ライフサイエンスコーパス: homodimerization

1 odimerization prompted us to investigate Fos homodimerization.

2 ysis revealed that Az1 sterically blocks ODC homodimerization.

3 ime-dependent manner to regulate 14-3-3gamma homodimerization.

4 of amino acid residues in the interface for homodimerization.

5 ed by the equilibrium constant governing its homodimerization.

6 ACT1 with IL-17 receptors, with no effect on homodimerization.

7 on correlated with the activity of AF2ER-LBD homodimerization.

8 g both MRE11 interaction with NBS1 and MRE11 homodimerization.

9 lylation, [3+2] annulation, and Sakurai-like homodimerization.

10 showed that pep4 could be involved in NKp46 homodimerization.

11 lating neuronal death, is sufficient for its homodimerization.

12 -Ala-40 (VVAA) as the TM1 motif required for homodimerization.

13 which is activated upon blue light-sensitive homodimerization.

14 tes on Nup159, promoting the Nup159 parallel homodimerization.

15 , responsible for the E3 ligase activity and homodimerization.

16 STAR that coincides with reduced 14-3-3gamma homodimerization.

17 hat function in biotin transfer also support homodimerization.

18 ellular accumulation through Zn(2+)-mediated homodimerization.

19 terminus and are predicted to interfere with homodimerization.

20 d RIMs activate priming by disrupting Munc13 homodimerization.

21 binding to Munc13, thereby relieving Munc13 homodimerization.

22 ated with a small molecule inhibitor of ATIC homodimerization.

23 between paired leucine zippers and promotes homodimerization.

24 superior cleavage activity while suppressing homodimerization.

25 the nuclease interface to prevent undesired homodimerization.

26 t reduce UL53-UL50 interactions also reduced homodimerization.

27 potent activation of EGFR TK than does EGFR homodimerization.

28 heterodimers, it only slightly blocked ErbB3 homodimerization.

29 re of the BAK BH3 and BH4 domains before BAK homodimerization.

30 ntly linked to Cys-319 and thereby hindering homodimerization.

31 an anti-TREM2 antibody, which induces their homodimerization.

32 further investigated the impact of Siglec-E homodimerization.

33 ular signaling molecules, and enhances their homodimerization.

34 F-araNAD(+)), dimeric F-araNAD(+), to induce homodimerization.

35 bgE is neither activated by K(+) ions nor by homodimerization.

36 termines the protein-protein recognition and homodimerization.

37 butes to MET activation through low affinity homodimerization.

38 of the catalytic core, and interfering with homodimerization.

39 A similar domain directs DKF-2A homodimerization.

40 inds CCL8, CCL7, and CCL18 and disrupts CCL8 homodimerization.

41 e hydrophobic interface mediates ZP-N domain homodimerization.

42 part to investigate the consequences for its homodimerization, a crucial step in forming higher-order

43 d Sin3L/Rpd3L complex by providing a crucial homodimerization activity.

44 These changes explain the higher homodimerization affinity of S1bx and provide a structur

45 We found that ASAP1 homodimerization aligns F-actin in predominantly unipola

46 that protein-protein interactions, including homodimerization, allow each ETS TF to display distinct

47 , which is required for both DNA binding and homodimerization, along with the homodimerization sequen

48 hly conserved interface required for protein homodimerization, an essential step in YARS catalytic fu

49 on of the C-terminus likely has no effect on homodimerization and a modest effect on the secondary st

50 0 amino acids of the kinase are required for homodimerization and association with isoform-specific P

51 cell cycle: the Asl N terminus promotes Plk4 homodimerization and autophosphorylation during interpha

52 The function of these loops in both homodimerization and biotin transfer was investigated by

53 g that the affected domain, necessary for TR homodimerization and corepressor binding, has a critical

54 e for employing 3E-1,3-dienes in Z-selective homodimerization and cross-metathesis with terminal alke

55 To identify residues of UL53 crucial for homodimerization and for heterodimerization with UL50, w

56 ever, the structural and functional roles of homodimerization and heterodimerization are still unclea

57 TM) that enables simultaneous measurement of homodimerization and heterodimerization of type I recept

58 Here, we utilize mutations that modulate the homodimerization and heterodimerization states to define

59 c model that addresses the dynamics of ErbB3 homodimerization and heterodimerization with ErbB2.

60 ralleled TONs of up to 7400, in a variety of homodimerization and industrially relevant metathesis re

61 k-to-back Mal homodimer interface affect Mal homodimerization and interaction with MyD88 and TLR4.

62 c complementation there are still changes in homodimerization and interactions with FGFR1c.

63 se of Plk4, autoinhibition is relieved after homodimerization and is accomplished by PB3 and by autop

64 cal inhibition of HuR by MS-444 inhibits HuR homodimerization and its cytoplasmic translocation, abro

65 EX domain results in the abrogation of MMP-9 homodimerization and leads to blockage of a downstream s

66 es from other herpesviruses, inhibited ORF57 homodimerization and led to proteasome-mediated degradat

67 tide identifies Ku-(1-229) as sufficient for homodimerization and LigD stimulation.

68 )X(3)AX(2)G(25) significantly contributes to homodimerization and lipid uptake activity.

69 nd mediates chitin-induced signaling through homodimerization and phosphorylation.

70 nd that the Dyn2-Pac11 complex promotes Dyn1 homodimerization and potentiates processivity.

71 l transmembrane domain that is essential for homodimerization and proapoptotic function.

72 of K-Ras4B mutants, respectively, inhibiting homodimerization and probably effector binding.

73 y in S1bx homodimerization, thus favoring LF homodimerization and prolactin-induced signaling.

74 ugh SGTA's N-terminal domain, which mediates homodimerization and recruits cellular adaptors, is disp

75 on of 14-3-3gamma showed similar patterns to homodimerization and STAR binding, respectively.

76 series of conformational changes that enable homodimerization and subsequent membrane fusion.

77 tes an allosteric change in the RR, enabling homodimerization and subsequently enhanced DNA binding.

78 ding of TDP-43 monomers necessary for proper homodimerization and TDP-43-regulated splicing.

79 nucleoplasm and is capable of promoting the homodimerization and telomeric association of TRF1, prev

80 found that blade IV is necessary for MMP-14 homodimerization and that blade I is required for CD44 M

81 e show that the core dsRBD is sufficient for homodimerization and that mutation of a conserved leucin

82 e the role of the alpha-interface in K-Ras4B homodimerization and the beta-surface in effector bindin

83 We investigated differences in homodimerization and the impact of the C-terminal extens

84 activated by ligand binding, which promotes homodimerization and then autophosphorylation in trans.

85 eucine zipper that regulates DNA binding and homodimerization and thereby promotes cell cycle arrest.

86 domain that are crucially involved in MyD88 homodimerization and TLR signaling in immune cells.

87 nside-out signal transfer required substrate homodimerization and was prevented by cleavage-inhibitor

88 the interaction strength among all possible homodimerizations and heterodimerizations of these three

89 ChEL has two identified functions: 1) homodimerization, and 2) binding to I-II-III that facili

90 t significantly affecting the glycosylation, homodimerization, and global folding of KAI1/CD82, the T

91 n hemagglutinin (H) and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1.

92 t favor heterodimerization over procaspase-8 homodimerization, and induce the latent active site of z

93 region within the CYTO (A375-P394) mediates homodimerization, and is dominant over effects observed

94 as required for Sstn binding and in addition homodimerization, and its removal disrupted Steppke furr

95 n of Munc13 inhibits the priming function by homodimerization, and that RIM disrupts the autoinhibito

96 B kinase epsilon (IKKepsilon) inhibits STAT1 homodimerization, and thus assembly of GAF, but does not

97 prior examples of an alkyne-metathesis-based homodimerization approach to natural products.

98 C-terminal SARAH domains that mediate their homodimerization as well as heterodimerization with othe

99 We mapped KLHL15 residues critical for homodimerization as well as interaction with Cul3 and B'

100 mbrane segments were used along with in vivo homodimerization assays (TOXCAT) to evaluate the determi

101 Hence, our data demonstrate that homodimerization autoregulates FGF9 and FGF20's receptor

102 t ventricular cardiomyopathy, V94D, promotes homodimerization, blocks beta-catenin binding, and in ca

103 ases are activated through proximity-induced homodimerization, but some studies infer that during apo

104 chromoshadow domain of HP1 proteins promotes homodimerization, but this alone cannot explain heteroch

105 nt p75(NTR) interactions, is not crucial for homodimerization, but this residue is required for norma

106 lencing NAC-1 expression or disrupting NAC-1 homodimerization by a dominant negative NAC-1 protein th

107 Since homodimerization by a GTPase-active human septin also cr

108 nd can bind to Dome, thus reducing Dome:Dome homodimerization by creating signaling-incompetent Dome:

109 ent within the stem region, mediates MT4-MMP homodimerization by forming a disulfide bond.

110 interface residues likely ensures selective homodimerization by preventing association with non-cogn

111 activity of K7L is substantially enhanced by homodimerization, by the substrate protein P25K as well

112 d that heterologous output domains requiring homodimerization can be fused to the photosensory module

113 These proteins form stable homodimerization complexes that localize to the outer me

114 des new evidence that NAC-1 upregulation and homodimerization contribute to tumor recurrence by equip

115 peptide secondary structure are explored by homodimerization, cross metathesis, and ring-closing met

116 ssociated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recogniti

117 Nef homodimerization-defective mutants retained their intera

118 ring mature HIV-1 capsid assembly requires a homodimerization-dependent conformational switching of C

119 support a novel regulatory mechanism wherein homodimerization dictates the equilibrium between the au

120 CD38 homodimerization did not affect RA-induced differentiati

121 Inactivation of Nanog was due to impaired homodimerization, DNA binding, promoter occupancy and p3

122 peptides reveal that the N-terminal Gly-rich homodimerization domain exchanges much faster than the C

123 our results indicate that a functional Qua1 homodimerization domain is required for QkI-5 function i

124 mains, which bind GTP-tubulin, a coiled-coil homodimerization domain, and a domain that interacts wit

125 F2 represses TERRA transcription through its homodimerization domain, which was previously shown to i

126 rg, at a highly conserved residue within the homodimerization domain.

127 self-association are limited to the alpha2-5 homodimerization domain.

128 amino acid 499, which falls within the GAF-B homodimerization domain.

129 e and arginine residues localized around its homodimerization domain.

130 response by fusing ZF-TFs to leucine zipper homodimerization domains.

131 rved and variable loops, significantly alter homodimerization energetics.

132 h its mitochondrial localization but disrupt homodimerization failed to induce autophagy in cells.

133 dogma that all initiator procaspases require homodimerization for activation.

134 ABCG2 requires homodimerization for function, though the mechanism for

135 O as a model, we observe a large increase in homodimerization for the constitutively active TM mutant

136 on, and that RIM disrupts the autoinhibitory homodimerization forming monomeric priming-competent Mun

137 PAK1 regulation is based on its homodimerization, forming an inactive complex.

138 Qua1-mediated homodimerization generates a scaffold that enables concu

139 levance of G protein-coupled receptor (GPCR) homodimerization has been limited by the insufficient to

140 We have now investigated AR homodimerization, hormone-dependent monomerization and n

141 In addition, disruption of DKF-2A homodimerization in C. elegans intestine impaired and de

142 e increase in variant possibilities, such as homodimerization in covalent and noncovalent forms.

143 ive parallel Monte Carlo simulations of ErbB homodimerization in dipalmitoyl-phosphatidylcholine lipi

144 ) to artificially induce protein hetero- and homodimerization in live cells using light.

145 While the IRAK4 kinase domain is capable of homodimerization in the unphosphorylated state, we found

146 Disrupting C2A/C2A homodimerization in UNC-13L-rescued animals had no effec

147 eats in Grp1 have also been shown to mediate homodimerization in vitro as well as heteromeric interac

148 PDZK1 can undergo modest homodimerization in vivo and in vitro through self-assoc

149 yts hetero- and homodimerize, and that ESyt2 homodimerization in vivo requires a TM adjacent sequence

150 Interestingly, enforced homodimerization increased PrP(C) levels at the plasma m

151 erin (H(4)B), an essential cofactor for NOS2 homodimerization, increased after M stimulation in the p

152 nge of two residues in the murine chronophin homodimerization interface (chronophin(A194K,A195K)) yie

153 ignal transduction mechanism between the PXR homodimerization interface and its coactivator binding s

154 a photoreceptor Vivid by orthogonalizing the homodimerization interface into complementary heterodime

155 To achieve this, a homodimerization interface is engineered onto the Drosop

156 otes the engagement of ORC at the N-terminal homodimerization interface of MCM.

157 duced point mutations that restored this NK1 homodimerization interface to create an agonistic ligand

158 contains a highly conserved Zn(2+)-dependent homodimerization interface, the Rad50 hook domain.

159 arison reveals a more favorable hetero- than homodimerization interface, thereby suggesting a possibl

160 domain (the Rad50 hook) that functions as a homodimerization interface.

161 tor antagonists due to a mutation at the NK1 homodimerization interface.

162 folding of loop L16, thereby perturbing the homodimerization interface.

163 PACT to divergence of the composition of the homodimerization interface.

164 The homodimerization interfaces serve as a fulcrum for a see

165 sted that their hydrophobic faces could form homodimerization interfaces.

166 tyrosine phosphorylation, dephosphorylation, homodimerization into gamma-activating factor and hetero

167 ng a mechanism that antagonist-dependent LBD homodimerization involving the F-domain results in antag

168 dislocation of H12 caused ICI-dependent LBD homodimerization involving the F-domain, the adjoining r

169 Sgo1 homodimerization is a prerequisite for PP2A binding.

170 Thus, our results show that PrP(C) homodimerization is an important regulator of PrP(C) alp

171 By contrast, homodimerization is characterized by a very large unfavo

172 from spreading excessively and show that the homodimerization is critical for WUS function.

173 rstanding the detailed mechanism driving the homodimerization is important and will impact future stu

174 ed cell invasion of Matrigel suggesting that homodimerization is not required for this process.

175 Mechanistically, we show that p4 homodimerization is required for maximal bactericidal ac

176 While we have previously noted that homodimerization is required for the transcriptional act

177 While syntaxin homodimerization is supposed to promote the transition f

178 We recently proposed that ZnT2 homodimerization is the underlying basis for the dominan

179 cell-penetrating peptide inhibitor of MUC1-C homodimerization, is effective in inducing reactive oxyg

180 ted phosphorylation abolished activated IRF3 homodimerization, its occupancy on chromatin, and subseq

181 re able to detect weak but reproducible Nank homodimerization (K(d) in the millimolar range).

182 We show that homodimerization leads to a considerable increase of PrP

183 roscopy (SMM) experiments to investigate KOR homodimerization, localization, and trafficking.

184 Tight homodimerization may be central to the scaffolding funct

185 gH/gL homodimerization may be conserved between alpha- and bet

186 gy transfer (FRET) method to investigate the homodimerization mechanism and intradimer molecular inte

187 ive pathway, including SARAH domain-mediated homodimerization, membrane recruitment, and complex form

188 allography, we have discovered a domain-swap homodimerization mode in CYP51 from a human pathogen, Ac

189 Collectively, our data suggest that MV homodimerization modulates microfilament attachment at m

190 However, rather than mediating p75 homodimerization, mutagenesis of the AXXXG motif reveals

191 he present study, we show that neither AR-V7 homodimerization nor AR-V7/AR-FL heterodimerization requ

192 telomeric sequence, alleviating the need for homodimerization observed in TRF-like proteins possessin

193 nc transport activity of the WT ZnT-2 due to homodimerization observed upon immunoprecipitation exper

194 FGF9 and FGF20 ligands undergo a reversible homodimerization, occluding their key receptor binding s

195 ity in a representative metathesis reaction (homodimerization of 1-nonene).

196 Here, we show that homodimerization of a cluster-of-differentiation-44 or o

197 This complementation involved homodimerization of A20 proteins, and we have defined an

198 In contrast, helix alphaB' is important for homodimerization of Act1, implicating a dual ligand-bind

199 teins, was recently suggested to mediate the homodimerization of ADAM10.

200 Our results showed that controlled homodimerization of APP-FKBP leads to a 50% reduction in

201 In this study, we show that homodimerization of Bnip3 is also a requirement for indu

202 ed dimers provide a structural basis for the homodimerization of both proteins.

203 at both cathepsin D-mediated proteolysis and homodimerization of caspase-8 are necessary to generate

204 oproteolytic activity but not recruitment or homodimerization of caspase-8 within the complex.

205 Our findings suggest that the homodimerization of CESA6 through its N-terminal zinc fi

206 e, we explore the function of the obligatory homodimerization of chronophin, a mammalian HAD phosphat

207 catalysis and late-stage copper(I)-mediated homodimerization of complex aryl stannane monomers.

208 In addition, although homodimerization of disordered molecules is spontaneous,

209 mic tail of the membrane protein DrrB and in homodimerization of DrrA.

210 Of special significance is the homodimerization of F-NC, in which this species is revea

211 t disrupting these interactions destabilizes homodimerization of full-length PTPRJ in cells, reduces

212 and indole scaffolds to inhibit IL-6 induced homodimerization of GP130.

213 ed by the transmembrane receptor (IL-6R) and homodimerization of gp130.

214 SARAH domain-mediated homodimerization of Hippo kinase leads to autophosphoryl

215 iochemical features of the system (including homodimerization of IDH and bifunctionality of IDHKP) th

216 he minimum requirements for PKR function are homodimerization of its kinase and RNA-binding domains,

217 uces a conformational change that couples to homodimerization of juxtamembrane structures in the Toll

218 gomers in the ER is provided by data showing homodimerization of misfolded hLHR mutants that are reta

219 s-talk that initiates cell migration through homodimerization of MMP-14 as well as heterodimerization

220 Thus, homodimerization of Munc13 inhibits its priming function

221 te that the model successfully describes the homodimerization of nuclear receptors.

222 ich is rich in alpha-helices, contributes to homodimerization of ORF57 to prevent proteasome-mediated

223 Thus, homodimerization of ORF57 via its C terminus prevents OR

224 The structured C-terminal domain mediates homodimerization of ORF57, and the critical region for t

225 Interestingly, when implementing the homodimerization of procaspase-9 as a prerequisite for a

226 We report here that homodimerization of protein tyrosine phosphatase recepto

227 dditionally, we find that the CR facilitates homodimerization of PrP(C) , attenuating the toxicity of

228 n of the G domains cannot be responsible for homodimerization of Ras reported in the literature.

229 The RXR agonist increased homodimerization of RXR suggesting that RXR may act as a

230 To test if homodimerization of SLK affects phosphorylation, the cDN

231 cysteine residue (Cys-277), which results in homodimerization of Src linked by a disulfide bridge.

232 IFN-II (IFN-gamma) induces the homodimerization of STAT1 to form the gamma-activated fa

233 ased catalysts are highly Z-selective in the homodimerization of terminal olefins.

234 those causing dominant Cole disease, impairs homodimerization of the ENPP1 enzyme that is mediated by

235 t ensure that crossed addition prevails over homodimerization of the individual components, as can be

236 Conserved tryptophan-187 facilitates homodimerization of the influenza A virus NS1 protein ef

237 utative upstream dimerization helix inhibits homodimerization of the isolated ChEL domain.

238 ped a cell-penetrating peptide that disrupts homodimerization of the MUC1-C subunit necessary for its

239 of Glu(183), Ser(244), and Arg(288) impaired homodimerization of the MyD88-TIR domain, recruitment of

240 endoplasmic reticulum stress results in the homodimerization of the N-terminal endoplasmic reticulum

241 Homodimerization of the NC, ND and NE sequences and dire

242 n-protein interactions that could facilitate homodimerization of the peroxidase-like domain or, in th

243 no acids surrounding the RxLR leader mediate homodimerization of the protein.

244 rmore, we report 20 novel PPIs including the homodimerization of the RNA dependent RNA polymerase (Rd

245 Ralpha1 SyCyRs failed to activate signaling, homodimerization of the second IL-22 signaling chain, Sy

246 ained and atomistic simulations to model the homodimerization of the sybII transmembrane domain and o

247 perturbing trans-helical interaction blocks homodimerization of the Tg ChEL domain.

248 o minimize unwanted cleavage attributable to homodimerization of the ZFNs.

249 We previously demonstrated constitutive homodimerization of this receptor through the lipid-expo

250 In contrast, PPE18-mediated homodimerization of TLR2 caused poorer cytoplasmic expor

251 mmatory-type response, whereas PPE18-induced homodimerization of TLR2 triggers anti-inflammatory type

252 Using this approach we observed homodimerization of unliganded FGFR1 that is independent

253 Homodimerization of ZnT1, -2, -3, -4, and -7 was reveale

254 To explore the role of PrP(C) homodimerization on the alpha-cleavage, we used a well d

255 tution of residues in UL44 that prevent UL44 homodimerization or abrogate the binding of UL54 to UL44

256 rupted protein stability by interfering with homodimerization or by causing aggregation.

257 Homodimerization or heterodimerization of TFs are requir

258 ll yeast protein domains that mediate either homodimerization or heterodimerization.

259 oncogenic p85alpha mutations that target the homodimerization or PTEN interaction surface.

260 er initiation signal (DIS) to discourage RNA homodimerization or to encourage RNA heterodimerization,

261 RB345, located respectively in the beta49-55 homodimerization patch and on the face of the molecule s

262 found to be opposite that of the 14-3-3gamma homodimerization pattern.

263 ntroversy in the literature concerning c-Fos homodimerization prompted us to investigate Fos homodime

264 OXE proteins possess similar DNA binding and homodimerization properties and can induce NCCs.

265 Importantly, PrPN1 produced after PrP(C) homodimerization protects against toxic amyloid-beta (Ab

266 s observed in the phosphine-catalyzed ketene homodimerization reaction.

267 The SBM-binding and homodimerization residues of SLIP1 are conserved in the

268 Similarly, inhibition of MyD88 homodimerization reversed the attenuation of human PMN t

269 binding and homodimerization, along with the homodimerization sequence located in the central part of

270 s within the WR is linked to the strength of homodimerization, Sox2 heterodimerization and self-renew

271 ly, we found that RTK heterodimerization and homodimerization strengths can be similar, underscoring

272 that restrict movement are required for WUS homodimerization, suggesting that formation of WUS dimer

273 ean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role

274 e were parallel with the degree of AF2ER-LBD homodimerization, supporting a mechanism that antagonist

275 e studies suggest that KLVS leads to altered homodimerization that indirectly leads to changes in pro

276 e role of phosphoinositide lipids to promote homodimerization that, together, have important physiolo

277 cooperativity) requires TSH receptor (TSHR) homodimerization, the latter involving primarily the tra

278 Other than its role in homodimerization, the rear end acidic cluster region of

279 anipulating the WUS-binding affinity and the homodimerization threshold of cis elements, and manipula

280 also present additional results on covalent homodimerization through disulfide formation of the full

281 owth factor (EGF) was found to stimulate CAR homodimerization, thus constraining CAR in its inactive

282 ha regulatory subunit of PI3K suppresses p85 homodimerization, thus enhancing insulin-stimulated bind

283 nt deacetylation of MORF4L1 enhances MORF4L1 homodimerization, thus facilitating the functionality of

284 c-association and increased affinity in S1bx homodimerization, thus favoring LF homodimerization and

285 rome 2 (CRY2) undergoes blue light-dependent homodimerization to become physiologically active.

286 SWEETs contain only a single THB and require homodimerization to form transport pores.

287 riggering spontaneous, switchlike TIR domain homodimerization to initiate downstream signaling.

288 tanding the basis of specificity in receptor homodimerization versus heterodimerization is essential

289 4 resulted in interferon regulatory factor 5 homodimerization via reduced melanoma differentiation-as

290 adherin EC1-2 adhesive region, which reveals homodimerization via the strand-swap mechanism common to

291 The opioid receptor homodimerization was associated with an increased recept

292 omain, blade IV was shown to be critical for homodimerization, whereas blade I was required for heter

293 ent reactivity for various type 1 alkenes in homodimerization which correlated with the aggregrate si

294 The N-terminal domain is responsible for Prf homodimerization, which brings two Pto kinases into clos

295 NTR) with TrkA increase full-length p75(NTR) homodimerization, which in turn potentiates the rate of

296 cJ 499T, the C57BL/6J 499A decreases PDE11A4 homodimerization, which removes PDE11A4 from the membran

297 acetylation at this position results in its homodimerization, while deacetylation promotes the forma

298 Nonetheless, PAR4SFT still supported homodimerization with PAR4.

299 CDK11(p110) phosphorylation was required for homodimerization without affecting its kinase activity.

300 nding, transactivation, phosphorylation, and homodimerization, without significantly affecting protei