ライフサイエンスコーパス: homomeric

1 active metabolite hydroxybupropion on mouse homomeric 5-HT(3A) and heteromeric 5-HT(3AB) receptors e

2 thadone inhibited currents mediated by human homomeric 5-HT(3A) receptors (IC(50) = 14.1 +/- 2.5 micr

3 (50)s for bupropion and hydroxybupropion for homomeric 5-HT(3A)Rs were 10- and 5-fold lower, respecti

4 inhibits heteromeric 5-HT(3AB)Rs as well as homomeric 5-HT(3A)Rs.

5 display allosteric agonist activity on human homomeric 5-HT3ARs (64 +/- 7% and 80 +/- 4% of the maxim

6 Homomeric 5-hydroxytryptamine (5-HT)(3A) and heteromeric

7 form multiple all-atom MD simulations of the homomeric 5-hydroxytryptamine 3A (5-HT(3A)) serotonin re

8 rize genotype-to-phenotype relationships for homomeric ACCase variants identified among 855 accession

9 duplicated nuclear gene (ACC2) that targets homomeric acetyl-coenzyme A carboxylase (ACCase) to plas

10 ACC2, a duplicated nuclear gene that targets homomeric acetyl-coenzyme A carboxylase to plastids, whe

11 In this work, homomeric AChBPs from Lymnaea and Aplysia snails were us

12 use calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that ca

13 lso reconstituted the Caenorhabditis elegans homomeric ACR-20 receptor in Xenopus oocytes.

14 Unlike subunit interfaces from the homomeric alpha GlyR, subunit interfaces from the hetero

15 The glycine receptor (GlyR) exists either in homomeric alpha or heteromeric alphabeta forms.

16 eceptor (AChR), the alpha3beta4 AChR and the homomeric alpha1 glycine receptor (GlyR).

17 In single-channel recordings, rat homomeric alpha1 K276E receptors were barely active, eve

18 f Held terminals were composed of dispersed, homomeric alpha1 receptors.

19 characterized the kinetic properties of rat homomeric alpha3 glycine receptors heterologously expres

20 he different existing receptor subtypes, the homomeric alpha7 nAChR has attracted considerable attent

21 We suggest that efficient assembly of the homomeric alpha7 nAChR may thus require mRIC-3 self-asso

22 Recently, we identified the homomeric alpha7 nicotinic acetylcholine receptor (alpha

23 results indicated that the columns contained homomeric alpha7 nicotinic acetylcholine receptors (alph

24 Homomeric alpha7 nicotinic acetylcholine receptors repre

25 The homomeric alpha7 nicotinic receptor (nAChR) is one of th

26 o types of nicotinic receptors (nAChRs) (the homomeric alpha7 receptors and the heteromeric alpha*ss*

27 ology to show that oAbeta(42) activates both homomeric alpha7- and heteromeric alpha7beta2-nAChR subt

28 heir development, adult-born neurons express homomeric alpha7-containing nicotinic acetylcholine rece

29 ain and compared pharmacological profiles of homomeric alpha7-nAChRs and alpha7beta2-nAChRs.

30 ble for concatenated (alpha7)5-nAChRs or for homomeric alpha7-nAChRs constituted from unlinked alpha7

31 Compared with homomeric alpha7-nAChRs from ventral tegmental area neur

32 f heteromeric alpha7beta2-nAChRs, but not of homomeric alpha7-nAChRs, heterologously expressed in Xen

33 ammalian alpha9 subunits can form functional homomeric alpha9 receptors, alpha10 subunits do not gene

34 We report here single-channel studies of a homomeric AMPA receptor (GluA3) activated by the full ag

35 Recently, a crystal structure of a homomeric AMPA receptor revealed that the four identical

36 We show that all HAS isoenzymes form homomeric and also heteromeric complexes with each other

37 modulation of desensitization of recombinant homomeric and heteromeric AMPA and kainate receptors.

38 Last, we show that the homomeric and heteromeric B4GALT1/ST6GAL1 complexes can

39 This mutation renders KCNQ5(dn)-containing homomeric and heteromeric channels nonfunctional.

40 Q1-5 (Kv7.1-7.5) subunits, form a variety of homomeric and heteromeric channels.

41 tion, we demonstrate that ITSN proteins form homomeric and heteromeric complexes with each other reve

42 eral tendency of HAS isoenzymes to form both homomeric and heteromeric complexes with potentially imp

43 ffect the speed of neuroblast migration, the homomeric and heteromeric GLU(K5) receptor antagonists,

44 of experiments using recombinantly expressed homomeric and heteromeric glycine receptor channels, inc

45 was approximately 10- and 7-fold faster for homomeric and heteromeric GlyRs, respectively.

46 nt with binding to an A+A- interface at both homomeric and heteromeric human 5-HT(3) receptors, and e

47 conducting a comprehensive comparison of the homomeric and heteromeric interactions of integrin alpha

48 Here we investigated the homomeric and heteromeric interactions of TbetaRIII with

49 Transmembrane (TM) helices engage in homomeric and heteromeric interactions that play essenti

50 same face of their respective TM helices for homomeric and heteromeric interactions, the interacting

51 unctionality and is maintained via ArPIKfyve homomeric and heteromeric interactions.

52 ich preferential subunit assembly occurs for homomeric and heteromeric kainate-type glutamate recepto

53 ect of Neto1 on the responses of recombinant homomeric and heteromeric KARs to varying concentrations

54 fects of the auxiliary subunit Neto1 on both homomeric and heteromeric KARs.

55 sized and tested on HEK-293 cells expressing homomeric and heteromeric opioid receptors, and in the m

56 tructural requirements for the activation of homomeric and heteromeric Orco channel complexes.

57 In recent decades, many thousands of homomeric and heteromeric protein complex structures hav

58 The same pattern of changes was seen at homomeric and heteromeric receptors containing cysteine

59 e different subunits (GluK1-5) that can form homomeric and heteromeric receptors with different funct

60 nded to 5-HT following DTT treatment in both homomeric and heteromeric receptors, indicating receptor

61 ifference in PI(4,5)P(2) sensitivity between homomeric and heteromeric TRPC channels.

62 Our mass spectrometric analysis of homomeric and heteromeric TRPM7 and TRPM6 channels ident

63 7- to 10-fold) in all mutant receptors, both homomeric and heteromeric.

64 hat G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well estab

65 r ASIC-1a subunit (ASIC1a(-/-)) suggest that homomeric ASIC-1as are mediating these currents in MNTB

66 A significant characteristic of these homomeric ASIC-1as is their permeability to Ca(2+) Activ

67 nsitivity to psalmotoxin 1 (PcTx1) and zinc, homomeric ASIC1a and heteromeric ASIC1a/2 channels were

68 apsules are generally identical, and lead to homomeric assemblies of high symmetry.

69 teromers, structural studies have focused on homomeric assemblies.

70 P2 mutant T448K significantly weakened TRPP2 homomeric assembly but had no obvious effect on TRPP2-PK

71 The homomeric assembly of E299V mutant proteins actually res

72 lular loops are also found to be involved in homomeric assembly.

73 es previously, and it has been proposed that homomeric association is important for integrin activati

74 homo-oligomers, suggesting that integrin TM homomeric association is not critical for integrin clust

75 out and outside-in signaling, the role of TM homomeric association remains elusive.

76 es Rho and E1 reveals a general mechanism in homomeric ATPases whereby complex allostery within the r

77 The structure of the homomeric beta(3) GABA(A)R, which is not activated by GA

78 a3gamma2L receptors to binary alphabeta3 and homomeric beta3 receptors.

79 etramer is stable in solution; corresponding homomeric bundles present unfavorable ligand-binding env

80 s suggests that the Cys-312 is essential for homomeric but not heteromeric receptor gating.

81 ory relied on the introduction of unnatural, homomeric, calcium-permeable AMPA receptors, we have use

82 Orai1 is a transmembrane protein that forms homomeric, calcium-selective channels activated by strom

83 tructures, both capable of forming their own homomeric capsules through hydrogen bonding.

84 Homomeric cbv1 or cbv1-beta2 channels were LTB4-resistan

85 subunit exhibit no functional difference in homomeric channel form.

86 y modules (PMs) of the human Kv7.2 and Kv7.3 homomeric channels and of Kv7.2/3 heteromeric channels b

87 TRP proteins mostly assemble to homomeric channels but can also heteromerize, preferenti

88 ow that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subuni

89 TRPC1 homomeric channels had different average diameter and pr

90 Panx1 and Panx2 formed active homomeric channels in Xenopus oocytes and in vitro vesic

91 urrents in the CNS, and activation of ASIC1a homomeric channels induces neuronal death after local ac

92 In the absence of an ORx, Orco forms homomeric channels that can be activated by a synthetic

93 It forms large-conductance homomeric channels that desensitize only modestly in res

94 KCNQ3 homomeric channels yield very small macroscopic currents

95 pulations consisting of both heteromeric and homomeric channels, additionally revealing the quantitat

96 Although Girk1 is unable to form functional homomeric channels, its presence in cardiac and neuronal

97 Whereas all the subunits can assemble into homomeric channels, the ability of the subunits to assem

98 voltage dependence of either KCNQ4 or KCNQ5 homomeric channels.

99 ations had striking but divergent effects on homomeric channels.

100 binant TRPC1 subunits do not form functional homomeric channels.

101 urrents with properties distinct from ASIC1a homomeric channels.

102 iffers from that of heterologously expressed homomeric channels.

103 ties intermediate between those observed for homomeric channels.

104 r acidification and closure of Cx43 and Cx40 homomeric channels.

105 was found to be intermediate to those of the homomeric channels.

106 e constants (i.e., k(op) and k(cl)) of GluA4 homomeric channels.

107 cal properties distinct from those seen with homomeric channels.

108 e absence of an inhibitory effect of GABA on homomeric channels.

109 TRPP2 functions as a cation channel in its homomeric complex and in the TRPP2/polycystin-1 receptor

110 Of all the homomeric complexes HAS1 had the lowest and HAS3 the hig

111 that alpha-synuclein multimerizes into large homomeric complexes upon membrane binding.

112 association between subunit flexibility and homomeric complexes with cyclic and asymmetric quaternar

113 etry and relative positions of interfaces of homomeric complexes with different oligomeric states.

114 Low pH inhibited the PC2 currents in PC2 homomeric complexes, but failed to affect PC2 currents i

115 other copies of themselves and assemble into homomeric complexes, the overwhelming majority of which

116 suggesting a potential to form higher-order homomeric complexes.

117 have distinct functional properties from the homomeric complexes.

118 t, suggesting that SALMs 4 and 5 mainly form homomeric complexes.

119 wed that all five SALMs form heteromeric and homomeric complexes.

120 models to GluK2/GluK4 heteromeric and GluK2 homomeric concentration-response data, we have determine

121 of vertebrate GPCRs are also thought to form homomeric contacts at TM1 and TM4.

122 fficking that can differ markedly from their homomeric counterparts.

123 erties of the heteromers compared with their homomeric counterparts.

124 Both the homomeric CpomOrco and heteromeric CpomOrco + OR complex

125 nisms have been postulated to underlie KCNQ3 homomeric current amplitudes, which are small compared w

126 12K, and I312R) dramatically decreased KCNQ3 homomeric currents as well as heteromeric KCNQ2/3 curren

127 Although homomeric Cxs forms have been largely described function

128 SKF 83959 (an agonist that does not activate homomeric D1 receptors or alter cAMP levels in other sys

129 ivity at mu-delta heteromers compared to the homomeric deltaOR or muOR and low beta-arrestin2 recruit

130 of a lysine-reactive cross-linker, parallel homomeric dimers are stabilized through K328-K328 and K3

131 Rds forms a mixture of disulfide-linked homomeric dimers, octamers, and higher-order oligomers,

132 NA-binding assays validate the importance of homomeric DnaC interactions, while pull-down experiments

133 on of heteromeric ISA not compensated for by homomeric enzyme affects granule initiation or growth, w

134 ISA1 homomeric enzyme complexes assembled in both double muta

135 Mutants lacking ISA2 still possess the ISA1 homomeric enzyme.

136 with one form of ISA1/ISA2 heteromer but no homomeric enzyme.

137 nase function and signal transduction at the homomeric EpoR.

138 result of failing signal transduction at the homomeric erythropoietin receptor (EpoR) and at the hete

139 und that the sensitivity is specific for the homomeric form of the channel and is completely abolishe

140 Cross-linking and native gels of purified homomeric full-length and a C-terminal Panx2 truncation

141 A recent modeling study of the beta3 homomeric GABA(A) receptor postulated a high-affinity pr

142 hosphorothionate binding to the His(8)-beta3 homomeric GABA(A) receptors in a concentration-dependent

143 sing high-density, recombinant, His(8)-beta3 homomeric GABA(A) receptors.

144 This tyrosine is conserved in homomeric GABA(A)Rs and in the Erwinia chrysanthemi liga

145 this, we studied the effects of DPA on human homomeric GABArho1, alpha7 nicotinic, and 5-HT3A seroton

146 bunits in vivo, we demonstrate that although homomeric GLR-1 AMPARs can diffuse to and accumulate at

147 ve examined the single-channel properties of homomeric GluA1 AMPARs in combination with the TARPs, ga

148 sence of gamma-2 shows that PhTX-74 inhibits homomeric GluA1 and GluA3 receptors nonselectively, with

149 mulating after cocaine incubation are mainly homomeric GluA1 receptors and that their accumulation is

150 ay drive formation and synaptic insertion of homomeric GluA1 receptors in the absence of detectable c

151 Homomeric GluA1 receptors may also exist.

152 ng of the NAMs into structural models of the homomeric GluA2 receptor and optimize side chain conform

153 GluA2/3 receptors follows the same rules as homomeric GluA2 receptors.

154 Single-channel recordings of reconstituted homomeric GluA2(flop) receptors recapitulate key electro

155 d potent UV-driven photoinactivation of both homomeric (GluA2) and heteromeric (GluA2:GluA1) AMPA rec

156 l as the whole-cell current amplitude of the homomeric GluA2Q AMPA receptor channels.

157 nit modulates the channel properties in both homomeric (GluA2Q) and complex (GluA2Q/2R and GluA1/2R)

158 lude that the impaired surface expression of homomeric GluA3 receptors is caused by nonproductive ass

159 Based on the recent crystal structure of a homomeric GluClalphaR, we introduced mutations at the in

160 creased to the same degree by Neto1 for both homomeric GluK2 and heteromeric GluK2/GluK5 receptors.

161 Most work thus far has been performed on homomeric GluK2 but, in vivo, kainate receptors are like

162 By contrast, homomeric GluK2 channels exhibited a monophasic steady s

163 We found that co-expression of Neto1 with homomeric GluK2 receptors had a small effect on sensitiv

164 valence and magnitude of Neto2 modulation of homomeric GluK2 receptors.

165 uK2/GluK4 and GluK2/GluK5 receptors, but not homomeric GluK2 receptors.

166 induced a preference in binding affinity for homomeric GluK3 over GluK1 (Ki = 0.87 and 4.8 muM, respe

167 a competitive antagonist, and high affinity homomeric glycine activated glutamate receptors.

168 and reveals a physio-molecular signature of homomeric glycine receptor channels, which provides unpr

169 reconstituting beta+/alpha- interfaces in a homomeric GlyR (alphaChb+a- GlyR), we were able to funct

170 ies with documented modulatory activities at homomeric GlyR-alpha1 and -alpha3 and built a database n

171 by disruption in the function of presynaptic homomeric GlyRs (rather than postsynaptic heteromeric Gl

172 e maximum single-channel open probability of homomeric GlyRs (to 0.16; cf. 0.99 for wild type) but re

173 han postsynaptic heteromeric GlyRs), because homomeric GlyRs are more sensitive to loss-of-function m

174 at the receptors responsible are presynaptic homomeric GlyRs, rather than postsynaptic heteromeric Gl

175 </= 30 muM), which selectively blocked alpha homomeric GlyRs.

176 ting that they are mediated by extrasynaptic homomeric GlyRs.

177 lso explaining the selectivity of PcTX-1 for homomeric hASIC-1a.

178 l rod, cone, and bipolar cells appear to use homomeric HCN channels.

179 ric HCN channels, which activate faster than homomeric HCN2 or homomeric HCN4 channels, and display p

180 which activate faster than homomeric HCN2 or homomeric HCN4 channels, and display properties similar

181 Cx26 KID mutants that do not show functional homomeric hemichannels.

182 acological properties distinct from those of homomeric hERG 1a channels.

183 h resulted in a profound inhibition of both homomeric hP2X3 and heteromeric hP2X2/3 receptors, an ef

184 fy the sequence of these proteins toward the homomeric human alpha7 nAChR.

185 molecules were docked to model structures of homomeric human ASIC-1 to generate potential interaction

186 )(+)alpha(1)(-) heteromeric interface in the homomeric human beta(3) GABA(A)R that enables GABA-media

187 this idea by testing propofol modulation of homomeric human glycine receptors (GlyRs) and nematode g

188 pared the effects of ML213 and ICA-069673 on homomeric human Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5

189 Our results show that TM homomeric interaction does not occur before or after sol

190 inely tuned heterodimeric interaction, while homomeric interaction is less specific.

191 escence complementation assays, HSFA4A shows homomeric interaction, which is reduced by alanine repla

192 By contrast, residues responsible for homomeric interactions are dispersed over a wider surfac

193 cence complementation (BiFC) assays revealed homomeric interactions for GnT1IP-L in the ER, and heter

194 A at chromosomal sites, probably by blocking homomeric interactions of PfRad51 proteins.

195 bacterial proteins to self-assemble and form homomeric interactions, even within the context of a het

196 Isolated motifs demonstrate hetero- and homomeric interactions, suggesting a propensity for unif

197 Most MORF proteins also undergo homomeric interactions.

198 orts that GluK4-GluK5 cannot form functional homomeric ion channels and require obligate coassembly w

199 meric arrangements of the PLH bundles within homomeric ion channels by building models using generic

200 PA and kainate receptors can form functional homomeric ion channels, the KA1 and KA2 subunits are obl

201 gnaling, whereas JH2 alphaC mutations reduce homomeric (JAK2-JAK2) erythropoietin signaling and almos

202 , K(v)7.2/3, and K(v)7.5/3 channels, whereas homomeric K(v)1.1, K(v)7.1, and K(v)7.2 channels were un

203 -fold higher apparent affinity compared with homomeric K(v)1.2 channels.

204 rrolidine-2-carboxylic acid (1b), for cloned homomeric kainic acid receptors subtype 1 (GluK1) was at

205 lu receptors potentiated heteromeric but not homomeric KAR-mediated currents, with no change in agoni

206 the exposures had significant effects on the homomeric Kir4.1 channel.

207 eteromeric Kir4.1-Kir5.1 channel but not the homomeric Kir4.1 is subject to the S-glutathionylation t

208 ane patch clamping in COSm6 cells expressing homomeric Kir4.1 or heteromeric Kir4.1/Kir5.1 channels.

209 aracterized SNPs (Q212R, L166Q, and G83V) on homomeric (Kir4.1) and heteromeric (Kir4.1-Kir5.1) chann

210 RNA editing as a novel mechanism to regulate homomeric Kv1.1 channel trafficking.

211 Here we found that currents generated by homomeric Kv1.4, Kv3.3, and Kv3.4 channels are all stron

212 NE1 and KCNE2 suppress currents generated by homomeric Kv1.4, Kv3.3, and Kv3.4 channels, by trapping

213 We characterized the differences between homomeric Kv2.1 and heteromeric Kv2.1/Kv8.2 channels and

214 generation and resulted in the formation of homomeric Kv2.1 channels only.

215 pyramidal neurons reflect the expression of homomeric Kv4.2 channels.

216 icantly increased the maximum conductance of homomeric Kv7.4 and Kv7.5, as well as heteromeric Kv7.4/

217 cy in activating heteromeric Kv7.2/Kv7.3 and homomeric Kv7.4 channels.

218 nels but was significantly less effective on homomeric Kv7.5 channels.

219 zed the kinetics and thermodynamics of small homomeric Lewis X-Lewis X ensembles formed in the contac

220 se was largely blunted in oocytes expressing homomeric MEC-4 or MEC-4d channels.

221 Homomeric MPTL-1 channels reconstituted in Xenopus oocyt

222 multiple, independent MD simulations of each homomeric mu-OR/mu-OR, delta-OR/delta-OR, and kappa-OR/k

223 Homomeric mutant channels reconstituted in COS cells sho

224 ical correction of the trafficking defect in homomeric mutant channels was possible for mutations wit

225 However, both heteromeric and homomeric mutant GlyRs became less sensitive to the neur

226 Homomeric mutants are more sensitive to DH-CBD than are

227 tes, which heterologously express functional homomeric nAChR composed of alpha9 subunits or heteromer

228 nitial stages of nicotine dependence, alpha7 homomeric nAChRs appear to be involved in the later stag

229 f alpha4 and beta2 subunits and low-affinity homomeric nAChRs composed of alpha7 subunits.

230 cetylcholine receptors (nAChRs) evolved from homomeric nAChRs in which all five subunits are involved

231 tion of emc-6 also reduced the expression of homomeric nicotine-sensitive AChRs and GABAA receptors i

232 enhance conotoxin potency and selectivity at homomeric nicotinic ion channels.

233 Although homomeric NR1 subunits form an active ion channel that c

234 n the C643A mutant, and KCNQ3 H646C produced homomeric or heteromeric (with KCNQ2) currents similar t

235 e expression no longer tetramerize in either homomeric or heteromeric assemblies.

236 istinct functional effects, depending on the homomeric or heteromeric composition of the target, its

237 Functional studies revealed that, in homomeric or heteromeric configuration with K(V)7.2 and/

238 st to ISA-null lines, indicating that either homomeric or heteromeric ISA is competent for starch bio

239 is the increased recruitment of MDM4 by the homomeric or heteromeric mutant p53(V172F) complex that

240 oline receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations

241 on channel (ASIC) subunits associate to form homomeric or heteromeric proton-gated ion channels in ne

242 subunits have different propensities to form homomeric or various heteromeric receptors expressed on

243 sults reveal the existence of two classes of homomeric P2X receptors with differential sensitivity to

244 UTP also facilitated bladder neuron homomeric P2X(2) sustained currents and homomeric P2X(3)

245 uron homomeric P2X(2) sustained currents and homomeric P2X(3) fast currents.

246 Homomeric P2X1 receptors open on binding ATP and then tr

247 Purinergic homomeric P2X3 and heteromeric P2X2/3 receptors are liga

248 d peak amplitudes of alpha,beta-meATP-evoked homomeric P2X3-mediated currents, but had no effect on h

249 ntially alters receptor function compared to homomeric P2X7A complexes.

250 a, the purification of which showed it to be homomeric PAFAH1b2.

251 over time, possibly because Panx1 and Panx2 homomeric pannexons have different monomer sizes and oli

252 contrast, abolished PC2 currents in both the homomeric PC2 complexes and the heteromeric PC2/TRPC1 co

253 The topological features of the homomeric PC2-, TRPC1- and heteromeric PC2/TRPC1 channel

254 al membrane protein complexes, including the homomeric PglK and the heteromeric BtuCD as well as BtuC

255 ria and suggest that interaction of S1P with homomeric PHB2 is important for cytochrome-c oxidase ass

256 ivities are due to heteromeric Pmt1-Pmt2 and homomeric Pmt4 complexes.

257 ion to surmount the noisy proximal region, a homomeric polyprotein marker, a carrier to mechanically

258 t switch from inactive heteromeric to active homomeric protein complexes.

259 There is increasing evidence that this homomeric purinoceptor, which is expressed in several ne

260 Here we present evidence that homomeric Q/R-edited AMPARs still allow ions to flow whe

261 tentiated responses of 10 muM L-glutamate at homomeric rat GluA2(Q)i receptors with EC50 values of 67

262 y of the five possible binding sites on this homomeric receptor.

263 e in hbeta3 allow expression as a functional homomeric receptor.

264 alpha7 subunit or alpha10 subunit and alpha9 homomeric receptors are also important.

265 of zebrafish alpha9 subunits indicates that homomeric receptors are functional and exhibit robust AC

266 five receptor subunits, as they do not form homomeric receptors but modify the properties of heterom

267 Here we show that Zn(2+) inhibits GluA2(Q) homomeric receptors in an activity- and voltage-dependen

268 previous reports suggested functional alpha homomeric receptors in mature nervous tissues.

269 er, a small number of Ca(2+)-permeable GluA1 homomeric receptors reside in extrasynaptic locations wh

270 In comparison to GluA2, GluA3 homomeric receptors showed a strong and Tyr-454/Arg-461-

271 e N46K mutation into recombinant GlyR alpha1 homomeric receptors, expressed in HEK cells, reduced the

272 r the poor ability of GluA3 subunits to form homomeric receptors, linked previously to two amino acid

273 mV) in healthy eosinophils, typical of P2X1 homomeric receptors, which were abolished by the selecti

274 ) subunits forming functional heteromeric or homomeric receptors.

275 uggesting that GluRdelta1 receptors can form homomeric receptors.

276 tion removed activation by propofol in beta3 homomeric receptors; however, this mutation alone or in

277 gously expressed GABA(C) receptors formed by homomeric rho subunits.

278 12 microm, but had no significant effect on homomeric rho1 receptors.

279 nt reduction of the GABA-elicited current on homomeric rho2 receptors with an IC(50) of about 12 micr

280 ule known as the prohead RNA (pRNA), and the homomeric ring ATPase gp16.

281 ensive mechanochemical characterization of a homomeric ring ATPase-the bacteriophage phi29 packaging

282 Homomeric ring ATPases perform many vital and varied tas

283 It is largely unknown how the typical homomeric ring geometry of ATPases associated with vario

284 thus maximize the efficiency of assembly for homomeric ring-like structures.

285 ll-cell contacts.The dynamic strength of the homomeric self-association was measured as a function of

286 Expression of homomeric SK1 channels produced current that displayed t

287 anged as a dimer of dimers as exemplified in homomeric structures, but no high-resolution structure c

288 GIRK4) or heterotetramers with nonfunctional homomeric subunits (GIRK1 and GIRK3).

289 Human (h) beta3 subunits assemble to form homomeric surface receptors in somatic cells, but hbeta1

290 an expression switch from neonatal alpha(2) homomeric to predominantly mature alpha(1)/beta glycine

291 parent inward (cytosolic) open state forming homomeric trimers.

292 iophysical and pharmacological properties of homomeric TRPC4 channels and depletion of TRPC1 or TRPC4

293 Inhibitors of homomeric TRPC4 channels were weak inhibitors of the Ica

294 of TRPC6/C7 subunits, while OAG activates a homomeric TRPC6 channel in mesenteric artery myocytes.

295 We show that homomeric TRPM6 is highly sensitive to intracellular fre

296 ansport and whether this involves functional homomeric TRPM6 plasma membrane channels or heteromeric

297 tivity to intracellular Mg.ATP compared with homomeric TRPM7.

298 binding interface, and (iii) the assembly of homomeric TRUSS complexes may contribute to its role in

299 Oligomers of homomeric voltage-gated potassium channels associate ear

300 lutamate by 9000-fold in comparison to GluK2 homomeric wildtype receptors.