ライフサイエンスコーパス: homologous recombination repair

1 nhibited, severe DNA damage is corrected via homologous recombination repair.

2 fied genes with a direct or indirect role in homologous recombination repair.

3 sis and the reinitiation of DNA synthesis by homologous recombination repair.

4 n between FANCD2 and 10 proteins involved in homologous recombination repair.

5 BRCA1 and BRCA2 pathways as they function in homologous recombination repair.

6 Rad51 gene family, thought to be central to homologous recombination repair.

7 6738 inhibited break-induced replication and homologous recombination repair.

8 osters resection, RAD51 binding and accurate Homologous Recombination repair.

9 o PARP inhibitors, suggestive of a defect in homologous recombination repair.

10 ibitors (PARPi), despite being proficient in homologous recombination repair.

11 AD51 recombinase foci formation and augments homologous recombination repair.

12 iated DNA damage repair signaling, impairing homologous recombination repair.

13 ation and subsequent removal of Rad51 during homologous recombination repair.

14 plifying gammaH2A.X production and promoting homologous recombination repair.

15 ts with a severe impact on BRCA2 binding and homologous recombination repair.

16 d DNA damage that requires BRCA1/2-dependent homologous recombination repair.

17 s early DNA end resection, the first step of homologous recombination repair.

18 tion with non-homologous end joining but not homologous recombination repair.

19 promoting early ATM checkpoint responses and homologous recombination repair.

20 er of DSB processing that is a requisite for homologous recombination repair.

21 precipitation studies) and together, promote homologous recombination repair.

22 g protein (CTIP)-dependent end resection and homologous recombination repair.

23 WI5 or MEI5 in human cells causes defects in homologous recombination repair.

24 has an evolutionarily conserved function in homologous recombination repair.

25 SG2285 was primarily dependent on ERCC1 and homologous recombination repair.

26 also govern the choice of templates used in homologous recombination repair.

27 ity, defective G2/M checkpoint, and impaired homologous recombination repair.

28 anded DNA, which is critically important for homologous recombination repair.

29 ensive end processing associated with failed homologous recombination repair.

30 se and subsequently recruit Rad51 to promote homologous recombination repair.

31 mpaired Fancd2 foci assembly and a defect in homologous recombination repair.

32 between BRCA1 and PALB2 is important for the homologous recombination repair.

33 ides an alternative to BRCA2/RAD51-dependent homologous recombination repair(10).

34 ak-induced DNA replication, a sub-pathway of homologous recombination repair activated at broken or c

35 CHK1i-induced DNA damage by attenuating DNA homologous recombination repair activity and RAD51 foci

36 nalysis demonstrated that TAK-931 suppressed homologous recombination repair activity, delayed recove

37 res with Rad51-dependent and BRCA2-dependent homologous recombination repair activity.

38 Tumors with homologous recombination repair alterations were associa

39 proved survival is not due to restoration of homologous recombination repair although decreased DNA d

40 ors by disrupting RAD51 loading required for homologous recombination repair, although this response

41 f SA2 but not SA1 decreased sister chromatid homologous recombination repair and affected repair path

42 Activation of this pathway rescued homologous recombination repair and allowed BRCA1-defici

43 BRCA1 promotes homologous recombination repair and antagonizes 53BP1-de

44 on of BRCA2 and links BRCA1 and BRCA2 in DNA homologous recombination repair and breast cancer suppre

45 ssion of miR-155 decreased the efficiency of homologous recombination repair and enhanced sensitivity

46 polymerase-helicase complex participates in homologous recombination repair and is essential for cel

47 PDAC deficient in homologous recombination repair and mismatch repair is a

48 ncodes a DNA helicase proposed to operate in homologous recombination repair and replicational stress

49 nomic instability and, consequently, require homologous recombination repair and the DNA damage check

50 mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive

51 genes, BLM and WRN, play important roles in homologous recombination repair and they have been impli

52 g assays of cellular survival and viability, homologous recombination repair, and genome instability.

53 plays a central role in DNA replication and homologous recombination repair, and is known to be invo

54 tion of Rad51 focus formation, inhibition of homologous recombination repair, and persistent gamma-H2

55 HGSC cells, including clonogenic growth, DNA homologous recombination repair, and poly-ADP ribosylase

56 ngle-strand break repair, XRCC3 and RAD51 in homologous recombination repair, and XRCC7 in nonhomolog

57 rate cells, the primary proteins involved in homologous recombination repair are RAD51 and the five R

58 s that are involved in DNA repair, including homologous recombination repair, are associated with res

59 All assays, except the homologous recombination repair assay, showed statistica

60 mid containing a sequence that could support homologous recombination repair between the two plasmids

61 uppression of Rad51 expression, required for homologous recombination repair, blocked the ability of

62 nly enhances reparation of DNA lesions (e.g. homologous recombination repair), but also prolongs acti

63 P1 to a DNA double-strand break (DSB) during homologous recombination repair, but a role in DSB repai

64 In addition, INT3 is involved in homologous recombination repair by regulating Rad51 foci

65 -induced BRCA2 expression, thereby enhancing homologous recombination repair capacity.

66 urthermore, cases were enriched with RDVs in homologous recombination repair [carrier frequency (CF)

67 We propose that not all components of the homologous recombination repair complex can act as cance

68 e S and G(2) phases of the cell cycle during homologous recombination repair, concomitantly with DNA

69 Homologous recombination repairs damage-induced DNA doub

70 been developed for treating tumors harboring homologous recombination repair defects that lead to a d

71 y changed treatment options for cancers with homologous recombination repair defects, especially thos

72 One involves homologous recombination repair deficiency (HRD) while t

73 natures, and compound algorithmic scores for homologous recombination repair deficiency (HRD), mismat

74 merase (PARP) in tumors with and without DNA homologous recombination repair deficiency (HRRm); and (

75 tion signatures in breast cancer and predict homologous recombination repair deficiency in held-out t

76 lotumumab plus erlotinib (MET), talazoparib (homologous recombination repair deficiency), and telisot

77 or high microsatellite instability (MSI-H), homologous recombination repair deficiency, or tumor mut

78 s tobacco exposure, and progression, such as homologous recombination repair deficiency.

79 classify tumors, 59% were predicted to have homologous-recombination-repair deficiency (HRDetect-hig

80 ions, a mutational signature associated with homologous-recombination-repair deficiency.

81 However, non-germline BRCA1/2 mutated and homologous recombination repair deficient (HRD) tumors a

82 nt nuclear depletion of BRCA1 and subsequent homologous recombination repair deficit was induced with

83 Homologous recombination repairs DNA breaks and sequence

84 Homologous recombination repairs DNA double strand break

85 Homologous recombination repairs DNA double-strand break

86 Homologous recombination repairs DNA double-strand break

87 ed in protecting stressed replication forks: homologous recombination repair, DNA inter-strand cross-

88 duplex determines how rapidly and accurately homologous recombination repairs double-strand breaks.

89 ithelium-derived growth factor and the Rad51 homologous recombination repair factor at DNA breaks.

90 is suppressed by concomitant deletion of the homologous recombination repair factor, Rhp51 (Rad51).

91 hat SETD2 facilitates the recruitment of the homologous recombination repair factors CtIP and Rad51 t

92 dependent on the XPF-ERCC1 heterodimer, and homologous recombination repair factors XRCC2 and XRCC3.

93 er DNA cleavage, lesser focal recruitment of homologous recombination repair factors, impaired DNA do

94 n PCa and CDK12 deficiency is known to cause homologous recombination repair gene alteration or BRCAn

95 MAGNITUDE found patients with homologous recombination repair gene alterations (HRR+),

96 tic castration-resistant prostate cancer and homologous recombination repair gene alterations who had

97 d sequence (block size of six, stratified by homologous recombination repair gene mutation status, pr

98 ock size of six with stratification based on homologous recombination repair gene mutation status, pr

99 The presence of homologous recombination repair gene variants in the tum

100 esistant prostate cancer with alterations in homologous recombination repair genes and disease progre

101 ate cancer who had qualifying alterations in homologous recombination repair genes and whose disease

102 CDKN2A mRNA downregulation), alterations of homologous recombination repair genes, and expression of

103 using on known pathogenic alterations within homologous recombination repair genes, we find 10 patien

104 J, the rejoining does not involve all of the homologous recombination repair genes.

105 , BRCA1 promoter methylation, or non-BRCA1/2 homologous recombination repair germline mutations.

106 vidence that Ape1 facilitates BRCA1-mediated homologous recombination repair (HR), while counteractin

107 of the genome are preferentially repaired by homologous recombination repair (HR).

108 lethal malignancy that harbors mutations in homologous recombination-repair (HR-repair) proteins in

109 s with metastatic prostate cancer who harbor homologous recombination repair (HRR) alterations.

110 r ubiquitin-mediated degradation to regulate homologous recombination repair (HRR) and anti-tumor imm

111 se cDNA or dominant-negative mutant inhibits homologous recombination repair (HRR) and increases sens

112 The BRCA1-BRCA2-RAD51 axis is essential for homologous recombination repair (HRR) and is frequently

113 SB repair pathways exist in mammalian cells: homologous recombination repair (HRR) and nonhomologous

114 e lesions are repaired by BCR/ABL-stimulated homologous recombination repair (HRR) and nonhomologous

115 sion cassette, allowing for the detection of homologous recombination repair (HRR) by GFP expression.

116 ration-resistant prostate cancer (CRPC) with homologous recombination repair (HRR) defects.

117 Homologous recombination repair (HRR) enables fault-free

118 ished for patients with prostate cancer with homologous recombination repair (HRR) gene alterations,

119 ion-resistant prostate cancer unselected for homologous recombination repair (HRR) gene alterations.

120 de for first-line treatment of patients with homologous recombination repair (HRR) gene-mutated metas

121 receptor inhibitor, suppresses expression of homologous recombination repair (HRR) genes and increase

122 uenced for BRCA1/2 and damaging mutations in homologous recombination repair (HRR) genes.

123 (CRPC) patients characterized by defects in homologous recombination repair (HRR) genes.

124 ded patients with and without alterations in homologous recombination repair (HRR) genes.

125 tive tumour cell lines are also defective in homologous recombination repair (HRR) induced by DNA dou

126 DSBs and speculate that the contribution of homologous recombination repair (HRR) is at a stage afte

127 urate joining of DNA double-strand breaks by homologous recombination repair (HRR) is critical to the

128 Homologous recombination repair (HRR) is functional duri

129 Homologous recombination repair (HRR) is required for bo

130 A role for D1-D2-G-X3 in homologous recombination repair (HRR) is supported by ou

131 Homologous recombination repair (HRR) maintains chromoso

132 ate the efficacy of PARPi in each individual homologous recombination repair (HRR) mutated (m) gene.

133 VM of Chk1 activation leads to inhibition of homologous recombination repair (HRR) of cellular DNA, w

134 These include a key role in homologous recombination repair (HRR) of DNA double-stra

135 The involvement of BRCA1 and BRCA2 in the homologous recombination repair (HRR) of double-strand b

136 PARP) inhibitors with drugs that inhibit the homologous recombination repair (HRR) pathway (such as P

137 The homologous recombination repair (HRR) pathway repairs DN

138 rom-encoded Flp recombinase and the cellular homologous recombination repair (HRR) pathway.

139 ated TNBC, exploiting vulnerabilities in the homologous recombination repair (HRR) pathway.

140 lex, an important factor in the ATM-mediated homologous recombination repair (HRR) pathway.

141 Homologous recombination repair (HRR) protects cells fro

142 PARP inhibitors (PARPis) regardless of their homologous recombination repair (HRR) status.

143 4 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome m

144 ed the ATM-dependent DNA damage response and homologous recombination repair (HRR) via decreasing DIC

145 Non-homologous end-joining (NHEJ) and homologous recombination repair (HRR), contribute to rep

146 for the RAD51 homolog XRCC2 and defective in homologous recombination repair (HRR), displays signific

147 FANCD2 in promoting RAD51 foci formation and homologous recombination repair (HRR), EGFR-mutant cells

148 BL stimulate unfaithful DSB repair pathways, homologous recombination repair (HRR), nonhomologous end

149 t depletion of BRCA1, an important factor of homologous recombination repair (HRR), preferentially se

150 though the SHU genes have been implicated in homologous recombination repair (HRR), their precise rol

151 gets, RAD51, known to play a pivotal role in homologous recombination repair (HRR), thus leading to s

152 ocking down Hus1 decreases the efficiency of homologous recombination repair (HRR), which is associat

153 ARPi) show selective efficacy in tumors with homologous recombination repair (HRR)-defects but the ac

154 shown significant efficacy as monotherapy in homologous recombination repair (HRR)-deficient cancers.

155 role of Jab1 in regulating the stability of homologous recombination repair (HRR)-related RNAs and e

156 which collapse replication forks and trigger homologous recombination repair (HRR).

157 in (nucleoprotein) filament is essential for homologous recombination repair (HRR).

158 wed decreased viability and failed to induce homologous recombination repair (HRR).

159 lls are nonhomologous end-joining (NHEJ) and homologous recombination repair (HRR).

160 cells: nonhomologous end joining (NHEJ) and homologous recombination repair (HRR).

161 tions in DNA damage repair genes involved in homologous recombination repair (HRR).

162 harbouring alterations in genes involved in homologous recombination repair (HRR).

163 air genes involved directly or indirectly in homologous recombination repair (HRR).

164 PaC) harboring genetic alterations impairing homologous recombination repair (HRR).

165 ons in DNA damage response genes involved in homologous recombination repair (HRR).

166 in genes involved directly or indirectly in homologous recombination repair (HRR).

167 ermore, reduced OFD1 impaired DSB repair via homologous recombination repair (HRR).

168 L cells, and its loss or inhibition disrupts homologous recombination repair (HRR).

169 hat is dependent on Exo1- and Shu1-dependent homologous recombination repair (HRR).

170 epair pathways-nonhomologous end-joining and homologous recombination repair (HRR).

171 thways: single-strand break (SSB) repair and homologous recombination repair (HRR).

172 cant pathway that is disabled as a result is homologous recombination repair (HRR).

173 an, or prostate cancer that have compromised homologous recombination repair (i.e., BRCA(-/-)).

174 SP39-associated spliceosome complex controls homologous recombination repair in a PAR-independent man

175 RecA protein mediates homologous recombination repair in bacteria through asse

176 tablishes a previously unidentified role for homologous recombination repair in correct neuronal deve

177 idelity repair of DSBs by not only promoting homologous recombination repair in G2/M phase but also f

178 enhanced both non-homologous end joining and homologous recombination repair in human cells, reduced

179 s (such as with etoposide), up-regulation of homologous recombination repair in response to p53 disru

180 ysine 9 dimethylation and enabled error-free homologous recombination repair in the germline of the F

181 s to repair DNA double-strand breaks through homologous recombination repair, increasing the involvem

182 suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribu

183 Homologous recombination repair is likely to be intact a

184 BRCA1, a key player of homologous recombination repair, is also involved in sta

185 onical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA

186 Owing to their function in homologous recombination repair, much research has focus

187 istant prostate cancer (mCRPC) unselected by homologous recombination repair mutation (HRRm) status,

188 BRCA2 is necessary for homologous recombination repair of DNA and the preventio

189 t the absence of BRCA2 substantially reduced homologous recombination repair of DNA breaks, whereas t

190 h the RAD51 protein complex is essential for homologous recombination repair of DNA damage and mainta

191 s and platinum agents owing to deficiency in homologous recombination repair of DNA damage.

192 defects but has no effect on BRCA2-dependent homologous recombination repair of DNA damage.

193 and Nse2 function together with Rhp51 in the homologous recombination repair of DNA double strand bre

194 he Archaea away from the eukaryotic model of homologous recombination repair of DNA double-strand bre

195 (BRCA2), the latter of which is involved in homologous recombination repair of DNA double-strand bre

196 ced radiation-induced cell death and reduced homologous recombination repair of DNA double-strand bre

197 2, and Rad54, plays an important role in the homologous recombination repair of double strand breaks.

198 ing the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks

199 oreover, we find that SETD2 is necessary for homologous recombination repair of DSBs by promoting the

200 ramework to understand how cells orchestrate homologous recombination repair of replication-associate

201 -way junctions are structures present during homologous recombination, repair of double stranded DNA

202 ed for the SOS response and are defective in homologous recombination, repair of UV damaged DNA, doub

203 who had alterations in genes with a role in homologous recombination repair, olaparib was associated

204 r sensitivity to nucleotide excision repair, homologous recombination repair, or postreplication repa

205 ts in two BRCA1-mediated DDR events: (i) the homologous recombination repair pathway and (ii) the arr

206 g PPP2R2A thereby impaired the high-fidelity homologous recombination repair pathway and sensitized c

207 necessary host polymerases, proteins of the homologous recombination repair pathway may be considere

208 e cancer have genomic alterations within the homologous recombination repair pathway with poly (ADP-r

209 w DNA repair, especially the RAD51-dependent homologous recombination repair pathway, is executed in

210 rand transferase RAD51 is a component of the homologous recombination repair pathway.

211 revisiae, mitotic cells preferentially use a homologous recombination repair pathway.

212 RCA2 mutations or those without a functional homologous recombination repair pathway.

213 ing and therefore directly competes with the homologous recombination repair pathway.

214 rocessing of DNA double-strand breaks in the homologous recombination repair pathway.

215 -excision repair and the double-strand break/homologous recombination repair pathways.

216 diesterases 1 and 2, nucleotide excision and homologous recombination repair pathways.

217 on synthesis (TLS), Fanconi anemia (FA), and homologous recombination repair pathways.

218 f the recA/RAD51 family may also function in homologous recombination-repair pathways.

219 e circulating tumor DNA mutational status in homologous recombination repair, PI3K alteration pathway

220 RS-1 seems to function in vivo to stimulate homologous recombination repair proficiency.

221 T also induces a distinct set of foci of the homologous recombination repair protein Rad51 that are c

222 that B02, a small-molecule inhibitor of DNA homologous recombination repair protein RAD51, significa

223 gle-stranded DNA binding protein RPA and the homologous recombination repair protein Rad52.

224 n maintaining RAD51 stability and protecting homologous-recombination repair sites by mitigating PARP

225 A2 prevents PARPi-induced PARP1 retention at homologous-recombination repair sites.

226 gnificant reduction in MRN/ATM signaling and homologous recombination repair, suggesting that Thr622

227 How this long-tract homologous recombination repair synthesis responds to co

228 Although components of the homologous recombination repair system are also involved

229 ntenance at stalled replication forks by the homologous recombination repair system in humans.

230 on yeast homologue Swi5-Sfr1 is critical for homologous recombination repair, the budding yeast count

231 epair components have been implicated in DNA homologous recombination repair, the exact function of h

232 oteins might function in a common pathway in homologous recombination repair to ensure accurate nucle

233 ionally, POH1 acts independently of 53BP1 in homologous recombination repair to promote RAD51 loading

234 reactive oxygen species as well as impaired homologous recombination repair underlie this DNA damage

235 RAD51 foci at 4 h after IR, as a measure for homologous recombination repair, was significantly reduc

236 Consistent with the involvement of homologous recombination repair, we observed extensive s