ライフサイエンスコーパス: hitherto

1 re extensive and impressive than was thought hitherto.

2 In this respect, hitherto 7-deazaadenosine (tubercidin) analogues attract

3 ergy-driven stimuli-responsive applications, hitherto a challenge to overcome.

4 s in low-salinity coastal wetlands, there is hitherto a paucity of direct and year-round measurements

5 This study shows that dissolved oxygen, hitherto an interferent purposefully removed from the so

6 Hitherto, ancient frozen soils have proved excellent in

7 ated receptor signalling is more common than hitherto appreciated.

8 f a broader breakdown of oral tolerance than hitherto appreciated.

9 Most of the cMOFs reported hitherto are 2D structures, and 3D cMOFs remain rare.

10 n histories, but inference methods developed hitherto are limited in model complexity and computation

11 results suggest that the dorsomedial region hitherto associated with action may instead represent th

12 l organ) is derived from medial endoderm, as hitherto assumed based on position deep in the pharynx.

13 ults are accessible to bioinformatic methods hitherto available.

14 ning realistic models of neural networks has hitherto been a task for computing professionals rather

15 therapies for monogenic disorders, which had hitherto been considered untreatable.

16 revious city-scale UF assessments which have hitherto been dependent on proxy data for UF.

17 The impact of choosing a combination has not hitherto been described but may bias comparisons across

18 fully calibrated astronomical time scale has hitherto been hampered beyond ~50 million years before t

19 d manufacturing for future applications, has hitherto been hardly addressed experimentally.

20 All stellar-mass black holes have hitherto been identified by X-rays emitted from gas that

21 This resource has hitherto been omitted from databases on global pest dist

22 which systematic mode identification has not hitherto been possible(6,7).

23 However, such analysis has hitherto been principally restricted to scent-marking te

24 globin, iron and transferrin saturation, has hitherto been used as a proxy for the iron status of neo

25 Overall, aggregation, hitherto believed to hinder the migration of NP in subsu

26 D shape and surface electrostatics with few, hitherto best known inhibitors of SOCE.

27 Here we report the hitherto brightest FBA that has ideal molecular rotor pr

28 ilaments and bilaterally branched filaments, hitherto considered unique to maniraptoran dinosaurs, an

29 on in freshwater communities, much more than hitherto demonstrated, and may arise in nutrient rich ma

30 ng the oldest and one of the few mantidflies hitherto described from amber.

31 assigned to any of the species of the genus hitherto described.

32 N-glycopeptides and N-glycoproteins that are hitherto difficult to obtain for structural and function

33 provides a clean gas-phase synthesis of this hitherto elusive cyclic radical species 1,2,4,7-cyclooct

34 bromides, the latter of which has remained, hitherto, elusive under thermal Ni catalysis.

35 ort a new specimen of Triassurus sixtelae, a hitherto enigmatic tetrapod from the Middle/Late Triassi

36 f any desired DNA sequence and surpasses all hitherto existing alternatives for gene editing in many

37 In contrast to hitherto existing steady-state assays, our single-turnov

38 BLAST jobs that hitherto failed or slogged inefficiently to completion n

39 al to expand their populations on reefs that hitherto had been dominated by scleractinians.

40 mine this ensemble computationally have been hitherto hampered by the necessity of reweighting molecu

41 B is potentially important, as no blood test hitherto has been suggested as having the utility to det

42 s mechanism of response amplification, which hitherto has not been reported for other cell-surface re

43 prevention and treatment, drug developments hitherto have been challenging, and the current pharmace

44 in potency and/or spectrum of activity but, hitherto, have not been predicted to substantially alter

45 This approach helps to unveil hitherto hidden functions of some inconspicuous componen

46 Although frequency measurements offer the hitherto highest precision due to the stable narrow atom

47 amines, amides, and sterically bulky amines hitherto inaccessible and a comparison of their reactivi

48 mbers of these synthetically challenging and hitherto inaccessible marine triterpenoids.

49 High-capacity phenotyping reaches hitherto inaccessible phenotypic characteristics.

50 k will provide unprecedented insights into a hitherto intractable panoply of complex models across ma

51 CITCO activity in liver cell models was not hitherto investigated.

52 Hitherto it has been used to harvest SMA-lipid-membrane

53 romise to cure genetic pathologies, although hitherto it has mostly been applied ex vivo.

54 anostructures in an electron microscope, but hitherto it has not been possible to map vibrational mod

55 Hitherto, it remains unknown whether presaccadic modulat

56 is regarded as among Earth's oldest, but has hitherto lacked precise age constraints.

57 practical value of this work in providing a hitherto lacking design tool for a novel technology.

58 , including many targets for approved drugs, hitherto largely unrecognized as targets of interest in

59 diazo compound partner in a mild fashion has hitherto limited their general use and the scope of the

60 arene arylations and benzylations, which was hitherto limited to the use of halide electrophiles.

61 Here, we present the hitherto longest reconstruction of damaging hydrological

62 ating the protective functions of IgA, these hitherto neglected mucosal antibodies may strengthen the

63 rich core-collapse supernova outflows, these hitherto neglected processes enhance the triple-alpha re

64 S sinks shows that HOBr may be an important, hitherto neglected sink for marine DMS that needs to be

65 termediacy of 1,3-oxazin-4-one intermediates hitherto never implicated in the Staudinger synthesis of

66 Yet, hitherto no tool was available for analyzing the quality

67 Hitherto, no animal model has been available for studyin

68 ever, the host galaxies and distances of the hitherto non-repeating fast radio bursts are yet to be i

69 sts that some should have been detected, yet hitherto none has been seen.

70 to be accessible in highly charged ions, and hitherto none have been observed as both experiment and

71 periodic paralysis (HypoPP), but these have hitherto not been associated with myotonia.

72 , including Xpert MTB/RIF Ultra (ULTRA), has hitherto not been comprehensively studied.

73 he sterile inflammatory process involved has hitherto not been defined.

74 t substance groups were identified that have hitherto not been described in horseradish.

75 of eyes have, to the best of our knowledge, hitherto not been described.

76 ubstances and bioelectrogenic functions, has hitherto not been explored.

77 nals could influence mitosis, but these have hitherto not been observed in mammalian cells.

78 lence-to-non-valence internal conversion has hitherto not been observed in the intramolecular photoph

79 pathological states in biological cells have hitherto not been systematically explored.

80 , the circuitry between these structures has hitherto not been systematically investigated.

81 high RIN of the mid-IR pump laser, which was hitherto not considered in numerical modelling of these

82 tion and potent destruction of targeted RNA, hitherto not found in nature.

83 lying the cytosolic calcium fluctuations are hitherto not fully understood.

84 s of the protein disulfide isomerase family, hitherto not linked to human developmental brain disease

85 s, including potentially pathogenic variants hitherto not observed in humans.

86 this optical modulation feasible, which were hitherto not reported for the bulk material.

87 e correlations give us a better grasp of the hitherto obscure Chinese family structure than that of m

88 ber of the glutarimide class of antibiotics, hitherto only isolated from Streptomyces species.

89 associated with methane seeps constitutes a hitherto overlooked and potentially widespread sink for

90 They reveal a hitherto overlooked dependence on (or 'propensity rule'

91 Our study reveals a hitherto overlooked ecological threat of climate change.

92 We show that this hitherto overlooked fluctuating symmetry-lowering is ele

93 getic viewpoint, small-scale internal tides, hitherto overlooked, account for the bulk (>50%) of glob

94 ressed by host cell factor 1 (HCF1), and the hitherto poorly characterized HCF2, which themselves are

95 r-outcome immunomodulatory microenvironment, hitherto poorly characterized, exhibited stromal restric

96 of bacterial genes within the human body via hitherto poorly understood mechanisms.

97 appreciated and suggest the delineation of a hitherto poorly-appreciated "Central Asian Flyway", whic

98 ons of enzymes led to a working model of the hitherto, poorly understood innermost xyloglucan-rich he

99 iates with PINs in a more direct manner than hitherto postulated.

100 ces have made it possible to investigate the hitherto rather elusive protein histidine phosphorylatio

101 unation is widespread, but more incipient in hitherto relatively intact major biomes that are rapidly

102 hand, full mapping of the magnetic field has hitherto remained challenging.

103 ical properties of these optical fields have hitherto remained more of a fundamental curiosity as opp

104 d what underlies individual differences have hitherto remained unanswered.

105 her prevalence of monofactorial obesity than hitherto reported and a plausible overlapping of obesity

106 h the highest hydrogen production efficiency hitherto reported, with a H(2) production rate of 655 mu

107 more than an order of magnitude greater than hitherto seen.

108 lography this unique functional readout of a hitherto silent state enabled us to examine cross-linked

109 ation mutations in FAM83H (OMIM *611927) are hitherto the sole cause of ADHCAI.

110 Hitherto, their role in cancer is unknown.

111 However, hitherto there is no comprehensive survey of genome-wide

112 Hitherto, these factors helped explain why no dance form

113 all of which recruit Ena/VASP family members hitherto thought to antagonize efficient cell motility.

114 ly that the control of endogenous attention, hitherto thought to reside in macaque dorsal cortical ar

115 agglomeration of rare variants, even in the hitherto unannotated and ill-understood regions of the g

116 Here we show a hitherto unanticipated function of MCM2 in cilia formati

117 ring methods used in these studies reveals a hitherto unappreciated difference between those studies

118 ing that the alligator lineage is capable of hitherto unappreciated extreme locomotor performance des

119 ment of rare progenitor subsets and revealed hitherto unappreciated ILC precursor heterogeneity.

120 This study not only reveals a hitherto unappreciated regulatory mechanism of ferroptos

121 These data reveal a hitherto unappreciated role for an IL-10-STAT3-Blimp-1 c

122 Collectively, these findings highlight a hitherto unappreciated role for BAs in WD-induced impair

123 Collectively, these data suggest a hitherto unappreciated role for CXCR2 in mediating cellu

124 echanism of ORAI1 inactivation, and reveal a hitherto unappreciated role for inactivation in shaping

125 Collectively, these findings identify a hitherto unappreciated role for tumor cell-derived IL1be

126 Taken together, these findings uncover the hitherto unappreciated role of tumor cell-expressed ANGP

127 We report here hitherto unavailable eight-membered chlorin-type PMPs us

128 eatures of the packaged chromatin fiber at a hitherto unavailable level of resolution.

129 oscytalin, a natural 3-spirotetramic acid of hitherto uncertain absolute configuration, was synthesiz

130 l senescence and alter gene expression via a hitherto uncharacterised epigenetic route.

131 This study uncovers a hitherto uncharacterized consequence of rhodopsin misloc

132 The disease-associated variants fall in a hitherto uncharacterized gene called HHIPL1 (hedgehog in

133 Here, we identified a hitherto uncharacterized hypoxia-induced lncRNA RAB11B-A

134 In summary, our data reveal a hitherto uncharacterized link between two translational

135 We present a detailed analysis of MFSD1, a hitherto uncharacterized lysosomal family member of the

136 Surprisingly, we uncovered a hitherto uncharacterized monosynaptic connection between

137 Rather, AutoN cooperated with a hitherto uncharacterized motif, termed AcidicN, to confe

138 1 cortical interneuron subtypes, including a hitherto uncharacterized neuron they term the 'canopy' c

139 we describe pyocyanin demethylase (PodA), a hitherto uncharacterized protein that oxidizes the pyocy

140 identity, gene expression, and binding of a hitherto uncharacterized SMC superfamily protein that we

141 H(2)S production in bacteria and the role, a hitherto uncharacterized transcription factor, YcjW, pla

142 alysis showed that AtTRAPPC11/ROG2 defines a hitherto uncharacterized TRAPPIII complex in plants.

143 ative of synergy or complementation of these hitherto unconnected pathways.

144 that the latent reservoir has important, and hitherto under-appreciated, roles in both within- and be

145 erature; likely reflecting that BDNF plays a hitherto under-recognized multifactorial role as both a

146 and cells in long-term culture, identifies a hitherto underappreciated link between the adhesion mach

147 matory monocytes constitute an important and hitherto underappreciated mechanism of the conflicting i

148 be rendered useful in chemical processes is hitherto underexplored.

149 -risk (CHR) for psychosis, we found that VI, hitherto underinvestigated, strongly predicted transitio

150 In our setting, this included the hitherto underrecognized dominant role of hospital-acqui

151 ive and information-rich measurement that is hitherto underused in battery diagnosis-with Gaussian pr

152 variety of organisms, and our work decodes a hitherto undescribed function of these classic hormones

153 The potential of hitherto undescribed polyketides from P. malabarica as n

154 the large subunit and the small subunit are hitherto undescribed protein folds of unknown evolutiona

155 ed stem-loop kissing interactions) forming a hitherto undescribed, higher-order, G4-based secondary s

156 The results reveal a hitherto undiscovered function of OsCAF1B deadenylase ge

157 brain, it also reveals feedback connections hitherto undiscovered in any animal species.

158 In addition, multiple hitherto undiscovered isotope shifts of comparable ampli

159 Our studies thus reveal a hitherto undiscovered novel interaction pattern that con

160 atively, they might regulate more global-but hitherto undiscovered-SFP functions and proteome composi

161 t of profound lymphodepletion that may cause hitherto unexpected immunological effects.

162 ZooMS analysis revealed hitherto unexpected species, notably black bear (Ursus a

163 ormula: see text] that captures detailed and hitherto-unexplained aspects of its dynamic spin structu

164 es highly acid-labile groups, results from a hitherto unexploited shifted selectivity in protonation,

165 Here, we report evidence for a hitherto unexplored Auger transition in oxides, where a

166 The process is based on the hitherto unexplored combination of supramolecular solven

167 ovel oligonucleotide (ON) analogues that are hitherto unexplored in the oligotherapeutics arena.

168 These findings reveal a hitherto unexplored mechanism of temperature-dependent r

169 o our surprise, alkyl electrophiles follow a hitherto unexplored S(N)2 pathway for the reaction with

170 gn strategy uncovered in this work reveals a hitherto unexplored space for the design of scalable and

171 arbon emissions mitigation, however, remains hitherto unexplored.

172 B. burgdorferi fitness and infection remains hitherto unexplored.

173 cell transformation and EBV latency that was hitherto unexplored.

174 O3-delta, the brownmillerite SrCoO2.5, and a hitherto-unexplored phase, HSrCoO2.5.

175 imal motifs, the classification also reveals hitherto unidentified motifs.

176 h suggest that Arg-AA9 proteins could have a hitherto unidentified role in fungal degradation of lign

177 cidated, although an IgE-mediated pathway by hitherto unidentified trigger/s might be the main underl

178 A hitherto unknown and unexplored integration intermediate

179 s additional conditional drivers and reveals hitherto unknown aspects of cancer evolution.

180 Hitherto unknown autoantibodies targeting extracellular

181 In addition, hitherto unknown beta-aryl alkylselenocyanates were also

182 atomy clearly reveals the existence of a new hitherto unknown body plan experimented by benthic sting

183 o the serendipitous discovery of an array of hitherto unknown byproducts, formed in the trimerization

184 These results reveal the hitherto unknown c-Src/mTORC1/PRC2 axis, which is essent

185 We identified sup-45 as one of the two hitherto unknown C. elegans orthologs of the human AF4/F

186 rachidonyl glycerol (2-AG), and elucidated a hitherto unknown cannabinoid receptor 2 (CB2)-mediated r

187 These defects are dependent on a hitherto unknown chromatin-binding region of LAP1 that w

188 Hitherto unknown cis- and trans-1-amino-3-hydroxy-3-meth

189 A hitherto unknown composition is highlighted in the red a

190 Two hitherto unknown conformationally rigid Huckel aromatic

191 bserved behavioral effects, which revealed a hitherto unknown connection between neural tuning shift

192 This hitherto unknown Del-1 function in the HSC niche represe

193 opy (SERS) was used to successfully identify hitherto unknown dimeric methylalumina surface species d

194 These include large hitherto unknown doubly boron-doped analogues of anthant

195 N(Dipp) )(O(2) C)}](2) [4](2) containing the hitherto unknown ethenetetraolate ligand, [C(2) O(4) ](4

196 tion of PG(22:6/22:6) level appeared to be a hitherto unknown feature of the metabolic shift observed

197 These findings identify a hitherto unknown function for Fgf20 in mammary budding a

198 ow that ACh released by motoneurons exerts a hitherto unknown function independent of myofiber contra

199 ivo approaches, we define CXorf21, a gene of hitherto unknown function, which escapes X-chromosome in

200 ividuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying diseas

201 ta identify a new form of IT and highlight a hitherto unknown fundamental role for PTPRJ in platelet

202 These compounds constitute hitherto unknown GaAs- or InAs-based supertetrahedral st

203 or strategy for elucidating the thousands of hitherto unknown gene defects underlying AR-ID, and it s

204 nsively characterized two individuals with a hitherto unknown genetic disorder caused by the same de

205 by a C2-symmetric salen ligand which shows a hitherto unknown high activity for the ROP of rac-lactid

206 tential to indirectly assess the behavior of hitherto unknown HMSA precursors, consequently identifyi

207 at this site has revealed the presence of a hitherto unknown hominin group, the Denisovans(1,2), and

208 The hitherto unknown homoleptic tetramethylaluminate complex

209 A hitherto unknown Indian Ocean pathway of the ITF was dis

210 ns, this method has drawbacks, including its hitherto unknown intrinsic lack of stability vis-a-vis p

211 Here, we identify a hitherto unknown inversion that traps a color pattern sw

212 activity, and enabled the identification of hitherto unknown kinase network topologies associated wi

213 Taken together, our data reveal a hitherto unknown link between Nck1 and IRAK-1 in atherog

214 We find that Cryo-OrbiSIMS reveals the hitherto unknown localization patterns of SVOCs with hig

215 We recently reported a hitherto unknown mechanism of regulating ER stress via a

216 R, promotes vascular SMCs proliferation by a hitherto unknown mechanism.

217 tes to initiate sexual development through a hitherto unknown mechanism.

218 Here we report on a hitherto unknown mechanism.

219 The strategy exploits hitherto unknown Michael addition of PH-containing compo

220 In this study, we discovered a hitherto unknown MMR mechanism that modulates genome sta

221 aled breath, with the capability to identify hitherto unknown molecules.

222 ted regions which, due to their proximity to hitherto unknown monoallelically expressed genes, may re

223 A hitherto unknown Neoproterozoic orogenic system, the Sah

224 Recently, hitherto unknown nutritional mutualisms involving ancien

225 paracyclophanes as small and strained as the hitherto unknown oxa[1.5]metaparacyclophane could be pre

226 an's antithrombotic potential is linked to a hitherto unknown rivaroxaban effect that impacts on plat

227 This study highlights a hitherto unknown role for GPAT6-generated cutin monomers

228 rLFPs during the PI-E2 transition identify a hitherto unknown role for the dorsal respiratory group.

229 sted from Cln5-/- brains we investigated the hitherto unknown role of Cln5 in the developing brain.

230 ivated HSCs upon injury and may hence define hitherto unknown roles for HSCs in the regulation of mic

231 g reproductive organ identity, but also play hitherto unknown roles in mediating perianth organ devel

232 We find an hitherto unknown sensitivity of the [Formula: see text]O

233 ies, including alkylated derivatives and two hitherto unknown series.

234 e characterize wild-type flies and uncover a hitherto unknown sexual dimorphism in climbing behavior.

235 The Ag(24) shell is composed of a hitherto unknown sodalite-type silver orthophosphate clu

236 tudy describes a PG hydrolytic enzyme with a hitherto unknown substrate specificity that contributes

237 l astrocytes drive such phenotypes through a hitherto unknown synaptic mechanism.

238 roscopy to reconstruct PNS neurons and their hitherto unknown synaptic networks in the tadpole larva

239 ical and immunohistological studies revealed hitherto unknown TAAR1 localization in brain areas proje

240 Collectively, these findings uncover a hitherto unknown transcriptional role and obligate requi

241 These results reveal a hitherto unknown transient enhancement of context recogn

242 ZFP708 binding to these hitherto unknown TRIM28 targets is DNA methylation and H

243 es on multiple stages of the mechanism and a hitherto unknown XB-glycosyl acceptor activation.

244 In addition, our method also discovered hitherto unknown, clinically relevant biomarker candidat

245 9 engineered human cell lines, we identify a hitherto unknown, H2AX-independent, function of MDC1 med

246 This represents a hitherto unknown, robust sensorimotor linkage and sugges

247 of capturing these complex chemical steps is hitherto unknown.

248 We identified a hitherto-unknown FBXW7-interacting protein, p53, which i

249 Thus, we reveal an important, hitherto-unnoticed cooperation between MDC1 and TOPBP1 i

250 This hitherto unobserved insulator-to-metal transition mediat

251 A hitherto unobserved requirement of short-chain lipids in

252 In a hitherto unobserved state (s4), the gate controlling acc

253 d its non-integral dimensionality point to a hitherto-unobserved magnetic fractal geometry in this sy

254 This novel imaging technique reveals hitherto unobtainable information on human motor unit st

255 ccus microfossils in Holocene sediments with hitherto unparalleled accuracy and rapidity.

256 We report the discovery of a hitherto unprecedented enzyme-promoted alpha-hydroxyketo

257 These findings unravel a hitherto unprecedented mechanism of ERalpha-dependent or

258 These findings suggest a hitherto unrecognised level of social complexity in hump

259 jubatus haplotype, suggesting a hitherto unrecognised South African route of cheetah imp

260 In this study, we revealed hitherto unrecognized actin-based zipper-like structures

261 tations of hematological disorders, can have hitherto unrecognized and clinically significant implica

262 These results indicate a hitherto unrecognized diversity in SH2 domain interactio

263 that pachytene piRNA diversity may provide a hitherto unrecognized driver of reproductive isolation.

264 fied understanding of SmB(6) centered on the hitherto unrecognized dynamical bonding effect: the coex

265 Natural Phl p 4 is a hitherto unrecognized early indicator of grass pollen al

266 Together, these results reveal a hitherto unrecognized epigenetic mechanism coupling gluc

267 Hitherto unrecognized episodes of cortical spreading dep

268 ates a feedback loop, controlled by a second hitherto unrecognized heteromeric transcription factor n

269 A preliminary mechanistic study shows a hitherto unrecognized inhibitory effect by the carboxyla

270 Together, these results reveal a hitherto unrecognized mechanism by which CS could exacer

271 We describe a hitherto unrecognized multiprotease complex containing a

272 Our findings illuminate a prevalent and hitherto unrecognized mutational process linking cellula

273 used by PDPs in vitro and in vivo suggests a hitherto unrecognized pathway contributing to the pathog

274 t monocyclic aromatics can also serve as the hitherto unrecognized precursors of AOSCs in the atmosph

275 iac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease.

276 indings therefore suggest that PCSK9 plays a hitherto unrecognized role in dengue pathogenesis and th

277 These results demonstrate a hitherto unrecognized role of the deubiquitinating enzym

278 Our screen unveiled hitherto unrecognized roles for Rho-mediated cytoskeleta

279 This occurs via a hitherto unrecognized signal transduction system whereby

280 These results uncover a hitherto unrecognized stress pathway, whereby a ROS-gene

281 the THP-1 human monocytic cell line revealed hitherto unrecognized trends, while opening the door to

282 d soil pore formation appears to be a major, hitherto unrecognized, determinant of whether new C inpu

283 The NMR structure of CshA_RD13 revealed a hitherto unreported all beta-fold, flanked by disordered

284 tricyclo[4.3.2.0(4,9)]undecane ring system-a hitherto unreported bridged azatricyclic ring system-beg

285 Overall, our study describes a hitherto unreported conserved mechanism of transcription

286 We identified a hitherto unreported disease mechanism (defective linear

287 een successfully applied to the syntheses of hitherto unreported imidazo-fused benzimidazoquinazoline

288 which the triazolo N1 atom coordinates in a hitherto unreported monodentate interaction with the act

289 ion has been reported, lengthwise cutting is hitherto unreported.

290 stratification and enhanced our knowledge on hitherto unresolved and contentious issues concerning th

291 The results provide a positive answer to the hitherto unresolved question of whether neurodegeneratio

292 es in four different states, including three hitherto unseen states, along with molecular dynamics si

293 probability estimation for encountering such hitherto unseen variants.

294 nal parameters of gene-regulatory mechanisms hitherto-unseen in vivo.

295 ot only provides a practical solution to the hitherto unsolved problems of observing negative OKAN, b

296 These studies reveal a hitherto unsuspected role for tmem33 and calcium oscilla

297 This study highlights the hitherto untapped potential of photochemical gas release

298 severity of acute pancreatitis in the rat, a hitherto untested species.

299 dala but also to the olfactory cortex, which hitherto was considered to arise from the lateral palliu

300 itation patterns for China and Mongolia have hitherto yielded contradictory results indicating that t