ライフサイエンスコーパス: homeostasis

1 is, iron-sulfur cluster formation, and redox homeostasis.

2 nse, early/late E2-response, and cholesterol homeostasis.

3 ecade ago in a genetic screen for ER protein homeostasis.

4 nd signaling pathways to alter physiological homeostasis.

5 molecular mechanisms of copper transport and homeostasis.

6 n and differentiation as well as adult organ homeostasis.

7 lar chaperones are known to maintain protein homeostasis.

8 et-induced weight gain and improve metabolic homeostasis.

9 ing cell-fate determination and adult tissue homeostasis.

10 ovascular disease, kidney disease, and fluid homeostasis.

11 lagen degradation by CTSK maintains collagen homeostasis.

12 infections and for the maintenance of tissue homeostasis.

13 bsorption to pathogen sensing and intestinal homeostasis.

14 n innate immune system, and control its iron homeostasis.

15 gene regulatory circuits controlling sterol homeostasis.

16 sorbed by supporting cells to maintain fluid homeostasis.

17 primary mechanism that maintains ER protein homeostasis.

18 regulates hepatic cholesterol and bile acid homeostasis.

19 f the KS-WNK1 isoform abundance on potassium homeostasis.

20 tion in vivo and the role of MRAP2 in energy homeostasis.

21 econd messenger in cell signaling and tissue homeostasis.

22 amental role in maintaining tissue and organ homeostasis.

23 as pulmonary/cardiovascular development and homeostasis.

24 auto-reactive T cells and maintaining immune homeostasis.

25 ting that Akt3 is required for mitochondrial homeostasis.

26 c physiologic functions, including in energy homeostasis.

27 em is fundamental for salt intake and tissue homeostasis.

28 rocess important for cellular metabolism and homeostasis.

29 tension during epithelial organogenesis and homeostasis.

30 cells is essential to maintain blood glucose homeostasis.

31 ith the host immune response to maintain the homeostasis.

32 uilibrate between the sites to maintain heme homeostasis.

33 d the long-term effects of infection on host homeostasis.

34 nate immune responses and for maintenance of homeostasis.

35 commensal and pathogen responses and tissue homeostasis.

36 action resulting in maintenance of metabolic homeostasis.

37 in adult adipose lineage did not affect WAT homeostasis.

38 ty necessitate the strict regulation of iron homeostasis.

39 es to regulate cell fate and maintain normal homeostasis.

40 brane proteins and maintain cellular protein homeostasis.

41 is crucial for controlling LD size and lipid homeostasis.

42 mediators that is aimed at restoring tissue homeostasis.

43 ential for intact islet function and glucose homeostasis.

44 esponses whose purpose is to restore glucose homeostasis.

45 autophagy is important to maintain neuronal homeostasis.

46 key regulator of intestinal microenvironment homeostasis.

47 tments to maintain embryonic carbon/nitrogen homeostasis.

48 are essential for maintaining intracellular homeostasis.

49 ed a molecular signature for microglia under homeostasis.

50 ells (Tregs) are crucial mediators of immune homeostasis.

51 ) deficiency are essential for physiological homeostasis.

52 into the mechanisms that maintain neutrophil homeostasis.

53 la to quantify production from initiation to homeostasis.

54 ch persist in remission, contribute to joint homeostasis.

55 t are involved in maintaining cardiovascular homeostasis.

56 alibrating rapid 5-HT release for intestinal homeostasis.

57 otide polymorphisms (SNPs) related to energy homeostasis.

58 temporal self-organization, resilience, and homeostasis.

59 maturation, function, and fate decisions at homeostasis.

60 ere they regulate numerous steps of membrane homeostasis.

61 ucagon is a critical regulator of amino acid homeostasis.

62 n organelles is essential for their cellular homeostasis.

63 neurovascular unit evolved to maintain brain homeostasis.

64 t plays a key role in the control of calcium homeostasis.

65 in quality control, calcium flux, and sterol homeostasis.

66 bile acid synthesis and regulates metabolic homeostasis.

67 how cells adapt to new molecules to maintain homeostasis.

68 n adiposity-dependent improvement in glucose homeostasis.

69 cal control of membrane potential and of ion homeostasis.

70 ver to maintain whole-body lipid and glucose homeostasis.

71 lactate metabolism in the control of energy homeostasis.

72 on also play roles in synapse maturation and homeostasis.

73 and the actin cytoskeleton play in podocyte homeostasis.

74 ral interactions regulating sleep and energy homeostasis.

75 cretion in the maintenance of 24-h metabolic homeostasis.

76 hat might disrupt neuronal membranes and ion homeostasis.

77 microbiota with profound effects on nutrient homeostasis.

78 on and functions and tissue organization and homeostasis.

79 tical to reestablish the mucosal barrier and homeostasis.

80 ose correct assembly is crucial for cellular homeostasis.

81 adhesion, signal transduction, or metabolite homeostasis.

82 of bile acids can greatly disrupt metabolic homeostasis.

83 IL-22) is a critical regulator of epithelial homeostasis.

84 further stress on their capacity for protein homeostasis.

85 ion, senescence, and deregulated cell/tissue homeostasis.

86 l for both cortical development and synaptic homeostasis.

87 acts developmentally to program body weight homeostasis.

88 molecular mechanisms that promotes cell size homeostasis.

89 nism involved in regulation of cellular iron homeostasis.

90 ant for surfactant biosynthesis and alveolar homeostasis.

91 on of energy metabolism and systemic glucose homeostasis.

92 lopment in maintenance of physiologic tissue homeostasis.

93 s regulate cell death, immune responses, and homeostasis.

94 role in the regulation of glucose and lipid homeostasis.

95 zes its importance for maintaining host cell homeostasis.

96 intake leads to oxidative stress disrupting homeostasis, activating signaling, and altering metaboli

97 esses mitophagy, disturbs mitochondrial Ca2+ homeostasis, affects ATP production, and attenuates DNA

98 play a key role to locally regulate cardiac homeostasis after MI.

99 WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD

100 T-NPC1 leading to restoration of cholesterol homeostasis, an effect that is largely driven by a reduc

101 findings reveal TRIM25 as a regulator of ER homeostasis and a potential target for tumor therapy.

102 ription of specific genes involved in nickel homeostasis and acid adaptation.

103 Endothelial integrity is vital for homeostasis and adjusted to tissue demands.

104 helial cells affects zonation patterns under homeostasis and after acute injury.

105 ) is important in the maintenance of calcium homeostasis and alterations in this mechanism are respon

106 Obesity disrupts physiological homeostasis and alters both systemic and local microenvi

107 tein, as a direct regulator of both cellular homeostasis and apoptosis.

108 1 and Mfrn2 contribute to mitochondrial iron homeostasis and are required for high-affinity iron impo

109 macrophages (RPMs) contribute to erythrocyte homeostasis and are required for iron recycling.

110 ) control the integrity of the endolysosomal homeostasis and cellular metabolism.

111 mals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain,

112 MENT Menkes and Wilson disease affect copper homeostasis and characteristically afflict the nervous s

113 while ablation results in altered ECM repair/homeostasis and conventional outflow physiology.

114 rnal low protein diet for offspring vascular homeostasis and define the sperm and seminal plasma spec

115 ht into microglia-astrocyte communication in homeostasis and disease.

116 ia and extraparenchymal brain macrophages in homeostasis and during disease.

117 her E-cadherin plays a role in regulating LC homeostasis and function, we generated CD11c-specific E-

118 Glucose homeostasis and growth essentially depend on the hormone

119 ed new insights into the regulation of lipid homeostasis and has revealed new molecular pathways invo

120 f intestinal neural circuits to maintain gut homeostasis and health.

121 ise that is essential for life-long cellular homeostasis and heart function.

122 between 9p21.3 and MI is modified by glucose homeostasis and lifestyle.

123 Disturbances in glucose homeostasis and low-grade chronic inflammation culminate

124 ta/TNF-induced necrosis from impaired energy homeostasis and lysosomal permeabilization and inflammat

125 LBL favored reactive oxygen species homeostasis and metabolic activities involving lipid met

126 ll activation to encompass both naive T cell homeostasis and models of weak activation, such as toler

127 fied c-Maf as an essential regulator of ILC3 homeostasis and plasticity that limits physiological ILC

128 ta relationship that is required to maintain homeostasis and prevent disease.

129 ted recognition of commensal fungi maintains homeostasis and prevents invasion from opportunistic com

130 ens in breast milk, which disrupt gut immune homeostasis and prevents oral tolerance induction to bys

131 creasing ATP hydrolysis restores NAD(+)/NADH homeostasis and proliferation even when glucose oxidatio

132 s a cellular process that preserves cellular homeostasis and promotes cellular survival during times

133 hosphatase 1 (FBP1) disrupts liver metabolic homeostasis and promotes tumour progression.

134 uroimmune interactions in maintaining tissue homeostasis and protection.

135 ation of memory T cells that supports tissue homeostasis and provides protective immunity.

136 the development of cells that support tissue homeostasis and repair, such as innate lymphoid cells.

137 e ICZ of aged mice and contributed to airway homeostasis and repair.

138 tory T cells (Tregs) are critical for immune homeostasis and respond to local tissue cues, which cont

139 global cytosine-5 methylome on development, homeostasis and stress remains unknown.

140 providing another link between cell envelope homeostasis and stringent response.

141 s a pivotal catabolic mechanism that ensures homeostasis and survival of the cell in the face of stre

142 work synergistically to maintain adult mouse homeostasis and survival.

143 ed by light driven perturbations of cellular homeostasis and that this biosensing concept is able to

144 to play an essential role in the endothelial homeostasis and the binding of BMP-9 to the receptor act

145 n system to regulating intestinal amino acid homeostasis and the gut microbiome.

146 a prominent role for CBX2 in heterochromatin homeostasis and the regulation of nuclear architecture.

147 a regulatory hub for cellular and organismal homeostasis, and an attractive therapeutic target for a

148 in animal evolution, tissue development, and homeostasis, and are disrupted in human cancers.

149 d mitochondrial respiratory capacity, Ca(2+) homeostasis, and attenuated superoxide production in res

150 populations of microbiota for the survival, homeostasis, and complete development of marine mollusks

151 Dietary lipids impact development, homeostasis, and disease, but links between specific die

152 An essential factor for the development, homeostasis, and function of mononuclear phagocytes is t

153 tes gastric acid secretion, salt and glucose homeostasis, and heart rhythm.

154 hich restores lysosomal proteolysis, calcium homeostasis, and normal autophagy flux.

155 Disorders of FGF23 homeostasis are associated with significant morbidity an

156 Adequate energy intake and homeostasis are fundamental for the appropriate growth a

157 emonstrated that changes in Ca(2+) and Na(+) homeostasis are responsible for the surprisingly modest

158 These findings show that mitochondrial homeostasis as controlled by the PGC family of transcrip

159 most abundant cellular effectors of protein homeostasis, assisting protein folding and preventing ag

160 to maintain neuronal activity-related solute homeostasis at the axon-myelin interface, and the integr

161 cally, sucrose supplementation disrupted the homeostasis between acid-producing and alkali-producing

162 levels of periodontal pathogens disrupt the homeostasis between the host and its microbiota and incr

163 arrier function, microbial flora, and immune homeostasis but also enhancing skin epithelial different

164 itical roles in immunity, cancer, and tissue homeostasis, but how these distinct cellular fates are t

165 Lysosome function is essential for cellular homeostasis, but quality-control mechanisms that maintai

166 rointestinal (GI) epithelium development and homeostasis, but the underlying mechanisms remain elusiv

167 tion pathway crucial to maintaining cellular homeostasis by clearing damaged organelles, pathogens, a

168 hat DPP3 regulates the RAS pathway and water homeostasis by degrading circulating angiotensin peptide

169 hronic hyperglucagonemia can improve glucose homeostasis by inducing glucagon resistance in the liver

170 TRADD modulates cellular homeostasis by inhibiting K63-linked ubiquitination of b

171 igated the hypothesis that SOD3 preserves HA homeostasis by inhibiting oxidative and enzymatic hyalur

172 apezoid nucleus in the brainstem(4-6) and pH homeostasis by kidney proximal tubule cells(7,8).

173 mocollin-2 (Dsc2) that contribute to mucosal homeostasis by strengthening intercellular adhesion betw

174 d protein with low basal levels under normal homeostasis conditions.

175 ndent control of shear flow sensing, calcium homeostasis, cytoskeletal dynamics and pressure-dependen

176 Maintaining ER lipid homeostasis despite these fluctuations is crucial to cel

177 inflammation, successful repair, and kidney homeostasis during aging.

178 artments, are essential to maintain cellular homeostasis during development and in stress responses.

179 shown to have protective effects on glucose homeostasis during high-fat overfeeding.

180 r mechanisms of telomeric DDR and CD4 T-cell homeostasis during HIV infection.IMPORTANCE The hallmark

181 are required to maintain osmotic and protein homeostasis during remodelling of eukaryotic proteomes,

182 , and thus for deciphering the role of lipid homeostasis during rice seed germination.

183 ole of AtPam16L in maintaining mitochondrial homeostasis, especially under stress conditions.

184 s for each factor may contribute to nutrient homeostasis from the functional and evolutional perspect

185 , the diminished ability to maintain protein homeostasis, has been established as a hallmark of nemat

186 macrophages play an important role in organ homeostasis, immunity and the pathogenesis of various in

187 ction but minimizes disruption of intestinal homeostasis.IMPORTANCE Enteric viral infections are a ma

188 paradigm that FOXM1 regulates mitochondrial homeostasis in a process independent of nuclear transcri

189 unction, highlighting requirements for brain homeostasis in aging.

190 Lipid homeostasis in animal cells is maintained by sterol regu

191 and metabolic pathways that control cellular homeostasis in B cells.

192 isoform alone in the liver improves glucose homeostasis in dietary and genetic mouse models of T2D.

193 o regulate reproductive processes and energy homeostasis in invertebrates.

194 also to trigger critical responses promoting homeostasis in its host.

195 is and apoptosis, and iii) altered ER Ca(2+) homeostasis in kidney disease, including podocytopathy,

196 ing combination of drugs, and restore tissue homeostasis in mice in which liver fibrosis is induced c

197 e tissue is associated with improved glucose homeostasis in mice.

198 her member of the BCL2 family, in intestinal homeostasis in mice.

199 and reverse obesity and dysregulated glucose homeostasis in multiple mouse models, prolonging the hea

200 esemble previously reported effects on lipid homeostasis in other species.

201 ssessed and compared determinants of mineral homeostasis in patients with nephropathic cystinosis acr

202 the chloroplast and cytosol is linked to Fe homeostasis in plants.

203 structures such as the appendages, or during homeostasis in postnatal stages and adulthood.

204 small RNA types that may systemically affect homeostasis in poststroke immune responses, and pinpoint

205 tions with the LINC complex regulate nuclear homeostasis in the cardiomyocyte.

206 that PRMT5 controlled thymic and peripheral homeostasis in the CD4+ Th cell life cycle and invariant

207 This mini-review is focused on: i) Ca(2+) homeostasis in the ER, ii) ER Ca(2+) dyshomeostasis and

208 sustained over time and defines an adaptive homeostasis in the infected macrophage.

209 adipose tissue (AT) and regulate both tissue homeostasis in the lean state and metabolic dysregulatio

210 r, we noted significant changes in glutamate homeostasis in the NA core of cocaine + alcohol rats rel

211 hese data suggest that DDR1 regulates tissue homeostasis in the neoplastic and injured pancreas.

212 olic, the molecular basis of the thiol redox homeostasis in the single mitochondrion of these parasit

213 lopmental CK1delta OE alters transcriptional homeostasis in the striatum, including specific alterati

214 While growing, coral maintained homeostasis in their nutrient pools, showing tolerance t

215 gy production and serves to maintain protein homeostasis in various cellular compartments.

216 estigated the role of ERdj5 in photoreceptor homeostasis in vivo by using an Erdj5 knockout mouse cro

217 y strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system

218 cell-associated SIV-DNA, and preserved Th17 homeostasis, including at pre-ART, are the main features

219 OPA1 is an important factor in mitochondrial homeostasis, including cristae remodeling; therefore, we

220 loss of 5-hmC in genes regulating stem cell homeostasis, including MBD1, RTN1, STRN4, PRKD2, AKT1, a

221 that dysregulation of mitochondrial calcium homeostasis is also related to tau and other risk factor

222 In animal cells, size homeostasis is controlled through two phenomenologically

223 Kidney homeostasis is critically determined by the coordinated

224 Dysregulation of this homeostasis is implicated in tumorigenesis and acquired

225 ow these integrate to maintain immunological homeostasis is incomplete.

226 The role of NIPP1 in tissue homeostasis is not fully understood.

227 ablished, but the function of chloroplast Pi homeostasis is poorly understood in Oryza sativa (rice).

228 e of beta-cell-derived exosomes in metabolic homeostasis is poorly understood.

229 Potassium homeostasis is vital for all organisms, but is challengi

230 trocytes postnatally produces loss of PFC DA homeostasis, leading to defective synaptic transmission

231 plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease

232 d evidence for an upregulation of the oxygen homeostasis maintaining pathway involving Hypoxia-induci

233 that the integrity of Golgi-dependent copper homeostasis mechanisms, requiring ATP7 and COG, are nece

234 An imbalance in cellular homeostasis occurring as a result of protein misfolding

235 ippase activity of ALA4 and ALA5 impacts the homeostasis of both glycerolipids and sphingolipids and

236 s review summarizes current knowledge on the homeostasis of c-di-AMP and its function(s) in the contr

237 ortant role of DNA methylation in the normal homeostasis of cardiomyocytes and during cardiac stress,

238 anelle that generates energy to maintain the homeostasis of cells.

239 m, mitochondria per se can influence protein homeostasis of cytosolic aggregation-prone proteins.

240 Evolutionarily conserved mechanisms maintain homeostasis of essential elements, and are believed to b

241 investigated the role of osteopontin in the homeostasis of IEL.

242 tal Fc receptor (FcRn) has a key role in the homeostasis of IgG.

243 The cellular homeostasis of lymphoid tissues is determined by the con

244 cell motility can help maintain longitudinal homeostasis of the Corti fluid.

245 es of influenza-induced changes in metabolic homeostasis on disease progression.

246 hich normally regulate vitamin D and mineral homeostasis, on testicular function.

247 ssue repair and restoration of normal tissue homeostasis once an infection is controlled.

248 tained in a lineage-restricted manner during homeostasis or after mild injuries.

249 irs were previously associated with neuronal homeostasis or HD pathogenesis, or both.

250 Fluoride exposure did not alter Ca(2+) homeostasis or increase the expression of ER stress-asso

251 trated programs that either restore cellular homeostasis or induce cell death depending on the insult

252 The fission yeast phosphate homeostasis (PHO) regulon comprises three phosphate acqu

253 into SP-B deficient mice restores surfactant homeostasis, prevents lung injury, and improves lung phy

254 phosphatidylinositol kinases and cholesterol homeostasis reduced replication of all three coronavirus

255 Despite its pivotal role in homeostasis, regeneration and cancer, little is known ab

256 Faithful maintenance of immune homeostasis relies on the capacity of the cellular immun

257 plays in the regulation of general cellular homeostasis remains unclear.

258 e to the robust outcomes that support tissue homeostasis remains unclear.

259 The maintenance of blood homeostasis requires a dynamic response of HSCs to stres

260 sed cell size, which suggests that cell size homeostasis requires coordinated control of plasma membr

261 Maintaining energy homeostasis requires coordinating physiology and behavio

262 icient melatonin levels impair mitochondrial homeostasis, resulting in mitochondrial DNA (mtDNA) rele

263 kin-29 sleep and energy homeostasis roles map to a set of sensory neurons that a

264 contributes to central nervous system (CNS) homeostasis specifically through its regulation of gasde

265 s is essential for the maintenance of kidney homeostasis, structure and function.

266 data show that bHLH121 is a regulator of Fe homeostasis that acts upstream of FIT in concert with IL

267 ction mutants displayed severe defects in Fe homeostasis that could be reverted by exogenous Fe suppl

268 Although a critical player in naive T cell homeostasis, the ability of VISTA to restrain naive T ce

269 lar accommodation of bacteria, nodule oxygen homeostasis, the control of bacteroid differentiation, m

270 e riboside, and CD38 inhibition improved NAD homeostasis, thereby alleviating telomere damage, defect

271 that they exert neuroprotective roles in CNS homeostasis through continued refinement of synaptic con

272 -helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity h

273 yte also has an endocrine role in whole body homeostasis through its varied secretome that targets di

274 ed in the maintenance of immunohematopoietic homeostasis through regulation of protein transport and

275 acellular Ca(2+) store that maintains Ca(2+) homeostasis through the ER Ca(2+) uptake pump, sarco/ER

276 trating a multi-level contribution to muscle homeostasis throughout life.

277 RP neuron activity and maintenance of energy homeostasis, thus providing new insight into the pathoph

278 portant roles in regulating apoptosis during homeostasis, tissue development, and infectious diseases

279 h key roles in organ development, epithelial homeostasis, tissue regeneration, wound healing and immu

280 cess and how it functions to maintain tissue homeostasis, tissue repair and organismal health.

281 Thus, during homeostasis, TM keratinocytes transit through a prolifer

282 new therapeutic approach to regulate immune homeostasis to promote immune tolerance in patients with

283 rate that MI induces alterations in systemic homeostasis, triggering cross-disease communication that

284 ponse to DNA damage is critical for cellular homeostasis, tumor suppression, immunity, and gametogene

285 brain development and a regulator of glycine homeostasis, uncovering hyperglycinemia as a driver of H

286 n prolonged fasting and maintaining systemic homeostasis under metabolic stress.

287 proteins that regulate GLUT4 trafficking and homeostasis via TBC1D1.

288 eep-deprived baseline, suggesting that sleep homeostasis was bypassed.

289 between autophagy and Lkb1 in normal tissue homeostasis, we generated genetically engineered mouse m

290 rnal hepcidin suppression is for embryo iron homeostasis, we mimicked the range of maternal hepcidin

291 C-niche interactions in altered nonmalignant homeostasis, we selected beta-thalassemia, a hemoglobin

292 roposed to facilitate visceral sensation and homeostasis, where sensation and pain are mediated by sp

293 gans to regulate their function and maintain homeostasis, whereas target cells also produce neurotrop

294 enters of proteins by LCO disrupts metabolic homeostasis, which negatively impacts the growth and dev

295 rophic growth requires maintaining metabolic homeostasis while suppressing plant defenses, but the me

296 Any defects in the maintenance of Fe homeostasis will alter plant productivity and the qualit

297 rtant for host defence against pathogens and homeostasis with commensal microbes.

298 f endoplasmic reticulum-mitochondria calcium homeostasis with hepatic HAX-1 inactivation suggest that

299 hepatocytes exhibited defects in liver iron homeostasis with low levels of liver iron, reduced activ

300 ose tissue is crucial for whole-body glucose homeostasis, with insulin resistance being a major risk