ライフサイエンスコーパス: histone deacetylase 1

1 ves SMAD4 (SMAD family member 4) and HDAC-1 (histone deacetylase 1).

2 n the recruitment of the co-repressor HDAC1 (histone deacetylase 1).

3 ing its sumoylation-dependent recruitment of histone deacetylase 1.

4 1 in cooperation with DNMT1 and, apparently, histone deacetylase 1.

5 is increase is reversed by overexpression of histone deacetylase 1.

6 with histone deacetylase 2 and of REST with histone deacetylase 1.

7 cued, at least in part, by the inhibition of histone deacetylase 1.

8 strain of Neurospora crassa with inactivated histone deacetylase 1.

9 and decreased expression of the corepressor histone deacetylase 1.

10 including the mSin3A protein and (for PLZF) histone deacetylase-1.

11 amily of multiprotein complexes that contain histone deacetylase 1/2 (HDAC1/2) and the histone demeth

12 r receptors and Atrophin-2 selectively binds histone deacetylase 1/2 (HDAC1/2) through its ELM2 (EGL-

13 h is associated with Sp1 directly or through histone deacetylase 1/2, respectively, at the promoter.

14 b dephosphorylation and its interaction with histone deacetylase 1/2.

15 ated by DNA methyltransferase1/3 (DNMT1/3)-, histone deacetylase 1/2/4 (HDAC1/2/4)-, Setdb1/Suv39h1-,

16 80, and a PHD zinc-finger subunit as well as histone deacetylases 1/2 and an MTA-like subunit, the tr

17 HD pathophysiology, we found that inhibiting histone deacetylase 1/3 activities rectified several fun

18 how that MUC1-C increases the recruitment of histone deacetylases 1/3, deacetylation of core histones

19 reporter system, we established that HDAC-1 (histone deacetylase 1), a gene that is frequently overex

20 coding ICP22 mediated the phosphorylation of histone deacetylase 1, a function of U(S)3 protein, but

21 Interestingly, histone deacetylase 1, a protein responsible for epigene

22 Histone deacetylase 1 acted as a corepressor of VEGF-C e

23 Histone deacetylase 1 activates PU.1 gene transcription

24 The role of histone deacetylase 1 and 2 (HDAC1 and HDAC2) in regulat

25 Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin

26 Histone deacetylase 1 and 2 (HDAC1/2) regulate histone a

27 We show that inhibition of histone deacetylase 1 and 2 (HDAC1/2) specifically count

28 ation was associated with the recruitment of histone deacetylase 1 and 2 to the endogenous c-myc gene

29 histone deacetylase 1 and combined knockdown histone deacetylase 1 and 2.

30 ne 3 (H3) methylation and the recruitment of histone deacetylase 1 and 3 with the concomitant deacety

31 Histone deacetylase 1 and a corepressor, mSin3A, were id

32 rescued the BPA effects as did knockdown of histone deacetylase 1 and combined knockdown histone dea

33 enhancer factor 1 and Pitx2, by dismissal of histone deacetylase 1 and loss of its enzymatic activity

34 The TATA binding protein, p53, histone deacetylase-1 and mSin3a could be co-immunopreci

35 This was associated with increased levels of histone deacetylase-1 and surprisingly an increase in H4

36 ity and can also be induced by inhibition of histone deacetylases 1 and 2 (HCAC 1/2), which is one of

37 Cellular proteins such as histone deacetylases 1 and 2 (HDAC1 and -2) also contain

38 Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucia

39 ses approximately 10 subunits, including the histone deacetylases 1 and 2 (HDAC1 and HDAC2), and is d

40 We show here that histone deacetylases 1 and 2 (HDAC1/2) are essential for

41 Histone deacetylases 1 and 2 (HDAC1/2) form the core cat

42 In the nucleus, SK2 binds to and inhibits histone deacetylases 1 and 2 (HDAC1/2).

43 enitors in the lung endoderm is regulated by histone deacetylases 1 and 2 (Hdac1/2).

44 This report examines the effects of histone deacetylases 1 and 2 (HDAC1/HDAC2) on MHC-II gen

45 The interaction of the co-repressors histone deacetylases 1 and 2 as well as lysyl oxidase-li

46 how that REST assembles with CoREST, mSin3A, histone deacetylases 1 and 2, histone methyl-transferase

47 conserved from nematodes to man and contains histone deacetylases 1 and 2, the MIDEAS corepressor pro

48 Cabin1 recruits mSin3 and its associated histone deacetylases 1 and 2; Cabin1 also competes with

49 s Mi-2beta, Sin3A, and Sin3B and the Class I histone deacetylases 1 and 2; the N-terminal domain can

50 sed presence of corepressor proteins such as histone deacetylases 1 and 3 and silencing mediator of r

51 ing motifs is also sufficient for binding to histone deacetylases 1 and 3, and both of these domains

52 termined whether MS-275, an inhibitor of the histone deacetylases 1 and 3, can inhibit these changes.

53 ubiquitin-related modifier-1, interacts with histone deacetylase 1, and represses c-Myb-mediated tran

54 65 acetylation was reversed by inhibitors of histone deacetylase 1, and the inhibitors partially rest

55 ding protein 2, Enhancer of Zeste homolog 2, histone deacetylase 1, and UHRF1, but it does require an

56 his work, we found that the levels of HDAC1 (histone deacetylase 1) are increased in quiescent livers

57 ted an in vivo CRISPR screen that identified histone deacetylase 1 as a target to reverse anti-PD-1 r

58 olleagues identified the CoREST complex, via histone deacetylase 1, as a vulnerability that can be ta

59 mediator for retinoid and thyroid receptors/histone deacetylase 1-associated repressor protein (SHAR

60 tion of a single nucleosome, to which it and histone deacetylase 1 bind.

61 Deletion of ARID1A resulted in loss of histone deacetylase 1 binding, increased histone 4 lysin

62 promoted the interaction of p68 and p72 with histone deacetylase 1 but had no effect on binding to hi

63 s mediated by CCAAT/Enhancer Binding Protein/histone deacetylase 1 (C/EBPbeta-HDAC1) complexes, which

64 ion in rhabdoid cells by directly recruiting histone deacetylase 1 complex to its promoter, leading t

65 These factors include histone deacetylase 1, de novo DNA methyltransferase 3A,

66 lear role for beta-catenin in preventing the histone deacetylase 1-dependent inhibitory functions of

67 roperties of purified recombinant Drosophila histone deacetylase 1 (dHDAC1, also known as dRPD3).

68 ocytes from SLE patients through a gene-wide histone deacetylase 1-directed deacetylation of histone

69 We show that chromium cross-links histone deacetylase 1-DNA methyltransferase 1 (HDAC1-DNM

70 We found that 2-aminoacetophenone regulates histone deacetylase 1 expression and activity, resulting

71 STAT3, DNMT1, and histone deacetylase 1 form complexes and bind to the SHP

72 lation of retinoblastoma protein, release of histone deacetylase 1 from the retinoblastoma protein in

73 increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcriptio

74 In contrast, directing histone deacetylase-1 (HD1) to a promoter using the GAL4

75 bition of maternal and zygotic expression of histone deacetylase 1 (HDA-1) causes embryonic lethality

76 The induced heterochromatin required histone deacetylase 1 (HDA-1), with an intact catalytic

77 In the absence of HISTONE DEACETYLASE-1 (HDA-1), PRC2-methylated genes wer

78 DNA methylation is deficient in a histone deacetylase 1 (HDA1) mutant (hda-1) strain of Ne

79 tone H3 (H3), acetylated histone H3 (AC-H3), histone deacetylase 1 (HDAC)1, tumor necrosis factor-alp

80 hat nuclear Bcl-3 associates with STAT-1 and histone deacetylase 1 (HDAC-1), increasing HDAC-1 recrui

81 ctivity of p300 and inhibits the activity of histone deacetylase 1 (HDAC-1), which then leads to an i

82 ng C-terminal-binding protein-1 (CtBP-1) and histone deacetylase-1 (HDAC-1) at the silencer E2-box.

83 way combinations of PLK1 inhibitors with the histone deacetylase-1 (HDAC-1) inhibitor Entinostat and

84 Here, we show that deregulation of histone deacetylase 1 (HDAC1) activity by p25/Cdk5 induc

85 Both kinases phosphorylate histone deacetylase 1 (HDAC1) and HDAC2 and enable the e

86 Histone deacetylase 1 (HDAC1) and HDAC2 are components o

87 Furthermore, we found that histone deacetylase 1 (HDAC1) and HDAC2 are recruited by

88 Histone deacetylase 1 (HDAC1) and HDAC2 are responsible

89 icient B cells had decreased accumulation of histone deacetylase 1 (HDAC1) and HDAC2 at the Cd86 locu

90 of B-hydroxybutyrate to lysine (Kbhb), while histone deacetylase 1 (HDAC1) and HDAC2 enzymatically re

91 ssion of FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC

92 we show that DeltaNp63alpha associates with histone deacetylase 1 (HDAC1) and HDAC2 to form an activ

93 Since both EBNA3C and CtBP interact with histone deacetylase 1 (HDAC1) and HDAC2, we examined whe

94 ly ORF66p results in hyperphosphorylation of histone deacetylase 1 (HDAC1) and HDAC2.

95 Herein we report that CBHA and SAHA inhibit histone deacetylase 1 (HDAC1) and histone deacetylase 3

96 romoter DNA, resulting in the recruitment of histone deacetylase 1 (HDAC1) and inhibition of the asso

97 responsible for the neurotoxic potential of histone deacetylase 1 (HDAC1) and its subcellular locali

98 dicate that the effect of CRISPR knockout of Histone Deacetylase 1 (HDAC1) and numerous individual re

99 HDRP also interacts with histone deacetylase 1 (HDAC1) and recruits it to the c-J

100 d that Nkx3.2 forms a complex, in vivo, with histone deacetylase 1 (HDAC1) and Smad1 and -4 in a BMP-

101 that PIASy can interact constitutively with histone deacetylase 1 (HDAC1) and that addition of HDAC

102 roximal promoter of Pdx1, recruitment of the histone deacetylase 1 (HDAC1) and the corepressor Sin3A,

103 tides with G9a histone methyltransferase and histone deacetylase 1 (HDAC1) and the disruption of thei

104 we demonstrated that the acetylase PCAF and histone deacetylase 1 (HDAC1) are in close spatial proxi

105 aser enzymes lysine demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) are known to have dramatic

106 n cycling cells, estrogen receptor alpha and histone deacetylase 1 (HDAC1) are recruited to the proxi

107 munoprecipitation that Twist interacted with histone deacetylase 1 (HDAC1) at the ER promoter, causin

108 acid and thyroid hormone receptor (SMRT) or histone deacetylase 1 (HDAC1) at the same sites.

109 Furthermore, histone deacetylase 1 (HDAC1) bound the AR both in vivo

110 GSK3beta promoter is repressed by C/EBPbeta-histone deacetylase 1 (HDAC1) complexes, leading to the

111 expectedly, it also interacts with Sin3A and histone deacetylase 1 (HDAC1) corepressors via its zinc

112 N-CoR, mammalian Sin3 (mSin3A and B), and histone deacetylase 1 (HDAC1) form a complex that alters

113 n with metals or VEGF led to dissociation of histone deacetylase 1 (HDAC1) from the promoter, leading

114 Histone deacetylase 1 (HDAC1) has been linked to cell gr

115 e hTERT promoter via deacetylation of Sp3 by histone deacetylase 1 (HDAC1) in A549 human lung adenoca

116 delling factor and transcriptional repressor Histone deacetylase 1 (Hdac1) in endodermal organogenesi

117 histone lysine methyltransferase G9a and the histone deacetylase 1 (HDAC1) in order to modify the chr

118 ted the role of the key epigenetic regulator histone deacetylase 1 (HDAC1) in the differentiation of

119 Further mechanism analyses show that histone deacetylase 1 (HDAC1) interacts with Daxx and bi

120 demonstrate that the recently characterized histone deacetylase 1 (HDAC1) interacts with Sin3A and S

121 al regulation of p73 by HDACs and found that histone deacetylase 1 (HDAC1) is a key regulator of TAp7

122 Histone deacetylase 1 (HDAC1) is a nuclear enzyme involv

123 a chromatin-remodeling NuRD complex in which histone deacetylase 1 (HDAC1) is associated with several

124 Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integ

125 e report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC.

126 in helicase DNA-binding protein 4 (CHD4) and histone deacetylase 1 (HDAC1) occupy the promoters of se

127 In this study, we have analyzed the role of histone deacetylase 1 (HDAC1) on HTLV-1 gene expression

128 and SOX11 expression was also observed after histone deacetylase 1 (HDAC1) or HDAC2 was depleted by R

129 that C/EBPalpha diminishes the occupation of histone deacetylase 1 (HDAC1) or HDAC3 on the endogenous

130 Pharmacological treatment or silencing of histone deacetylase 1 (Hdac1) or histone deacetylase 2 (

131 how that the NRE constitutively binds to the histone deacetylase 1 (HDAC1) present in GH(3 )cells.

132 Here, we show that histone deacetylase 1 (Hdac1) progressively binds to the

133 to the DNA-binding domain of Slug, impeding histone deacetylase 1 (HDAC1) recruitment and antagonizi

134 ment to c-Myc target promoters and increased histone deacetylase 1 (HDAC1) recruitment, thereby decre

135 Histone Deacetylase 1 (HDAC1) removes acetyl groups from

136 otein complex comprised of MRG15, Sin3B, and histone deacetylase 1 (HDAC1) that functions as a transc

137 pressors DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1) through its distinct domai

138 of HBx, histone acetyl-transferase P300 and histone deacetylase 1 (HDAC1) to circularized HBV DNA (w

139 BRG1 (Brahma-related gene 1) cooperates with histone deacetylase 1 (HDAC1) to regulate Nanog expressi

140 desensitizes c-fos expression by recruiting histone deacetylase 1 (HDAC1) to the c-fos gene promoter

141 st factors YY1 and LSF cooperatively recruit histone deacetylase 1 (HDAC1) to the HIV-1 long terminal

142 in mouse lung epithelial cells by recruiting histone deacetylase 1 (HDAC1) to the promoters of Ifna a

143 n and its DNA-binding activity by recruiting histone deacetylase 1 (HDAC1) to the protein complexes.

144 er (ASE) region in Pitx2 gene and recruiting histone deacetylase 1 (HDAC1) to this region.

145 Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was shown previously to pr

146 Ago1), DNA methyltransferase 3a (DNMT3a) and histone deacetylase 1 (HDAC1) were required for the init

147 factor that has been shown to interact with histone deacetylase 1 (HDAC1) when cotransfected in huma

148 Association of histone deacetylase 1 (HDAC1) with the promoter decrease

149 Interestingly, histone deacetylase 1 (HDAC1), a major HDAC responsible

150 ing viral UL69 and cellular cyclin T1, Brd4, histone deacetylase 1 (HDAC1), and HDAC2.

151 g transcription factor corepressor (CoREST), histone deacetylase 1 (HDAC1), and histone deacetylase 2

152 US in DDR involved a direct interaction with histone deacetylase 1 (HDAC1), and the recruitment of FU

153 NLK can directly phosphorylate histone deacetylase 1 (HDAC1), as well as T cell factor/

154 n with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and dec

155 IL-1beta, (GRIK2/3), TGF-beta2, TGF-betaR1, histone deacetylase 1 (HDAC1), death associated protein

156 sely, on cFLIP promoter, NF-kappaB increases histone deacetylase 1 (HDAC1), decreases p300 and histon

157 /2 co-regulate enhancers by interacting with histone deacetylase 1 (HDAC1), HDAC2 and lysine-specific

158 ases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3.

159 that several deacetylase enzymes, including histone deacetylase 1 (HDAC1), HDAC8, and HDAC6, influen

160 f repressive epigenetic modifiers, including histone deacetylase 1 (HDAC1), SET domain, bifurcated 1

161 s bound VDR but exhibited reduced binding to histone deacetylase 1 (HDAC1), suggesting that the impai

162 DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A an

163 ut rather through its ability to deconjugate histone deacetylase 1 (HDAC1), thereby reducing its deac

164 sis-stimulating of P53 protein 2 (ASPP2) and histone deacetylase 1 (HDAC1), were also identified.

165 dy, we demonstrate that bICP0 interacts with histone deacetylase 1 (HDAC1), which results in activati

166 cells is because of lack of a p50-dependent histone deacetylase 1 (HDAC1)-mediated repression of TNF

167 ication state of chromatin by recruitment of histone deacetylase 1 (HDAC1).

168 ation decreases the association of NF-Y with histone deacetylase 1 (HDAC1).

169 egulatory factors such as retinoblastoma and histone deacetylase 1 (HDAC1).

170 e (HAT)-containing co-activator proteins, or histone deacetylase 1 (HDAC1).

171 with the normal interactions between FUS and histone deacetylase 1 (HDAC1).

172 We observed that pUL97 associates with histone deacetylase 1 (HDAC1).

173 n of CCAAT enhancer binding protein beta and histone deacetylase 1 (HDAC1).

174 ar receptor corepressors (NCoR and SMRT) and histone deacetylase 1 (HDAC1).

175 We now show that MyoD associates with a histone deacetylase-1 (HDAC1) in these cells and that th

176 rofoundly represses P2 promoter activity and histone deacetylase-1 (HDAC1) potentiates such inhibitio

177 terminus of Rb protein involved in c-Abl and histone deacetylase-1 (HDAC1) regulation.

178 LRF associated with histone deacetylase-1 (HDAC1), and experiments utilizing

179 t the deacetylation of p53 is mediated by an histone deacetylase-1 (HDAC1)-containing complex.

180 xic roles have previously been described for histone deacetylase-1 (HDAC1).

181 mice correlate with a widespread increase of histone-deacetylase 1 (Hdac1) expression that is linked

182 ntified the methyl CpG binding protein Mbd3, histone deacetylase 1(Hdac1), and components of Brg1 com

183 sphatase inhibitor microcystin-LR identified histone deacetylase 1(HDAC1), HDAC6, and HDAC10 as novel

184 e, we show that endothelial morphogenesis is histone deacetylase-1- (HDAC1) dependent and that inters

185 further show that atrophin 2 associates with histone deacetylase 1 in mouse embryos, providing a bioc

186 Jag1 suppressed fzd expression by retaining histone deacetylase 1 in the complex with the transcript

187 hyperacetylating agent, trichostatin A, and histone deacetylase 1 indicate that growth arrest and p2

188 cetylation with the clinically used specific histone deacetylase 1 inhibitor MS-275 both cognitive an

189 ion, Tax dissociates transcription repressor histone deacetylase 1 interaction with the CREB response

190 Histone deacetylase 1 interacts with the MLL repression

191 This analysis revealed that histone deacetylase 1 is predominantly responsible for t

192 Histone deacetylase 1 is recruited to Myc-Sin3b complexe

193 pha-dependent transcriptional repression via histone deacetylase 1-mediated histone deacetylation.

194 Additionally Nkx2.2 recruited a histone deacetylase 1-mSin3A complex to the myelin basic

195 Finally, genes affected by A. thaliana histone deacetylase 1 mutation tend to show high levels

196 e SMRT/N-CoR polypeptides, mSin3A or -B, and histone deacetylase 1 or 2.

197 her validated the interaction of NOTCH1 with histone deacetylase 1 or GATAD2B using protein network a

198 ed by (i) broad spectrum as well as specific histone deacetylase 1 or histone deacetylase 4 inhibitor

199 Depletion of SMRT, but not histone deacetylases 1 or 3, negatively impacts estradio

200 Inhibition of histone deacetylase 1 prevented the immunomodulatory eff

201 methyl binding domain protein-2 (MBD-2) and histone deacetylase 1 proteins but differed from MeCP-1.

202 Interferon-induced PLZF phosphorylation and histone deacetylase 1 recruitment probably mediates the

203 HDAC1 (histone deacetylase 1) regulates a number of biological

204 nuclear factor (NF)-kappaB association with histone deacetylase 1, repressing cytokine production.

205 polymerase 1 recruited the acetylated APE-1/histone deacetylase-1 repressor complex to bax nCaRE.

206 dimensional (2D) gels identified the primary histone deacetylase 1 target as histone H2B.

207 es correlate with reduced acetylation of the histone deacetylase 1 target site H3K18 in mice.

208 ract with the corepressors mSin3A and HDAC1 (histone deacetylase 1) through its zinc finger domain.

209 Mecp2 targeted histone deacetylase 1 to a sharply defined, approximatel

210 els was associated with increased binding of histone deacetylase 1 to p130 in the hepatic extracts.

211 hreonine cluster promoted the recruitment of histone deacetylase 1 to specific target gene promoters

212 e of the alternative recruitment of p300 and histone deacetylase 1 to the cyclin E promoter in prolif

213 These factors then cooperatively recruit histone deacetylase 1 to the LTR, resulting in inhibitio

214 ated at the CD1D promoter and interacts with histone deacetylase-1 to facilitate the transcriptional

215 ene expression (Tcf4 and Id4), by recruiting histone deacetylase-1 to their promoters during oligoden

216 tine, an indirect inhibitor of p300 HAT, and histone deacetylase-1 transfection completely abolished

217 Histone deacetylase 1, which could be recruited by Sp1,

218 ntagonizing GABPalpha binding and recruiting histone deacetylase 1, which deacetylated the Il7ra prom