorylation and
85 ically thought to be mediated exclusively by histidine kinases as part of two-component signaling sys
86 e TipN polar marker, and indirectly the PleC histidine kinase, at the cell pole, but it is not requir
88 receipt of a stimulus, a homodimeric sensor histidine kinase autophosphorylates and then transfers i
91 lubolar C-terminal structure, and the sensor histidine kinase BovK contains eight transmembrane segme
92 been demonstrated to occur by their cognate histidine kinases but also by low molecular weight phosp
93 ls binding to sensor domains activate sensor histidine kinases by causing localized strain and unwind
97 ospho-signalling proteins, the transmembrane histidine kinase CckA and the cytoplasmic phosphotransfe
102 ges from a strict linear organization of the histidine kinase CheA in Treponema denticola cells, whic
103 ay, involving the receptor signaling domain, histidine kinase CheA, and adaptor protein CheW, as well
106 heW that interact with the large multidomain histidine kinase CheA, as well as with the transmembrane
107 n CheW, which bridges the chemoreceptors and histidine kinase CheA, is essential for chemotaxis.
108 phosphorylated form of the receptor-coupled histidine kinase CheA, thereby providing a biochemical l
111 nt of the component transmembrane receptors, histidine kinases (CheA) and CheW coupling proteins.
112 e chemoreceptors associated with a dedicated histidine kinase, CheA, and a linker protein, CheW, that
114 ing increases the autophosphorylation of the histidine kinase CheA2, followed by CheY2-mediated depho
115 nt derivatives lacking the chemotaxis master histidine kinase, CheA4, or the central response regulat
116 tners of TlpD, which included the chemotaxis histidine kinase CheAY2, the central metabolic enzyme ac
120 n transporter PiaA, or competence regulatory histidine kinase ComD significantly decreased transmissi
121 y this phosphodiesterase is dependent on the histidine kinase component of the chemotaxis machinery,
122 ea-nodulating endosymbiont, encodes a sensor histidine kinase containing a LOV domain at the N-termin
123 Bioinformatics analysis showed that the SrrB histidine kinase contains several domains, including an
124 of two-component systems, in which multiple histidine kinases converge to PhyR, the phosphorylation
126 se system is comprised of the inner membrane histidine kinase CpxA, the cytosolic response regulator
127 erminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, a
128 hosphorylation of the receiver domain of the histidine kinase CYTOKININ-INDEPENDENT 1 (CKI1RD) from A
129 ansduction proteins such as bacterial sensor histidine kinases, designed to transition between multip
130 rylation is conserved in orthologous sets of histidine kinases despite highly dissimilar loop sequenc
132 have multiple Per/Arnt/Sim (PAS) domains, a histidine kinase domain and a C-terminal receiver (REC)
134 d extent of structural change orientates the histidine kinase domain to elicit the desired light-acti
139 that the coiled coil linker and the attached histidine kinase domains undergo a left handed rotation
141 nditions, its induction is controlled by two histidine kinases, DosS and DosT, and recent experimenta
143 ays for Spo0A activation, one dependent on a histidine kinase encoded by cac0323, the other on both h
144 G antagonizes the bacterial receptor QseC, a histidine kinase encoded within the core Enterobacteriac
146 erization specificity, focusing on the model histidine kinase EnvZ and RstB, its closest paralog in E
148 activation of a minimal, blue-light-sensing histidine kinase from Erythrobacter litoralis HTCC2594,
149 l biosynthesis operon, a bacteriophytochrome-histidine kinase gene and the fnr-type regulatory gene,
151 p phosphorelay system, was phosphorylated by histidine kinase GHK4, which was essential for flagellar
152 ever, the detailed mechanism(s) by which the histidine kinase, GraS, senses specific HD-CAPs is not w
155 alyses reveal that up 1.7% of all identified histidine kinases have the potential to be split and bif
156 requires the presence of a group III hybrid histidine kinase (HHK) and the high osmolarity glycerol
159 ity of downstream signaling proteins such as histidine kinases (HisKa) in a NO-dependent manner.
162 gnaling pathways composed of two proteins: a histidine kinase (HK) and a response regulator (RR).
163 nal transduction system (TCST) consists of a histidine kinase (HK) and a response regulator (RR).
165 ble this reconstitution, coding sequences of histidine kinase (HK) and response regulator (RR) compon
166 lves two-component systems in which a sensor histidine kinase (HK) autophosphorylates in response to
167 we aimed to target the TCS signal transducer histidine kinase (HK) by focusing on their highly conser
168 pically used very high concentrations of the histidine kinase (HK) compared to the RR approximately P
169 ponent systems (TCS) which comprise a sensor histidine kinase (HK) containing a phosphorylatable cata
172 gnal-induced autophosphorylation of a sensor histidine kinase (HK) followed by phosphoryl transfer to
175 ed approach to disrupt a subset of cytokinin histidine kinase (HK) receptors in rice (Oryza sativa) i
178 flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex
183 mbined NMR and crystallographic study on the histidine kinase HK853 and its response regulator RR468
184 arly through phosphotransfer between cognate histidine kinases (HKs) and response regulators (RRs) to
188 the HisKA and HATPase-ATP-binding domains of histidine kinases identified amino acid interactions for
190 o identify the downstream target of the DifE histidine kinase in the regulation of exopolysaccharide
191 en sensor protein AfGcHK is a globin-coupled histidine kinase in the soil bacterium Anaeromyxobacter
192 tivity of the largest family of bifunctional histidine kinases in response to the change of environme
193 y simple orthologous relationships among the histidine kinases in rice and Arabidopsis (Arabidopsis t
194 ation of DNA replication, the essential CckA histidine kinase is activated by phosphorylation, which
195 tation and computation we here show that the histidine kinase is activated by piston-like displacemen
196 udies showed that cheA(2), a gene encoding a histidine kinase, is essential for the chemotaxis of B.
197 ct positions in the Bacillus subtilis sensor histidine kinase KinA and by restoration of activity in
198 N-terminal sensor domain of the cytoplasmic histidine kinase KinA is responsible for detection of th
201 iofilm formation was dependent on the sensor histidine kinase KinD and in particular on an extracellu
202 AI-2 also binds to the dCACHE domains of histidine kinase KinD from Bacillus subtilis and diguany
205 ranscription of either response regulator or histidine kinase leads to the coexistence of an approxim
206 presence of homologous domains in bacterial histidine kinase-like ATP binding region-containing prot
207 e demonstrate that the flavin-binding sensor histidine kinase, LovhK (bab2_0652), functions as a prim
209 Caulobacter crescentus encodes a soluble LOV-histidine kinase, LovK, that regulates the adhesive prop
211 f microrchidia Gyrase, Heat Shock Protein90, Histidine Kinase, MutL (GHKL) ATPases, were previously s
215 mutations in bfmS, which encodes the sensor histidine kinase of the BfmRS two-component system (TCS)
219 s known about the signals sensed by the WalK histidine kinase or the function of the WalJ ancillary p
222 ain response regulator (SDRR) SdrG and seven histidine kinases, PakA to PakG, belonging to the HWE/Hi
223 ese data indicate that Nla28S is the in vivo histidine kinase partner of Nla28 and that the primary f
224 d through phosphorylation from their cognate histidine kinase partners, which in turn facilitates an
226 erichia coli, it was recently shown that the histidine kinase PhoQ is also modulated by at least two
228 orrespond to different states of the sensory histidine kinase PhoR: an inhibition state, an activatio
229 date regulatory controls, mutant strains for histidine kinases PhoR and AioS were employed, and illus
231 ect the localization of two polar cell cycle histidine kinases, PleC and DivJ, and the pole-specific
233 n the tandem sensor domains of a dual-sensor histidine kinase PPHK (phosphorylation-responsive photos
234 rA and the FPI-encoded pdpD, and KdpD is the histidine kinase primarily responsible for phosphorylati
235 interaction screen we further identified the histidine kinase protein KdpD that in many bacteria is a
236 has the in vitro biochemical properties of a histidine kinase protein: it hydrolyzes ATP and undergoe
238 how a single amino acid substitution in the histidine kinase receptor AgrC of ST22 strains determine
239 oorganisms, and each comprises a homodimeric histidine kinase receptor and a cytoplasmic response reg
241 CS) are signalling complexes manifested by a histidine kinase (receptor) and a response regulator (ef
245 xperimental and calculated distances for the histidine-kinase region when both subunits are in a para
246 le, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not partici
248 Two-component signaling pathways involve histidine kinases, response regulators, and sometimes hi
252 We also establish that KinD is a principal histidine kinase responsible for sensing the presence of
253 indicated that the TCS comprising the sensor histidine kinase RgfC and the response regulator RgfA me
255 and ground-state dynamics of the UV form of histidine kinase rhodopsin 1 (HKR1) from eukaryotic alga
257 and some other S. aureus strains, the sensor histidine kinase SaeS has an L18P (T53C in saeS) substit
258 e its importance, the mechanism by which the histidine kinase SaeS recognizes specific host stimuli i
259 ion of RpaA is regulated by two antagonistic histidine kinases, SasA and CikA, which are sequentially
261 a template for signal transduction in sensor histidine kinases.Sensor histidine kinases (SHK) consist
262 lases, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases and
263 nd to and inhibited the intramembrane sensor histidine kinase SGO_1180, thus preventing activation of
264 nsduction in sensor histidine kinases.Sensor histidine kinases (SHK) consist of sensor, linker and ki
265 , usually via phosphotransfer from a cognate histidine kinase, stabilizes the active conformation.
266 In Vibrio species, CqsS is a membrane-bound histidine kinase that acts as the receptor for the CAI-1
268 sitive autoregulatory loop involving KinC, a histidine kinase that is activated by potassium leakage.
270 y, we identified and characterized Nla28S, a histidine kinase that modulates the activity of this imp
271 ion pathways, typically composed of a sensor histidine kinase that receives the input stimuli and the
272 g pathways, which typically involve a sensor histidine kinase that specifically phosphorylates a sing
273 ulation is regulated by at least five sensor histidine kinases that are activated in response to vari
274 ivity and localization of two key regulatory histidine kinases that control cell fate and differentia
275 ial phytochromes are dimeric light-regulated histidine kinases that convert red light into signaling
276 Most species encode numerous paralogous histidine kinases that exhibit significant structural si
277 ermosensor DesK is a multipass transmembrane histidine-kinase that allows the bacterium Bacillus subt
278 K (phosphorylation-responsive photosensitive histidine kinase) that operates a molecular logic OR, by
280 ammable redirection of phosphate flux from a histidine kinase to response regulators based on targeti
281 to follow the flow of phosphate groups from histidine kinases to the cognate response regulators in
282 gate the contribution of the localization of histidine kinases to the establishment of cellular asymm
283 A interacts with DcuS, the membrane embedded histidine kinase, to transfers DcuS to the responsive st
284 rotein was engineered as a functional sensor histidine kinase (TolRSK) and an independent response re
286 hing mechanism, involving HWE/HisKA_2-family histidine kinases, underlies sigma(EcfG) activation.
289 is activated by phosphorylation by multiple histidine kinases via a multicomponent phosphorelay.
291 gain-of-function mutations in the essential histidine kinase WalK, which also elevates expression of
292 sion levels (> 10-fold) of phoR, a P-sensing histidine kinase, were only observed under conditions of
293 old greater than the amount of the WalK(Spn) histidine kinase, which is present at approximately 460
294 d RpBphP3, are configured as light-regulated histidine kinases, which initiate a signal transduction
296 sma0114, encode the proteins Sma0113, an HWE histidine kinase with five PAS domains, and Sma0114, a C
297 echanism underlying interaction of a protein histidine kinase with this tight-binding inhibitor.
299 ilarly, photoreduction of the engineered LOV histidine kinase YF1 to the NSQ modulates activity and d
300 mesS) encoding the predicted cognate sensor (histidine) kinase yielded a mutant with the same inabili