ライフサイエンスコーパス: homer protein

1 lternative splicing generates a family of 17 Homer proteins.

2 lu receptors (mGluRI) to PI 3-kinase through Homer proteins, adaptors that bind mGluRI.

3 Here, we demonstrate that Homer proteins also physically associate with ryanodine

4 Homer proteins also self associate and function as adapt

5 dices of PI3K/Akt1/mTOR activity, as well as Homer protein and mGlu1/5 expression, within the prelimb

6 These findings support the link between Homer proteins and monogenic autism, and lay the groundw

7 However, although Homer proteins and their interaction with mGluRs have be

8 gm constitutively express high levels of the Homer proteins and their mRNAs.

9 ugh group I mGluRs is regulated, in part, by Homer proteins, and it was found that the blunting of gr

10 f group I mGluR localization and function by Homer proteins appears to be a viable means for neurons

11 Homer proteins are a family of multidomain cytosolic pro

12 Homer proteins are a family of scaffolding proteins of t

13 Homer proteins are integral components of the postsynapt

14 Homer proteins are integral to the assembly of proteins

15 We tested whether Homer proteins are involved in axon pathfinding in vivo,

16 e first insight into the structure of native Homer protein as a tetramer and the functional significa

17 Homer proteins bind specifically to the C termini of the

18 The selective expression of Homer proteins contributes to these differentiation-depe

19 neuronal function associated with changes in Homer protein expression described in the recent literat

20 alteration of mGluR signaling by changes in Homer protein expression may represent a viable mechanis

21 Here, we present evidence that Homer proteins form a physical tether linking mGluRs wit

22 Homer proteins form an adapter system that regulates cou

23 Homer proteins form multivalent complexes that bind prol

24 As CC-Homer proteins, Group1 mGluRs and NMDA receptors activel

25 R1/5 signal regulation by natively expressed Homer proteins has been elusive.

26 Homer proteins have been proposed to play a role in syna

27 Moreover, Homer proteins have been shown to modulate RyR-dependent

28 ia a PPxxF domain, with the coiled-coil (CC)-Homer proteins Homer-1b and Homer-2, two components of t

29 in expression of Homer2a/b with a related CC-Homer protein Homer1b/c, as well as their associated glu

30 competed with the cross-linking isoforms of Homer proteins (Homer1b/c and Homer2a/b) to uncouple the

31 The constitutively expressed (CC) Homer protein Homer2a/b actively regulates behavioral an

32 xpressed in the frontal cortex, derived from Homer protein homolog 1 (HOMER1), is significantly reduc

33 The role of Homer proteins in channel modulation was investigated by

34 nt on the distribution of group I mGluRs and Homer proteins in GP and STN, specific changes in the ul

35 the expression levels of group I mGluRs and Homer proteins in GP and striatum.

36 portance of the IP3/Ca2+ signaling and novel Homer proteins in group I mGluR-mediated activation of e

37 2b was used to demonstrate the importance of Homer proteins in neuroplasticity produced by repeated e

38 ges in AMPA transmission can be regulated by Homer proteins in response to physiologically relevant s

39 VSMCs and are the first to show the role of Homer proteins in VSMCs and its importance in neointima

40 ice showed a reduced expression of the short Homer protein isoform Homer 1a, and an increased couplin

41 TRP channel regulation, we hypothesized that Homer proteins play a significant role in skeletal muscl

42 etabotropic glutamate receptors (mGluRs) and Homer proteins play critical roles in neuronal functions

43 Furthermore, Homer proteins regulate mGluR1/5 function by acting as a

44 Homer proteins regulate signal transduction, synaptogene

45 (H1a) immediate-early gene produces a short homer protein that lacks the domain required for homer o

46 most studies focusing on mGluR regulation by Homer proteins used relatively long-term overexpression.

47 work has demonstrated direct interaction of Homer proteins with type 1 and type 2 ryanodine receptor