ライフサイエンスコーパス: homologous chromosome

1 form single-stranded DNA, which can invade a homologous chromosome.

2 nd could accompany gene conversions with the homologous chromosome.

3 a the sister chromatid but failed to use the homologous chromosome.

4 a new region of the same chromosome or a non-homologous chromosome.

5 s Vbeta14Dbeta1Jbeta1.4 rearrangement on the homologous chromosome.

6 1 stimulated bias for strand invasion of the homologous chromosome.

7 via homology-directed repair (HDR) onto the homologous chromosome.

8 of the acentrosomal spindles that segregate homologous chromosomes.

9 or represent different overlapping events on homologous chromosomes.

10 C), a proteinaceous structure formed between homologous chromosomes.

11 d Hi-C data cannot fully distinguish between homologous chromosomes.

12 des a transient but tight connection between homologous chromosomes.

13 essful meiosis, crossovers must form between homologous chromosomes.

14 complex (SC), a protein scaffold juxtaposing homologous chromosomes.

15 t MutSgamma-independent associations between homologous chromosomes.

16 re double-strand breaks for synapsis between homologous chromosomes.

17 bly of the synaptonemal complex (SC) between homologous chromosomes.

18 estry across a genome segment among a set of homologous chromosomes.

19 oofread and stabilize the pre-DSB pairing of homologous chromosomes.

20 otic prophase with defective synapsis of the homologous chromosomes.

21 be related to the exchange of parts between homologous chromosomes.

22 ic paralog of Rad51, mediates the pairing of homologous chromosomes.

23 genetic diversity and ensures segregation of homologous chromosomes.

24 it requires programmed recombination between homologous chromosomes.

25 without considering the differences between homologous chromosomes.

26 over following mitotic recombination between homologous chromosomes.

27 ganization factors, and the biorientation of homologous chromosomes.

28 east one crossover (CO) between each pair of homologous chromosomes.

29 recombination to establish a tether between homologous chromosomes.

30 n, which promotes pairing and segregation of homologous chromosomes.

31 ves the segregation of replicated recombined homologous chromosomes.

32 has several structural polymorphisms between homologous chromosomes.

33 nto DNA and promotes strand exchange between homologous chromosomes.

34 s in these species are controlled by loci on homologous chromosomes.

35 , rather than copy number in each of the two homologous chromosomes.

36 generated, initiating recombination between homologous chromosomes.

37 f homology contained in sister chromatids or homologous chromosomes.

38 quences and those that act to align and pair homologous chromosomes.

39 zed recombination between highly polymorphic homologous chromosomes.

40 d system that allocates DSBs to all pairs of homologous chromosomes.

41 cal recombination and orderly segregation of homologous chromosomes.

42 erhomolog repair to yield crossovers between homologous chromosomes.

43 f double-stranded breaks and pairing between homologous chromosomes.

44 ds upon the formation of connections between homologous chromosomes.

45 genetic complementation of mutant alleles on homologous chromosomes.

46 reciprocal exchange of DNA segments between homologous chromosomes(2).

47 contacts form between maternal and paternal homologous chromosomes, a phenomenon known as somatic ho

48 Differential methylation of the homologous chromosomes, a well-known mechanism leading t

49 sis is the synapsis of maternal and paternal homologous chromosomes, accompanied by exchange of genet

50 that DSBs stimulate gene conversion between homologous chromosomes (allelic conversion) by >30-fold

51 c prophase I and mediates adhesion of paired homologous chromosomes along their entire lengths.

52 ations between bona fide nuclease targets on homologous chromosomes, an undesired collateral effect t

53 elies on the formation of crossovers between homologous chromosomes and a series of precisely control

54 mplified by improper pairing and synapsis of homologous chromosomes and altered processing of recombi

55 crossover recombination is essential to link homologous chromosomes and drive faithful chromosome seg

56 tic crossovers facilitate the segregation of homologous chromosomes and increase genetic diversity.

57 f such meiosis-specific events as pairing of homologous chromosomes and initiation of recombination.

58 Contact involves short segments of homologous chromosomes and is centered on a DSB in activ

59 ved from yeast to mammals, assembles between homologous chromosomes and is essential for accurate chr

60 mbination is required for the segregation of homologous chromosomes and is essential for fertility.

61 repair which ensures the proper synapsis of homologous chromosomes and normal meiotic progression.

62 ission of exchanged genetic material between homologous chromosomes and plays a crucial role in incre

63 th particular regard to the juxtaposition of homologous chromosomes and potential nonallelic, ectopic

64 The pairing of homologous chromosomes and the intimate synapsis of the

65 s a prerequisite for the pairing of parental homologous chromosomes and the reductional division, whi

66 xchange of genetic material between parental homologous chromosomes, and ensures faithful chromosome

67 of chiasmata, the physical linkages between homologous chromosomes, and loss of the tight associatio

68 ombination (HR) between sister chromatids or homologous chromosomes, approximately 2% of all DSBs giv

69 ns- or interallele CSR), suggesting that the homologous chromosomes are aligned during CSR.

70 Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linear elements

71 intermediates, in which sister chromatids or homologous chromosomes are covalently linked by four-way

72 Recombination and pairing of homologous chromosomes are critical for bivalent formati

73 uniparental disomy (UPD), in which a pair of homologous chromosomes are derived from a single parent,

74 s) that physically link sister chromatids or homologous chromosomes are formed as intermediates durin

75 Crossovers formed by recombination between homologous chromosomes are important for proper homolog

76 ous end-joining, even in haploid cells where homologous chromosomes are not present during much of th

77 s on trans interactions in Drosophila, where homologous chromosomes are paired in somatic cells from

78 Homologous chromosomes are paired in somatic cells of Dr

79 In this system, homologous chromosomes are positioned off-center on the

80 eres move together to the same pole, and the homologous chromosomes are pulled apart.

81 Crossover recombination events between homologous chromosomes are required to form chiasmata, t

82 ter-chromosomal interaction patterns between homologous chromosomes are similar, and the similarity i

83 Strikingly, in the absence of the distal homologous chromosome arm dnTA is further increased, wit

84 Despite the conservation of genes within homologous chromosome arms across species, the karyotype

85 ollowing this centromere depolarization were homologous chromosome arms connected, as observed by the

86 recombination, the broken chromosome uses a homologous chromosome as a repair template.

87 nduced and preferentially repaired using the homologous chromosome as a template.

88 We propose the heterospecific pairing of homologous chromosomes as a preexisting condition of asy

89 netics, employ both NHEJ and HR, and can use homologous chromosomes as an HR template.

90 effects could underlie interactions between homologous chromosomes as required for gametogenesis.

91 e of replication near paused RNA polII using homologous chromosomes as template leads to LOH.

92 During meiosis, homologous chromosomes associate to form the synaptonema

93 he synaptonemal complex (SC), which mediates homologous chromosome association before crossover forma

94 d reads overwhelmingly derived from only one homologous chromosome at any given location.

95 t induces contact between allelic regions of homologous chromosomes at sites of DSBs in human somatic

96 The proper behavior of homologous chromosomes at the first meiotic division is

97 on, is essential for accurate segregation of homologous chromosomes at the first meiotic division, re

98 k alleles (at MPL) or duplicated them to the homologous chromosome (at FH, NBN, MRE11, ATM, SH2B3 and

99 ure assembles in a continuous manner between homologous chromosome axes, enforcing a 100-nm separatio

100 In budding yeast meiosis, homologous chromosomes become linked by chiasmata and th

101 fic structure that assembles between aligned homologous chromosomes, both constrains and is altered b

102 cation as well as pairing and segregation of homologous chromosomes, but the double-strand breaks (DS

103 synapsis, recombination, and segregation of homologous chromosomes, but the molecular organization o

104 the exchange of genetic information between homologous chromosomes by recombination.

105 eiosis requires that crossovers form between homologous chromosomes by recombination.

106 Allelic differences between the two homologous chromosomes can affect the propensity of inhe

107 ic variation, sequence polymorphisms between homologous chromosomes can feedback onto the recombinati

108 In Drosophila, somatic pairing of homologous chromosomes can lead to transvection, by whic

109 Homologous chromosomes colocalize to regulate gene expre

110 species, where genomic polymorphisms between homologous chromosomes commonly result in unpaired DNA d

111 study, we report the unexpected finding that homologous chromosomes contact each other at the sites o

112 air are then highly regulated to ensure that homologous chromosomes contain at least one crossover an

113 In the absence of KNL-1,3, pairs of homologous chromosomes did not separate and did not move

114 Segregation of homologous chromosomes during meiosis depends on linkage

115 l complex (SC), which forms between pairs of homologous chromosomes during meiosis from yeast to huma

116 ecific adaptations enable the segregation of homologous chromosomes during meiosis I to reduce ploidy

117 modifications that ensure the segregation of homologous chromosomes during meiosis I.

118 Pairing and synapsis of homologous chromosomes during meiosis is crucial for pro

119 In most eukaryotes, segregation of homologous chromosomes during meiosis is dependent on cr

120 Proper partitioning of homologous chromosomes during meiosis relies on the coor

121 Faithful segregation of homologous chromosomes during meiosis requires pairing,

122 tion facilitates the accurate segregation of homologous chromosomes during meiosis.

123 enables correct synapsis and segregation of homologous chromosomes during meiosis.

124 n loxP sites located at allelic positions on homologous chromosomes during meiosis.

125 c1 are essential for strand exchange between homologous chromosomes during meiosis.

126 are important for the correct segregation of homologous chromosomes during meiosis.

127 ipartite protein scaffold that forms between homologous chromosomes during meiosis.

128 tion and maintaining faithful segregation of homologous chromosomes during meiosis.

129 s a polymer that spans 100 nm between paired homologous chromosomes during meiosis.

130 The faithful alignment of homologous chromosomes during meiotic prophase requires

131 synaptonemal complex (SC) that forms between homologous chromosomes during meiotic prophase.

132 t assembles at the interface between aligned homologous chromosomes during meiotic prophase.

133 id1 proteins are required for the pairing of homologous chromosomes during meiotic recombination.

134 , mediating the stable pairing (synapsis) of homologous chromosomes during prophase I.

135 nserved protein assembly that holds together homologous chromosomes during prophase of the first meio

136 a meiosis-specific structure formed between homologous chromosomes during prophase that promotes DSB

137 nformation and allow balanced segregation of homologous chromosomes during the first division of meio

138 w that size differences between telomeres on homologous chromosome ends are greater for atm tert than

139 t meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation.

140 Crossovers (COs) between homologous chromosomes ensure their faithful segregation

141 Meiotic recombination between homologous chromosomes ensures their proper segregation

142 Recombination between homologous chromosomes facilitates accurate meiotic chro

143 absent in oocytes during meiotic resumption, homologous chromosomes failed to segregate accurately du

144 s display meiotic arrest in which pairing of homologous chromosomes fails.

145 apture and next-generation sequencing of the homologous chromosome for ten 16p13.11-deletion patients

146 Two homologous chromosomes for each of the 10 sorghum chromo

147 se paints allow identification of individual homologous chromosomes for many applications as demonstr

148 genes were randomly distributed across eight homologous chromosome groups.

149 We have previously shown that homologous chromosomes have a tendency to associate duri

150 in meiosis I, where bivalents consisting of homologous chromosomes held together by chiasmata biorie

151 sis, recombination events that occur between homologous chromosomes help prepare the chromosome pairs

152 ombination using the sister chromatid or the homologous chromosome (homolog) as a template.

153 ation of healthy gametes requires pairing of homologous chromosomes (homologs) as a prerequisite for

154 During meiosis, paired homologous chromosomes (homologs) become linked via the

155 How homologous chromosomes (homologs) find their partner, pa

156 lanced distribution of chromosomes, pairs of homologous chromosomes (homologs) must recognize each ot

157 id organisms to produce haploid gametes: (1) homologous chromosomes (homologs) pair and undergo cross

158 ng, among other outcomes, crossovers between homologous chromosomes (homologs), which provide physica

159 sed into crossovers, ensuring segregation of homologous chromosomes (homologs).

160 Genes on the remaining homologous chromosome, however, are not recurrently muta

161 proper pairing, synapsis, and segregation of homologous chromosomes; however, it is dispensable for t

162 construct from its site of insertion to its homologous chromosome in a faithful, site-specific manne

163 the sister chromatid in mitotic cells or the homologous chromosome in meiotic cells, as a template fo

164 romatin bridges between the telomeres of non-homologous chromosomes in Atrecq4A at metaphase I, in so

165 r SNP allele compositions in each of the two homologous chromosomes in CNV regions using real data.

166 otic and early somatic chromosome pairing of homologous chromosomes in flies that are mutant for vari

167 EPSPS gene to pericentromeric regions of two homologous chromosomes in glyphosate sensitive A tubercu

168 r of PRDM9-dependent DSBs and for pairing of homologous chromosomes in male mice.

169 sually distinguish the maternal and paternal homologous chromosomes in mammalian and insect systems.

170 2B of wild emmer accessions substituted for homologous chromosomes in tetraploid and hexaploid backg

171 regation involves pairing and segregation of homologous chromosomes in the first division and segrega

172 segregation is enabled by crossovers between homologous chromosomes in the first meiotic division.

173 Thus, an interruption of BIR involving fully homologous chromosomes in yeast triggers a switch to MMB

174 rogram of recombination and synapsis between homologous chromosomes, including loading of recombinati

175 otype structure and heterozygosities between homologous chromosomes, including the identification of

176 rrecombination between sister chromatids and homologous chromosomes, indicating an anti-recombination

177 mbly of the synaptonemal complex (SC) brings homologous chromosomes into close apposition along their

178 ent in strictly asexual organisms results in homologous chromosomes irreversibly accumulating mutatio

179 dedicated protein machinery ensures that the homologous chromosome is favored over the nearby sister

180 dination of V rearrangements between loci on homologous chromosomes is critical for Ig and TCR alleli

181 In meiosis, crossover (CO) formation between homologous chromosomes is essential for faithful segrega

182 Pairing of homologous chromosomes is facilitated by telomere-led ch

183 Crossing over between homologous chromosomes is initiated in meiotic prophase

184 ei's speculation that full-length pairing of homologous chromosomes is mediated by the extension of t

185 ucing organisms, crossover formation between homologous chromosomes is necessary for proper chromosom

186 Recombination between homologous chromosomes is required for the faithful meio

187 This bivalent, a linked pair of homologous chromosomes, is essential for proper chromoso

188 which provides a physical connection between homologous chromosomes, is essential in most species for

189 cialized, proteinaceous structure connecting homologous chromosomes, is stabilized in cis on chromoso

190 der shuffling from independent assortment of homologous chromosomes (Mendel's second law).

191 Homologous chromosomes must pair and establish stable co

192 In most species, homologous chromosomes must recombine in order to segreg

193 ks occurs primarily by recombination between homologous chromosomes, not sister chromatids.

194 ation and sequencing to show that alleles on homologous chromosomes occupy distinct territories, and

195 During meiosis, reciprocal exchange between homologous chromosomes occurs as a result of crossovers

196 Nondisjunction of homologous chromosomes occurs in mei-38 mutants primaril

197 ysis, genetic variants are not assigned to a homologous chromosome of origin.

198 re into chiasmata, which hold and orient the homologous chromosomes on the meiotic spindle to ensure

199 on from a homologous template, typically the homologous chromosome or sister chromatid.

200 including selection for efficient pairing of homologous chromosomes or for recombination of deleterio

201 nuclear compartments, which are regulated by homologous chromosome organisation.

202 ), in which an individual contains a pair of homologous chromosomes originating from only one parent,

203 s from diploid precursors requires that each homologous chromosome pair be properly segregated to pro

204 rental disomy describes the inheritance of a homologous chromosome pair from only one parent.

205 of structural changes between members of the homologous chromosome pair.

206 As a prelude to haploidization, homologous chromosomes pair and recombine to undergo seg

207 During meiosis, homologous chromosomes pair and recombine via repair of

208 During meiosis, homologous chromosomes pair and recombine, enabling bala

209 During zygotene, as homologous chromosomes pair and synapse, a synaptonemal

210 In meiosis I, homologous chromosomes pair and then attach to the spind

211 During meiosis homologous chromosomes pair and undergo reciprocal genet

212 The mechanism by which homologous chromosomes pair during meiosis, as a prelude

213 Homologous chromosomes pair in somatic cells in Drosophi

214 In Drosophila, homologous chromosomes pair throughout development, prom

215 first and most complex stage of meiosis when homologous chromosomes pair to exchange genetic informat

216 with abnormal chromosome dynamics, affecting homologous chromosome pairing and synapsis.

217 DSB repair catalyzed solely by HOP2 supports homologous chromosome pairing and synapsis.

218 as nuclear anchorage, nuclear migration, and homologous chromosome pairing during meiosis.

219 We propose that innate preference of homologous chromosome pairing exists in nascent allopoly

220 Homologous chromosome pairing is a prerequisite to estab

221 Thus, homologous chromosome pairing is favored to partners wit

222 In meiotic prophase I, homologous chromosome pairing is promoted through chromo

223 The contribution of the bouquet structure to homologous chromosome pairing is uncertain.

224 InDrosophila, homologous chromosome pairing leads to "transvection," i

225 ive and one inactive centromere are present, homologous chromosome pairing reduces the frequency of i

226 king the Ph1 locus, a locus ensuring correct homologous chromosome pairing, and discover that bouquet

227 those observed in Cdk2 KO mice including non-homologous chromosome pairing, unrepaired double-strand

228 chromosomal interactions are dispensable for homologous chromosome pairing.

229 contribute to the establishment of exclusive homologous chromosome pairing.

230 hich is essential for proper SC assembly and homologous chromosome pairing.

231 mal complex (SC) and its role in maintaining homologous chromosome pairings, the critical roles of th

232 f large single-stranded DNA fragments of the homologous chromosome pairs allows for the independent s

233 formation of at least one chiasma/CO between homologous chromosome pairs is essential for accurate ch

234 In order to accommodate their lack of homologous chromosome pairs, some hymenopterans such as

235 rophase, incomplete and aberrant synapsis of homologous chromosomes, persistence of strand exchange p

236 For this program, crossovers between homologous chromosomes play an essential mechanical role

237 The genetic exchange between homologous chromosomes plays a major role in evolution b

238 o model genomes having more than two sets of homologous chromosomes (polyploidy).

239 H is mitotic crossover recombination between homologous chromosomes, potentially initiated by a doubl

240 -protein ring complex (RC) localized between homologous chromosomes, promotes chromosome congression

241 tility require meiotic recombination between homologous chromosomes rather than the equally available

242 In Drosophila, homologous chromosomes remain paired in somatic tissues,

243 protein PRDM9 fails to bind to the unbroken homologous chromosome, revealing that PRDM9 also functio

244 s in meiosis, when cross-overs (COs) between homologous chromosomes secure an exchange of their genet

245 In meiosis I, homologous chromosomes segregate, while sister chromatid

246 Homologous chromosome segregation during meiosis I (MI)

247 vers (COs) are crucial for ensuring accurate homologous chromosome segregation during meiosis I.

248 However, we also found that random homologous chromosome segregation during ploidy reductio

249 engineered degradation of Atg14 and observed homologous chromosome segregation followed by sister chr

250 spindles, misaligned chromosomes, errors of homologous chromosome segregation, and production of ane

251 s cyclin CLB3 in meiosis I, thereby ensuring homologous chromosome segregation.

252 se defects result in meiosis I arrest before homologous chromosome segregation.

253 genes are expressed from only one of the two homologous chromosomes, selected at random in each cell.

254 ther during the first meiotic division (when homologous chromosomes separate) and then segregate away

255 rescent reporters at equivalent positions on homologous chromosomes so that they would pair via the e

256 ithin this structure 'crosslink' the axes of homologous chromosomes, stabilizing their pairing.

257 During meiosis, homologous chromosomes synapse and recombine at sites ma

258 heir disruption results in severe defects in homologous chromosome synapsis and an early-stage failur

259 Deletion of Hop2 in mice eliminates homologous chromosome synapsis and disrupts double-stran

260 d that Bsg KO spermatocytes displayed normal homologous chromosome synapsis and progression through m

261 Reduction of SYN3 caused defects in homologous chromosome synapsis and synaptonemal complex

262 p2-Mnd1 heterodimer, which are essential for homologous chromosome synapsis during meiosis.

263 upramolecular protein assembly that mediates homologous chromosome synapsis during meiosis.

264 trum of meiotic defects including incomplete homologous chromosome synapsis or persistent histone H2A

265 olyploid somatic nucleus: multiple copies of homologous chromosomes tended to cluster, consistent wit

266 c recombination generates crossovers between homologous chromosomes that are essential for genome hap

267 nation establishes physical linkages between homologous chromosomes that are required for their prope

268 These counterintuitive findings suggest that homologous chromosomes that have successfully engaged on

269 Phylogenetic analyses reveal two sets of homologous chromosomes that may have merged ~5.6 million

270 mata, which are physical connections between homologous chromosomes that provide the tension necessar

271 n examine how sequence polymorphisms between homologous chromosomes, that is, heterozygosity, can inf

272 pread from their chromosome of origin to the homologous chromosome, thereby converting heterozygous m

273 Sequence exchange between homologous chromosomes through crossing over and gene co

274 ination between the polymorphic sequences of homologous chromosomes, thus contributing to gene conver

275 nd tails that undergo strand exchange with a homologous chromosome to form joint molecule (JM) interm

276 incenp mutation leads to a failure of paired homologous chromosomes to biorient, such that bivalents

277 , recombination is directed to occur between homologous chromosomes to create connections necessary f

278 ng meiosis, crossover recombination connects homologous chromosomes to direct their accurate segregat

279 Thus, buttons pair homologous chromosomes to facilitate cell-type-specific

280 ocal exchange of genetic information between homologous chromosomes to generate new allelic combinati

281 Failure of homologous chromosomes to recombine is arguably the most

282 he 3D nucleus revealed that distances of the homologous chromosomes to the center of nucleus are almo

283 conserved proteinaceous structure that holds homologous chromosomes together and is required for the

284 lated to occur only between aligned pairs of homologous chromosomes, ultimately ensuring proper chrom

285 During meiosis, homologous chromosomes undergo crossover recombination,

286 During meiosis, homologous chromosomes undergo crossover recombination,

287 During meiosis homologous chromosomes undergo crossover recombination.

288 During meiosis paired homologous chromosomes undergo recombination, which can

289 During meiosis, homologous chromosomes undergo synapsis and recombinatio

290 ng and generates crossovers (COs) to connect homologous chromosomes until their separation at anaphas

291 inding locations and lifespans to individual homologous chromosomes using a genetically engineered hy

292 on the pericentromeric region on one pair of homologous chromosomes was detected.

293 so that there is at least one CO per pair of homologous chromosomes whereas the maximum number of COs

294 e conflicting alterations occur on different homologous chromosomes, which argues for multi-centric o

295 bination and correct segregation of multiple homologous chromosomes, which can form complex multivale

296 A central feature of meiosis is pairing of homologous chromosomes, which occurs in two stages: coal

297 ositions generally serves to loosely coalign homologous chromosomes, while crossover-bound recombinat

298 The engagement of homologous chromosomes with each other regulates the dis

299 individual variation and differences between homologous chromosomes within the same individual (allel

300 We observe high frequencies of homologous chromosome X colocalization (or coalescence),