ライフサイエンスコーパス: homology region

1 s 114 to 176, directly centered on the major homology region.

2 ith PGC-1alpha via its activation function-2 homology region.

3 mouse and the corresponding human 11p14-p15 homology region.

4 tivated upon deletion of the entire calponin-homology region.

5 mosome 19 and the human chromosome 10q23-q26 homology region.

6 f the molecule located just after the yotiao homology region.

7 in and the C-terminal germinal center kinase homology region.

8 stinct domain lying adjacent to the TSC2 GAP homology region.

9 eside 18 cM proximal to the ACE locus in the homology region.

10 in or in the C-terminal section of the major homology region.

11 e to identify transcripts containing the tau homology region.

12 c protein synthesis initiation factor 2alpha homology region.

13 for SV with breakpoints located in sequence homology regions.

14 increase in vivo with truncation of the gRNA homology regions.

15 they appear outside previously noted kinase homology regions.

16 the C-terminal domains of the NF-kappaB Rel homology regions.

17 ished by their PER, AHR, ARNT, and SIM (PAS) homology regions.

18 ins another short conserved sequence, the En homology region 1 (eh1)/GEH motif, that is likely to pla

19 ology 3 (SH3) domain and a G protein-binding homology region 1 (HR1) domain.

20 ced apoptosis are clustered within the Bcl-2-homology regions 1 and 2 (BH1 and BH2 regions).

21 are Bcl-2 family members which contain Bcl-2 homology regions 1, 2, and 3 (BH1, BH2, and BH3), which

22 Each contains a Dock homology region-1 (DHR-1) domain that is required to loc

23 SspH1 and the SspH1-binding activity of the homology region 1b (HR1b) domain from PKN1.

24 bility in a hinge region within the cytokine homology region 2 (CHR2) that is connected to rigid memb

25 use either the Dbl homology (DH) or the DOCK homology region 2 (DHR-2) catalytic domain.

26 rk oncogene product consist primarily of Src homology region 2 (SH2) and 3 (SH3) domains.

27 gene product are composed exclusively of Src homology region 2 (SH2) and SH3 domains.

28 expressed on cancer cells, activates the Src homology region 2 (SH2) domain -phosphatases SHP-1 and S

29 Here, we report that Src homology region 2 (SH2) domain-containing phosphatase 1

30 we show that binding is mediated via the Src homology region 2 (SH2)-containing inositol phosphatase

31 Loss of nerve homology region 2 abrogated the development of leukemia,

32 embrane region, myristylation sites, and Src homology region 2 and 3 domains.

33 with similarity to mouse Whdc1 (WAS protein homology region 2 domain containing 1) and human JMY pro

34 n of inhibitory effectors (such as CD22, Src homology region 2 domain containing phosphatase 1, and S

35 A mutation within the Src homology region 2 domain of mutant p85 (Deltap85) preven

36 The role of tyrosine phosphatase Src homology region 2 domain-containing phosphatase (SHP)-1

37 lar importance, the key immune regulator src homology region 2 domain-containing phosphatase 1 (SHP-1

38 t study, we investigated the role of the Src homology region 2 domain-containing phosphatase 1 (SHP-1

39 Phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1

40 Src homology region 2 domain-containing phosphatase 1 (SHP-1

41 ify the cytoplasmic tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1

42 The tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1

43 a selective increase in the activity of Src homology region 2 domain-containing phosphatase 1 (SHP-1

44 the tyrosine kinase Lyn, the phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP1)

45 d that approximately 10- to 16-fold more Src homology region 2 domain-containing phosphatase 1 (SHP1)

46 Deficiency in Src homology region 2 domain-containing phosphatase 1/protei

47 activator of transcription 3 and induced Src homology region 2 domain-containing phosphatase 2 (SHP2)

48 ietic protein tyrosine phosphatase (PTP) Src homology region 2 domain-containing phosphatase-1 (Shp-1

49 tein kinase A-mediated activation of the Src homology region 2 domain-containing phosphatase-1 (SHP-1

50 ctivation correlated with recruitment of Src homology region 2 domain-containing phosphatase-1 (SHP-1

51 ophilin (SPL), the tyrosine phosphatase, Src homology region 2 domain-containing phosphatase-1 (SHP-1

52 We found that the abrogation of Src homology region 2 domain-containing phosphatase-1 (SHP-1

53 We show that Src homology region 2 domain-containing phosphatase-1 (SHP-1

54 e revealed that the tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP-1

55 everal tumor suppressor genes, including Src homology region 2 domain-containing phosphatase-1 (SHP-1

56 hibitory tyrosine phosphatases including Src homology region 2 domain-containing phosphatase-1 (Shp1)

57 These results indicate that the Lyn-CD22-Src homology region 2 domain-containing phosphatase-1 inhibi

58 lation of its ITIM motifs and subsequent Src homology region 2 domain-containing phosphatase-1 recrui

59 ibitor, as well as the novel DPC protein Src homology region 2 domain-containing phosphatase-1, was a

60 naling pathways because of activation of Src homology region 2 domain-containing phosphatase-1, which

61 Finally, we found that ATSP could detect Src homology region 2 domain-containing phosphatase-2 and PK

62 Indeed, Src homology region 2 domain-containing phosphatase-2 has a

63 ppresses tyrosine phosphorylation of the Src homology region 2 domain-containing phosphatase-2/protei

64 stimulatory receptor CD28 via activating Src homology region 2 domain-containing phosphatases (SHPs).

65 encoding a dominant negative isoform of Src homology region 2 domain-containing tyrosine phosphatase

66 We fused the inter-Src homology region 2 of the regulatory p85alpha subunit of

67 activity originating from its DHR2 (for DOCK homology region 2) domain.

68 The dimerization domain (nervy homology region 2) of ETO is responsible for the reduced

69 within the protein tyrosine phosphatase Src homology region 2, phosphatase 2 (SHP2) are responsible

70 ent of the protein tyrosine phosphatase, Src homology region 2-containing protein tyrosine phosphatas

71 ubiquitin-like modification, inactivates Src homology region 2-containing protein tyrosine phosphatas

72 infection also induced the activation of Src homology region 2-containing protein tyrosine phosphatas

73 Recently, the tyrosine phosphatase Src homology region 2-containing protein tyrosine phosphatas

74 Src homology region 2-containing protein tyrosine phosphatas

75 type protein tyrosine phosphatase SHP-2 (src homology region 2-domain phosphatase-2), cause NS, accou

76 e ETO transcription factor through the nervy homology region 2.

77 nine amino acid region similar to the Bcl-2 homology region 3 (BH3) domain but does not contain a BH

78 also contains a region similar to the Bcl-2 homology region 3 (BH3) domain that allows Mule to speci

79 ach with a hydrophobic pocket in which Bcl-2 homology region 3 (BH3) helices bind.

80 ntaining a conserved region designated Bcl-2 homology region 3 (BH3) were sufficient for specific bin

81 trate that oligomerization of the ETO2 nervy homology region 3 (NHR3) enhances its affinity for pepti

82 The src homology region 3 (SH3) domain-bearing protein Bem1p and

83 of Nef with this motif is similar to the Src homology region 3 (SH3) ligand domain found in many cell

84 g studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicat

85 s, in which the BH3-domain-containing (Bcl-2 homology region 3) protein EGL-1 binds the cell-death in

86 three unique domains including a myosin tail homology region 4 (MyTH4), a talin-like domain, and a ca

87 The ETO2 nervy homology region 4 (NHR4) domain interacts with multiple

88 o zinc fingers contained in C-terminal Nervy homology region 4 (NHR4) of ETO.

89 n internal region overlapping with the G box-homology region (a putative G protein-interacting site).

90 It has a DD homology region, a box-B-like ring finger, and a zinc fi

91 sed of three domains: an amino-terminal SacI homology region, a central inositol 5'-phosphatase homol

92 inal domain of N-WASP containing a verprolin-homology region, a cofilin-homology sequence, and an aci

93 mology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal

94 s of four highly conserved sites in this FHA homology region abolishes the KI domain's interaction wi

95 Deletion of either alpha-homology region (amino acids 29-55 or 226-267) from the

96 step involved in RNA release, while the Rif homology region, amino acids 455 to 521, interacts with

97 ORF1 encoded a retrovirus-like major homology region and a Cys/His box motif, also present in

98 l assembly into particles; both the CA major homology region and the adjacent C-terminal CA sequences

99 and its donor template share a 108-base-pair homology region and the donor carries different densitie

100 of TSP-1 has been mapped to the procollagen homology region and the type 1 repeats (TSR) using synth

101 erin beta3 contains two putative Ran-binding homology regions and bound to Ran-GTP in a solution-bind

102 of targeting DNA encompassing both flanking homology regions and the marker into hDNA.

103 gy region, a central inositol 5'-phosphatase homology region, and a carboxyl-terminal proline-rich re

104 n SH3 domain, a Cdc42-binding region, a Ralt homology region, and a proline-rich region.

105 cell cycle-dependent element/cell cycle gene homology region, and p53-binding sites.

106 tails of its interaction with the photolyase homology region are not yet fully understood and differ

107 ticular, hydrophobic residues near the major homology region are partially buried in HTLV-I CA, which

108 ecisely when conserved residues in the major homology region are required during assembly, these stud

109 Highly conserved residues in the major homology region are required for assembly of retroviruse

110 The 149 amino acids derived from the KLC homology region are required for colocalization of the t

111 proteins, defined by the presence of 'formin homology' regions, are important for a number of actin-d

112 pairs into delta-rec, primers derived from a homology region between human and mouse led to the detec

113 The three functionally important Bcl-2 homology regions (BH1, BH2 and BH3) are in close spatial

114 nding on RetGC1 requires not only the kinase homology region but also directly involves the dimerizat

115 ed the 55-amino acid carboxyl-terminal TALIN homology region but not the leucine zipper domain.

116 irst indication that regions outside the Rel Homology Region can participate in the control of bindin

117 cts the complex to promoter cell cycle genes homology region (CHR) elements.

118 The cell cycle genes homology region (CHR) has been identified as a DNA eleme

119 that IL-6/IL-Ralpha and the cytokine-binding homology region (CHR) of gp130 (D2D3) form a stable trim

120 ent elements (CDEs), and one cell cycle gene homology region (CHR), typically found in G2-M-expressed

121 amino acids 1-450, including the coiled-coil homology region) completely abolished the formation of o

122 in subfamily a, 8E) and WHDC1L1 (WAS protein homology region containing 1-like 1) and have further ch

123 regulatory subunit contains three conserved homology regions (CR1, CR2, and CR3).

124 Spo7 contains three conserved homology regions (CR1-3) that are important for the inte

125 at contains FADD/Mort1 death effector domain homology regions, designated FLAME-1.

126 In particular, the major homology region does not contribute to defining particle

127 d PI(3,4,5)P(3), was fused to the photolyase homology region domain of CRY2, and the CRY2-binding dom

128 We previously showed how the PHR (photolyase homology region) domain of CRY1 interacts with distinct

129 d linear donors with extremely short (50 bp) homology regions drive transgene integration into 5-10%

130 an ancillary N-terminal domain, the Extended Homology Region (EHR), endow maf proteins with unique DN

131 inding is directed via CHR (cell cycle genes homology region) elements.

132 ement pathway in which incorporation of both homology regions from a single strand of targeting DNA i

133 more complete understanding of how the major homology region functions.

134 ccharomyces cerevisiae EF-3 (spanning the S5 homology region) has been cloned, expressed, and purifie

135 EpsC is periplasmic, containing a so-called homology region (HR) domain and a PDZ domain.

136 with gp130 domains 2 and 3 (cytokine-binding homology region), identified a variant, VI120EE, that wa

137 p interacts directly with Hsp82p via its p23 homology region in a nucleotide-dependent manner.

138 determined the solution structure of the RBD homology region in ALY by nuclear magnetic resonance met

139 has been assembled that extends from the XY homology region in Xq21.3 to proximal Xq24, approximatel

140 irected mutagenesis of the BH1, BH2, and BH3 homology regions in Bax to determine the ability of wild

141 ealing, cloned junctions map to four of five homology regions in subtelomeric DNA.

142 le Forkhead-binding elements within two high homology regions in the Itgb3 promoter.

143 We show that the photolyase-homology region interacts with the C-terminal domain, in

144 Dephosphorylation of the NFAT homology region is critical for NFAT nuclear translocati

145 The homology region is likely to reside on human chromosome

146 f 6 amino acids at the C terminus of the Rel-homology region is necessary for nuclear localization.

147 This homology region is preceded by an N-terminal extension a

148 however, one region of Gag, termed the major homology region, is conserved among all retroviruses and

149 copies of highly conserved protein kinase C homology regions known as the C2A and C2B domains, acts

150 of the eukaryotic initiation factor 2-alpha homology region, mapping to the 34 aa within the sixth P

151 We propose that the C-terminal Mig6 homology region (MHR) (residues 802-990) participates in

152 eromultimers using a region containing major homology region (MHR) and zinc knuckle (CCHC) motifs, se

153 ransposons but which is similar to the major homology region (MHR) described for retrovirus CA.

154 different interface that includes the major homology region (MHR) has been suggested as the function

155 are divergent except in the 20-residue major homology region (MHR) in the CTD.

156 The major homology region (MHR) is a highly conserved motif that i

157 The major homology region (MHR) is a highly conserved sequence in

158 s with amino acid substitutions in the major homology region (MHR) of CA.

159 ughly interrogate the conserved HTLV-1 major homology region (MHR) of the CA(CTD) to determine whethe

160 e +TIP-binding motif within the capsid major homology region (MHR) that binds SxIP motifs found in se

161 The most conserved region of CA, the major homology region (MHR), has been implicated in both immat

162 arbors a conserved sequence motif, the major homology region (MHR), in the otherwise highly variable

163 A, approximately 20 amino acids of the major homology region (MHR), lies within the carboxy-terminal

164 ow that CA sequences N terminal to the major homology region (MHR), which form a distinct domain, are

165 s a stretch of 20 residues, called the major homology region (MHR), which is conserved across retrovi

166 ghly conserved structural element, the major homology region (MHR), within the carboxyterminal domain

167 highly conserved subdomain termed the major homology region (MHR).

168 mutation at CA residue 157 within the major homology region (MHR).

169 highly variable Gag protein called the major homology region (MHR).

170 The major homology region (MHR, aa 285-304), a highly conserved se

171 helical 'ribs' spanning the N-terminal TRPM homology regions (MHRs), thus holding four subunits in a

172 i) Regions containing zinc knuckle and major homology region motifs, characteristic of retroviral Gag

173 terestingly, capsid proteins of mature major homology region mutant particles could be cysteine cross

174 In at least one major homology region mutant, Ty3 protein concentrated in foci

175 ion of the fusion protein includes the nervy homology region (NHR) 3 domain, which shares homology wi

176 volutionarily conserved domains termed nervy homology regions (NHR) 1-4.

177 protein, which contains four conserved nervy homology regions, NHR1-4.

178 ll-length N protein containing the Toll-IL-1 homology region, nucleotide binding site, and LRR, is mo

179 The N gene, a member of the Toll-IL-1 homology region-nucleotide binding site-leucine-rich rep

180 o N gene, a member of the Toll-interleukin 1 homology region/nucleotide binding site/leucine-rich rep

181 that the conserved BH3, but not BH1 or BH2, homology region of Bax is necessary for its interaction

182 kyrin domain for its binding site on the Rel-homology region of CSL, enabling docking of the ankyrin

183 he presence of a 93-bp exon in the PI kinase homology region of DNA-PKcs that was not present in the

184 ried out by regions within the conserved Rel-homology region of Dorsal.

185 nteraction is dependent on the C-terminal EB homology region of EB1 and partially dependent on an SxL

186 nst 23 amino acids, representing the highest homology region of eubacterial transducers.

187 in a 10-codon segment overlapping the major homology region of Fv1; this segment is known to be invo

188 fusion protein that contains only the TALIN homology region of HIP1 fused to PDGFbetaR is incapable

189 possible three-dimensional structure for the homology region of IF3chl has been modeled using the X-r

190 that required the predicted integrin-binding homology region of ImaA.

191 maturity-onset diabetes of the young (MODY2) homology region of mouse chromosome 11 (logarithm of odd

192 ith PKR did not require the C-terminal DNA-J homology region of P58IPK but was dependent on the prese

193 1, whereas 149 residues derived from the KLC homology region of PAT1 are important for binding to Us1

194 he three flexibly linked segments of the rel homology region of Rel/NF-kappaB proteins (the nuclear l

195 omoters by directly interacting with the Rel homology region of RelA and represses proinflammatory ge

196 neither the p53-binding region nor the Bcl-2 homology region of T antigen was sufficient to prevent c

197 Mutants with mutations in the J-domain homology region of TAg are defective for altering p130 a

198 We further demonstrate that the J-domain homology region of TAg confers a growth advantage to wil

199 hybrid assay that the entire Tetrahymena p80 homology region of TEP1 is required for its interaction

200 Expression of a CP2 mutant lacking the Elf-1-homology region of the DNA-binding domain inhibited IL-4

201 the conserved Enhancer of Polycomb A (EPcA) homology region of the Epl1 component and the N-terminal

202 hat the SRs primarily contact the pleckstrin homology region of the GEF1 domain, reducing GEF1 bindin

203 folded state HJ rapidly migrates over entire homology region of the HJ in one hop.

204 nized in a region corresponding to the major homology region of the human immunodeficiency virus, a r

205 ne-rich repeats and intracellular Toll/IL-1R homology region of TLR5 as well as the adaptor protein M

206 his activation is mediated solely by the GCK homology region of TNIK.

207 nciples in order to form crystals of the Rel homology region of transcription factor NF-kappaB in com

208 The crystal structure of the homology regions of Idas in complex with Geminin showed

209 The three complete human LDL receptor homology regions of the LDL receptor-related protein (sL

210 34 residue fragment spanning the KH and QUA2 homology regions of the Quaking protein from Xenopus lae

211 DNA-binding domain (DBD) and C-terminal IRF homology regions of vIRF4.

212 native C-terminal CA cysteines or that major homology regions on neighbor capsid proteins are in clos

213 In addition to SP100 homology regions, one LYSP100 cDNA isoform contains a br

214 o acid 216, located between the PER-ARNT-SIM homology region (PAS) A and PAS B repeats.

215 These receptors consist of a photolyase homology region (PHR) carrying the oxidized flavin adeni

216 found that the second half of the photolyase homology region (PHR) of CRY is important for repression

217 a small domain extending from the photolyase homology region (PHR) of CRY1 regulates the specificity

218 g alpha-helical domain within the photolyase homology region (PHR) of CRY1, designated as CRY1-PHR(31

219 ly conserved, 22-amino acid segment, the PHO homology region (PHR), which is located within its centr

220 eceptors bind oxidized FAD in the photolyase homology region (PHR).

221 important, the recognition of eukaryote-wide homology regions provides extensive and detailed informa

222 in the N-terminal domain 1 of the Dorsal Rel homology region rather than at the Cactus binding site.

223 ll cycle-Dependent Elements-Cell cycle genes Homology Region) region of cyclin A promoter as a target

224 cates to the nucleus and binds to cell cycle homology region repressor elements within the cyclin A p

225 A forkhead-associated (FHA) homology region resides in this minimal KI domain.

226 dues within an 86-residue segment of the Rel homology region (RHR) of c-Rel are responsible for the c

227 ined the crystal structure of the entire Rel homology region (RHR) of human NFAT1 (NFATc2) bound to D

228 tween v-Rel and c-Rel located within the Rel homology region (RHR) of the family that might confer fu

229 amics of the homodimer (p50)2 of the p50 Rel homology region (RHR) of the transcription factor NF-kap

230 ng bioinformatics tools, we identified a Rel homology region (RHR) within CSL that was used as a guid

231 c-Rel, and RelB, all have amino-terminal Rel-homology regions (RHRs).

232 sms (SNPs)) were selected from the segmental homology regions (SHRs) of 13 QTLs.

233 (PNA) within or adjacent to the probe-target homology region significantly enhances the yield of hybr

234 main upstream of the Dbl homology-pleckstrin homology region similar to mammalian RhoGEFs with RGS do

235 no acids 1-169), containing the immunophilin homology region, similarly reduced PDE4A5 activity and i

236 on gp130, now known as the cytokine binding homology region (site II contact surface), which fortuit

237 and glycosylation sites in each LDL receptor homology region (sLRP), all were shown to be competent f

238 lts show that binding-competent LDL receptor homology regions (sLRPs) can be produced in high yield i

239 All TRAF proteins share a C-terminal homology region termed the TRAF domain that is capable o

240 ce time was obtained for the design with the homology region that consists of only GC pairs.

241 ontains one or two copies of a 26 amino acid homology region that has been recently termed the WWP or

242 xy-terminal extensions beyond the photolyase-homology region that have been shown to mediate phototra

243 Within a 135-bp core homology region, the human HS12 enhancers are approximat

244 Alignment of IRS-1 and IRS-2 reveals two homology regions: the IH1(PH) contains a pleckstrin homo

245 cassettes and, in one approach, a dystrophin homology region to fully correct the mutation.

246 RT-PCR) using primers specific to peroxidase homology regions was used to survey for novel peroxidase

247 that the two Ig-like subdomains of each Rel-homology region, which are connected by a flexible linke

248 nase binds to a site overlapping a verprolin homology region, which has been shown to interact with a

249 ins; the third is similar to the discs-large homology region, which was first found in a Drosophila D