ライフサイエンスコーパス: histone acetylation

1 ion in cells by Western blotting (tubulin vs histone acetylation).

2 unable to differentiate and exhibit altered histone acetylation.

3 3, thus impairing its activity and enhancing histone acetylation.

4 aberrant spreading of contacts that involved histone acetylation.

5 tify spatial and temporal dynamic changes in histone acetylation.

6 nase suppresses T(H)1 cell proliferation and histone acetylation.

7 l memory, a cognitive process that relies on histone acetylation.

8 une activity and changes in global H3 and H4 histone acetylation.

9 s, however, it is unknown whether NO affects histone acetylation.

10 where it induces nucleosome displacement and histone acetylation.

11 ing genes that display putative NO-regulated histone acetylation.

12 e that PAF up-regulates CXCR4 expression via histone acetylation.

13 cancer cell nuclei where it plays a role in histone acetylation.

14 anscriptional activator, p65, which promotes histone acetylation.

15 s mutagenic process can be regulated through histone acetylation.

16 duction and this was accompanied by enhanced histone acetylation.

17 l mechanism of transcriptional regulation is histone acetylation.

18 ulated neuronal genes near sites of elevated histone acetylation.

19 RNAs (eRNAs) and display CBP/p300-dependent histone acetylation.

20 ) indicating it is not a global activator of histone acetylation.

21 actin increased HDAC activity and decreased histone acetylation.

22 combination; and (iii) a general increase in histone acetylation.

23 ted histones stimulate transcription through histone acetylation.

24 ch precludes recruitment of CBP and prevents histone acetylation.

25 is disrupted by histone H3K4 methylation and histone acetylation.

26 etabolites, resulting in re-establishment of histone acetylation.

27 r development and cell viability but not for histone acetylation.

28 ulating the genome via chromatin looping and histone acetylation.

29 ulatory mechanisms linking Wnt signaling and histone acetylation.

30 ransferase (HAT) family of proteins performs histone acetylation.

31 global DNA hypomethylation and increased H4 histone acetylation.

32 trate for de novo lipogenesis as well as for histone acetylation.

33 A (CoA) from glucose resulting in augmented histone acetylation.

34 ional environment and genetic alterations on histone acetylation.

35 g at histone gene promoters where it reduces histone acetylation.

36 ing sites, while enhancers with pre-existing histone acetylation/accessibility confer a permissible c

37 PAX8 recruits histone acetylation activity at bound enhancers looping

38 We demonstrate that the fly ADA complex has histone acetylation activity on histones and nucleosome

39 ferase to the viral promoter, which promoted histone acetylation after ERK-mediated histone phosphory

40 one deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acety

41 led patterns of DNA methylation, deregulated histone acetylation, altered gene expression levels, dis

42 by Wnt3a corresponds to a global decrease in histone acetylation, an epigenetic modification that is

43 disequilibrium with rs16947 (r(2) = 0.9539), histone acetylation analysis showed they are located wit

44 OFD Type I cells exhibit reduced histone acetylation and altered chromatin dynamics in re

45 Histone acetylation and associated gene activation plays

46 ne promoters systematically harbor competing histone acetylation and butyrylation marks at H4 K5 and

47 Distinct histone acetylation and chromatin accessibility signatur

48 dentify additional interactors implicated in histone acetylation and chromatin biology.

49 VOR, an HDACi, induces histone acetylation and chromatin remodeling and modulat

50 Changes in histone acetylation and class IIa histone deacetylases e

51 om abnormal epigenetic alterations including histone acetylation and deacetylation has been demonstra

52 SKI controls histone acetylation and deacetylation of the Rorc locus

53 Histone acetylation and deposition of H2A.Z variant are

54 g aging and whether epigenetic mechanisms of histone acetylation and DNA methylation may contribute t

55 rexpression of which results in elevation of histone acetylation and enhanced ethylene-inducible gene

56 er risk variants are associated with reduced histone acetylation and GARP expression.

57 chnique, we elucidated the temporal order of histone acetylation and gene activation, as well as the

58 glucose and acetate uptake is important for histone acetylation and gene expression.

59 acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and gene regulation, but the precise

60 This effect was accompanied by inappropriate histone acetylation and genome-wide mis-regulation of ge

61 Peripheral blood histone acetylation and HDAC2 gene expression were assoc

62 hese data demonstrate that NMT1, CKII-alpha, histone acetylation and histone acetyl-transferase modul

63 igenetic mechanisms such as DNA methylation, histone acetylation and histone phosphorylation.

64 ashion, with concomitant global reduction of histone acetylation and increased sensitivity of leukemi

65 e TOPLESS/TOPLESS-RELATED family followed by histone acetylation and induction of gene expression.

66 g elements in response to TGF-beta, reducing histone acetylation and inhibiting transcription.

67 g appears to correlate with residue-specific histone acetylation and is able to counteract the detrim

68 ytosolic concentration of acetyl-CoA affects histone acetylation and links metabolism and chromatin s

69 romoter, thereby licensing CBP/p300-mediated histone acetylation and local chromatin opening.

70 pioids promoting higher levels of permissive histone acetylation and lower levels of repressive histo

71 that microbial colonization regulates global histone acetylation and methylation in multiple host tis

72 es are accompanied by dynamic alterations to histone acetylation and methylation levels that are larg

73 ens (NAc), and epigenetic mechanisms-such as histone acetylation and methylation on Lys residues-have

74 strictly ordered epigenetic markers such as histone acetylation and methylation, as well as recruitm

75 from GPR41 and GPR43 but were accompanied by histone acetylation and mimicked by trichostatin A, a pa

76 31, SUM149) revealed that Stattic attenuated histone acetylation and neutralized effects of the histo

77 stinct patterns of DNase I hypersensitivity, histone acetylation and NFAT1 transcription factor bindi

78 data define the molecular connection between histone acetylation and Nr4a gene expression after learn

79 deling and deacetylation complex to regulate histone acetylation and nucleosome occupancy in the beta

80 ts discernable by differential regulation of histone acetylation and recruitment of STAT3, CDK8 and c

81 animals to environmental enrichment enhances histone acetylation and reopens juvenile-like plasticity

82 Analysis of histone acetylation and RNA-seq reveals that HDAC3-defic

83 DTPs exhibited reduced histone acetylation and sensitivity to HDAC inhibitors (

84 f STAT3 phosphorylation and demonstrate that histone acetylation and STAT3 tyrosine705 phosphorylatio

85 pyruvate dehydrogenase (PDH), which induced histone acetylation and subsequently promoted the differ

86 that Stattic directly or indirectly reduces histone acetylation and suggest reevaluation of Stattic

87 ng adipocyte differentiation is regulated by histone acetylation and the binding protein bromodomain

88 tingly, acetate supplementation rescues both histone acetylation and the differentiation defects.

89 Histone acetylation and the families of enzymes responsi

90 or instance, we discovered crosstalk between histone acetylation and the glycolytic pathway resulting

91 yl-CoA generation 'on-site' at chromatin for histone acetylation and the transcription of key neurona

92 red for maintaining chromatin accessibility, histone acetylation and transcription factor binding spe

93 ncentrations of acetyl-coenzyme A to enhance histone acetylation and transcription of Ifng Ablation o

94 resumptive neuroectoderm, resulting in their histone acetylation and transcriptional activation.

95 Both histone acetylation and trimethylation of H3K4 (H3K4me3)

96 We found that the downregulation of histone acetylation and upregulation of HDAC1 expression

97 els in cells by western blotting (tubulin vs histone acetylation), and by assessing their effects on

98 duced cytosine hydroxymethylation, decreased histone acetylation, and altered expression levels of mu

99 ulate histone acetyltransferase recruitment, histone acetylation, and chromatin accessibility at RARa

100 ne methylations occur first in prometaphase, histone acetylation, and CTCF in anaphase/telophase, tra

101 rhythms of epigenetic modification including histone acetylation, and DNA methylation.

102 alyzed by Bicoid and Zelda, possibly through histone acetylation, and found that this model can predi

103 e element binding protein (ChREBP) activity, histone acetylation, and gluco-lipogenic gene expression

104 myelination depends on chromatin remodeling, histone acetylation, and methylation, which all affect S

105 romatin, spatial arrangement of nanodomains, histone acetylation, and methylation.

106 omatin, leading to an increase and spread of histone acetylation, and prevents the positioning of RNA

107 e in ACSS2 lowers nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the co

108 ort and the malate-aspartate shuttle promote histone acetylation, and specifically regulate the expre

109 KG2D ligands include PI-3 kinase activation, histone acetylation, and the integrated stress response.

110 Ethanol markedly changes histone acetylation, and the sirtuin Sir2/SIRT1 that dea

111 results indicate that DNA demethylation and histone acetylation are coordinated to generate the tran

112 Our results reveal PCAF and histone acetylation as critical regulators of fork stabi

113 Histone acetylation assays with purified variant KAT5 de

114 of early and late inflammatory genes rely on histone acetylation associated with recruitment of histo

115 ACLY facilitates histone acetylation at double-strand break (DSB) sites,

116 he transcriptional coactivator p300 mediates histone acetylation at DUSP4, prompting increased gene e

117 thereby inducing autophagy and reduction of histone acetylation at effector and exhaustion loci, whi

118 ts the availability of acetyl coenzyme A for histone acetylation at genes encoding inflammatory media

119 te that Geminin associates with and promotes histone acetylation at neurodevelopmental genes, while G

120 ith TFIIB but for transit into elongation by histone acetylation at other genes.

121 of p300 and CBP to DSBs and the induction of histone acetylation at sites of damage.

122 Our work shows that histone acetylation at specific sites at G1/S target gen

123 creased nuclear acetyl-CoA levels, increased histone acetylation at the FOXP3 promotor and induction

124 Calcitriol attenuated specific histone acetylation at the Il9 gene.

125 data support the notion that the balance of histone acetylation at the Nr4a promoters is critical fo

126 ransferase, p300/CBP, resulting in increased histone acetylation at the promoter of Puma.

127 th gene activation and we observed decreased histone acetylation at the promoters of cell cycle genes

128 terations, but no changes in the patterns of histone acetylation at the proximal regulatory regions o

129 cetylases, which corresponded with decreased histone acetylation at the TNF and IL6 promoters.

130 ed cancer cells show widespread increases in histone acetylation at transcriptionally enhanced genes,

131 r function of PCAF that bound TIP60-mediated histone acetylations at DSBs to recruit a DUB complex to

132 hose regions with significant differences in histone acetylation between tissues.

133 ranslation is blocked, whereas inhibition of histone acetylation blocks genome activation.

134 ted production of acetyl-CoA, which promotes histone acetylation, BRCA1 recruitment, and subsequent H

135 is increased pS81 enhances p300 recruitment, histone acetylation, BRD4 binding and subsequent further

136 In addition, inhibition of histone acetylation by anacardic acid reduces the UV-B i

137 ween the remodeling activity of SMARCAD1 and histone acetylation by CBP sheds light on the function o

138 ogens, inhibited HDAC activity and increased histone acetylation by inducing endogenous NO production

139 Histone acetylation by p300 antagonizes chromatin phase

140 uired RHO family GTPase signaling and caused histone acetylation by p300/CBP, chromatin remodeling, a

141 f1 and Vps75 can increase the specificity of histone acetylation by Rtt109, but neither alter selecti

142 These data suggest that NO affects histone acetylation by targeting and inhibiting HDAC com

143 th activator-bound p300 that facilitate core histone acetylation (by p300) and concomitant eviction o

144 Mutation of these sites disrupts histone acetylation changes in response to DNA damage, B

145 Despite previous reports that showed histone acetylation changes upon using these agents, the

146 ryonic stem cells Myst2 is part of H3 and H4 histone acetylation complexes similar to those described

147 targeting HMGN1 or its downstream effects on histone acetylation could be therapeutically active in A

148 nalyses to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral prefronta

149 d to modulate epigenetic mechanisms, such as histone acetylation/deacetylation balance, in part via h

150 roles of histone methylation/demethylation, histone acetylation/deacetylation, chromatin remodeling,

151 usion, dominant missense KAT5 variants cause histone acetylation deficiency with transcriptional dysr

152 l and ligand-inducible Ah responsiveness and histone acetylation, demonstrating that acetate was an H

153 odulated by epigenetic mechanisms, including histone-acetylation dependant pathways.

154 AMPK deletion reduced acetyl-CoA and histone acetylation, displacing BET proteins from chroma

155 ed the method to an AD dataset consisting of histone acetylation, DNA methylation, and RNA transcript

156 estigated a role for metabolic regulation of histone acetylation during the DNA damage response.

157 olic changes were coordinated with increased histone acetylation during transdifferentiation.

158 a recruitment hierarchy, where NSL-deposited histone acetylation enables BRD4 recruitment for transcr

159 XAB2 also promotes histone acetylation events linked to HR proficiency.

160 Subsequent increases in histone acetylation facilitate recruitment of the coacti

161 SRC-1-p300 complex to promote H4K5 and H4K16 histone acetylation, facilitating transcription of CXCR4

162 sion, miRNA expression, DNA methylation, and histone acetylation from ASD and control brains to ident

163 r levels of acetyl-CoA, resulting in altered histone acetylation, gene expression, cytoskeletal archi

164 al sex-dependent manner, including decreased histone acetylation (H3K27 acetylation) and increased pr

165 ZRS, recruits p300, which is associated with histone acetylation (H3K27ac) indicative of an active en

166 ression, which also associates with elevated histone acetylation (H3K27ac).

167 Histone acetylation has a regulatory role in gene expres

168 The discovery of acyl marks, besides histone acetylation, has added to the functional diversi

169 to the chromatin state, specifically through histone acetylation, has an important role in the regula

170 Thus, bromodomain readers of histone acetylation have emerged as attractive targets f

171 ive SphK2 inhibitor K-145, that nuclear S1P, histone acetylation, HIF-1alpha expression, and TNBC tum

172 Histone acetylation homeostasis, maintained by the antag

173 e a hierarchical view about the functions of histone acetylation in auxin signaling and root morphoge

174 ype, while histone methylation in D2-MSNs or histone acetylation in D1-MSNs increases resilience to s

175 We report that Fosb-targeted histone acetylation in D2-MSNs or histone methylation in

176 ucleoid compaction, analogous to the role of histone acetylation in eukaryotes.

177 Here we investigate the role of histone acetylation in G1/S transcriptional regulation i

178 ty, we also detected increased SAGA-mediated histone acetylation in H4 basic patch mutants.

179 ociation between these specific TF and local histone acetylation in human hearts.

180 indicated that butyrate redistributed global histone acetylation in human mast cells, including signi

181 e the significance of nuclear ACSS2-mediated histone acetylation in maintaining cell homeostasis and

182 d evidence that CUDC-907 treatment increased histone acetylation in MCL cells.

183 Lastly, CUDC-907 treatment increased histone acetylation in MCL cells.

184 he effects of HFD on levels of acyl-CoAs and histone acetylation in mouse white adipose tissue (WAT),

185 -CoA synthetase 2 (ACSS2) directly regulates histone acetylation in neurons and spatial memory in mam

186 Histone acetylation in neurons may thus be under the inf

187 The role of histone acetylation in plant defense is well established

188 Reciprocal histone acetylation in TH+ and SST+ neurons indicates th

189 How can we regulate histone acetylation in the adult brain in a noninvasive

190 teracting protein that functions to regulate histone acetylation in the EGFL7/miR-126 promoter/enhanc

191 ent studies have elucidated the functions of histone acetylation in the modulation of auxin signaling

192 The involvement of histone acetylation in the regulation of transcription w

193 d CREB phosphorylation, CBP recruitment, and histone acetylation in these promoters.

194 er, but the impact of diet on acetyl-CoA and histone acetylation in these tissues remains unknown.

195 at a time after learning marked by promoter histone acetylation in wild-type mice.

196 ncy is regulated by Brd4- and P300-dependent histone acetylation in zebrafish.

197 he pancreas, HFD also impacted the levels of histone acetylation; in particular, histone H3 lysine 23

198 Histone acetylation, including acetylated H3K14 (H3K14ac

199 Histone acetylation increased in TH+ neurons and decreas

200 min A/C binding was accompanied by increased histone acetylation, increased c-Jun binding, and upregu

201 Histone acetylation is a fundamental epigenetic mechanis

202 Histone acetylation is generally associated with active

203 In the absence of Setd5, histone acetylation is increased at transcription start

204 The Wnt-induced decrease in histone acetylation is independent of beta-catenin signa

205 enhancers, a more comprehensive analysis of histone acetylation is required than has previously been

206 chanistically, A-485 inhibited p300-mediated histone acetylation, leading to disruption of BRD4-NUT b

207 eviction in spermiogenesis and that loss of histone acetylation leads to defects that disrupt male f

208 y, exposure of histones to acrolein prior to histone acetylation leads to the inhibition of remodelin

209 nd in human RCC tumors correlate with higher histone acetylation levels (H3K9, H3K14, or both) at reg

210 nce that diet can impact tissue acyl-CoA and histone acetylation levels and that acetyl-CoA abundance

211 Such interaction regulates histone acetylation levels at heterochromatin and promot

212 HDAC) inhibitor was accompanied by increased histone acetylation levels at this promoter region.

213 CoA in the nucleus and cytosol and regulates histone acetylation levels in many cell types.

214 ifferentiation by controlling acetyl-coA and histone acetylation levels, identifying a link between m

215 e deacetylases and quantitatively determines histone acetylation levels, transcriptional activity, an

216 ed adipocytes also suppressed acetyl-CoA and histone acetylation levels.

217 acellular antibody, is capable of monitoring histone-acetylation levels in both cultured cells and li

218 Using these two parameters, endogenous histone-acetylation levels were quantified over a high d

219 found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved ac

220 examined changes to the enhancer-associated histone acetylation mark H3K27ac by mapping matched tumo

221 tore ADA3-dependent global or locus-specific histone acetylation marks and cell proliferation in Ada3

222 and deacetylase activities established that histone acetylation marks are necessary for both hot spo

223 CAF complex, and enhances PCAF occupancy and histone acetylation marks at E2F1-target promoters.

224 conclude that there are functional roles for histone acetylation marks at mammalian meiotic recombina

225 Although over 35 different histone acetylation marks have been described, the overw

226 ne (GSNO) increased the abundance of several histone acetylation marks in Arabidopsis (Arabidopsis th

227 we reveal that BRD4, an epigenetic reader of histone acetylation marks, is necessary for enhancing br

228 DAC1 and licensing the removal of activating histone acetylation marks.

229 n, hypoxic activation of HIF-1, and specific histone acetylation marks.

230 ving low LINC00152 expression indicated that histone acetylation may be one mechanism underlying LINC

231 on manifests in RNA-dependent changes in the histone acetylation mediated by CBP, such as H3K27ac, an

232 loci expression remained unaltered following histone acetylation-mediated increased accessibility.

233 esis, germ cell chromatin undergoes dramatic histone acetylation-mediated reorganization, whereby 90%

234 , but not p35, is selectively upregulated by histone acetylation-mediated transcription, which underl

235 roduced synchronized diurnal oscillations in histone acetylation, metabolic gene expression, and nutr

236 Data is in the form of genome wide maps of histone acetylations, methylations, and histone variant

237 y role in plasticity and so we asked whether histone acetylation might be dysregulated in TSC.

238 Our data suggests that histone acetylation might modulate the amplitude of G1/S

239 tional modifications, but it is not known if histone acetylation modulates base excision repair of DN

240 he genomic alterations of the genes encoding histone acetylation modulator proteins (HAMPs) in the Ca

241 drug discovery efforts has been on targeting histone acetylation modulators.

242 acetylase inhibition abrogates the decreased histone acetylation observed upon iron deprivation and r

243 Given our recent finding that targeted histone acetylation of Cdk5 regulates stress responsivit

244 deacetylases (HDACs 1/2), thereby decreased histone acetylation of H3K9/14ac and H4K8ac.

245 Finally, targeted histone acetylation of hippocampal Cdk5 promoter attenua

246 ng of immune cells occurs via alterations in histone acetylation of immune cytokines in vivo and in v

247 yte-derived macrophages restored the reduced histone acetylation on cytokine promoters and the decrea

248 ide transcriptional competency by regulating histone acetylation on the first zygotic genes in zebraf

249 In order to examine the influence of histone acetylation on the initial steps of BER, we asse

250 RD4 depletion reduced P-TEFb recruitment and histone acetylation on the transcribed region of the Adi

251 ption factors, or epigenetically by aberrant histone acetylation or DNA methylation, and posttranscri

252 hat ADA3 is required for establishing global histone acetylation patterns and for normal cell cycle p

253 f up-regulated transcripts are closer to the histone acetylation peaks in hda6 compared to the wild-t

254 results suggest that the loss or absence of histone acetylation, perhaps at stalled forks, may contr

255 Histone acetylation plays a central role in gene regulat

256 Histone acetylation plays a pivotal role in transcriptio

257 Since histone acetylation plays important roles in DNA repair

258 Our findings demonstrate that Gcn5-mediated histone acetylation promotes chromatin accessibility and

259 We postulate that metabolic licensing of histone acetylation provides another layer of control th

260 To identify cardiac histone acetylation quantitative trait loci (haQTLs), we

261 Together, our data identify ENL as a histone acetylation reader that regulates oncogenic tran

262 s including the histone acetylases P300/CBP, histone acetylation readers including BRDs, the Mediator

263 robust gene activation, whereas MyoD induces histone acetylation, recruits Pol II, and robustly activ

264 Histone acetylation regulates chromatin structure and ge

265 sm-associated changes in gene expression and histone acetylation require TRbeta1.

266 ent revealed a critical role for CBP/p300 in histone acetylation required for the transcriptional act

267 For instance, increases in levels of histone acetylation seem to protect kidneys from AKI and

268 inflammation, suggested a putative role for histone acetylation signaling in the altered hypertrophy

269 , a figure comparable to the known number of histone acetylation sites.

270 ual cortex, linking this effect to increased histone acetylation, specifically at the BDNF gene level

271 g resistance, respectively, was sensitive to histone acetylation status.

272 Histone acetylation such as H3K27ac is an excellent mark

273 he crosstalk between ERalpha methylation and histone acetylation that governs the epigenetic regulati

274 f these nucleosomes in a mechanism involving histone acetylation that is poorly understood.

275 s the thermal induction of POR genes through histone acetylation that promotes the accessibility of R

276 gh expression of Myc and patterns of altered histone acetylation that were localized to intragenic re

277 The corepressor SIN3 controls histone acetylation through association with the histone

278 Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene

279 expression of zinc finger proteins targeting histone acetylation to the Cdk5 promoter was paired with

280 XNIP expression is associated with increased histone acetylation, transcription factor [Abeta(42) or

281 ochromatin regions, which leads to increased histone acetylation, transcription of repeats, and the d

282 cale datasets comprising of DNA methylation, histone acetylation, transcriptome- and genome-wide asso

283 re ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-C

284 to the MSMP enhancer region was decreased by histone acetylation under hypoxic conditions in cancer c

285 g nuclear tension and causing an increase in histone acetylation via deactivation of histone deacetyl

286 MYST3 is involved in histone acetylation via its histone acetyltransferase do

287 AP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C ter

288 ly identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to

289 the interaction between the YEATS domain and histone acetylation via structure-based mutagenesis redu

290 However, in IR64, histone acetylation was observed only during salt stress

291 To understand the role played by the histone acetylation, we also treated our animals with an

292 In the liver, no significant effects on histone acetylation were observed with a HFD despite low

293 +)/NADH ratio, which correlates with nuclear histone acetylation, whereas nuclear NAD(+)/NADH ratio c

294 These compounds increase histone acetylation, which correlates with the synergist

295 Histone acetylation, which is an important mechanism to

296 (IECs) after allo-BMT resulted in decreased histone acetylation, which was restored after local admi

297 Pharmacologically, modulating histone acetylation with acetyl-L-carnitine (LAC) or ace

298 criptional control of MITF by p300-dependent histone acetylation within proximal gene regulatory regi

299 de but have distinct functions: Myf5 induces histone acetylation without Pol II recruitment or robust

300 Fs build SEs that have the highest levels of histone acetylation, yet paradoxically the same SEs also