ライフサイエンスコーパス: histone modifying enzyme

1 -dependent nucleosome remodeling enzymes and histone modifying enzymes.

2 e elements, co-activators/co-repressors, and histone modifying enzymes.

3 tors, and epigenetic programming mediated by histone modifying enzymes.

4 with changes in expression of corresponding histone modifying enzymes.

5 iated degradation of mRNAs encoding critical histone modifying enzymes.

6 uitment of nucleosome remodeling factors and histone modifying enzymes.

7 icate balance between opposing activities of histone modifying enzymes.

8 of nucleosome disruption in the presence of histone modifying enzymes.

9 tion of individual histone modifications and histone-modifying enzymes.

10 otes association of chromatin-remodeling and histone-modifying enzymes.

11 among the DNA methyltransferases, CAF-1, and histone-modifying enzymes.

12 ses transcription without the requirement of histone-modifying enzymes.

13 existing PTMs, as is the case for many other histone-modifying enzymes.

14 ithout changing the expression of the causal histone-modifying enzymes.

15 hibits BA synthesis by recruiting repressive histone-modifying enzymes.

16 elements through RNAi-mediated targeting of histone-modifying enzymes.

17 eged state, which is partially controlled by histone-modifying enzymes.

18 essive effect of energy restriction on these histone-modifying enzymes.

19 onal regulation by partnering with different histone-modifying enzymes.

20 n real-time by measuring the balance between histone-modifying enzyme activities.

21 Manipulation of histone modifying enzymes and the signaling pathways tha

22 ther, our study reveals an interplay between histone-modifying enzymes and chromatin remodelers in th

23 genes disrupted in autism are identified as histone-modifying enzymes and chromatin remodelers, most

24 The activity of histone-modifying enzymes and histone modifications of d

25 s those encoding ribosomal proteins, DNA and histone-modifying enzymes and proteins involved in post-

26 ion factors, chromatin remodeling complexes, histone-modifying enzymes and subset-specific transcript

27 ess has been made in the characterization of histone-modifying enzymes and the roles they play in tra

28 understanding of physiological functions of histone-modifying enzymes and their molecular mechanisms

29 ordinated activity of transcription factors, histone modifying enzymes, and ATP-dependent chromatin r

30 -specific DNA-binding transcription factors, histone-modifying enzymes, and chromatin-remodeling enzy

31 splicing regulation via local recruitment of histone-modifying enzymes, and emerging evidence points

32 are present in the promoters of the affected histone-modifying enzymes, and luciferase reporter assay

33 , including other AP2 transcription factors, histone-modifying enzymes, and regulators of nucleosome

34 o interact with other transcription factors, histone-modifying enzymes, and transcription elongation

35 Consistent with this, mutations in histone modifying enzymes are amongst the most frequent

36 Histone-modifying enzymes are implicated in the control

37 volving DNA sequence-specific recruitment of histone-modifying enzymes are prevalent in nature, examp

38 Histone-modifying enzymes are responsible for regulating

39 ts the argument that HDACs, and perhaps most histone modifying enzymes, are much more versatile and f

40 he results support pharmaceutical control of histone modifying enzymes as a strategy for controlling

41 Gene silencing at these loci requires histone-modifying enzymes as well as factors that regula

42 These genes encode putative histones and histone-modifying enzymes, as well as putative virulence

43 studies have defined how several classes of histone-modifying enzymes bind to and function on nucleo

44 ctivity-dependent regulation is unique among histone-modifying enzymes but consistent with redox sens

45 tudies have reported that catalytically dead histone-modifying enzymes can rescue the function of the

46 verse set of chromatin regulators, including histone-modifying enzymes, chromatin remodelers, and his

47 d previously unappreciated interplay between histone-modifying enzymes, citrullination of nonhistone

48 "active" and "repressive" cross-talk between histone-modifying enzymes coexist on the same multigene

49 Histone-modifying enzyme complements are largely conserv

50 ize DNA in a sequence-specific manner, and a histone modifying enzyme complex are responsible for ind

51 Histone modifying enzymes contribute to the activation o

52 nct patterns of modifications established by histone-modifying enzymes control diverse chromosomal pr

53 of 16 long intergenic noncoding RNAs and key histone modifying enzymes critical for circadian gene ex

54 e demethylases are the most recent family of histone-modifying enzymes discovered.

55 actors that drive these processes, including histone modifying enzymes, DNA methylation and demethyla

56 out ESCs and the inhibitors of Lsd1 and p300 histone modifying enzymes during differentiation of E14T

57 rmediary metabolites serve as co-factors for histone-modifying enzymes during metabolic flux, how the

58 many IL-6-dependent genes, catalyzed by the histone-modifying enzyme enhancer of zeste homolog 2 (EZ

59 c studies revealed that the function of many histone-modifying enzymes extends independently and beyo

60 DNA methylation then leads to recruitment of histone-modifying enzymes, followed by establishment of

61 However, the functional roles of histone modifying enzymes for carbon metabolism remain l

62 anti-senescence role in primary cells, this histone-modifying enzyme functions more broadly in the r

63 The histone-modifying enzyme G9a/KMT1C can act both as a coa

64 onse, but not earlier, Blimp-1 recruited the histone-modifying enzymes G9a and HDAC2 to the Il2ra and

65 Our data suggest that layered condensates of histone-modifying enzymes generate chromatin-associated

66 Dysregulation of histone modifying enzymes has been associated with numer

67 Many histone-modifying enzymes have additional nonhistone sub

68 Accordingly, several histone-modifying enzymes have been described as proto-o

69 Histone-modifying enzymes have enormous potential as reg

70 ne residues remains a challenge because many histone-modifying enzymes have nonhistone targets.

71 Small-molecule inhibitors of histone-modifying enzymes have significant clinical util

72 of histone deacetylases (HDACs), a class of histone-modifying enzymes, have promising effects in can

73 f the Notch signaling pathway, we found that histone modifying enzymes HDAC1 and KDM5A play critical,

74 The functions of histone-modifying enzymes Hdac1(rpd3) and Su(var)3-9 and

75 We found that two histone-modifying enzymes, HDAC1 and HDAC2, were require

76 we showed that during mouse development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) r

77 Recent studies have shown that the histone-modifying enzymes histone acetyltransferase (HAT

78 Like many histone modifying enzymes, histone deacetylases (HDACs)

79 Histone-modifying enzymes, histone deacetylases (HDACs),

80 lymphoma (DLBCL) tumors contain mutations in histone-modifying enzymes (HMEs), indicating a potential

81 combinations of reader and writer domains in histone-modifying enzymes implement local rewriting rule

82 Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenes

83 With a limited number of histone-modifying enzymes, implying less redundancy, Try

84 USF1 is present in complexes with histone modifying enzymes in cell extracts, and these en

85 These results implicate MET-2 as a second histone-modifying enzyme in germ-line reprogramming and

86 This study identifies LSD1 as a novel histone-modifying enzyme in the orchestrated regulation

87 romatin remodeler, transcription factor, and histone-modifying enzyme in the regulation of the plurip

88 ble decision-making, demonstrating a role of histone-modifying enzymes in complex cognitive function.

89 cent advances have shown the crucial role of histone-modifying enzymes in controlling gene activation

90 ever, the cellular and molecular etiology of histone-modifying enzymes in craniofacial disorders is u

91 fragments were occupied by LANA-interacting histone-modifying enzymes in naturally infected cells.

92 However, the role of histone-modifying enzymes in the adult brain is still fa

93 Although an essential role for histone-modifying enzymes in these processes is well est

94 ndent chromatin remodeling factors, and some histone-modifying enzymes including Elongator were repea

95 een the human alpha-arrestin, TXNIP, and the histone-modifying enzymes, including HDAC2, we undertook

96 reversibly on lysine or arginine residues by histone-modifying enzymes, including lysine and arginine

97 of variegation 3-9 homolog 2 (SUV39H2), key histone-modifying enzymes involved in promoting reduced

98 We therefore conclude that a histone modifying enzyme is necessary to permit an ATP-d

99 In worms, a histone-modifying enzyme is necessary to keep small RNA-

100 t of transcriptional coactivators, including histone modifying enzymes, is an important step in trans

101 ors confers sensitivity to inhibition of the histone-modifying enzyme KDM2A as an immunotherapeutic s

102 t polycomb group (PcG) proteins, a subset of histone-modifying enzymes known to be crucial for B-cell

103 How mutations in histone modifying enzymes lead to neurodevelopmental def

104 However, regulatory mechanisms for histone modifying enzymes like Set2 that travel with elo

105 (KS) is commonly caused by mutations in the histone-modifying enzyme lysine methyltransferase 2D (KM

106 w heterozygous loss-of-function mutations in histone-modifying enzymes may cause severe neurodevelopm

107 e-dependent chromatin-remodeling enzymes and histone-modifying enzymes may regulate transcription by

108 rk for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GAT

109 nstrate that the somatic inactivation of one histone modifying enzyme might leave lymphomas uniquely

110 In addition, histone-modifying enzymes often have multiple nonhistone

111 lting from fluctuations in the expression of histone-modifying enzymes or the availability of their s

112 e of effects on CNS2-mediated recruitment of histone-modifying enzymes p300 and JmjC domain-containin

113 Histone-modifying enzymes play a critical role in modula

114 As Pol II associates with histone-modifying enzymes, Pol II tracking might be crit

115 Targeting epigenetic regulators, such as histone-modifying enzymes, provides novel strategies for

116 Histone-modifying enzymes regulate transcription and are

117 sion via morpholino technologies of a single histone-modifying enzyme, Rps6ka4/Msk2, resulted in clea

118 pe is the result of the abnormal activity of histone-modifying enzymes, specifically, class I histone

119 in remodeling factors occurs in concert with histone modifying enzymes such as histone acetyltransfer

120 enders it unable to bind LSD1 and associated histone-modifying enzymes such as HDACs.

121 ating evidence in the past decade implicates histone-modifying enzymes, such as class I histone deace

122 harmacological modulation of the activity of histone-modifying enzymes, such as histone deacetylases,

123 d structure of heterochromatin by recruiting histone-modifying enzymes, such HDAC1/2, SETDB1, and nuc

124 eading strand DNA polymerase, and associated histone modifying enzymes that spread heterochromatin wi

125 We identify a histone-modifying enzyme that selectively methylates the

126 ing platform for various mRNA processing and histone-modifying enzymes that act co-transcriptionally.

127 e the epigenetic regulation of metabolism by histone-modifying enzymes that alter chromatin accessibi

128 ISPR screening approach, we identified seven histone-modifying enzymes that alter the efficiency of h

129 Therefore, we tested whether RD2 contacts histone-modifying enzymes that may mediate both repressi

130 ugh recruitment of transcription factors and histone-modifying enzymes that shape muscle differentiat

131 oteins (MBPs) followed by the recruitment of histone-modifying enzymes that together promote chromati

132 ding surfaces, preventing the recruitment of histone modifying enzymes, thereby specifying a new patt

133 from the repressive effect of CG-12 on these histone-modifying enzymes, thereby abolishing the activa

134 hemical reagents for capturing site-specific histone-modifying enzymes, thus providing molecular insi

135 ction with cccDNA and altered recruitment of histone modifying enzymes to cccDNA.

136 ins, which involves the physical coupling of histone modifying enzymes to histone binding proteins.

137 L) complex composed of noncoding roX RNA and histone modifying enzymes to hypertranscribe most genes

138 es a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other th

139 icity in histones that makes it possible for histone-modifying enzymes to access residues within the

140 H1 also helps to tether DNA- and histone-modifying enzymes to chromatin.

141 Most coregulator complexes contain histone-modifying enzymes to control ERalpha target gene

142 ssor complexes comprised of corepressors and histone-modifying enzymes to control gene expression pro

143 lomeres in Saccharomyces cerevisiae requires histone-modifying enzymes to create chromatin domains th

144 on protein 16 of transcriptional factors and histone-modifying enzymes to immediate early (alpha) gen

145 ns, which is initiated by the recruitment of histone-modifying enzymes to nucleation sites.

146 These TALE factors recruit histone-modifying enzymes to promote an active chromatin

147 as transcriptional repressors by recruiting histone-modifying enzymes to promoters and enhancers of

148 interaction suggested that CHD7 may recruit histone-modifying enzymes to target loci independently o

149 ecruiting chromatin-remodeling complexes and histone-modifying enzymes to the HIV-1 long terminal rep

150 Etv5 recruits histone-modifying enzymes to the Il17a-Il17f locus, resu

151 Furthermore, Ssdp1/2 recruit histone-modifying enzymes to the motor neuron-specifying

152 expression in VSMCs by identification of the histone-modifying enzymes, transcription factors, and co

153 e disruption of the complex between GFI1 and histone-modifying enzymes, we have used knock-in mice ha

154 during the epigenetic reprogramming process, histone-modifying enzymes work together with Smad1 to fa