ライフサイエンスコーパス: histone modification

1 ns that can regulate gene expression through histone modification.

2 F1alpha binding to the Il22 promoter through histone modification.

3 nto biochemical compartments that facilitate histone modification.

4 ar link between the depositions of these two histone modifications.

5 ses involved in the hypoxia response and DNA/histone modifications.

6 ions between genes with specific euchromatic histone modifications.

7 active enhancers with higher resolution than histone modifications.

8 enomic annotations including kidney-specific histone modifications.

9 scale for alterations in gene expression and histone modifications.

10 with almost no additional power derived from histone modifications.

11 hanges in nucleosome location and associated histone modifications.

12 heir activating marks and not via repressive histone modifications.

13 gions marked with both active and repressive histone modifications.

14 and putative enhancer regions identified by histone modifications.

15 ne regulation that usually requires specific histone modifications.

16 ich are marked by and enriched with specific histone modifications.

17 epigenetic reprogramming that alter DNA and histone modifications.

18 patterns of their association with specific histone modifications.

19 ene expression, DNA replication, and DNA and histone modifications.

20 at are abrogated with inhibitors of specific histone modifications.

21 iling genome-wide epigenetic changes such as histone modifications.

22 promoter-related marks, and enhancer-related histone modifications.

23 s involved in transcriptional elongation and histone modifications.

24 with previously curated LADs and repressive histone modifications.

25 fter mitosis to generate genome-wide maps of histone modifications.

26 y modified by DNA methylation and repressive histone modifications.

27 h has a regulatory function in SAGA-mediated histone modifications.

28 play between euchromatic and heterochromatic histone modifications.

29 tion embryos, including atypical patterns of histone modifications(2-4) and differences in chromosome

30 in sex-specific chromatin accessibility and histone modifications accompanied these cGH-induced sex-

31 s by which Mec1(ATR) and Tel1(ATM) propagate histone modifications across chromatin.

32 stinct mechanism involving the modulation of histone modifications across domains and that this activ

33 Here, we study histone modifications across thirteen tissues during hum

34 pport the importance of physical coupling of histone modification activities to promote epigenetic sw

35 egulatory regions depleted of H3.3K4A showed histone modification alterations and changes in enhancer

36 Integration of genome-wide DNA methylation, histone modification and chromatin accessibility data en

37 of gene regulation, such as DNA methylation, histone modification and chromatin remodelling, and non-

38 se findings reveal an important mechanism of histone modification and demonstrate that local generati

39 impairs the acquisition of such differential histone modification and expression patterns at MAC-/OC-

40 etermine whether CBD would alter genome-wide histone modification and gene expression in MOG sensitiz

41 n regulation that involves crosstalk between histone modification and RNA methylation.

42 tation with sequencing (ChIP-seq) assays for histone modifications and 132 assay for transposase-acce

43 Our results highlight the importance of histone modifications and 3D chromatin architecture in P

44 Histone modifications and acetyltransferase occupancy we

45 ra1-scaffolded complexes, likely by altering histone modifications and Atf2 activity.

46 iptional negative feedback loops and require histone modifications and chromatin remodeling to ensure

47 ions for the mechanism by which PRC2 spreads histone modifications and compacts chromatin.

48 Jurkat cells alters chromatin accessibility, histone modifications and CTCF-mediated TAD leading to i

49 gside commonly accepted mechanisms including histone modifications and disruption of DNA methyltransf

50 hot spots by PRDM9 and is necessary for both histone modifications and DNA accessibility at hot spots

51 We found that VNS activated specific histone modifications and DNA methylation changes at imp

52 Chromatin patterns, including histone modifications and DNA methylation, are also resp

53 damage-induced histone removal, we screened histone modifications and found that histone ADP-ribosyl

54 Here, through analysis of genome-wide histone modifications and gene expression profiles, we s

55 Salient features, including GC-content, histone modifications and Hi-C interactions are further

56 Histone modifications and histone variants are maintaine

57 CpG-rich promoters are targeted by histone modifications and histone variants, while CpG-po

58 el reproduces statistical correlations among histone modifications and identifies well-known states.

59 en cell type using combinatorial patterns of histone modifications and other regulatory signals.

60 unique and shared epigenetic alterations in histone modifications and potential regulators for BCCs

61 tissues that have examined DNA methylation, histone modifications and regulatory RNAs.

62 al epigenetic regulators of DNA methylation, histone modifications and RNA methylation in adult F1 ma

63 Histone modifications and RNA splicing, two seemingly un

64 we will discuss the many different types of histone modifications and the biological processes with

65 Our knowledge of histone modifications and the corresponding histonemodif

66 current thinking regarding the functions of histone modifications and their associated enzymes.

67 unds to study the functional significance of histone modifications and their clinical implications.

68 focus on methods to profile gene-associated histone modifications and their impacts on chromatin str

69 IP)-seq and RNA-seq were performed to assess histone modifications and transcriptional changes follow

70 e been described, including DNA methylation, histone modification, and microRNA expression.

71 es a molecular link between DNA methylation, histone modification, and the PIWI pathway in the germli

72 measured the cellular levels of 6 classes of histone modifications, and 1 histone variant in 11 major

73 kit facilitates searches for factor binding, histone modifications, and chromatin accessibility in an

74 otation of the genome by chromatin proteins, histone modifications, and differential compaction is la

75 with gain of chromatin accessibility, active histone modifications, and ERV RNA transcription.

76 e found enrichment in targets for miRNAs, in histone modifications, and in parent-of-origin DNA methy

77 modeling, DNA methylation, posttranslational histone modifications, and involvement of small and long

78 genetic machinery involving DNA methylation, histone modifications, and microRNAs mediates hyperglyce

79 cetyllysine residues, alter the landscape of histone modifications, and modulate chromatin structure

80 These genes were enriched for inflammation, histone modifications, and neuronal death functional cla

81 io-fluids) were considered: DNA methylation, histone modifications, and non-coding miRNAs.

82 acteristics include coactivator recruitment, histone modifications, and noncoding RNA transcription.

83 These include DNA methylation, histone modifications, and regulation of transcription v

84 Analysis of chromatin accessibility, histone modifications, and sequence conservation identif

85 hypersensitive sites, coincided with active histone modifications, and specifically marked actively

86 igated the relationship among ERK signaling, histone modifications, and transcription factor activity

87 accompanied by variation in gene expression, histone modifications, and transcription factor binding.

88 ic alterations including DNA methylation and histone modifications are being characterized in ovarian

89 the pathways that deposit, remove, and read histone modifications are deeply conserved.

90 Although histone modifications are important markers of gene regu

91 largely on correlative evidence, posits that histone modifications are instructive for transcriptiona

92 Growing evidence suggests histone modifications are involved in the response to 'g

93 Post-translational histone modifications are major regulators of gene expre

94 Distinct histone modifications are often associated with ON/OFF e

95 These data demonstrate that histone modifications are one mechanism through which ep

96 However, DNA methylation and histone modifications are reversible, and therapies targ

97 nt Homeodomain (PHD) fingers in catalysis of histone modifications are unknown.

98 features including the presence of specific histone modifications are used to demarcate potentially

99 K4me3 (activating) and H3K27me3 (repressive) histone modifications, are a key property of pluripotent

100 overview specifically of DNA methylation and histone modifications as "clothes of the ovarian cancer

101 ana histone acetyltransferase GCN5 regulates histone modifications as part of the Spt-Ada-Gcn5 Acetyl

102 sine 36 methylation (H3K36me) is a conserved histone modification associated with transcription and D

103 ), which classifies broad regions exhibiting histone modifications associated with gene activation.

104 Changes in histone modification at HPV integration events were corr

105 ngs suggest that exposure to cocaine induces histone modification at the hippocampal FosB gene promot

106 TF based solely on the correlation between a histone modification at the TF's binding site and the ex

107 mice exhibited more transcriptionally active histone modifications at M2 gene promoters than did macr

108 on the identification of DNA methylation and histone modifications at specific genes.

109 itoring of recruitment of repair proteins or histone modifications at the damage site (e.g. gammaH2AX

110 Further, we characterize changes in histone modifications at the FosB promoter in hippocampu

111 Profiling of various histone modifications at the genome scale using tissues

112 association with HDAC2-dependent repressive histone modifications at the mGlu2 promoter.

113 ion were used to monitor gene expression and histone modifications at the retinoic acid-related orpha

114 decreased DNA methylation levels and altered histone modifications at the targeted VM-IAPs.

115 region connecting the different TTD and PHD histone modification-binding domains causes distinct H3K

116 g, including its combinatory assemblies, DNA/histone modification-binding modules and post-translatio

117 clear localization, genomic distribution and histone-modification-binding preference.

118 romatin domains display major differences in histone modifications, biophysical properties, and spati

119 Alongside DNA methylation and histone modifications, bromodomain and extra-terminal re

120 ed at DSB-prone sites upon PRDM9 binding and histone modification, but independent of DSB activity.

121 key mechanism that mediates the function of histone modifications, but how the dysregulation of thes

122 Epigenetic analyses reveal that histone modifications, but not DNA methylation, underlie

123 nomic locations of active enhancers based on histone modifications, but the accuracy and resolution o

124 hypermethylation at its promoter as well as histone modification by methylation and acetylation.

125 tro, blocks transcription by abrogating core histone modifications by p300 but not activator and p300

126 Changes in global levels of histone modifications can be detected with exogenous ref

127 Also, because histone modifications can be modulated by more than one

128 machinery to deposit the H3K9me3 repressive histone modification, can activate expression from the n

129 NA methylation, chromatin accessibility, and histone modification changes.

130 grated DNAs were marked by posttranslational histone modifications characteristic of transcriptionall

131 the relationship between thousands of TF and histone modification ChIP-seq data sets with thousands o

132 le datasets of DNA methylation, ATAC-seq and histone modification ChIP-seq.

133 se viral genomes, including DNA methylation, histone modification, chromatin remodeling, and noncodin

134 t have examined epigenetic mechanisms (e.g., histone modifications, chromatin remodeler-associated mo

135 were enriched for genes involved in covalent histone modification/chromatin remodeling (34.5%; MEN1,

136 istal regulatory regions or not, given their histone modifications' combinatorial signatures.

137 g small noncoding RNAs, DNA methylation, and histone modifications, contribute to the establishment o

138 mere can reveal general principles about how histone modifications control chromatin-bound membranele

139 on of H2B K120 (H2B-Ub) and is an example of histone modification cross-talk that is conserved from y

140 understanding the long-studied H2Bub-H3K4me histone modification crosstalk.

141 broadly, a meta-analysis of other conserved histone modifications demonstrates that nucleosome turno

142 body specificity and absolute measurement of histone modification density (HMD) at genomic loci on a

143 sine 36 methylation (H3K36me) is a conserved histone modification deposited by the Set2 methyltransfe

144 blishment: removal of transcription-favoring histone modifications deposited by Dot1, Sas2, and Rtt10

145 r mechanisms, including, but not limited to, histone modification, DNA methylation and nucleosome rem

146 by epigenetic mechanisms involving chromatin histone modifications, DNA methylation and non-coding RN

147 dney repair, involving remarkable changes in histone modifications, DNA methylation and the expressio

148 Using analysis of genome-wide histone modifications, DNA methylation, and hydroxymethy

149 Rtf1 bound to nucleosomes through its histone modification domain, supporting its role as a co

150 e2s following excision of Cdc73 placing this histone modification downstream of the PAFc and revealin

151 lar mechanisms of epigenetic events, such as histone modification dynamics and epigenetic priming.

152 expression, which in turn regulate rhythmic histone modification dynamics for the clock and its outp

153 This study demonstrates that levels of histone modification enzyme KDM5B determine hyperactivat

154 (NPC) proteins, transcription factors (TFs), histone modification enzymes, Mediator, and factors invo

155 omoters or enhancers associated with various histone modification enzymes.

156 plethora of chromatin-remodeling complexes, histone-modification enzymes and transcription elongatio

157 However, the role of histone modifications, especially histone H3 lysine-27 d

158 the memory T cells are marked by activating histone modifications even in the resting state.

159 t with nucleosome occupancy and placement of histone modifications facilitate the temporal order of A

160 od (called TFChrome) using both MTTFsite and histone modification features is also presented.

161 When MTTFsite is combined with histone modification features, a significant 5.7% perfor

162 Recently, a genetically encoded histone-modification fluorescent probe using a single-ch

163 erved as the central method for the study of histone modifications for the past decade.

164 a high-resolution technique for analysis of histone modifications for use with patient-derived fine-

165 or understanding conserved crosstalk between histone modifications found at actively transcribed gene

166 eq to identify H3K18ac, H3K27ac and H3K27me3 histone modifications genome-wide.

167 Among various histone modifications, H3 Lys27 acetylation (H3K27ac) ex

168 dent dioxygenases that remove the repressive histone modification H3K27me3 and activate differentiati

169 despread enrichment domain of the repressive histone modification H3K27me3 and is further enriched wi

170 level and the localization of the repressive histone modification H3K27me3 and the histone variant H2

171 chromosomes inherited lacking the repressive histone modification H3K27me3 are maintained in that sta

172 ally through maternally inherited repressive histone modification H3K27me3.

173 was coupled with depletion of the repressive histone modification, H3K27me3, and enrichment of activa

174 s in the PWWP domain abrogate binding to the histone modifications H3K36me2 and H3K36me3, and alter D

175 Consequently, the levels of the histone modifications H3K4me1/3, H3K9ac, and H3K27ac wer

176 protein MeCP2 and with the active chromatin histone modification H3K4me2 in mouse neurons.

177 embryonic ectoderm (ExE) by assaying allelic histone modifications (H3K4me3, H3K36me3, H3K27me3), gen

178 suggesting a novel, noncanonical role of the histone modification H3K9me3 in the HBV life cycle.

179 r and can distinguish between the repressive histone modification H3K9me3, H3K9me2 and H3K27me3.

180 However, it is unclear how the repressive histone modification H4K20me3 or the histone methyltrans

181 ulatory elements of the genome, any specific histone modification has not been assayed in more than a

182 regulatory factors that orchestrate specific histone modifications has not been broadly mapped.

183 regulatory states, as only a small number of histone modifications have been profiled across many cel

184 the potential impact of that small RNAs and histone modifications have in regulation of NAT expressi

185 DNA and histone modifications have notable effects on gene expre

186 for lactate whereby it is utilized in a new histone modification, histone lysine lactylation, to reg

187 t the enzymes related to the methyl cycle or histone modification; however, it remains largely unknow

188 blishing the functional role of ATM-mediated histone modification in plant growth under genotoxic str

189 rnal regulation of circadian clock genes and histone modifications in Arabidopsis.

190 However, nothing is known about the role of histone modifications in contributing to the neurologica

191 eaks, suggesting specific roles of different histone modifications in diurnal gene expression.

192 We profiled 7 histone modifications in embryonic hearts from each of 9

193 analysis were used to measure the levels of histone modifications in human bronchial epithelial BEAS

194 Our study is the first analysis of histone modifications in primary bladder cancer tissue a

195 nitoring the dynamic changes associated with histone modifications in real-time by measuring the bala

196 e no association was found for the other two histone modifications in relation to basal and luminal s

197 the dynamic and global-scale distribution of histone modifications in single cell types in plants.

198 ent works have highlighted the importance of histone modifications in the regulation of transcription

199 esting an ancient role for posttranslational histone modifications in transcription.

200 We used the protocol to study a number of histone modifications in various types of mouse and huma

201 d the transcription factor binding motifs or histone modifications, indicating the involvement of the

202 tructural mechanics play in the spreading of histone modifications involved in epigenetic regulation.

203 Modulation of chromatin structure via histone modification is a major epigenetic mechanism and

204 ile the association between RNA splicing and histone modifications is beginning to be recognized, a l

205 f other chromatin proteins, DNA sequence and histone modifications is less understood.

206 The enzymatic erasure of histone modifications is widely assumed to be the primar

207 etic functions including DNA methylation and histone modification, is induced by Sonic Hedgehog (SHH)

208 ce the identification of DNA methylation and histone modification, it has become evident that genes e

209 tigated phosphorylated H2A.X (gammaH2A.X), a histone modification known to colocalize with DSBs.

210 We thus provide insights into the histone modification landscape that allows faithful rees

211 Histone modifications, largely regulated by histone acet

212 DNA methylation, chromatin accessibility and histone modification level, that can be partially recapi

213 labeling technique to monitor the changes in histone modification levels during zygotic genome activa

214 a genome-wide assessment of 5mC, 5hmC, four histone modifications linked to promoter/enhancer functi

215 evolution, we integrate DNAme analysis with histone modification mapping and single cell analyses of

216 sine 9 dimethylation (H3K9me2), a repressive histone modification mark that was increased in the hipp

217 ription (H3K9(ac) or H3K27(ac)), but not the histone modifications marking constitutive (H3K9(me3)) o

218 c quantitative trait loci [mQTLs]) and under histone-modification marks in several tissues were disco

219 llowed by eQTLs, young variants, those under histone-modification marks, and selection signatures.

220 eq gene transcripton and up to four ChIP-seq histone modification measurements.

221 ts into the nucleosome-based recognition and histone-modification mechanisms of NSD2 and NSD3, which

222 ots are decorated by a unique combination of histone modifications not found at other regulatory elem

223 le levels including through DNA methylation, histone modification, nucleosome remodelling and modulat

224 or (TF) binding motifs, patterns of covalent histone modifications, nucleosome occupancy, GC content,

225 r peak detection to reveal global changes in histone modification occupancy.

226 nhanced chromatin accessibility and bivalent histone modifications of active genes.

227 Rorgammat and T(H)17 differentiation through histone modifications of Rorgammat; Foxp3 expression and

228 oning, expression of CDK5, and enrichment of histone modifications of the Cdk5 gene.

229 nation hotspots activated by PRDM9-catalyzed histone modifications on open chromatin.

230 nce of germline-inherited post-translational histone modifications on priming early mammalian develop

231 ted the repressed hTERT promoter and altered histone modifications only in telomerase-negative cells.

232 a set of genome-wide measurements such as of histone modification or DNA accessibility and output an

233 st algorithm was accurate and relied only on histone modifications or DNA methylation patterns within

234 ovel interactions between co-transcriptional histone modification pathways, which link regulation of

235 , targeted chromatin ligation, that captures histone modification patterns with only 200 cells.

236 Epigenetic mechanisms such as histone modifications play critical roles in adaptive tu

237 Chromatin regulation through histone modifications plays an essential role in coordin

238 f gene repression is sustained by cis-acting histone modifications, PRC2-mediated H3K27me3 and cPRC1-

239 ion, nucleosomes were found carrying various histone modifications primarily in the regulatory region

240 n of DNA methylation triggers changes in the histone modification profile and chromatin-remodeling ev

241 A histone modification profile for each individual sample

242 This altered histone modification profile promotes a unique gene expr

243 of inhibiting KDM enzymes, globally changing histone modification profiles, and with specific anti-tu

244 gains in 5mC and 5hmC, and markedly altered histone modification profiles, particularly remodeling o

245 ns (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating

246 n proposed for use in disease diagnosis, and histone modification profiling for disease stratificatio

247 Dysregulation of histone modifications promotes carcinogenesis by alterin

248 uggest sequential ubiquitin-histone and SUMO-histone modifications recruit Ulp2, which removes polySU

249 observed JAK2-mediated epigenetic changes in histone modifications, reflected in a reduction of histo

250 Recently, several non-classical functions of histone modification regulators (HMRs), independent of t

251 o cancer development, with posttranslational histone modifications representing attractive targets fo

252 te of several target promoters, indicated by histone modifications resulting in transcriptional repre

253 of the 5hmC profiles with transcriptomes and histone modifications revealed that 5hmC is preferential

254 onstrate the utility of CUT&Tag by profiling histone modifications, RNA Polymerase II and transcripti

255 Our method for analyzing histone modifications, scChIC-seq (single-cell chromatin

256 Understanding how this histone modification 'senses' external glucose changes r

257 t activating H3K4me3 and repressive H3K27me3 histone modifications, silencing basal MHC-I expression

258 prehensive atlas of m(6)A methylation sites, histone modification sites, and chromatin accessibility

259 ive survey of chromatin-associated RNAs in a histone modification-specific manner.

260 ated with the reduction of cccDNA-associated histone modifications specifying active transcription (H

261 This histone modification spreads beyond the DSB into neighbo

262 nment through MSCs and consequent changes to histone modification state and chromatin-based nuclear r

263 itive ion channels and consequent changes to histone modification state and chromatin-based nuclear r

264 Thus, chromatin histone modification state is a major determinant of nuc

265 protein that integrates readout of different histone modification states and DNA methylation with enz

266 result, the effects of genetic variation on histone modification states in the liver are poorly unde

267 ies an SE-specific requirement for balancing histone modification states to maintain SE architecture

268 h these findings, inhibition of Cdk1 altered histone-modification status of ESCs.

269 egulators (HMRs), independent of their known histone modification substrates and products, have been

270 In mammals, repressive histone modifications such as trimethylation of histone

271 n the human lung, including genes related to histone modifications, such as HAT1, HDAC2, and KDM5B.

272 me of these motifs were also associated with histone modifications, suggesting a possible interplay b

273 mutually exclusive activating and repressing histone modifications, suggestive of intra-tumoral epige

274 r transcription factor (TF) binding sites or histone modifications surrounding DNAm differences were

275 mbryos contained more varieties of mRNAs for histone modification than for DNA.

276 istone 2A K119 monoubiquitination (H2Aub), a histone modification that correlates with gene repressio

277 ne 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in

278 y between a key nucleosome binding hub and a histone modification that underlies the disease-specific

279 he placing (writing) or removal (erasing) of histone modifications that allow heterochromatin to tran

280 otein called ZCWPW1 is able to recognize the histone modifications that initiate the recombination of

281 Many ASHCEs show differential histone modifications that may participate in regulation

282 level as well as prominent associations with histone modifications that typify active genes and enhan

283 Similarly to the pattern of histone modifications, the histone code, this complex pa

284 nt regulatory roles in gene expression, from histone modification to protein stability.

285 suggest a novel candidate mechanism linking histone modifications to hESC fate decision.

286 erference (RNAi) pathways work together with histone modifications to regulate gene expression and en

287 tion of ZIC2 shifted the balance of bivalent histone modifications toward more active forms and induc

288 ly used to generate epigenetic data, such as histone modification, transcription factor binding sites

289 ing measurements of chromatin accessibility, histone modification, transcription, and protein binding

290 ar processes, including splicing regulation, histone modification, transcriptional pause release, hyp

291 e regulatory processes including genome-wide histone modification, transcriptional regulation, and RN

292 by sequencing (MOWChIP-seq) for profiling of histone modifications using as few as 100 cells per assa

293 The histone modification valleys detected by EpiSAFARI exhib

294 Using genome-wide profiling of the H3K27ac histone modification, we identify neuron-subtype-specifi

295 s, typical enhancer-associated proteins, and histone modifications, we determine that both enhancer c

296 s in vivo By analyzing active and repressive histone modifications, we show that stem cell identity g

297 interaction enrichment, enhancer-associated histone modifications were evident, and known functional

298 During the present study, genome-wide histone modifications were examined in a pair of near is

299 solic ribosomal proteins, underwent distinct histone modifications, yet retained RNAPII engagement an

300 tion are associated with profound changes to histone modifications, yet their in vivo function remain