ライフサイエンスコーパス: homeostatic

1 Astroglial homeostatic actions are initiated and controlled by inte

2 iant on melatonin orchestration of circadian homeostatic activities.

3 While homeostatic adaptation of membrane fluidity to temperatu

4 In striking contrast, homeostatic adaptations of intrinsic excitability and sp

5 ng sickness may be because of alterations in homeostatic adenosine signaling.SIGNIFICANCE STATEMENT S

6 ical systems, which is crucial to understand homeostatic alterations with disease.

7 and contribute to the regulation of multiple homeostatic and behavioral processes.

8 top-down regulatory mechanisms, such as the homeostatic and circadian processes.

9 Monocytic cells perform crucial homeostatic and defensive functions.

10 PRMT5 regulates developmental, homeostatic and disease processes in vertebrates and inv

11 dings not only uncover commonalities between homeostatic and Hebbian plasticity but also connect home

12 Dysregulation of homeostatic and hedonic brain nuclei can lead to patholo

13 Intact cartilage was enriched for homeostatic and hypertrophic chondrocytes, while damaged

14 l type plays distinct functional roles under homeostatic and inflammatory conditions, but mechanisms

15 ontribution of different PI3K isoforms under homeostatic and inflammatory conditions.

16 or skin homeostasis, and that IL-17 has dual homeostatic and inflammatory function in the skin.

17 r cell types, with possible implications for homeostatic and inflammatory processes of the pancreas.

18 how self-renewing and other tissues execute homeostatic and injury-responsive stem cell activity.

19 behavior by connecting AgRP neurons to both homeostatic and nonhomeostatic neuronal inputs.

20 dWAT) expansion is associated with important homeostatic and pathologic processes in skin.

21 r lymphocytes that are present in the CNS in homeostatic and pathological conditions.

22 and discusses how these mechanisms differ in homeostatic and pathological settings.

23 Astrocytes are homeostatic and protective cells of the central nervous

24 d Sun et al., 2020) demonstrate an equitable homeostatic and reparative potential of all hepatocytes,

25 representing a disruption in somatosensory, homeostatic and semantic processing, underpinned by atro

26 adrenal endocrine axes, possibly influencing homeostatic and stress responses.

27 iscuss how MAIT cells display antimicrobial, homeostatic, and amplifier roles in vivo, and how this m

28 unsorted cells from regenerating, scarring, homeostatic, and developing skin, we identified neonatal

29 ycosyltransferase ST6Gal-I is known to block homeostatic apoptosis through alpha2,6-linked sialylatio

30 ons to weight loss, both at the level of the homeostatic appetite control system and energy expenditu

31 adapt their active exploratory behavior in a homeostatic attempt to preserve sensorimotor coverage un

32 combat microbial incursion and maintain host homeostatic balance.

33 uxes during a single beat which is away from homeostatic balance.

34 igratory gene signatures, and contributes to homeostatic BEC turnover and to neogenesis of high endot

35 Specifically, homeostatic beta2AR redox states are vital toward agonis

36 dence indicates the presence of dysregulated homeostatic biological pathways in depressed patients, s

37 ategies to improve brain health by restoring homeostatic brain metabolism and CSF dynamics.

38 rocess that is characterized by a decline in homeostatic capacity, best described at the molecular le

39 Our work establishes requirements for homeostatic cDC2 positioning in the spleen and provides

40 apoptosis accounts for approximately 90% of homeostatic cell turnover in the body(1), and regulates

41 Programmed cell death promotes homeostatic cell turnover in the epithelium but is dysre

42 rosophila intestine, a well-studied model of homeostatic cell turnover, the linchpin of cell equilibr

43 Genetic studies have revealed critical homeostatic cellular functions of SIRT6, underscoring th

44 To avoid the effects of homeostatic changes and the interaction with the action

45 Homeostatic changes of intrinsic excitability occurred a

46 o bidirectional presynaptic and postsynaptic homeostatic changes with increased and decreased acousti

47 hese data offer evidence that disturbance of homeostatic, circadian signaling, conveyed through a mut

48 nfolded protein response (UPR) is a cellular homeostatic circuit regulating protein synthesis and pro

49 This mechanism generates a metabolic homeostatic circuit that protects cells from bioenergeti

50 ht prevent interference or provide unopposed homeostatic compensation when it is needed most.

51 olarization and microbiota composition under homeostatic conditions and during colitis development.

52 al Treg cell development and phenotype under homeostatic conditions but that loss of PI3Kdelta alone

53 ferentiation of MP cell subpopulations under homeostatic conditions is still unclear.

54 rise to lineage-traced cardiomyocytes under homeostatic conditions with an increase in this contribu

55 d products that regulate hematopoiesis under homeostatic conditions, during atherosclerosis and after

56 Under homeostatic conditions, gammadelta T cells provide immun

57 nity maturation occurs in mouse PP GCs under homeostatic conditions.

58 ere generally thought to be an essential but homeostatic contributor to complex bacterial behaviors.

59 These changes require precise homeostatic control by subcortical neuromodulatory struc

60 work module, maximizing potential for stable homeostatic control of allergen-induced Th2 responses vi

61 baroreceptors and play an important role in homeostatic control of arterial blood pressure and brain

62 and suggest an important role for MARCH2 in homeostatic control of innate immune responses.

63 d and reveal dynamic properties of the sleep homeostatic control system.

64 ro-secretory center in the brain involved in homeostatic control, and express insulin-like peptides w

65 eural circuitry underlying motor patterning, homeostatic control, and social behavior.

66 Sleep is under homeostatic control, whereby increasing wakefulness gene

67 While such energy homeostatic coordination suggests brain origin, whether

68 can also be maintained by the stroma-derived homeostatic cytokine IL-7, and priming diminishes if Il7

69 t effects on the host CNS, which promote the homeostatic developmental balance of neural connections

70 ns, sodium appetite is suppressed to prevent homeostatic deviations.

71 ary supplementation with spermidine promotes homeostatic differentiation of Treg cells within the gut

72 ochondrial transport in the maintenance of a homeostatic distribution of mitochondria in neurons and

73 trograde mitochondrial transport impacts the homeostatic distribution of mitochondria throughout the

74 onomous fashion and provide insight into how homeostatic DSB controls respond to aneuploidy during me

75 variabilities and is a reasonable measure of homeostatic dysregulation and frailty.

76 Our homeostatic dysregulation hypothesis' predicted that neo

77 his process of neurodegeneration ensues from homeostatic dysregulation of excitability and have teste

78 cal age and system integrity: Levine Method, homeostatic dysregulation, Klemera-Doubal method biologi

79 ular mechanisms and circuitry underlying non-homeostatic eating.

80 ch plays a fundamental role in maintaining a homeostatic environment in the brain.

81 up-regulated ST6Gal-I expression in blocking homeostatic epithelial cell apoptosis in gastric cancer

82 mechanisms control cell turnover to enforce homeostatic equilibrium between cell division and death

83 Understanding the mechanisms of T cell homeostatic expansion is crucial for clinical applicatio

84 immune regulation in the intestine, whereby homeostatic expression of ERbeta normally functions to l

85 f autologous plasma neither improved newborn homeostatic extravasation nor shaped age-specific differ

86 unctional role for CD31 and CD54 in neonatal homeostatic extravasation.

87 Macrophage production and secretion of these homeostatic factors are controlled by endogenous puriner

88 We propose that the engagement of these homeostatic feedback circuits by internal and external c

89 cing mechanism may allow for a physiological homeostatic feedback system.

90 Homeostatic feeding (i.e. titration of caloric intake),

91 and recall potential, greater than expected homeostatic fitness, refined transcription factor depend

92 veral studies highlighted a counterbalancing homeostatic function for the glycolytic metabolite lacta

93 ore distinctions between memory encoding and homeostatic functions and consider the potential for per

94 Our findings suggest that microglia enhance homeostatic functions in MDD but are not immune activate

95 ndent production of IL-17A and IL-17F, exert homeostatic functions in the gut upon microbiota-directe

96 ts are targeted for lysosomal digestion, has homeostatic functions including maintenance of protein a

97 ticularly important in this context, but the homeostatic functions of human islet macrophages are not

98 rainstem senses blood gas levels and adjusts homeostatic functions such as breathing and cardiovascul

99 of serine proteases with a diverse array of homeostatic functions, including skin desquamation and i

100 genetic profiles and influence a variety of homeostatic functions.

101 Finally, we identify homeostatic gene regulatory networks within spindle and

102 neuronal IL-18 is specifically required for homeostatic goblet cell AMP production.

103 in functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new met

104 Fragmentation of homeostatic high molecular weight HA promoted HPASMC pro

105 Homeostatic imbalance is caused by a range of pathophysi

106 crucial mediators of antiviral immunity and homeostatic immune system regulation.

107 lerate the resident microbiota while keeping homeostatic integrity.

108 d tips and embryonic kidney tips, as well as homeostatic intestinal crypts.

109 The homeostatic iron regulator (HFE) also regulates hepcidin

110 Maintaining MYC at homeostatic levels is critical to normal cell function;

111 pleted of NK cells, microglia demonstrated a homeostatic-like morphology, decreased proliferative res

112 The homeostatic link between oxidative stress and autophagy

113 udy, we explored the effect of calcitriol on homeostatic (M-CSF, TGF-beta-treated) and proinflammator

114 o leads to changes in the expression of iron homeostatic machinery.

115 but a unified understanding of ARHL - or the homeostatic maintenance of hearing before its breakdown

116 synaptic strength are both implicated in the homeostatic maintenance of physiological levels of neuro

117 rstanding the roles of neuronal autophagy in homeostatic maintenance of synaptic functions, with part

118 e may promote adaptation or maladaptation in homeostatic, maintenance and disease settings - especial

119 inhibition, including microglia with reduced homeostatic markers and elevated markers of inflammatory

120 This homeostatic mechanism in mammalian cells is driven by th

121 identify macrophage O-GlcNAc signaling as a homeostatic mechanism maintaining whole-body metabolism

122 dicative of cooption and modification of the homeostatic mechanism that buffers feather growth in the

123 y, it indicates that autophagy is not only a homeostatic mechanism to maintain the integrity of cells

124 ptation functions as a stress response and a homeostatic mechanism, allowing cells to maintain invari

125 ries controlling hedonic feeding may disrupt homeostatic mechanisms and lead to eating disorders.

126 at the interplay of different plasticity and homeostatic mechanisms can capture the initial drop and

127 Endogenous homeostatic mechanisms can restore normal neuronal funct

128 ed with adverse pregnancy outcomes, yet iron homeostatic mechanisms during pregnancy are poorly under

129 However, little is known about homeostatic mechanisms in the intact central brain in vi

130 f cellular debris, but little is known about homeostatic mechanisms in the TM epidermis.

131 ch as M-channel inhibition triggers multiple homeostatic mechanisms that operate at different timesca

132 Using mouse models, we documented maternal homeostatic mechanisms that protect the placenta and fet

133 egrity during growth or stress conditions by homeostatic mechanisms that regulate membrane flux and b

134 The underlying homeostatic mechanisms that regulate mitochondrial morph

135 e conventional transcriptional/translational homeostatic mechanisms that replace damaged proteins wit

136 s the ability of central circuits to harness homeostatic mechanisms to compensate for perturbations i

137 le of experience and activity in influencing homeostatic mechanisms to generate a robust sexually dim

138 ges were more marked in ISF and suggest that homeostatic mechanisms were preserved over time and were

139 In response, homeostatic mechanisms would be expected to increase neu

140 ex vivo was upregulated, presumably through homeostatic mechanisms, (4) STN neurons were not hyperac

141 Owing to internal homeostatic mechanisms, cellular traits may experience l

142 ory hub coordinating microbiota assembly and homeostatic mechanisms.

143 chronically target cellular bactericidal and homeostatic metabolic pathways for successful bacterial

144 Th17 cells, without substantially affecting homeostatic microbiota-specific Th17 cells.

145 , movement and cognition, the CNS requires a homeostatic microenvironment that is not only enriched i

146 her plasma insulin and triglycerides, higher homeostatic model assessment of insulin resistance (e.g.

147 ters, blood pressure (BP), lipid parameters, homeostatic model assessment of insulin resistance (HOMA

148 The primary outcome, homeostatic model assessment of insulin resistance (HOMA

149 besity and mild-moderate insulin resistance (homeostatic model assessment of insulin resistance [HOMA

150 Body weight, insulin resistance (homeostatic model assessment of insulin resistance [HOMA

151 M(+) exosomes and systemic IR as assessed by homeostatic model assessment of IR in HC, but not in sub

152 itochondrial DNA (mtDNA) haplogroups and the homeostatic model assessments of beta-cell function (HOM

153 able in Mendelian randomization analyses for homeostatic modeling-derived insulin resistance index, b

154 ed that by recognizing and implementing mini-homeostatic modules-often composed of very different phy

155 We found that both neuron types show homeostatic myelin remodeling under normal vision.

156 d two distinct populations of nerve-resident homeostatic myeloid cells that transcriptionally differe

157 In a model of chronic autoimmune neuritis, homeostatic myeloid cells were outnumbered by infiltrati

158 pressed high levels of CYP27B1 compared with homeostatic myeloid cells.

159 on while retaining the phagocytic ability of homeostatic myeloid cells.

160 s are scalably inhibited by palatability and homeostatic need during consumption.

161 a role for dopamine in motivation induced by homeostatic need.

162 neurons is not sufficient to account for the homeostatic normalization of the MFR.

163 ated by discrete brain nuclei that integrate homeostatic nutritional requirements with the hedonic pr

164 in if gas-exchange regulation strategies are homeostatic or dynamical in response to increasing c(a),

165 riation which is necessary for achieving the homeostatic osmolality.

166 and arousal transitions within a novel, non-homeostatic paradigm of sleep regulation.SIGNIFICANCE ST

167 nsor for the regulation of developmental and homeostatic pathways in most mammalian cell types.

168 Recently, specific macrophages dedicated to homeostatic peripheral nerves have come into focus.

169 sistent alterations in synaptic input elicit homeostatic plastic changes in neuronal activity.

170 tent alterations in neuronal activity elicit homeostatic plastic changes in synaptic transmission and

171 Here, we demonstrate that presynaptic homeostatic plasticity (PHP) is induced at degenerating

172 ivergent scaling" shifts the current view of homeostatic plasticity as a process that alters all syna

173 inhibition, triggered intrinsic and synaptic homeostatic plasticity at different timescales in cultur

174 inhibition, triggered intrinsic and synaptic homeostatic plasticity at different timescales in hippoc

175 tablish the fly mushroom body as a model for homeostatic plasticity in vivo.

176 tionarily conserved mechanism of presynaptic homeostatic plasticity induced by ALS-like motor neuron

177 This steep decline in homeostatic plasticity is accompanied by reduced light r

178 Homeostatic plasticity is likely to play a role in disea

179 These results, suggest that while homeostatic plasticity is normal, Fmr1(-/y) circuits exh

180 Whether such homeostatic plasticity occurs during progressive photore

181 Chronic optical stimulation revealed normal homeostatic plasticity of Up-states, however, Fmr1(-/y)

182 The effect of homeostatic plasticity on functional outcomes identify i

183 Homeostatic plasticity rules are well described for glut

184 Homeostatic plasticity stabilizes input and activity lev

185 tro abolished synaptic scaling and intrinsic homeostatic plasticity, deficits that could be rescued b

186 dence that the SAGA complex is necessary for homeostatic plasticity, demonstrating involvement of fou

187 vidence that glia participate in presynaptic homeostatic plasticity, invoking previously unexplored i

188 gnaling from the extracellular matrix during homeostatic plasticity.

189 f glial epigenetic signaling and presynaptic homeostatic plasticity.

190 xcitation and inhibition to be maintained by homeostatic plasticity.

191 monstrating involvement of four new genes in homeostatic plasticity.

192 F1R signaling and reestablish the microglial homeostatic population after CSF1R signaling returns.

193 ing compensated by unlabeled PCs, supporting homeostatic population turnover in these tissues.

194 y, TEC-derived LXRalphabeta protects against homeostatic premature involution and orchestrates thymic

195 siologic, sleep regulatory processes-a sleep homeostatic process and a circadian process.

196 Disruptions in this homeostatic process may contribute to disease.

197 It remains unclear how this homeostatic process modulates phagocyte functions in inf

198 major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is hig

199 Autophagy is a homeostatic process with multiple functions in mammalian

200 However, it is unknown whether these homeostatic processes operate in concert or at different

201 as M-channel inhibition can trigger multiple homeostatic processes that operate at different timescal

202 ather from the multilevel control of complex homeostatic processes.

203 on of the peripheral nerves and restores the homeostatic profiles of MPZ and PMP22.

204 Autophagy is a cellular homeostatic program for the turnover of cellular organel

205 sses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability.

206 ast to KLRG1(+) effector cells, LLEC undergo homeostatic proliferation and are not critically depende

207 turbations of cell membrane potential induce homeostatic reactions and modulate transduction mechanis

208 ch are incapable of further participating in homeostatic redox reactions (i.e., redox-deficient).

209 throughout the ATI lifespan through a potent homeostatic reduction in presynaptic neurotransmitter re

210 A biosynthetic activity produces a selective homeostatic reduction in ribosomal subunits, thereby off

211 sults indicate that genes implicated in both homeostatic regulation and conscious sensations are foun

212 d here reveals that genes implicated in both homeostatic regulation and pain are found in afferents a

213 pes, suggesting that conscious sensation and homeostatic regulation are the result of convergence, an

214 my, which is achieved through the continuous homeostatic regulation of body temperature and metabolis

215 indicate that there is a body weight-sensing homeostatic regulation of body weight in postpubertal ro

216 Immune surveillance and homeostatic regulation of skin function are governed by

217 S577A) and Sik2(S587A) mice exhibited proper homeostatic regulation of sleep need after sleep depriva

218 a genetic screen for genes required for the homeostatic regulation of sleep.

219 atic and Hebbian plasticity but also connect homeostatic regulation of synaptic transmission and neur

220 Homeostatic regulation protects organisms against hazard

221 isms underlying intestinal barrier function, homeostatic regulation, and graft rejection in intestina

222 Adult-specific manipulation of homeostatic regulators in the fly's auditory neurons acc

223 EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel in

224 ates, suggesting a new role for microglia as homeostatic regulators of perineuronal net formation and

225 of the neurovascular unit where they act as homeostatic regulators, especially after brain injuries,

226 namic representations of rhythms of multiple homeostatic regulatory systems.

227 our distinct STM subpopulations with diverse homeostatic, regulatory and inflammatory functions.

228 ked ER-E3s and their interactors to multiple homeostatic, regulatory, and metabolic pathways.

229 and stress immunity, revealing an unexpected homeostatic relationship between development and disease

230 apt their apparent density with respect to a homeostatic remodeling stimulus.

231 M-Channel blockade triggered slow homeostatic renormalization of the mean firing rate (MFR

232 ral activity (functional hyperemia), a vital homeostatic response in which NMDA receptors (NMDARs) pl

233 One homeostatic response is the increase in synaptic strengt

234 racellular calcium in astrocytes impairs the homeostatic response to sleep deprivation.

235 sition is an important component of archaeal homeostatic response.

236 Astroglial homeostatic responses are tightly coordinated with neuro

237 Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane

238 To examine how these temporally distinct homeostatic responses influenced hippocampal network act

239 ating localization of cellular materials and homeostatic responses).

240 Thus, endogenous Gal1 serves as a homeostatic rheostat that safeguards immune tolerance an

241 The homeostatic role of these gammadelta T cell subsets is t

242 ry immune cells of the CNS, carrying out key homeostatic roles and undergoing context-dependent and t

243 In addition to homeostatic roles, astrocytes respond to neurotransmitte

244 s, tissue-dwelling granulocytes with several homeostatic roles, have a surprising association with fi

245 direction of ChC synaptic plasticity follows homeostatic rules that depend on the polarity of axo-axo

246 or (NMDAR) signaling and was associated with homeostatic scaling down of synaptic strengths.

247 evealed no extinction deficit, likely due to homeostatic scaling up of extinction-dependent S845 GluA

248 s in GluA2 phospho-Y876 were observed during homeostatic scaling, with a decrease during downscaling

249 s of three rules: Hebbian, anti-Hebbian, and homeostatic scaling.

250 ansmitter release across all inputs around a homeostatic set point, caused a compensatory decrease in

251 eir body temperature decreases far below its homeostatic set-point(3-5).

252 llostatic process, which modulates the sleep homeostatic setpoint across days and weeks and is respon

253 non-microbial mode of transmission of their homeostatic setpoint.

254 nvoking previously unexplored intercellular, homeostatic signaling at a tripartite synapse.

255 Our work suggests that homeostatic signaling molecules are likely to be differe

256 rovide novel evidence linking aberrations in homeostatic signaling pathways within depression subtype

257 ion of the blood-neural barrier, restricting homeostatic signaling to a subset of arteriolar endothel

258 f DKaiR1D receptors near active zones during homeostatic signaling.

259 er fundamentally reflects disruption of this homeostatic signaling.

260 presence of fully functioning fungal Ca(2+) homeostatic/signaling machinery.

261 Here, in homeostatic skeletal muscle, we identify two quiescent s

262 sine, a neuromodulator involved in mediating homeostatic sleep drive, may be reduced in infected mice

263 c L-type Ca(2+) channel and is necessary for homeostatic sleep rebound.

264 regulation of monoamine bioavailability and homeostatic sleep.

265 an inability to obtain human microglia under homeostatic states.

266 a means by which gyrase can evolve distinct homeostatic supercoiling setpoints in a species-specific

267 ns (NPTXs), a family of proteins involved in homeostatic synapse plasticity, as novel biomarkers in g

268 In the last two decades, extensive work on homeostatic synaptic plasticity mechanisms have shown th

269 es to date have identified specific forms of homeostatic synaptic plasticity that are elicited by the

270 Potential homeostatic synaptic plasticity was either absent or mas

271 euronal Ca(2+) signalling yielded pronounced homeostatic synaptic plasticity, suggesting a critical r

272 g a screen for genes involved in presynaptic homeostatic synaptic plasticity, we identified an essent

273 ncode and respond to specific stimuli; while homeostatic synaptic scaling is a counterbalancing mecha

274 mechanisms with well-characterized forms of homeostatic synaptic scaling.

275 neurotransmitter release and acts as a major homeostatic system.

276 xtensive evolutionary conservation in copper homeostatic systems between human and Saccharomyces cere

277 Homeostatic systems combine an ability to maintain integ

278 (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of sol

279 e of B cell-derived IL-1beta and IL-6 during homeostatic T cell expansion in a clinically relevant mo

280 In homeostatic Th17 cells, partial blockade of glycolysis u

281 Our findings demonstrate that homeostatic threats recruit neurons across multiple hypo

282 s during defensive responses to a variety of homeostatic threats.

283 ty, angiogenesis, inflammatory responses and homeostatic tissue maintenance.

284 show that models of cell fate choice can, in homeostatic tissues, be categorized by exactly two 'univ

285 explant, and live-cell imaging, we show that homeostatic TM epidermis is distinct from other epiderma

286 ciency promotes microglial transition from a homeostatic to a disease-specific state that causes endo

287 males, accompanied by microglial shift from homeostatic to a functional state with enhanced phagocyt

288 of NK cells and to a functional shift from a homeostatic to a multifunctional proinflammatory state.

289 Most studies of homeostatic turnover assume an initial steady-state bala

290 NK cell homeostatic turnover is further accelerated without the

291 We found that the homeostatic turnover of tissue-resident ILC1s is much sl

292 ILC1s) to characterize the dynamics of their homeostatic turnover.

293 protein synthesis and/or degradation during homeostatic up- and down-scaling.

294 er mild or moderate levels of ER stress, the homeostatic UPR sets in motion transcriptional and trans

295 ts demonstrate that AMPAR trafficking during homeostatic upscaling can be gated by a single phosphory

296 t is essential for both in vivo and in vitro homeostatic upscaling.

297 nce of thermoregulation of T(leaf) towards a homeostatic value.

298 ue has the tendency to return to its desired homeostatic value.

299 link and interact with gustatory, olfactory, homeostatic, visceral, and cognitive systems; and 4) dis

300 nuous BrdU administration, fewer than 10% of homeostatic ZCs incorporated BrdU, whereas 88% of neck c