ライフサイエンスコーパス: histone deacetylase 2

1 (such as PI3K) leading to the inhibition of histone deacetylase 2.

2 rescued by the simultaneous decrease of the Histone Deacetylase 2.

3 se in levels of the memory repressor protein histone deacetylase 2.

4 uding BRG1, BRM, hSNF2H, BAF155, mSin3a, and histone deacetylase 2.

5 dent repression domain, which interacts with histone deacetylase 2.

6 icosteroid resistance though inactivation of histone deacetylase 2.

7 of brain sections showed that TopIIbeta and histone deacetylase 2, a known TopIIbeta-interacting pro

8 ed inflammatory genes through recruitment of histone deacetylase-2, activating anti-inflammatory gene

9 effect may be due to inhibition of PDE4 and histone deacetylase-2 activation, resulting in switching

10 of 1) chromatin perturbation by mutation of histone deacetylases, 2) activation of Snf1, and 3) the

11 lar value in severe asthma and COPD, wherein histone deacetylase-2 activity is reduced.

12 ardiac function via p27/casein kinase-2alpha/histone deacetylase 2 and indicate that mutations within

13 e demonstrate that Hu proteins interact with histone deacetylase 2 and inhibit its deacetylation acti

14 nflammation enhanced the interaction between histone deacetylase 2 and methyl-CpG-binding protein 2,

15 1 and methylated CpG binding protein 2 with histone deacetylase 2 and of REST with histone deacetyla

16 r the development of selective inhibitors of histone deacetylase 2 and suggest that cognitive capacit

17 progression, where it interacts with class I histone deacetylases 2 and 3 (HDAC2 and HDAC3) to regula

18 eacetylase 1 but had no effect on binding to histone deacetylases 2 and 3, the coactivator p300, or e

19 stem, we design cyclic peptides that inhibit histone deacetylases 2 and 6 (HDAC2 and HDAC6) with enha

20 select chromatin regulators (e.g., ARID1A/B, histone deacetylase 2, and HCF1), mutations of which und

21 and increased methyl-CpG binding protein-2, histone-deacetylase-2, and switch-independent-3a binding

22 Histone deacetylase 2 associates with and reduces the hi

23 rodegeneration, and a human homolog of RPD3, histone deacetylase 2, bound ATM and abrogated ATM activ

24 Importantly, reversing the build-up of histone deacetylase 2 by short-hairpin-RNA-mediated knoc

25 anscription, and FosB in turn, utilizes FosB/histone deacetylase 2 complex to repress E-cadherin expr

26 de novo methylation of the promoter, whereas histone deacetylase 2 cooperates with DNMT1 to inhibit t

27 sor 1, methylated CpG binding protein 2, and histone deacetylase 2 enrichment, but not of sirtuin 1 o

28 through epigenetic modifications mediated by histone deacetylase 2 (HDAC-2).

29 recruitment of the transcriptional repressor histone deacetylase-2 (HDAC-2) to this site.

30 A reduction in histone deacetylase 2 (HDAC2) activity and expression ha

31 NF-kappaB) pathway, as an LRA and identified histone deacetylase 2 (HDAC2) and bromodomain-containing

32 ubiquitin ligase activity, by recruiting the histone deacetylase 2 (HDAC2) and CCAAT/enhancer-binding

33 , and mice suggested that cross-talk between histone deacetylase 2 (HDAC2) and DNA methyltransferase

34 ng molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in

35 FOXP3 specifically inhibited binding of histone deacetylase 2 (HDAC2) and HDAC4 to the site and

36 LPS stimulates S-nitrosylation of histone deacetylase 2 (HDAC2) and interferes with its bi

37 , we demonstrate that epigenetic regulator's histone deacetylase 2 (HDAC2) and polycomb repressive co

38 e nucleus, accompanied by S-nitrosylation of histone deacetylase 2 (HDAC2) and Sirtuin 1 (SIRT1), dea

39 RFX5 specifically interacts with histone deacetylase 2 (HDAC2) and the mammalian transcri

40 expression by recruiting chromatin modifier histone deacetylase 2 (HDAC2) as revealed by chromatin i

41 lying mechanism involves recruitment of MTA1-histone deacetylase 2 (HDAC2) complexes onto two selecti

42 previously shown that subunits of the mSin3A/histone deacetylase 2 (HDAC2) corepressor complex copuri

43 onstrate that the chromatin-modifying enzyme histone deacetylase 2 (Hdac2) functions with a small hom

44 The epigenetic eraser histone deacetylase 2 (HDAC2) has been connected to less

45 triggers NO synthesis and S-nitrosylation of histone deacetylase 2 (HDAC2) in neurons, resulting in c

46 ilencing of histone deacetylase 1 (Hdac1) or histone deacetylase 2 (Hdac2) in OPCs did not affect BMP

47 ation is associated with decreased levels of histone deacetylase 2 (HDAC2) in the nucleus accumbens.

48 Histone deacetylase 2 (HDAC2) is a member of a large fam

49 Under normal conditions, histone deacetylase 2 (HDAC2) is highly enriched at the

50 Histone deacetylase 2 (HDAC2) negatively regulates excit

51 ressor complexes containing PRMT5 and either histone deacetylase 2 (HDAC2) or HDAC3, enhanced binding

52 estingly, we found that limiting endothelial histone deacetylase 2 (HDAC2) prevented cerebral ECs fro

53 ng to the glucocorticoid response element of histone deacetylase 2 (HDAC2) promoter, resulting in the

54 ted by acetylation of core histones, whereas histone deacetylase 2 (HDAC2) suppresses inflammatory ge

55 Corticosteroids recruit histone deacetylase 2 (HDAC2) to the actively transcribi

56 es FOXM1 bound to the FHRE before recruiting histone deacetylase 2 (HDAC2) to the promoter, leading t

57 Association of histone deacetylase 2 (Hdac2) with T-Cad promoter and re

58 d the glucocorticoid receptor (GR-alpha) and histone deacetylase 2 (HDAC2), a corepressor important f

59 s of inhibitor kappaB-alpha (IkappaB-alpha), histone deacetylase 2 (HDAC2), acetylated (ac-) histone

60 bromodomain-containing protein 4 (BRD4) and histone deacetylase 2 (HDAC2), along with ubiquitin-spec

61 luding methyl-CpG binding protein 2 (MeCP2), histone deacetylase 2 (HDAC2), and SIN3 transcription re

62 ted to its N-terminal domain, which recruits histone deacetylase 2 (Hdac2), as demonstrated by (i) im

63 l splicing variant in the mouse kidney) with histone deacetylase 2 (HDAC2), as well as the function o

64 ition controlled by the epigenetic regulator histone deacetylase 2 (HDAC2), which controls endothelia

65 istance is largely caused by inactivation of histone deacetylase 2 (HDAC2), which is critical for the

66 munoprecipitation assay experiments revealed histone deacetylase 2 (HDAC2)-MTA1 protein-protein inter

67 eacetylase (HDAC) inhibitors or knockdown of histone deacetylase 2 (HDAC2).

68 tipsychotic treatment is mediated mostly via histone deacetylase 2 (HDAC2).

69 ach virus results in hyperphosphorylation of histone deacetylase 2 (HDAC2).

70 cription factor activator protein 1, reduced histone deacetylase-2 (HDAC2) expression, raised macroph

71 ve inflammation via reduced transcription of histone deacetylase-2 (HDAC2) in lung epithelial and mac

72 Histone deacetylase-2 (HDAC2) is a component of a comple

73 Here we show that histone deacetylase-2 (Hdac2) regulates expression of ma

74 oter by binding to nearby DNA and recruiting histone deacetylase-2 (HDAC2) to reduce histone acetylat

75 Histone deacetylase-2 (HDAC2), an epigenetic regulator,

76 yperacetylation and diminished enrichment of histone deacetylase-2 (HDAC2), but not HDAC3, at the Cac

77 4 (also called Mi-2beta) is a component of a histone-deacetylase-2 (HDAC2)-containing complex, the nu

78 (CoREST), histone deacetylase 1 (HDAC1), and histone deacetylase 2 in erythroleukemia and T cell leuk

79 e repressor CoREST (also known as RCOR1) and histone deacetylase 2 in these early dividing cells; and

80 at the essential nuclear gene, P. falciparum histone deacetylase 2 (PfHda2), is a global silencer of

81 AR formed a repressive complex by recruiting histone deacetylase 2 to the SIRT3 promoter, and depleti

82 ownstream molecules casein kinase-2alpha and histone deacetylase 2 were significantly elevated in Eya

83 This blockade is mediated by histone deacetylase 2, which is increased by Alzheimer's