ライフサイエンスコーパス: hnRNP

1 hnRNP and SR proteins also regulate the expression of ot

2 hnRNP F stimulated Sirtuin-1 transcription via hnRNP F-r

3 hnRNP K directly binds to C-rich single-stranded DNA wit

4 hnRNP K protein was bound to antioxidant NFE2L2 transcri

5 hnRNP K regulates cellular programs, and changes in its

6 hnRNP-Q1 is an mRNA-binding protein that regulates mRNA

7 hnRNP-Q1 is highly expressed in brain tissue, suggesting

8 G motifs enriched within approximately 2,500 hnRNP A2/B1 binding sites and an unexpected role for hnR

9 Interestingly, AS targets of the QKI-6-hnRNP F/H pathway in OLs are differentially affected in

10 dentified heterogenous ribonucleoprotein A1 (hnRNP A1) as a G-quadruplex-unwinding helicase, which un

11 heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as a possible mechanism of neurodegeneration i

12 Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multipurpose RNA-binding protein (RBP) in

13 heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), a protein with multiple roles in mRNA metabol

14 d heterogenous nuclear ribonucleoprotein A1 (hnRNP-A1) as a pharmacodynamic biomarker of type I PRMT

15 heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) has been implicated in telomere protection and

16 Notably, hnRNP A1, hnRNP A2, and hnRNP B1 bound to many dispersed sites acr

17 heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) for access to BC RNAs.

18 heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) for DTE access and significantly diminish BC R

19 uence called the A2 response element (A2RE), hnRNP A2 proteins that bind specifically (with high affi

20 y attenuates viral replication by abrogating hnRNP A1 interactions.

21 Although hnRNP I and AUF1 can interact with many RNA species and

22 n-dependent interplay between a miRNA and an hnRNP that regulates their functions in a bidirectional

23 We have identified an hnRNP E1 consensus-binding motif and genomically resolve

24 cerevisiae Likewise, recruitment of Npl3 (an hnRNP involved in mRNA export via formation of export-co

25 eported that competition between miR-297 and hnRNP L to bind a 3UTR-localized CA-rich element (CARE)

26 ognition algorithm, we found that IMC-48 and hnRNP LL share 80% similarity in stabilizing i-motifs wi

27 Notably, hnRNP A1, hnRNP A2, and hnRNP B1 bound to many dispersed sites across viral mRNA

28 oly(C) binding proteins, PCBPs (alphaCPs and hnRNP E proteins), are encoded by a highly conserved and

29 nuclear ribonucleoprotein (hnRNP)-A2/B1 and hnRNP-R as interactors binding directly to the ASCL1 mRN

30 Here we demonstrate that the RBPs CELF2 and hnRNP C regulate the expression of each other, such that

31 Mutations of human Slo2 channel and hnRNP U are strongly linked to epileptic disorders and i

32 expression level, suggesting that Chtop and hnRNP H regulate intron 2 retention of Chtop mRNA antago

33 PCBP2, IGF2BP1, and hnRNP L binding were blocked by preannealing the single-

34 ron-bound Rbfox is associated with LASR, and hnRNP M motifs are enriched adjacent to Rbfox crosslinki

35 rentially spliced gene isoforms in LIN28 and hnRNP A1 small interfering RNA (siRNA)-treated cells.

36 between miR-574-3p, a CA-rich microRNA, and hnRNP L.

37 ibrium perspective, that small molecules and hnRNP LL can modulate bcl-2 transcription through intera

38 kinetics of the consensus-binding motif and hnRNP E1, its various K-homology (KH) domains and p-hnRN

39 ding proteins, such as hnRNP L, PTB/nPTB and hnRNP A1/A2.

40 t comprise the NES can modulate both p17 and hnRNP A1 interaction and nucleocytoplasmic shuttling of

41 neous nuclear ribonucleoproteins hnRNP R and hnRNP U as KPNA7-interacting proteins.

42 Knockdown of RALY and hnRNP-C increased levels of viral RNA splicing, protein

43 at viral-mediated ubiquitination of RALY and hnRNP-C relieves a restriction on viral RNA processing a

44 ocused on two RNA-binding proteins, RALY and hnRNP-C, which we confirm are ubiquitinated without degr

45 We observed that SR and hnRNP proteins tend to act coordinately with each other,

46 vestigate the protein connectivity of SR and hnRNP proteins to the core spliceosome using probabilist

47 g of each factor demonstrated that SRSF1 and hnRNP H antagonistically modulate splicing by binding ex

48 tors and repressors, such as SR proteins and hnRNPs, modulate spliceosome assembly and regulate alter

49 Anti-hnRNP A1 antibodies were found to surround neuronal cell

50 Additionally, anti-hnRNP A1 antibodies were found within neuronal cell bodi

51 y shown to undergo neurodegeneration in anti-hnRNP A1 antibody injected EAE mice.

52 s (EAE), we show here that injection of anti-hnRNP A1 antibodies, in contrast to control antibodies,

53 al gray matter of the spinal cord where anti-hnRNP A1 antibodies localized.

54 s suggest that autoimmunity to RBPs, such as hnRNP A1, play a role in neurodegeneration in EAE with i

55 by additional RNA-binding proteins, such as hnRNP L, PTB/nPTB and hnRNP A1/A2.

56 nts on 19 RBPs involved in splicing (such as hnRNPs, U2AF2, ELAVL1, TDP-43 and FUS) and processing of

57 ALS-associated hnRNP A2/B1 D290V mutant patient fibroblasts and motor n

58 erogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) bound PBT-1 in CL1-5 cells.

59 o a thermodynamically stable complex between hnRNP K and the unfolded i-motif.

60 further exploration of the interplay between hnRNP K (or other hnRNPs) and Nrf2-mediated antioxidant

61 control of IDR-mediated interactions between hnRNPs represents an important and recurring mechanism u

62 native name for TOG protein) that binds both hnRNP A2 molecules and RNA.

63 underlying neurological disorders caused by hnRNP U mutations.

64 translational silencing at the mRNA level by hnRNP E1.

65 We show that splicing repression mediated by hnRNP M is stimulated by Rbfox.

66 basis for the recognition of the i-motif by hnRNP LL is determined, and we demonstrate that the prot

67 gether, our data indicate that protection by hnRNP L overrides the presence of multiple 3'UTR introns

68 within the 4CT element and is recognized by hnRNP K, which leads to a low level of transcription act

69 IAV-induced splicing events are regulated by hnRNP K, a host protein required for efficient splicing

70 of either RRM impairs splicing repression by hnRNP A1.

71 Genes that are translationally silenced by hnRNP E1 and expressed by its dissociation are highly im

72 trast, suppression of CGG repeat toxicity by hnRNP A2/B1 is not affected by RNAi-mediated knockdown o

73 e heterogeneous nuclear ribonucleoprotein C (hnRNP C) family.

74 We used RNA sequencing (RNA-seq) to confirm hnRNP A1 and A2/B1 motif-dependent roles genome-wide, pr

75 ng and in vitro evolution identify consensus hnRNP A1 binding motifs; however, such data do not revea

76 that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways.

77 transcription-repressive complex containing hnRNP-K/L proteins and show that knockdown of these fact

78 Conversely, hnRNP H1 bound to a few discrete purine-rich sequences,

79 574-3p, acting as a decoy, binds cytoplasmic hnRNP L and prevents its binding to the CARE and stimula

80 ng to known splicing factors including DDX5, hnRNP K, and PRPF6.

81 he G2 and M phases and that DNA-PK-dependent hnRNP-A1 phosphorylation promotes the RPA-to-POT1 switch

82 our results indicate that DNA-PKcs-dependent hnRNP-A1 phosphorylation is critical for capping of the

83 cells lacking hnRNP-A1 or DNA-PKcs-dependent hnRNP-A1 phosphorylation, impairment of the RPA-to-POT1

84 Drosophila hnRNP A1, Hrp38, is required for germ line stem cell mai

85 heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1).

86 These findings establish hnRNP K as a new critical regulator of synaptic transmis

87 ed survival in long-term culture and exhibit hnRNP A2/B1 localization to cytoplasmic granules as well

88 g heterogeneous nuclear ribonucleoprotein F (hnRNP F) in their RPTCs and immortalized rat renal proxi

89 f heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D

90 The RNA processing factor hnRNP L is required for T cell development and function.

91 C repeat RNA in vitro is the splicing factor hnRNP H, and that this interaction is linked to G-Q form

92 otif (RRM1) of putative transcription factor hnRNP LL containing nucleobase amino acids at specific p

93 RRM1 domain of putative transcription factor hnRNP LL was cotransformed with plasmid pTECH-Pyl-OP in

94 ugh interaction with a host splicing factor, hnRNP A1, and regulates E6 and E7 expression of the earl

95 -dependent rescue does, however, require fly hnRNP A2/B1 homologues Hrb87F and Hrb98DE.

96 While Linc-RoR is required for hnRNP I to bind to c-Myc mRNA, interaction of Linc-RoR w

97 /B1 binding sites and an unexpected role for hnRNP A2/B1 in alternative polyadenylation.

98 Thus, we identified a potential role for hnRNP H in basal and dynamic mitochondrial function that

99 led an unexpected splicing enhancer role for hnRNP H1 through binding to its target element.IMPORTANC

100 Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol ho

101 iments using the individual RRM domains from hnRNP LL confirm the role of this transcription factor i

102 nformational change to assemble a functional hnRNP A1-RNA complex.

103 ex containing the proteins hnRNP M, hnRNP H, hnRNP C, Matrin3, NF110/NFAR-2, NF45, and DDX5, all appr

104 LANA and identified a cellular RNA helicase, hnRNP A1, regulating the translation of LANA mRNA.

105 How hnRNP K contributes to the analgesic effects of morphine

106 This study provides novel insights into how hnRNP A1 and lamin A/C modulate nucleocytoplasmic shuttl

107 /CG9983, the fruit fly ortholog of the human hnRNP A1/A2 factors.

108 o phase-separated forms of full-length human hnRNPs (TDP-43, FUS, hnRNPA2) and their low-complexity d

109 A screen identified hnRNP A1 (A1) and RPS25 as IRES-binding trans-acting fac

110 Here, we identify hnRNP L as a factor that protects mRNAs with NMD-inducin

111 Together, these data implicate hnRNP K in the development of hematological disorders an

112 lysis identified a corresponding decrease in hnRNP H protein in 114 kb congenic mice.

113 urprisingly, there was a twofold increase in hnRNP H protein in the striatal synaptosome of H1(+/-) m

114 Finally, we find an increase in hnRNP K in nuclear speckles upon IAV infection, which ma

115 omain, the domain most frequently mutated in hnRNP-related proteins that cause ALS.

116 i-system congenital defects and are found in hnRNPs.

117 We provide evidence that morphine increases hnRNP K protein expression via MOR activation in rat pri

118 ns, which correlates with elevated insoluble hnRNP H/G-Q aggregates.

119 s, likely due to increased nuclear-insoluble hnRNP A2/B1.

120 this study provide mechanistic insights into hnRNP A1 and lamin A/C-modulated nucleocytoplasmic shutt

121 esented here provide the first insights into hnRNP A1-RNA interactions.

122 h heterogeneous nuclear ribonucleoprotein K (hnRNP K) in the nucleus and acts as a transcription fact

123 r heterogeneous nuclear ribonucleoprotein K (hnRNP K) was found to bind selectively to the i-motif sp

124 d heterogeneous nuclear ribonucleoprotein K (hnRNP K).

125 These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 si

126 The K17-hnRNP K partnership is regulated by the ser/thr kinase R

127 rate dysregulated splicing of multiple known hnRNP H-target transcripts in C9 patient brains, which c

128 loops represent an important class of known hnRNP A1 targets, yet little is known about the structur

129 Consequently, in cells lacking hnRNP-A1 or DNA-PKcs-dependent hnRNP-A1 phosphorylation,

130 enrichment of numerous splicing factors like hnRNP proteins before ZGA was surprising, because matern

131 ion with the ribonucleoprotein hnRNP L-like (hnRNP LL) has prompted a more detailed study of the natu

132 ric complex containing the proteins hnRNP M, hnRNP H, hnRNP C, Matrin3, NF110/NFAR-2, NF45, and DDX5,

133 tions of HRPU-2, a worm homolog of mammalian hnRNP U, result in dysfunction of a Slo2 potassium chann

134 For maximal hnRNP K transcription activation, two additional cytosin

135 re modulated by a bivalent adaptor molecule (hnRNP A2).

136 Laccase2 gene product but rather by multiple hnRNP (heterogeneous nuclear ribonucleoprotein) and SR (

137 formation of tyrosine-dependent multivalent hnRNP assemblies that, in turn, function to globally reg

138 degeneration, regulated by normal and mutant hnRNP A2/B1.

139 esembles sequence elements of several native hnRNP A1-RNA stem loop targets.

140 Notably, hnRNP A1, hnRNP A2, and hnRNP B1 bound to many dispersed

141 infection, which may alter accessibility of hnRNP K for host transcripts thereby leading to a progra

142 utes to the morphine-induced accumulation of hnRNP K protein in regions of the central nervous system

143 ogether, this work reveals new activities of hnRNP C and CELF2, provides insight into a previously un

144 We determined the affinity of hnRNP A1 for all possible sequence variants (n = 16,384)

145 ittle is known about the structural basis of hnRNP A1-RNA recognition.

146 Binding of hnRNP C1 to the HPV16 early, untranslated region activat

147 CRISPR/Cas9 deletion of hnRNP L binding sites near the BCL2 stop codon reduces e

148 tiple RNA recognition motif (RRM) domains of hnRNP L, synergizes with miR-297, reduces VEGFA mRNA tra

149 of CELF2 results in decreased efficiency of hnRNP C translation.

150 eded to assemble an EDC with the eviction of hnRNP proteins, the late recruitment of SR proteins, and

151 Most importantly, the expression of hnRNP A1/A2 and PTB/nPTB is significantly altered in pat

152 e for inducing EMT by aberrant expression of hnRNP E1 silenced targets.

153 more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidn

154 re, we determined the location and extent of hnRNP binding to HIV-1 mRNAs and their impact on splicin

155 NA processing, including selective groups of hnRNP proteins, through its N-terminal region, and direc

156 f hnRNP L, we validate numerous instances of hnRNP L-dependent alternative splicing of genes critical

157 s methylation facilitates the interaction of hnRNP A1 with IRES RNA to promote IRES-dependent transla

158 This interaction of hnRNP A1 with LANA mRNA could be exploited for controlli

159 species and destabilizes the interaction of hnRNP K with the Mid-region i-motif.

160 irus resulted in an increased interaction of hnRNP-C with viral RNA and attenuation of viral RNA proc

161 to the hnRNP A1-binding site or knockdown of hnRNP A1 expression promoted 233^416 splicing and reduce

162 Knockdown of hnRNP A1 or lamin A/C led to inhibition of nucleocytopla

163 TGFbeta treatment or knockdown of hnRNP E1 relieves silencing of the inhibin betaA transcr

164 ing T cell differentiation, and knockdown of hnRNP L or hnRNP A1 results in the lower induction of Tr

165 Neurons displayed increased levels of hnRNP A1 nucleocytoplasmic mislocalization and stress gr

166 gh abundance of p-hnRNP E1 and low levels of hnRNP E1.

167 required for the cytoplasmic localization of hnRNP K and for its role in regulating the expression of

168 Specifically, we show that loss of hnRNP C reduces the transcription of CELF2 mRNA, while l

169 Loss of hnRNP U expression in cardiomyocytes also leads to aberr

170 tablished a strong link between mutations of hnRNP U and human epilepsies and intellectual disability

171 However, it is unclear how mutations of hnRNP U may cause such disorders.

172 Importantly, based on the binding profile of hnRNP L, we validate numerous instances of hnRNP L-depen

173 his post-translational modification (PTM) of hnRNP E1 promotes its dissociation from a 3' untranslate

174 ts located in the 5' untranslated regions of hnRNP K transcripts that were regulated by morphine.

175 ion was down-regulated with up-regulation of hnRNP F.

176 Finally, we found that down-regulation of hnRNP K mediated by siRNA attenuated morphine-induced hy

177 Here, we investigated the role of hnRNP K in synapse function.

178 ells, in agreement with the critical role of hnRNP L throughout T cell biology.

179 onclusive evidence for the essential role of hnRNP U in heart development and function and in the reg

180 The role of hnRNP-A1 in telomere protection also involves DNA-depend

181 n addition, we show by NMR that both RRMs of hnRNP A1 can bind simultaneously to a single bipartite m

182 The RNA recognition motifs (RRMs) of hnRNP LL were expressed individually, and both RRM1 and

183 icate C9 expansion-mediated sequestration of hnRNP H as a significant contributor to neurodegeneratio

184 TGFbeta stimulation or silencing of hnRNP E1 increases ILEI translation and induces an EMT p

185 IP-seq) to identify the RNA binding sites of hnRNP L within the transcriptomes of human CD4(+) and cu

186 sults reveal general rules of specificity of hnRNP A1 and provide a quantitative framework for unders

187 rotein 43 (Gap-43) mRNA as a novel target of hnRNP-Q1 and have demonstrated that hnRNP-Q1 represses G

188 criptome-wide analysis of the RNA targets of hnRNP L in lymphoid cells and add to the functional unde

189 and the Gly-rich region of the C terminus of hnRNP A1.

190 s and add to the functional understanding of hnRNP L in human biology.

191 methylation of specific arginine residues on hnRNP-A1.

192 cold inducible RNA-binding protein (CIRP or hnRNP A18) as a telomerase-interacting factor.

193 neous nuclear ribonucleoprotein (hnRNP) L or hnRNP A1 are Akt substrates during Treg induction and ha

194 differentiation, and knockdown of hnRNP L or hnRNP A1 results in the lower induction of Treg cells.

195 Transfection of p44/42 MAPK or hnRNP F small interfering RNA (siRNA) prevented insulin

196 Overexpression of RALYL or hnRNP C1 induced HPV16 late gene expression from HPV16 s

197 n of the interplay between hnRNP K (or other hnRNPs) and Nrf2-mediated antioxidant signaling is warra

198 in Akita mice and Akita mice overexpressing hnRNP F suppressed Bmf expression and RPTC apoptosis.

199 sgenic (Tg) mice specifically overexpressing hnRNP F in their RPTCs.

200 onucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1).

201 a signature high level of Akt2, p-Akt2 and p-hnRNP E1 protein expression, coupled to a significantly

202 1, its various K-homology (KH) domains and p-hnRNP E1.

203 n cellular models by the high abundance of p-hnRNP E1 and low levels of hnRNP E1.

204 Levels of p-hnRNP E1 are highly upregulated in metastatic cancer cel

205 The formation of p17-hnRNP A1-transportin 1 carrier-cargo complex is required

206 our results reveal that the formation of p17-hnRNP A1-transportin 1 carrier-cargo complex is required

207 lasmic accumulation of Tyr359-phosphorylated hnRNP L sequesters miR-574-3p, overcoming its decoy acti

208 of Sirtuin-1 small interfering RNA prevented hnRNP F stimulation of Foxo3alpha and downregulation of

209 lect transcripts via the RNA-binding protein hnRNP E1 during EMT.

210 iscovered a role for the RNA binding protein hnRNP H in methamphetamine reward and reinforcement.

211 t K17 interacts with the RNA-binding protein hnRNP K, which has also been implicated in cancer.

212 ing site for the pre-mRNA processing protein hnRNP A1.

213 is heterogenous nuclear ribonuclear protein (hnRNP) has multiple functions in RNA processing includin

214 a splicing-suppressing RNA-binding protein, hnRNP H.

215 demonstrating that the RNA-binding protein, hnRNP L, protects a subset of RNAs from degradation by N

216 a multimeric complex containing the proteins hnRNP M, hnRNP H, hnRNP C, Matrin3, NF110/NFAR-2, NF45,

217 heterogeneous nuclear ribonuclear proteins (hnRNPs).

218 Mechanisms and putative hnRNP A1-RNA interactions have been inferred primarily f

219 d by its 3'UTR length and ability to recruit hnRNP L.

220 Reduced hnRNP K expression attenuated p21 activation, downregula

221 duced negative superhelicity, where relative hnRNP K and nucleolin expression shifts the equilibrium

222 voring recruitment of the splicing repressor hnRNP A1 and interfering with that of U2AF65 at the 3' s

223 As a result, hnRNP A2 is displaced, and BC RNAs are impaired in their

224 the heterogeneous nuclear ribonucleoprotein hnRNP H2.

225 the heterogeneous nuclear ribonucleoprotein hnRNP K.

226 n via interaction with the ribonucleoprotein hnRNP L-like (hnRNP LL) has prompted a more detailed stu

227 ng, heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins.

228 The heterogeneous nuclear ribonucleoprotein (hnRNP) A1 protein is a multifunctional RNA binding prote

229 hat heterogeneous nuclear ribonucleoprotein (hnRNP) A1 serves as a carrier protein to modulate nucleo

230 tor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 form the basis for activity-dependent dendriti

231 Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 binds this element and promotes readthrough

232 the heterogeneous nuclear ribonucleoprotein (hnRNP) family of proteins that bind thousands of pre-mRN

233 ith heterogeneous nuclear ribonucleoprotein (hnRNP) I and AU-rich element RNA-binding protein 1 (AUF1

234 hat heterogeneous nuclear ribonucleoprotein (hnRNP) K is a transactivator of Th transcription.

235 ly, heterogeneous nuclear ribonucleoprotein (hnRNP) L or hnRNP A1 are Akt substrates during Treg indu

236 ied heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 and hnRNP-R as interactors binding directly

237 The heterogeneous nuclear ribonucleoprotein, hnRNP A1, is an IRES transacting factor (ITAF) that regu

238 ied heterogeneous nuclear ribonucleoproteins hnRNP R and hnRNP U as KPNA7-interacting proteins.

239 he heterogeneous nuclear ribonucleoproteins (hnRNP) form a large family of RNA-binding proteins that

240 ed heterogeneous nuclear ribonucleoproteins (hnRNPs) A1 and A2/B1, which are required for transcript

241 by heterogeneous nuclear ribonucleoproteins (hnRNPs) and their viral target sequences, which typicall

242 Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins t

243 nd heterogeneous nuclear ribonucleoproteins (hnRNPs) are families of sequence-specific, posttranscrip

244 in heterogeneous nuclear ribonucleoproteins (hnRNPs) binding to A3B.

245 rs, heterologous nuclear ribonucleoproteins (hnRNPs) F and H.

246 he heterogeneous nuclear ribonucleoproteins (hnRNPs) family cause ALS.

247 of heterogeneous nuclear ribonucleoproteins (hnRNPs) in the control of alternative splicing at cis-ac

248 of heterogeneous nuclear ribonucleoproteins (hnRNPs) regulates the posttranscriptional fate of RNA du

249 ed heterogeneous nuclear ribonucleoproteins (hnRNPs).

250 letion and mutation of a prominent viral RNA hnRNP H1 binding site decreased the use of splice accept

251 pment of hematological disorders and suggest hnRNP K acts as a tumor suppressor.

252 to the mechanisms linking increased synaptic hnRNP H with decreased methamphetamine-induced dopamine

253 rked increase in basal level of synaptosomal hnRNP H and mitochondrial proteins that decreased in res

254 by the conserved RNA binding protein Syncrip/hnRNP Q.

255 We conclude that hnRNP and NF90 are important host factors for HCV replic

256 Herein, we demonstrate that hnRNP E1 knockdown significantly shifts normal mammary e

257 Our results demonstrate that hnRNP F protects kidneys against oxidative stress and ne

258 Our results demonstrate that hnRNP F suppression of Bmf transcription is an important

259 We demonstrated that hnRNP K regulates dendritic spine density and long-term

260 ecent evidence has further demonstrated that hnRNP-A1 plays a crucial role in maintaining newly repli

261 arget of hnRNP-Q1 and have demonstrated that hnRNP-Q1 represses Gap-43 mRNA translation and consequen

262 Here we report that hnRNP A1 and lamin A/C serve as carrier and mediator pro

263 Here we report that hnRNP-A1 is phosphorylated by DNA-PKcs during the G2 and

264 Our results reveal that hnRNP-Q1 knockdown increased nascent axon length, total

265 We analyze RNA-Seq data to show that hnRNP C is a potential regulator of SMN6B expression and

266 In addition, we show that hnRNP H accelerates intron 2 splicing of Chtop mRNA in a

267 xpressing TDP-43Q331K mutation, we show that hnRNP K expression is impaired in urea soluble extracts

268 We showed that hnRNP A1 is methylated by PRMT5 on two residues, R218 an

269 Our results suggested that hnRNP C1 controls HPV16 late gene expression.

270 ith RNA-seq revealed that exons carrying the hnRNP H-binding GGGGG motif are predisposed to be skippe

271 Introduction of point mutations into the hnRNP A1-binding site or knockdown of hnRNP A1 expressio

272 ary changes impact nearly all members of the hnRNP A and D families of RNA binding proteins.

273 RALY is a member of the hnRNP family that binds poly-U-rich elements within seve

274 RNPA1, hnRNPA3 and hnRNPU-all members of the hnRNP family.

275 antagonistic effects on the formation of the hnRNP LL-i-motif complex as well as on the transcription

276 ting cells and reduced metastasis within the hnRNP E1 knock-down cell populations in vivo.

277 Therefore hnRNP-Q1-mediated repression of Gap-43 mRNA translation

278 MS patients make antibodies to hnRNP A1, which have been shown to lead to neuronal dysf

279 o 40) of p17 that is critical for binding to hnRNP A1 and for nucleocytoplasmic shuttling of p17.

280 icing of HPV18 E6E7 pre-mRNAs via binding to hnRNP A1, a well-characterized, abundantly and ubiquitou

281 effects of mutant TDP-43-mediated changes to hnRNP K metabolism by RNA binding immunoprecipitation an

282 organization of the two RRMs is essential to hnRNP A1 function.

283 ed to a significantly reduced level of total hnRNP E1 in metastatic cells.

284 heterogenous nuclear ribonuclear protein U (hnRNP-U), is phosphorylated on serine 59 by the DNA-depe

285 T Heterogeneous nuclear ribonucleoprotein U (hnRNP U) belongs to a family of RNA-binding proteins tha

286 e heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the heart develop lethal dilated cardiomyopa

287 n heterogeneous nuclear ribonucleoprotein U (hnRNP U), plays an important role in regulating the expr

288 is translationally regulated by TGFbeta via hnRNP E1.

289 HnRNP F inhibited Bmf transcription via hnRNP F-responsive element in the Bmf promoter.

290 RNP F stimulated Sirtuin-1 transcription via hnRNP F-responsive element in the Sirtuin-1 promoter.

291 uences, a finding that was mirrored in vitro hnRNP H1 depletion and mutation of a prominent viral RNA

292 In vitro, hnRNP F overexpression stimulated Sirtuin-1 and Foxo3alp

293 bind to degenerative binding motifs, whereas hnRNP H strictly requires an uninterrupted stretch of po

294 on in metabolic control and a model by which hnRNPs can impact health and disease states.

295 pansion, and more frequently colocalize with hnRNP H.

296 By selectively coordinating with hnRNP H/F and U proteins, AKAP95 appears to mainly promo

297 in of TDP-43 that preclude interactions with hnRNP A2/B1 abolish TDP-43-dependent rescue of CGG repea

298 -mediated toxicity through interactions with hnRNP A2/B1 and suggest a convergence of pathogenic casc

299 he discovery that ubiquilin-2 interacts with hnRNP proteins and that mutation in either protein disru

300 of Gap-43 mRNA that directly interacts with hnRNP-Q1 as a means to inhibit Gap-43 mRNA translation.

301 ndicated that direct interaction of p17 with hnRNP A1 maps within the amino terminus (amino acids [aa