ライフサイエンスコーパス: homologous recombination

1 tch (SgRNA With Induction/Termination by Cre Homologous recombination).

2 ps) are critical intermediates formed during homologous recombination.

3 ndings provide key mechanistic insights into homologous recombination.

4 onment and integrate it into their genome by homologous recombination.

5 biallelic deletions mediated by non-allelic homologous recombination.

6 P1 and BARD1, exhibiting unexpected roles in homologous recombination.

7 critical for D-loop formation, a key step in homologous recombination.

8 s in enhancing plaque size were validated by homologous recombination.

9 uppress pathological end joining and promote homologous recombination.

10 DDR initiation and telomere maintenance via homologous recombination.

11 DNA damage sites, interaction with BRCA2 and homologous recombination.

12 resection, BRCA1 and Rad51 recruitment, and homologous recombination.

13 bacteria can be concatenated into dimers by homologous recombination.

14 gulator of DNA double-strand break repair by homologous recombination.

15 ologous end-joining (NHEJ) at the expense of homologous recombination.

16 d break repair based on its coevolution with homologous recombination.

17 motes DNA double-strand break repair through homologous recombination.

18 rned by vertical inheritance, gene loss, and homologous recombination.

19 p.R37H [c.110G>A] compromised PALB2-mediated homologous recombination.

20 for DNA double-strand break (DSB) repair by homologous recombination.

21 several are implicated in DNA repair through homologous recombination.

22 y can result from sequence homogenization by homologous recombination.

23 t acetylation by PCAF, and repair of DSBs by homologous recombination.

24 ally, DDIAS-depleted cells are deficient for homologous recombination.

25 movement aids in finding a donor strand for homologous recombination.

26 consequently promotes meiotic DSB repair and homologous recombination.

27 th loss of high-fidelity double-strand break homologous recombination.

28 s) are signature intermediates formed during homologous recombination.

29 RCA2 acts as the predominant mediator during homologous recombination.

30 ning sequence conservation in the absence of homologous recombination.

31 re genome evolution for prokaryotes modeling homologous recombination.

32 t, the Rad52 protein mediates DSB repair via homologous recombination.

33 t homology arms for directed integration via homologous recombination.

34 The strand-exchange reaction is central to homologous recombination.

35 trand-break intermediate that is repaired by homologous recombination(2).

36 To repair a DNA double-strand break by homologous recombination, 5'-terminated DNA strands must

37 the repair of double-stranded DNA breaks by homologous recombination(8-13), and consequently exhibit

38 al, but these organisms frequently engage in homologous recombination, a process that differs from me

39 tivity, which correlated with an increase in homologous recombination activity.

40 Inversion associated allelic homologous recombination (AHR) may well be a common mech

41 This promotes DNA repair by homologous recombination and also assembly of signaling

42 RAD51 to mediate chromosome damage repair by homologous recombination and also to protect stressed DN

43 y an important role in transcription-coupled homologous recombination and DNA replication restart.

44 ional profiling of BRD proteins revealed new homologous recombination and genome stability pathways,

45 e diverse ways that HPV oncogenes manipulate homologous recombination and ideas on how the resulting

46 ant lineage is associated with high rates of homologous recombination and infection in high-risk sexu

47 rects TIP60-dependent acetylation to promote homologous recombination and maintain genome stability.

48 ch may be crucial for CtIP functions in both homologous recombination and microhomology-mediated end-

49 ation and the recruitment of proteins of the homologous recombination and non-homologous end joining

50 repair of DNA double-strand breaks (DSBs) by homologous recombination and nonhomologous end joining i

51 ype through downregulating expression of key homologous recombination and nonhomologous end-joining (

52 dishevelled2 gene using CRISPR/Cas9-induced homologous recombination and observed its dynamics direc

53 ls extensive genomic heterogeneity driven by homologous recombination and overlaid with high levels o

54 otes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication fo

55 teracting macroH2A1.2 histone variant during homologous recombination and replication stress (RS).

56 of replication forks, inducing dsDNA breaks, homologous recombination, and a PP2A-dependent replicati

57 sms include premature mitosis, inhibition of homologous recombination, and activation of double-stran

58 asmids, unusual codon usage, and inefficient homologous recombination are among the obstacles limitin

59 Given that defects in homologous recombination are present in only a subset of

60 e response (DDR)-dependent manner to promote homologous recombination-associated ALT pathways.

61 itor olaparib reflects delayed engagement of homologous recombination at DNA-replication-fork associa

62 ications were likely mediated by non-allelic homologous recombination at regions of high sequence ide

63 also a negative regulator of RAD51-mediated homologous recombination at stalled forks.

64 We discover that HELLS facilitates homologous recombination at two-ended breaks and contrib

65 ition (PARPi) kills tumor cells defective in homologous recombination-based repair (HR-) but not thei

66 DNA double-strand break repair by homologous recombination begins with nucleolytic resecti

67 robably preceded inter-chromosomal 'allelic' homologous recombination between differently oriented LC

68 yndrome (22q11.2DS) results from non-allelic homologous recombination between low-copy repeats termed

69 ave a deletion that is caused by non-allelic homologous recombination between two of four low copy re

70 otein 1 (RAD51AP1) plays an integral role in homologous recombination by activating RAD51 recombinase

71 reventing DSB ligation by NHEJ, or enhancing homologous recombination by BRCA1-A complex disruption,

72 pressor BRCA2 plays a key role in initiating homologous recombination by facilitating RAD51 filament

73 terodimeric helicase-nuclease that initiates homologous recombination by resecting DNA double-strand

74 pathway involving Pif1's ability to promote homologous recombination-coupled replication.

75 CA1 or BRCA2, making APE2 a prime target for homologous recombination-defective cancers.

76 y oral doses of TLZ in growth suppression of homologous recombination-defective tumors in mouse xenog

77 s (OCs) harboring BRCA mutations, generating homologous recombination deficiencies (HRDs).

78 patients with BRCA mutations, patients with homologous recombination deficiencies, and the intention

79 including microsatellite instability (MSI), homologous recombination deficiency (HRD) enriched with

80 Homologous recombination deficiency (HRD) is a defining

81 lish that ALC1 loss is synthetic lethal with homologous recombination deficiency (HRD), which we attr

82 Cells with homologous recombination deficiency are reliant on TMEJ

83 er susceptibility genes BRCA1 and BRCA2, and homologous recombination deficiency for DNA damage respo

84 cases or the absence of BRCA1/BRCA2-mediated homologous recombination deficiency in a MM cohort.

85 Testing for BRCA1/2 mutations and homologous recombination deficiency is essential.

86 R deficiency, including a novel signature of homologous recombination deficiency, cosegregates with r

87 tion rates were associated with APOBEC3B and homologous recombination deficiency, increasing neoantig

88 y in cancers not classically associated with homologous recombination deficiency.

89 ree survival in patients who had tumors with homologous-recombination deficiency and in those in the

90 bo, regardless of the presence or absence of homologous-recombination deficiency.

91 t randomization, 373 (50.9%) had tumors with homologous-recombination deficiency.

92 9.37 months [95% CI, 6.65 to 11.85 months]); homologous recombination deficient (HRD) cohort (236 ruc

93 s LSTs are a primary functional component of homologous recombination deficient cellular phenotypes,

94 mmonly upregulated in cancers, especially in homologous recombination-deficient cancers, which displa

95 TR is a major target for cancer therapies in homologous recombination-deficient cancers.

96 ucaparib than placebo in the BRCA-mutant and homologous recombination-deficient cohorts.

97 y, the increase of base substitutions in the homologous recombination-deficient Rad51 mutant, specifi

98 they represent a tractable vulnerability in homologous recombination-deficient tumor cells.

99 emerged as a novel clinical therapy to treat homologous recombination-deficient tumors.

100 variants in TONSL impair DNA replication and homologous recombination-dependent repair processes, and

101 This study explores the concept that homologous recombination DNA repair is not an all-or-not

102 ation status of 22 genes associated with the homologous recombination DNA repair pathway or PARP inhi

103 mutational signature 3 reflecting defective homologous recombination DNA repair, and positive immune

104 ss-of-function mutations in genes related to homologous recombination DNA repair, compared to early t

105 ion down-regulates mismatch repair (MMR) and homologous recombination DNA-repair genes and concomitan

106 RAD51 plays a central role in homologous recombination during double-strand break repa

107 characterize the spatiotemporal dynamics of homologous recombination during NT in Vibrio cholerae.

108 The parental mtDNAs interacted through 28 homologous recombination events and a single case of ill

109 Thus, naturally occurring homologous recombination events between 2 strains can in

110 This happened as part of 11 simultaneous homologous recombination events involving 2 phylogenetic

111 for example, they play critical roles in the homologous recombination events that can restore broken

112 to detect several known and novel nonallelic homologous recombination events.

113 ment of breast cancers that are deficient in homologous recombination exemplifies the utility of synt

114 vergence in relation to their involvement in homologous recombination, exemplifying a duplicate reten

115 Approximately 15% of cancers use homologous recombination for alternative lengthening of

116 Thus, our HDR-based method, enhanced homologous recombination for genome targeting (eHOT), is

117 d DDR signaling, but did not directly impact homologous recombination function.

118 ver, recent developments show that, although homologous recombination gene expression and markers of

119 genomes become isolated by barriers impeding homologous recombination, gene and genome evolution proc

120 ex evolutionary history, including extensive homologous recombination, gene loss, gene duplications,

121 Yet, one essential aspect of homologous recombination has largely been overlooked whe

122 Recent homologous recombination has resulted in extensive genom

123 Homologous recombination helps ensure the timely complet

124 ) inhibitors in cancers with deficiencies in homologous recombination highlights the potential of thi

125 epair by excision, translesion synthesis and homologous recombination; however, its function remains

126 elta cells exhibit defects in DNA repair and homologous recombination (HR) and abnormal DNA repair fa

127 DSBs are repaired by two major pathways, homologous recombination (HR) and classical nonhomologou

128 Loss of TRDMT1 compromises homologous recombination (HR) and increases cellular sen

129 plays a critical role in the choice between homologous recombination (HR) and non-homologous end-joi

130 orter cassette for simultaneous detection of homologous recombination (HR) and nonhomologous end join

131 erent mechanistic roles for deSUMOylation in homologous recombination (HR) and nonhomologous end join

132 ner and regulate the relative utilization of homologous recombination (HR) and nonhomologous end-join

133 regulates DNA double-strand break repair by homologous recombination (HR) and other functions centra

134 d9/ATR-ETAA1 interactions; thereby promoting homologous recombination (HR) and PARPi resistance.

135 to RAD51AP1's involvement in RAD51-dependent homologous recombination (HR) and RAD52-POLD3-dependent

136 s in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersen

137 Inhibition of TTK impaired homologous recombination (HR) and repair efficiency, but

138 elomeres, which is associated with increased Homologous Recombination (HR) and TERRA transcription.

139 icroscopy, cell cycle by flow cytometry, and homologous recombination (HR) by a GFP reporter assay.

140 replication fork collapse and inhibition of homologous recombination (HR) by targeting HR-regulator

141 l breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutation

142 Translesion DNA synthesis (TLS) and homologous recombination (HR) cooperate during S-phase t

143 collateral repair pathway in the context of homologous recombination (HR) deficiency.

144 m BRCA1 germline mutations are deficient for homologous recombination (HR) DNA repair and are sensiti

145 ly, we have shown that NUCKS1 helps maintain homologous recombination (HR) DNA repair in human cells

146 BRCA1 gene mutations impair homologous recombination (HR) DNA repair, resulting in c

147 find that Ino80 is selectively required for homologous recombination (HR) DNA repair, which is mecha

148 ss and enhances therapeutic efficacy against homologous recombination (HR) DNA repair-deficient HGSOC

149 trategies that can target BRCA wild-type and homologous recombination (HR) DNA repair-proficient canc

150 BRCA1 plays a key role in homologous recombination (HR) DNA repair.

151 h a subgroup harboring evidence of defective homologous recombination (HR) DNA repair.

152 s to introduce genome editing reagents and a homologous recombination (HR) donor template into embryo

153 eground' at the DNA replication fork between homologous recombination (HR) factors and L1 retrotransp

154 es to stalled replication forks and recruits homologous recombination (HR) factors such as CtBP inter

155 The defect in homologous recombination (HR) found in BRCA1-associated

156 Mutations in homologous recombination (HR) genes were significantly a

157 Homologous recombination (HR) helps maintain genome inte

158 We report that VEGF-NRP2 promote homologous recombination (HR) in BRCA1 wild-type TNBC ce

159 atopoietic stem cells despite the defects in homologous recombination (HR) in FA cells, we constructe

160 here the role, mechanisms, and regulation of homologous recombination (HR) in the formation of simple

161 Rad52 is a key factor for homologous recombination (HR) in yeast.

162 Homologous Recombination (HR) is a high-fidelity process

163 Homologous recombination (HR) is a universally conserved

164 Homologous recombination (HR) is an important route for

165 Homologous recombination (HR) is considered a major driv

166 DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain gen

167 Although error-free repair by homologous recombination (HR) is crucial to prevent exce

168 Homologous recombination (HR) is essential for high-fide

169 Homologous recombination (HR) is important for error-fre

170 DNA repair via homologous recombination (HR) is indispensable for genom

171 eagues underscores that DNA damage repair by homologous recombination (HR) is not an all-or-nothing p

172 The homologous recombination (HR) machinery plays multiple r

173 howed that ERbeta plays an important role in homologous recombination (HR) mediated repair and ERbeta

174 Homologous recombination (HR) mediates the error-free re

175 of BRCA-deficient cancer and that defects in homologous recombination (HR) or fork protection (FP) do

176 breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologou

177 the recombinase RAD51 in DNA repair via the homologous recombination (HR) pathway.

178 ing those of the Fanconi anemia (FA) and the homologous recombination (HR) pathways.

179 inaccessible to 53BP1 but permissive to the homologous recombination (HR) proteins RNF169, RAD51, an

180 For example, defects in homologous recombination (HR) repair arise in cancer cel

181 Reduced BRCA1 expression causes homologous recombination (HR) repair defects in high-gra

182 Homologous recombination (HR) repair deficiency arising

183 (DDC) is often robustly activated during the homologous recombination (HR) repair of DNA double stran

184 ploid cells, FANCJ is believed to operate in homologous recombination (HR) repair of DNA double-stran

185 A defective homologous recombination (HR) repair program increases t

186 we noted CHK1's regulation on RAD51-mediated homologous recombination (HR) repair was not altered in

187 Homologous recombination (HR) uses a homologous template

188 loops (D-loops) are pivotal intermediates of homologous recombination (HR), a universal DNA double st

189 Cells lacking ZPET displayed enhanced homologous recombination (HR), accelerated replication f

190 tes DNA damage repair through enhancement of homologous recombination (HR), and prevents epithelial-m

191 be restarted and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform p

192 To correct this mutation by homologous recombination (HR), we designed a series of s

193 mbination of cisplatin and Nutlin-3 inhibits homologous recombination (HR), which leads to persistenc

194 Meiotic DSBs initiate homologous recombination (HR), which subsequently ensure

195 her re-activating telomerase or adopting the homologous recombination (HR)-based Alternative Lengthen

196 BRCA1-PALB2-BRCA2 axis that is essential for homologous recombination (HR)-based DNA doublestrand bre

197 reatment of different malignances, including homologous recombination (HR)-deficient breast and ovari

198 Homologous recombination (HR)-directed DNA double-strand

199 nwinding activity potentiates the downstream homologous recombination (HR)-mediated DNA repair.

200 uently occurs in PFA ependymomas, suppresses homologous recombination (HR)-mediated DNA repair.

201 tic (s)BRCA1/2 mutations or g/s mutations in homologous recombination (HR)-related genes other than B

202 hality in BRCA1-deficient mice by inhibiting homologous recombination (HR).

203 Bs are Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR).

204 al aberrations stemming from dysfunctions in homologous recombination (HR).

205 BRCA1 functions at two distinct steps during homologous recombination (HR).

206 ouble-strand breaks (DSBs) primarily through homologous recombination (HR).

207 susceptibility gene II (BRCA2) is central in homologous recombination (HR).

208 sed approach to kill cancers with defects in homologous recombination (HR).

209 dependent motor proteins that participate in homologous recombination (HR).

210 DNA end resection and RAD51 loading steps of homologous recombination (HR).

211 on forks, phenotype reminiscent of defective homologous recombination (HR).

212 regulator to initiate DNA end resection and homologous recombination (HR).

213 ut impede the resumption of DNA synthesis by homologous recombination (HR).

214 DSBs in hESCs are also repaired via homologous recombination (HR); however, DSB overload, to

215 ghly effective in killing cells deficient in homologous recombination (HR); thus, PARPi have been cli

216 35d inhibits the homologous recombination in a human pancreatic adenocarc

217 Ensuring faithful homologous recombination in allopolyploids is essential

218 ased DNA resection tracks and an increase of homologous recombination in cellulo.

219 Dmc1 recombinases are essential to homologous recombination in meiosis.

220 ired for normal levels of DNA damage-induced homologous recombination in somatic tissues.

221 iple endonucleases that unhook ICLs, resolve homologous recombination intermediates, and perhaps remo

222 Homologous recombination is a fundamental process in all

223 Whilst it is known that homologous recombination is deployed in such instances t

224 Homologous recombination is essential for preserving gen

225 The timely activation of homologous recombination is essential for the maintenanc

226 DNA double-strand break repair by homologous recombination is initiated by the Ctp1 protei

227 The repair of DNA double-strand breaks by homologous recombination is of crucial importance for ma

228 not without risk as replication restarted by homologous recombination is prone to template switching

229 on, and how this role relates to its role in homologous recombination, is unclear.

230 markers of pathway activation are increased, homologous recombination itself is attenuated.

231 How the homologous recombination machinery is recruited to repli

232 ication intermediates, where it recruits the homologous recombination machinery to mediate strand spe

233 sion of RAD51, an essential component of the homologous recombination machinery, which repairs DNA da

234 Cybrid plant mitochondria undergo homologous recombination, mainly BIR, keep a single alle

235 The model explains how homologous recombination maintains the cohesiveness of t

236 tion to several additional genes involved in homologous recombination may also have predictive value

237 rearrangements, mostly mediated by different homologous recombination mechanisms including single-str

238 Three main homologous recombination mechanisms were recognized in t

239 ic processing of DNA ends in preparation for homologous recombination-mediated chromosome damage repa

240 s binding site modulates USP11's function in homologous recombination-mediated DNA repair.

241 biquitylated MRE11 to mediate early steps of homologous recombination-mediated DSB repair (HRR).

242 Facilitated by linear plus linear homologous recombination-mediated recombineering (LLHR),

243 BRCA1 promotes error-free, homologous recombination-mediated repair (HRR) of DNA do

244 d that this was likely mediated by decreased homologous recombination-mediated repair (HRR), since si

245 ions and DSB-induced optimal ATM activation, homologous recombination-mediated repair and genome inte

246 he induction of meiotic DNA breaks and their homologous recombination-mediated repair in Caenorhabdit

247 ulated genes were correlated negatively with homologous recombination, mismatch repair and G2M checkp

248 romosome 22 LCRs (LCR22s) mediate nonallelic homologous recombination (NAHR) leading to the 22q11 del

249 deletion of ~ 3 Mbp occurring by non-allelic homologous recombination (NAHR) mediated by LCR22s.

250 One of them is nonallelic homologous recombination (NAHR).

251 Direct comparison to genetic screens for homologous recombination or Fanconi anemia factors indic

252 light on how BRCA1 influences the choice of homologous recombination over non-homologous end joining

253 utations affecting genes associated with the homologous recombination pathway may be underrepresented

254 RAD52 is a member of the homologous recombination pathway that is important for s

255 s it seemed that HPV oncogenes activated the homologous recombination pathway to facilitate the HPV l

256 erphase has not, and the question of whether homologous recombination proceeds to completion in G1 ph

257 Exploiting bacteriophage-derived homologous recombination processes has enabled precise,

258 oor protection of nascent strands but retain homologous recombination proficiency, thus defining doma

259 proteins MSH2, MSH6, and EXO1 as well as the homologous recombination protein RAD51, which was downre

260 repressive activity of CDK4/6 inhibitors on homologous recombination proteins required for the recov

261 egion, which could then lead to suppress the homologous recombination-related BRCA1 expression via di

262 The BRCA1-BRCA2-RAD51 axis is essential for homologous recombination repair (HRR) and is frequently

263 uenced for BRCA1/2 and damaging mutations in homologous recombination repair (HRR) genes.

264 PARP) inhibitors with drugs that inhibit the homologous recombination repair (HRR) pathway (such as P

265 The homologous recombination repair (HRR) pathway repairs DN

266 cant pathway that is disabled as a result is homologous recombination repair (HRR).

267 CHK1i-induced DNA damage by attenuating DNA homologous recombination repair activity and RAD51 foci

268 mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive

269 tion signatures in breast cancer and predict homologous recombination repair deficiency in held-out t

270 lotumumab plus erlotinib (MET), talazoparib (homologous recombination repair deficiency), and telisot

271 ock size of six with stratification based on homologous recombination repair gene mutation status, pr

272 ate cancer who had qualifying alterations in homologous recombination repair genes and whose disease

273 CDKN2A mRNA downregulation), alterations of homologous recombination repair genes, and expression of

274 s and platinum agents owing to deficiency in homologous recombination repair of DNA damage.

275 RCA2 mutations or those without a functional homologous recombination repair pathway.

276 reactive oxygen species as well as impaired homologous recombination repair underlie this DNA damage

277 s that are involved in DNA repair, including homologous recombination repair, are associated with res

278 onical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA

279 who had alterations in genes with a role in homologous recombination repair, olaparib was associated

280 RAD51 foci at 4 h after IR, as a measure for homologous recombination repair, was significantly reduc

281 fied genes with a direct or indirect role in homologous recombination repair.

282 nhibited, severe DNA damage is corrected via homologous recombination repair.

283 d DNA damage that requires BRCA1/2-dependent homologous recombination repair.

284 Unlike previous in planta or intra-genomic homologous recombination reports in which the original c

285 Repair of broken DNA by homologous recombination requires coordinated enzymatic

286 ulting cleavage of the genome is repaired by homologous recombination restoring the WT version.

287 petitive genetic parts substantially reduces homologous recombination, resulting in greater genetic s

288 H2A.1 promotes high-fidelity homologous recombination, sister chromatid recombination

289 Double-strand breaks (DSBs) initiate the homologous recombination that is crucial for meiotic chr

290 To repair DNA double-strand breaks by homologous recombination, the 5'-terminated DNA strands

291 In the repair of DNA double-strand breaks by homologous recombination, the DNA break ends must first

292 into the genome of Physcomitrella patens by homologous recombination, this moss has been a premier m

293 in genome integrity, a process skewed toward homologous recombination through the evolutionary loss o

294 nt with inhibition of NHEJ and activation of homologous recombination to facilitate gene insertion.

295 ckout ESC lines generated by CRISPR/Cas9 and homologous recombination, we demonstrate that EtOH signa

296 Furthermore, DNA repair factors involved in homologous recombination were among the most prominently

297 These DNA breaks are repaired by homologous recombination, which facilitates proper chrom

298 evisiae that contribute to the regulation of homologous recombination, which is an essential DNA repa

299 sation episodes through real-time intra-host homologous recombination while the rest are co-transmitt

300 Homologous recombination without allele replacement at S