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1 a mechanism for chromatin remodeling (i.e., histone deacetylation).
2 stent with the idea that repression involves histone deacetylation.
3 methylation in the absence of HDA6-mediated histone deacetylation.
4 ng, recombination, DNA repair, and aging via histone deacetylation.
5 ir ability to remodel chromatin and modulate histone deacetylation.
6 cancer cells does not involve inhibition of histone deacetylation.
7 ic gene lateral root primordium 1 (LRP1) via histone deacetylation.
8 s that induce DNA hypomethylation or inhibit histone deacetylation.
9 ocess concomitant with Rpd3p recruitment and histone deacetylation.
10 argets through Sirt1 recruitment followed by histone deacetylation.
11 s Id2 and Gadd153 by a process that involves histone deacetylation.
12 romatic marks that are maintained by ongoing histone deacetylation.
13 an epigenetic identity that is initiated by histone deacetylation.
14 78 transcriptional activity independently of histone deacetylation.
15 reated with inhibitors of DNA methylation or histone deacetylation.
16 pression of these genes requires blocking of histone deacetylation.
17 ppression of the rDNA promoter also involves histone deacetylation.
18 epression via histone deacetylase 1-mediated histone deacetylation.
19 vity by binding to MEF2 and catalyzing local histone deacetylation.
20 ndently of HP1 through a mechanism involving histone deacetylation.
21 ption in a manner that is not dependent upon histone deacetylation.
22 omous pathway regulates flowering in part by histone deacetylation.
23 oxia causes decreased Mlh1 transcription via histone deacetylation.
24 ts target DNA sequence and is independent of histone deacetylation.
25 required for transcriptional inhibition and histone deacetylation.
26 ively repress transcription in parallel with histone deacetylation.
27 s tested, activator binding is unaffected by histone deacetylation.
28 m(s) other than promoter hypermethylation or histone deacetylation.
29 oxide, and inhibitors of DNA methylation and histone deacetylation.
30 rinciples required to achieve locus-specific histone deacetylation.
31 d the level of activation, not the extent of histone deacetylation.
32 cancer development by a mechanism involving histone deacetylation.
33 2)D(3) are suppressed by a process involving histone deacetylation.
34 induced by inhibition of DNA methylation and histone deacetylation.
35 f cancer cells can be manifested by improper histone deacetylation.
36 s vulval developmental target genes by local histone deacetylation.
37 d transcriptional repression associated with histone deacetylation.
38 lve DNA methylation, histone methylation, or histone deacetylation.
39 Hdac2 and repressed transcription of Il6 via histone deacetylation.
40 ducing epigenetic modifications that include histone deacetylation.
41 region) and could be inhibited by SIRT1 via histone deacetylation.
42 siveness gradually declines as a function of histone deacetylation.
43 cytoplasm by acetylation eventually affects histone deacetylation.
44 presses antisense transcription by promoting histone deacetylation.
45 enetic modifications such as methylation and histone deacetylation.
46 cells demonstrates that DNA methylation and histone deacetylation act largely independently to suppr
47 tion recruits the methyltransferase Set2 and histone deacetylation activities in cis, leading to stab
51 e element binding protein (CREB), leading to histone deacetylation and altered neuronal gene expressi
52 rs for selected genes, (ii) by inhibition of histone deacetylation and attendant chromatin remodeling
53 tylase 1 (HDAC1) at the ER promoter, causing histone deacetylation and chromatin condensation, furthe
56 esults unveil an important crosstalk between histone deacetylation and citrullination, suggesting tha
57 ed in basal breast cancer cell lines through histone deacetylation and CpG methylation of the promote
59 ivity is triggered by Lsd1-Mi2/NuRD-mediated histone deacetylation and demethylation at these pluripo
60 key epigenetic regulators necessary for (i) histone deacetylation and demethylation, (ii) binding to
63 ated with gene silencing, and a link between histone deacetylation and DNA methylation has been estab
66 s osteoblast differentiation in part through histone deacetylation and epigenetic suppression of an a
67 we treated cultures with a drug that impairs histone deacetylation and examined spontaneous synaptic
68 to the nucleation region in vivo, promoting histone deacetylation and FLC transcriptional silencing,
69 ranscription repression activity of Tet2 via histone deacetylation and for the prevention of constant
74 HA treatment suppressed the effects of PH on histone deacetylation and hepatocellular bromodeoxyuridi
75 y, HDAC3 activity is largely responsible for histone deacetylation and inflammatory responses of prim
77 alpha activity via indirect association with histone deacetylation and interaction with the basal tra
78 ed for microRNAs (miRs) that are affected by histone deacetylation and investigated the effects in he
84 g and demonstrate distinct contributions for histone deacetylation and nucleosome binding in the sile
87 Various genes controlling transcription, histone deacetylation and proteasome-mediated protein de
88 The two SANT motifs synergistically promote histone deacetylation and repression through unique func
89 itutively bind the latent HIV LTR and induce histone deacetylation and repressive changes in chromati
90 ollowed by iterative cycles of NAD-dependent histone deacetylation and spreading of SIR complexes ove
91 xo function by influencing fasting-dependent histone deacetylation and subsequent chromatin modificat
92 e analyses uncover a role for Asf1 in global histone deacetylation and suggest that HP1-associated hi
93 a local increase in chromatin remodeling and histone deacetylation and suppression of lymphoid cell-s
94 results of our study show that PML modulates histone deacetylation and that loss of this function in
95 gene expression screenings demonstrates that histone deacetylation and transcriptional dysregulation
97 as N-CoR, to its target promoter, leading to histone deacetylation and transcriptional repression.
98 se unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel com
99 tocin receptor, were dominantly regulated by histone deacetylation and were also frequently downregul
101 two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of ge
105 cted by the inhibition of DNA methylation or histone deacetylation, and may thus involve other mechan
107 the contributions of nucleosome positioning, histone deacetylation, and Mediator interference in the
108 promoting H3K36 methylation, which leads to histone deacetylation, and preventing the 3' spread of H
109 echanisms involving negative feedback loops, histone deacetylation, and recognition of the cognate DN
110 results link the MRG family protein Alp13 to histone deacetylation, and suggest that Clr6 and its ass
113 rt a model in which cytosine methylation and histone deacetylation are each upstream of one another i
114 wide epigenetic modifications such as global histone deacetylation are essential for the binding of A
118 ures, including aberrant DNA methylation and histone deacetylation, are among the most prevalent modi
119 ata implicate inactive chromatin mediated by histone deacetylation as a critical component of ER gene
121 Silencing of the HLA class-I APM is due to histone deacetylation as inhibition of histone deacetyla
122 nuclear morphology, levels of lamin A,C, and histone deacetylation, as these tensile stresses 1) are
123 richostatin A, pharmacological inhibitors of histone deacetylation, as well as viral Ski protein, a d
125 Our data reveal that loss of FBP1 due to histone deacetylation associates with poor prognosis of
129 orward mechanism that promotes and maintains histone deacetylation at genomic sites of SMRT recruitme
130 eptor (LHR) gene is subject to repression by histone deacetylation at its promoter region, where a hi
131 We have also observed a distinct pattern of histone deacetylation at the donor locus during homologo
135 and seizures, in which it binds and triggers histone deacetylation at the promoter of the calbindin g
136 in response to high temperature and mediates histone deacetylation at the YUCCA8 locus, a rate-limiti
137 encing was influenced by DNA methylation and histone deacetylation because both 5-aza-2'-deoxycytidin
138 onclude that the U(S)3 protein kinase blocks histone deacetylation by a mechanism distinct from that
140 hese results implicate the importance of non-histone deacetylation by HDAC9 and confirm and further e
144 n chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family, but less is kn
147 d the Sfmbt2 gene followed the inhibition of histone deacetylation caused by glucose deprivation-indu
148 lation is usually associated with triggering histone deacetylation, chromatin condensation, and gene
149 onent of the NuRD (Nucleosome Remodeling and Histone Deacetylation) co-repressor complex, and NuRD-me
150 sion of the Dleu2 promoter via inhibition of histone deacetylation combined with BSAP knockdown incre
151 a component of the nucleosome remodeling and histone deacetylation complex, is widely up-regulated in
153 r Rb and the NuRD (nucleosome remodeling and histone deacetylation) complex have been implicated in t
154 n ZMYND8 and NuRD (nucleosome remodeling and histone deacetylation) complex in the DNA damage respons
156 These data suggest that MSI1, HDA19, and HISTONE DEACETYLATION COMPLEX1 protein form a core compl
158 entiation and that mechanisms in addition to histone deacetylation contribute to activation of late g
159 itors, we show that both DNA methylation and histone deacetylation contribute to CFTR transcriptional
160 clusion in a subset of occluded genes, while histone deacetylation contributes to the implementation
161 deacetylation, we tested the hypothesis that histone deacetylation contributes to the maintenance of
162 tinct from that of ICP0 and that debilitated histone deacetylation contributes to the permissiveness
163 pigenetic modifications (DNA methylation and histone deacetylation), contributes in different ways to
164 we delineated a novel pathway through which histone deacetylation could contribute to CORT regulatio
165 rmacologic inhibition of DNA methylation and histone deacetylation, coupled with expression microarra
167 ate that HDA6 regulates polyadenylation in a histone deacetylation-dependent manner in Arabidopsis.
168 ion initiation timing supports the idea that histone deacetylation directly influences initiation tim
169 n-activated protein kinase, calcium flux, or histone deacetylation) do not significantly induce virus
170 It appears that, unlike DNA methylation, histone deacetylation does not target the promoter, and
171 We have previously shown that, in rodents, histone deacetylation favors oligodendrocyte differentia
174 ated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stabi
175 results suggest that the domain of localized histone deacetylation generated by recruitment of Rpd3 m
176 repression through chromatin remodelling and histone deacetylation has been postulated to represent a
177 that global inhibition of DNA methylation or histone deacetylation has complex, nonredundant effects
178 ant CpG island promoter hypermethylation and histone deacetylation, have not been thoroughly investig
179 (SPB) is currently under investigation as a histone deacetylation (HDAC) inhibitor in Huntington dis
180 and Prdm1 mRNA-3'UTRs through inhibition of histone deacetylation (HDAC) of those miRNA host genes.
182 t to understand how H3-K9 methylation led to histone deacetylation in both H3 and H4, we found that H
184 ciation allows OGT to act cooperatively with histone deacetylation in gene repression by catalyzing t
185 nd supports a central role of HDA-1-mediated histone deacetylation in heterochromatin spreading and g
186 es IL-6 transcription through HDAC1-mediated histone deacetylation in LPS-induced macrophages, acting
187 mmalian cells, and recent findings implicate histone deacetylation in methylation-mediated repression
189 richostatin A, suggesting the involvement of histone deacetylation in negative regulation of PSA prom
190 rmacologic inhibition of DNA methylation and histone deacetylation in non-small cell lung cancer (NSC
191 ion.SIGNIFICANCE STATEMENT The importance of histone deacetylation in normal brain functions and path
193 s, prompting an investigation of the role of histone deacetylation in replication timing control in S
194 dominance of methylation over TSA-sensitive histone deacetylation in silencing genes with a high CpG
195 notion of the dominance of methylation over histone deacetylation in silencing through CpG-rich sequ
196 ulators of differentiation through continual histone deacetylation in stem cells enables self-renewal
198 dditional evidence also suggested a role for histone deacetylation in the regulation of DsRed transge
203 demethylating drug 5-aza-2 deoxycytidine and histone deacetylation inhibiting drug trichostatin A.
206 ed RASSF1A expression, while exposure to the histone deacetylation inhibitor trichostatin A had no ef
207 methylating agent 5-aza-deoxycytidine and/or histone deacetylation inhibitor trichostatin A induced g
212 ion occurs in many cancers and inhibition of histone deacetylation is a promising approach to modulat
214 ptional repression activity, suggesting that histone deacetylation is involved in Dermo-1-mediated tr
216 of histones near silencers, we conclude that histone deacetylation is not sufficient for the full rec
218 er, which is repressed by TGF-beta, and that histone deacetylation is required for repression of Runx
220 s DNA-hypermethylated genes from those where histone deacetylation is responsible for transcriptional
222 P-dependent chromatin remodeling, as well as histone deacetylation, is needed for REST-mediated repre
224 ify HDC1 as a rate-limiting component of the histone deacetylation machinery and as an attractive too
226 transcriptional regulation and suggest that histone deacetylation may be important for the different
227 roductive shoot apex in parallel with MP via histone-deacetylation mediated transcriptional silencing
228 tion by DNA-binding repressors involves core histone deacetylation, mediated by their interaction wit
229 These data support a cooperative model for histone deacetylation, methylation, and DNA methylation
230 acetylation promotes transcription, whereas histone deacetylation negatively regulates transcription
231 component of the nucleosome remodelling and histone deacetylation (NuRD) complex - were viable but f
232 a component of the nucleosome remodeling and histone deacetylation (NuRD) complex that functions as a
233 that recruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromati
234 , a subunit of the nucleosome remodeling and histone deacetylation (NuRD) complex, at a subset of HDA
235 a component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is widely upregula
240 associate with the nucleosome remodeling and histone deacetylation (NuRD) transcriptional repression
241 ity underscores the cellular imperative that histone deacetylation occur only in targeted regions of
243 ncing, accompanied by partial Sir2-dependent histone deacetylation, occurs independently of Sir3 and
244 pRb represses the cyclin E promoter through histone deacetylation of a single nucleosome, to which i
247 in repression is due to a failure to mediate histone deacetylation of ribonucleotide reductase, dihyd
249 action leads to preferential association and histone deacetylation of the 3' portions of coding regio
250 irpin RNA indicate that HDAC3 is involved in histone deacetylation of the Il12b promoter by IL-10.
254 Repression by prohibitin correlates with histone deacetylation on promoters and this was reversed
256 tion of miR-193b-3p expression was caused by histone deacetylation on the miR-193b-3p promoter in the
257 ribed but repressed by REST independently of histone deacetylation or DNA methylation and does not co
259 d telomeric DNA, but not by DNA methylation, histone deacetylation, or histone trimethylation at telo
260 Treatment of cells with an inhibitor of histone deacetylation, or transient transfection with co
261 We questioned whether DNA methylation and histone deacetylation overlap in the regulation of endog
265 rtuins catalyze a well characterized protein/histone deacetylation reaction, there are a number of re
269 pressed by an epigenetic mechanism involving histone deacetylation, resulting in increased PGE2 activ
271 tic signal that inhibits gene transcription, histone deacetylation similarly represses transcription
272 pa3' enhancer and experimental inhibition of histone deacetylation suggest changes therein may determ
273 of DNA methylation, as well as HCHC-mediated histone deacetylation, suggesting that spreading is depe
274 lexes to promoters and generating domains of histone deacetylation that extend over a limited number
275 iptional repression is associated with local histone deacetylation that is reversed by the presence o
277 l evidence linking nucleosome remodeling and histone deacetylation to methylated gene silencing.
278 NAc modification, which acts in concert with histone deacetylation to promote gene silencing in an ef
284 associated with the RI gene, suggesting that histone deacetylation was involved in the transcriptiona
285 rtially relieved repression, suggesting that histone deacetylation was necessary but not sufficient f
288 rivative MS-27-275 (MS-275), an inhibitor of histone deacetylation, was evaluated in a series of pedi
289 lase 1 (HDAC1), a major HDAC responsible for histone deacetylation, was shown to interact with maspin
290 mal deposition at the core promoter, but not histone deacetylation, was the cause of transcriptional
291 possibly interfere with DNA methylation and histone deacetylation, we attempted to maintain and expa
292 ional regulation by DNA methylation involves histone deacetylation, we explored whether differences i
293 s by which CUDC-907 dually inhibits PI3K and histone deacetylation were assessed using reverse protei
295 ir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the l
296 ion at the MMTV promoter nor does it inhibit histone deacetylation, which accompanies deactivation of
297 dinates G1-specific chromatin remodeling and histone deacetylation with the DNA replication initiatio
300 d that succeeding nucleosomal remodeling and histone deacetylation worked in parallel to establish th