ライフサイエンスコーパス: homoserine

1 to be a slow substrate-producing O-ureido-L-homoserine.

2 lactam 1 is reported starting from natural L-homoserine.

3 e formation of a syn substituted beta-phenyl homoserine.

4 in the presence and absence of N-decanoyl-l-homoserine.

5 of AHLs and their lactonolysis products acyl homoserines.

6 e isolation of the host signals and identify homoserine and asparagine, two free amino acids found in

7 e NaK channel with the unnatural amino acids homoserine and cysteine sulfonic acid.

8 ombinant TbHSK specifically phosphorylates L-homoserine and displays kinetic properties similar to ot

9 ween the product forming pathway (O-ureido-L-homoserine and free enzyme) and an inactivation pathway

10 undergoes slow hydrolysis to form O-ureido-L-homoserine and regenerated enzyme.

11 Acyl homoserines and their lactones are better substrates for

12 acid azidohomoalanine (AHA) using protected homoserine as a starting material.

13 this, a new strategy was developed utilizing homoserine as an aspartic acid precursor.

14 ase MetX converts L-homoserine to O-acetyl-L-homoserine at the committed step of this pathway.

15 Rapid death of threonine and homoserine auxotrophs points to a distinct susceptibilit

16 nium compound N,N,N-trimethyl homoserine (or homoserine betaine) and elucidated its biosynthetic path

17 ffold with conserved catalytic machinery and homoserine binding sites.

18 pon the promiscuous cleavage of O-succinyl-L-homoserine by cystathionine gamma-synthase (MetB).

19 Aspartate kinase (AK) and homoserine dehydrogenase (HSD) function as key regulator

20 kinases (AKs) and dual-functional Asp kinase-homoserine dehydrogenases (AK-HSDHs).

21 istinguish isomers Leu from Ile and Thr from homoserine even when chromatographic resolution is incom

22 nes metA and metB, which function to convert homoserine for downstream production of l-methionine, be

23 llowing transformation into procyclic forms, homoserine, homoserine lactone and certain acyl homoseri

24 Homoserine kinase (HSK) produces O-phospho-l-homoserine (HserP) used by cystathionine gamma-synthase

25 nssuccinylase catalyzes the succinylation of homoserine in several bacterial species, the first uniqu

26 hat tsetse endosymbionts possess part (up to homoserine in Wigglesworthia glossinidia) or all of the

27 nase family that includes galactokinase (G), homoserine kinase (H), mevalonate kinase (M), and phosph

28 des only the last two steps in this pathway: homoserine kinase (HSK) and threonine synthase.

29 Homoserine kinase (HSK) produces O-phospho-l-homoserine

30 SK36 in aerobic broth culture except for the homoserine kinase mutant.

31 entified genes encoding undecaprenol kinase, homoserine kinase, anaerobic ribonucleotide reductase, a

32 tylgalactosamine kinase, 7.4 x 10(-17) m for homoserine kinase, and 6.4 x 10(-18) m for hexokinase.

33 e enhancements produced by yeast hexokinase, homoserine kinase, and N-acetylgalactosamine kinase (obt

34 uX homologues and other GHMP (galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalon

35 al strain revealed the presence of an N-acyl homoserine lactonase, an enzyme that hydrolyzes the este

36 bel-free, realtime detection of N-hexanoyl-L-homoserine lactone (199 Da), a gram-negative bacterial i

37 rast to its parent molecule 3-oxo-dodecanoyl homoserine lactone (3-oxo-C(12)-HSL), neither activation

38 dem mass spectrometry identified 3-oxo-C(14)-homoserine lactone (3-oxo-C(14)-HSL), C(16)-HSL, 3-oxo-C

39 ave determined that the AHL, 3-oxododecanoyl homoserine lactone (3-oxo-C12-(L)-HSL) can down-regulate

40 anoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lactone (3-oxo-C12-HSL), and N-(3-oxotetradec

41 of evidence establish that N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HL), the major AHL analog p

42 nI directs the synthesis of N-3-(oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoylhomoseri

43 ne lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL) in Y. enterocolitica a

44 n was dependent on LuxR and 3-oxo-hexanoyl-l-homoserine lactone (3-oxo-C6-HSL).

45 patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacterial gene e

46 ine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm fo

47 onas aeruginosa utilizes the 3-oxododecanoyl homoserine lactone (3OC(12)-HSL) autoinducer as a signal

48 The cognate autoinducer, 3OC(12) homoserine lactone (3OC(12)HSL), is a more potent activa

49 catalyses the synthesis of N-3-oxododecanoyl homoserine lactone (3OC12) and LasR is a transcription f

50 s aeruginosa produces N-(3-oxo-dodecanoyl)-L-homoserine lactone (3OC12), a crucial signaling molecule

51 N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) is a key component of P.

52 The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a cent

53 t triggers the cascade is N-3-oxo-dodecanoyl homoserine lactone (3OC12-HSL), which interacts with two

54 ctone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL).

55 heri quorum-sensing signal N-3-oxohexanoyl-l-homoserine lactone (3OC6-HSL) activates expression of th

56 inding the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6HSL), an acyl-HSL with a carbony

57 ing its cognate quorum signal, 3-oxohexanoyl-homoserine lactone (3OC6HSL).

58 the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component re

59 differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-

60 element and increased production of the acyl-homoserine lactone (acyl-HSL) quormone.

61 nistic pathogen Pseudomonas aeruginosa, acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) regula

62 Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control

63 Acyl-homoserine lactone (acyl-HSL) quorum-sensing signaling i

64 rine bacterium Vibrio fischeri uses two acyl-homoserine lactone (acyl-HSL) quorum-sensing systems.

65 Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor

66 Acyl-homoserine lactone (acyl-HSL) signaling is thought to me

67 a are capable of quorum sensing using N-acyl-homoserine lactone (acyl-HSL) signaling molecules that a

68 monas aeruginosa possesses two complete acyl-homoserine lactone (acyl-HSL) signaling systems.

69 pathogen Pseudomonas aeruginosa has two acyl-homoserine lactone (acyl-HSL) signalling systems, LasR-I

70 respond to the LasI- and RhlI-generated acyl-homoserine lactone (acyl-HSL) signals 3OC12-HSL and C4-H

71 sensing systems that produce and detect acyl-homoserine lactone (acyl-HSL) signals.

72 BtaI2 is an acyl-homoserine lactone (acyl-HSL) synthase that produces two

73 Many bacteria use acyl-homoserine lactone (acyl-HSL) synthases to generate fatt

74 (QS) as the common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lowe

75 Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detecte

76 example of membrane-bound receptors for acyl-homoserine lactone (AHL) autoinducers.

77 In Erwinia carotovora subspecies, N-acyl homoserine lactone (AHL) controls the expression of vari

78 oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) intercellular signaling molecul

79 N-acyl homoserine lactone (AHL) is required by Erwinia carotovo

80 N-Acyl-l-homoserine lactone (AHL) mediated quorum-sensing regulat

81 Acyl-homoserine lactone (AHL) quorum sensing controls gene ex

82 interactions with their plant hosts via acyl-homoserine lactone (AHL) quorum sensing, pectin metaboli

83 vosphingobium genus that produces the N-acyl-homoserine lactone (AHL) quorum-sensing (QS) signals.

84 N-acyl-homoserine lactone (AHL) quorum-sensing molecules produc

85 QS) system, which is mediated by an N-acyl L-homoserine lactone (AHL) signal (C(8)-AHL) and its cogna

86 ation based on chemical gradients of an acyl-homoserine lactone (AHL) signal that is synthesized by '

87 Although each system generates an acyl-homoserine lactone (AHL) signal, the protein sequences o

88 on in the presence of their cognate acylated homoserine lactone (AHL) signal.

89 g affinity is modulated by diffusible N-acyl homoserine lactone (AHL) signalling molecules.

90 olves at least half a dozen different N-acyl homoserine lactone (AHL) signals and perhaps an equal nu

91 strain M2 was found to produce distinct acyl-homoserine lactone (AHL) signals based on the use of an

92 of lasRI/rhlRI or the production of N-acyl-L-homoserine lactone (AHL) signals.

93 -sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs p

94 fects of non-thermal plasma exposure on acyl homoserine lactone (AHL)-dependent quorum sensing (QS).

95 a LuxR homologue that is inactivated by acyl-homoserine lactone (AHL).

96 ter bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

97 CviI synthesizes the autoinducer C(10)-homoserine lactone (C(10)-HSL), and CviR is a cytoplasmi

98 The bacterial molecule N-3-oxo-dodecanoyl-l-homoserine lactone (C12) has critical roles in both inte

99 owed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulat

100 ing molecules, including N-(3-oxododecanoyl)-homoserine lactone (C12), for intercellular communicatio

101 g- and short-chain AHLs, N-3-(oxododecanoyl)-homoserine lactone (C12-HSL) and N-butyryl homoserine la

102 RhlI catalyses the synthesis of N-butanoyl homoserine lactone (C4) and RhlR is a transcription fact

103 )-homoserine lactone (C12-HSL) and N-butyryl homoserine lactone (C4-HSL), on cell viability and mucus

104 growth, addition of the RhlI product butyryl-homoserine lactone (C4-HSL), or bacteria that produce C4

105 ion by a large excess of exogenous N-butyryl homoserine lactone (C4-HSL).

106 the diet, reduce the levels of N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-hom

107 oli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solut

108 SUPB145, was restored by 1 microM N-octanoyl homoserine lactone (C8-HSL).

109 nsing system consisting of TraR and its acyl-homoserine lactone (HSL) ligand.

110 g systems that produce and detect fatty acyl-homoserine lactone (HSL) signals.

111 Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, resto

112 mutants, which do not respond to 3-oxo-C(12)-homoserine lactone (HSL)-mediated QS, exhibit reduced vi

113 monas aeruginosa secrete N-(3-oxododecanoyl)-homoserine lactone (HSL-C12) as a quorum-sensing molecul

114 sing (QS) signal molecule 3-oxo-dodecanoyl-L-homoserine lactone (OdDHL) is produced by the opportunis

115 s on the production of a N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) quorum sensing (QS) signal.

116 nsing (QS) signal molecule, 3-oxo-hexanoyl-l-homoserine lactone (OHHL), and (ii) the intracellular 'a

117 the signalling molecule, N-(3-oxohexanoyl)-l-homoserine lactone (OHHL).

118 ing signalling molecule, N-(3-oxohexanoyl)-L-homoserine lactone (OHHL).

119 the quorum-sensing signal N-3-oxooctanoyl- l-homoserine lactone (OOHL) and a C-terminal domain that b

120 raR requires the pheromone N-3-oxooctanoyl-L-homoserine lactone (OOHL) for biological activity, and i

121 ires its cognate autoinducer N-3-oxooctanoyl-homoserine lactone (OOHL) for resistance of proteolysis

122 he presence of the autoinducer 3-oxooctanoyl-homoserine lactone (OOHL).

123 N-3-oxo-tetradecanoyl-l-homoserine lactone (oxo-C14-HSL) primed plants for enhan

124 The yenI(+) EHEC produces oxo-C6-homoserine lactone (oxo-C6-HSL) and had a significant re

125 signal synthase, which produces p-coumaroyl-homoserine lactone (pC-HSL) and RpaR, which is a pC-HSL-

126 ynthesized quorum-sensing signal p-coumaroyl-homoserine lactone (pC-HSL).

127 sely related molecule paraquat) and the acyl-homoserine lactone 3-OC12-HSL significantly increased th

128 nts from A. tumefaciens (i.e. 3-oxooctanyl-l-homoserine lactone [OOHL]) synthesized by the TraI prote

129 sformation into procyclic forms, homoserine, homoserine lactone and certain acyl homoserine lactones

130 t PAO-MW1 alongside plasma treated N-butyryl-homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine l

131 the predominant AHLs were N-3-oxooctanoyl-L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lac

132 cited against a lactam mimetic of the N-acyl homoserine lactone and represents the only reported mono

133 em is RhlI and RhlR, which generate butanoyl-homoserine lactone and respond to butanoyl-homoserine la

134 t is measured for hydrolysis of N-hexanoyl-l-homoserine lactone and the corresponding thiolactone by

135 of the ring-opened product of N-hexanoyl- l-homoserine lactone are determined at 0.95 and 1.4 A reso

136 to quorum sensing inhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dos

137 es that bind in place of the native acylated homoserine lactone autoinducer, provided that they stabi

138 x reactions to some irritants including acyl-homoserine lactone bacterial quorum-sensing molecules, w

139 ous virulence factors, by N-3-oxododecanolyl homoserine lactone binding to the quorum sensing recepto

140 e catalyzes the hydrolysis of N-hexanoyl-(S)-homoserine lactone but not the (R) enantiomer.

141 al signals, most of which belong to the acyl-homoserine lactone class.

142 Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype.

143 n density by utilizing members of the N-acyl homoserine lactone family as inducers and a transcriptio

144 the esaR gene and responds to exogenous acyl-homoserine lactone for derepression.

145 on factor, QscR, bound to N-3-oxo-dodecanoyl-homoserine lactone from the opportunistic human pathogen

146 three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase (AHL lactonase) from Bacill

147 tivator A (AiiA) is a metal-dependent N-acyl homoserine lactone hydrolase that displays broad substra

148 The N-acyl- l-homoserine lactone hydrolases (AHL lactonases) have attr

149 des the quorum-sensing receptor for N-acyl-l-homoserine lactone in Escherichia coli.

150 Furthermore, N-(3-oxo-dodecanoyl)homoserine lactone induced distension of mitochondria an

151 icient in the synthesis of a diffusible acyl-homoserine lactone inducer remain repressed for EPS synt

152 Although acyl-homoserine lactone levels in cultures of this strain are

153 The acyl-homoserine lactone molecular species (AHLs) produced by

154 , in the presence of 1-100 nM exogenous acyl-homoserine lactone molecules has been quantified.

155 enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

156 anding of the effects of N-(3-oxo-dodecanoyl)homoserine lactone on host cells and its role in persist

157 n secretion profile and increased N-butanoyl homoserine lactone production and influenced several quo

158 rkholderia thailandensis contains three acyl-homoserine lactone quorum sensing circuits and has two a

159 in, which appears to bind and sequester some homoserine lactone quorum signals, resulting in the inab

160 aeruginosa utilizes two interconnected acyl-homoserine lactone quorum-sensing (acyl-HSL QS) systems,

161 The acyl-homoserine lactone quorum-sensing (QS) systems of these

162 thelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules secreted by

163 yet another subtle regulatory layer for acyl-homoserine lactone quorum-sensing signal-responsive tran

164 c bacterium Pseudomonas aeruginosa uses acyl-homoserine lactone quorum-sensing signals to coordinate

165 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone reporter assays, showing that Fap fib

166 the cps cluster are significantly more acyl-homoserine lactone responsive than genes located towards

167 ion of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wil

168 The LasI-generated 3-oxododecanoyl-homoserine lactone serves as a signal molecule for QscR.

169 QscR uses the LasI-generated acyl-homoserine lactone signal and controls a specific regulo

170 I and LasR, which generate a 3-oxododecanoyl-homoserine lactone signal and respond to that signal, re

171 transcriptional regulator that responds to a homoserine lactone signal to activate expression of acut

172 In such a system, binding of an acyl-homoserine lactone signal to its cognate transcriptional

173 ng signals for many Proteobacteria, and acyl-homoserine lactone signaling is known to control coopera

174 nd the glyoxylate bypass are induced by acyl-homoserine lactone signaling.

175 P. aeruginosa uses at least two N-acyl l-homoserine lactone signals and three homologous LuxR-typ

176 any Gram-negative bacteria involves acylated homoserine lactone signals that are perceived through bi

177 converse bidirectionally by exchanging acyl-homoserine lactone signals.

178 LasI is an acyl-homoserine lactone synthase that produces a quorum-sensi

179 to discovering inhibitors of LuxI-type acyl-homoserine lactone synthases.

180 P. aeruginosa releases N-(3-oxo-dodecanoyl) homoserine lactone to suppress host immunity for its own

181 reased amounts of rhamnolipids and N-butyryl homoserine lactone were detected in the biofilm effluent

182 hat recognizes the naturally-occuring N-acyl homoserine lactone with high affinity.

183 C3193 produce 3-oxo-C8-HL (N-3-oxooctanoyl-l-homoserine lactone) as the major AHL analog as well as l

184 ble levels of 3-oxo-C6-HL (N-3-oxohexanoyl-l-homoserine lactone).

185 to its cognate substrate 3-oxo-C10 AHL (Acyl-Homoserine Lactone).

186 actor(s) that is not lipopolysaccharide, C12 homoserine lactone, alginate, CIF, or exotoxin A, S, T,

187 ned biochar sorption of N-3-oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) int

188 ased production of the QS molecule 3-O-C(12)-homoserine lactone, and QS-regulated virulence factors p

189 odecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and the Pseudomonas quinolone signal

190 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone, and the redox mediator pyocyanin bin

191 its cell-to-cell signal, N-(3-oxododecanoyl) homoserine lactone, and the rhl system is composed of Rh

192 -homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exhibited marked attenuation of viru

193 sa's main QS molecule, N-(3-Oxododecanoyl)-L-homoserine lactone, induces candidal resistance to fluco

194 AHLs synthesized via YenI: N-(3-oxodecanoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lacton

195 cell-to-cell signals, N-(3-oxododecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and

196 gulated by the quorum-sensing signal, N-acyl homoserine lactone, plant signals, an assortment of tran

197 l-homoserine lactone and respond to butanoyl-homoserine lactone, respectively.

198 d the bacterial signaling molecule 3-oxo-C12-homoserine lactone, showing the necessity for cholinergi

199 N-(3-oxo-dodecanoyl) homoserine lactone, the autoinducer of the Pseudomonas a

200 Compound 12b, 3-oxo-12-phenyldodecanoyl-L-homoserine lactone, was identified as a lead compound wi

201 n of the AinS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously

202 Our analysis revealed that acyl-homoserine lactone-based quorum sensing controls the exp

203 wn to be positively regulated by an N-acyl-L-homoserine lactone-based quorum sensing system, but oper

204 on of mRFP1 with ahlI, which exhibits N-acyl homoserine lactone-dependent transcriptional activity, a

205 Many Proteobacteria use acyl-homoserine lactone-mediated quorum-sensing (QS) to activ

206 we provide evidence that N-(3-oxo-dodecanoyl)homoserine lactone-mediated signaling does not require t

207 of TraR and its signal N-(3-oxo-octanoyl)-L-homoserine lactone.

208 ative transfer in response to exogenous acyl-homoserine lactone.

209 e (3-oxo-C12-HSL), and N-(3-oxotetradecanoyl)homoserine lactone.

210 -L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lactone.

211 thentic N-butyrylvinylglycine to N-butyryl-L-homoserine lactone.

212 is composed of RhlR and the signal N-butyryl homoserine lactone.

213 the quorum sensing molecule (N-3-oxohexanoyl-homoserine lactone; OHHL) and PCWDEs.

214 bacteria produce a specific set of N-acyl-L-homoserine-lactone (AHL) signaling molecules for the pur

215 QS in P. aeruginosa involves two acyl-homoserine-lactone circuits, LasI-LasR and RhlI-RhlR.

216 ession, resulting in increased N-(butyryl)-l-homoserine-lactone quorum sensing signal and decreased E

217 ene, which is co-transcribed with the N-acyl-homoserine-lactone synthase gene cinI, is required to fu

218 oof of concept, we characterize a set of Lux homoserine-lactone-inducible genetic devices with differ

219 eived through binding to LuxR-type, acylated-homoserine-lactone-responsive transcription factors.

220 s in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules.

221 antibiotics, as well as a suite of six acyl-homoserine lactones (acyl-HSLs) that includes four 3-hyd

222 nities, the exchange of signals such as acyl-homoserine lactones (AHL) enables communication within a

223 pe enzymes catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-met

224 biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might ac

225 LuxR-type transcription factors detect acyl homoserine lactones (AHLs) and are typically used by bac

226 Acyl homoserine lactones (AHLs) are a major class of quorum s

227 tive of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed

228 quorum sensing in bacteria that use N-acyl-l-homoserine lactones (AHLs) as intercellular signaling mo

229 in natural biofilm communities using N-acyl homoserine lactones (AHLs) as one type of signaling mole

230 Quorum sensing (QS) using N-acyl homoserine lactones (AHLs) as signal molecules is a comm

231 mber of Gram-negative bacteria employ N-acyl homoserine lactones (AHLs) as signaling molecules in quo

232 ignal exchange, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria.

233 sensing systems are those that use acylated homoserine lactones (AHLs) for communication.

234 Enzymes able to degrade or modify acyl-homoserine lactones (AHLs) have drawn considerable inter

235 ent manner by auto-inducers, like the N-acyl homoserine lactones (AHLs) in numerous Gram-negative bac

236 We reported that SdiA senses acyl homoserine lactones (AHLs) in the bovine rumen to activa

237 Profiles of N-acyl-homoserine lactones (AHLs) isolated from the wild type a

238 phiphilic inducer molecules such as N-acyl-L-homoserine lactones (AHLs) or isopropyl-beta-D-thio-gala

239 uxR homolog, SdiA, which can detect the acyl-homoserine lactones (AHLs) produced by other bacteria an

240 C harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria.

241 reviously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by the microbiota in

242 Enzymes capable of hydrolyzing N-acyl- l-homoserine lactones (AHLs) used in some bacterial quorum

243 oserine, homoserine lactone and certain acyl homoserine lactones (AHLs) were found to substitute for

244 Here, we propose a mechanism for how N-acyl-homoserine lactones (AHLs), a group of QS molecules, inf

245 ensing-associated signaling molecules N-acyl homoserine lactones (AHLs), such as butanoyl and hexanoy

246 onella is a LuxR homolog that detects N-acyl homoserine lactones (AHLs).

247 cell-cell communication via exchange of acyl homoserine lactones (AHLs).

248 ctones (AHLs), such as butanoyl and hexanoyl homoserine lactones (C(4)- and C(6)-HSLs), as well as N-

249 Acyl-homoserine lactones (HSLs) serve as quorum-sensing signa

250 tor QscR responds to a variety of fatty acyl-homoserine lactones (HSLs), including N-3-oxododecanoyl-

251 ed library of synthetic, non-native N-acyl l-homoserine lactones and identified compounds that can dr

252 focused collections of non-native N-acylated homoserine lactones and the systematic evaluation of the

253 rum-sensing systems, ain and lux, using acyl homoserine lactones as signaling molecules.

254 systems (Sin, Tra, and Mel) that use N-acyl homoserine lactones as their quorum-sensing signal molec

255 However, other homoserine lactones can elicit LasR-dependent quorum-sen

256 ydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterpart

257 Signaling via acyl-homoserine lactones is the paradigm for QS in Proteobact

258 We identify mutants that alter which homoserine lactones LasR detects.

259 These findings suggest that N-(3-oxo-acyl)homoserine lactones might be recognized by receptors of

260 and rhlI genes, impairing the production of homoserine lactones necessary for quorum-sensing, an imp

261 Because acyl-homoserine lactones serve as quorum-sensing molecules fo

262 Acyl-homoserine lactones serve as quorum-sensing signals for

263 L were found to efficiently hydrolyze N-acyl homoserine lactones that mediate quorum sensing in many

264 ds, including expensive N-alkyl amino acids, homoserine lactones, and Agl lactams, and to achieve the

265 ch as diffusible signal factors (DSFs), acyl-homoserine lactones, and autoinducer-2 systems.

266 mall diffusible molecules, specifically acyl-homoserine lactones, are produced by P. aeruginosa to pr

267 ssor of Pig and Car when levels of N-acyl- l-homoserine lactones, produced by SmaI, are low.

268 ssion system, whereas in the absence of acyl homoserine lactones, the protein is expressed into insol

269 kers of the effects induced by N-(3-oxo-acyl)homoserine lactones, the secreted products of a number o

270 es, with low efficiency, lactones other than homoserine lactones, thus preceding the detoxifying func

271 s a more potent activator of LasR than other homoserine lactones.

272 irects the enzyme toward production of 3-oxo-homoserine lactones.

273 llei strain GB8 that was unable to make acyl-homoserine lactones.

274 ncreases the potency of 3OC(12)HSL and other homoserine lactones.

275 AiiA, a lactonase enzyme that degrades acyl-homoserine lactones.

276 lactonase catalyzing the hydrolysis of acyl-homoserine lactones; these molecules are involved in Gra

277 haride, rhamnolipids, lipopeptides, and acyl-homoserine-lactones-do not trigger LORE-dependent respon

278 The galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP

279 force in beta(3)-peptides containing beta(3)-homoserine or beta(3)-homothreonine, and (4) demonstrate

280 quaternary ammonium compound N,N,N-trimethyl homoserine (or homoserine betaine) and elucidated its bi

281 ex with the ring-opened product N-hexanoyl-l-homoserine revealed binding interactions near the metal

282 enoic acid (fluoroallylglycine), (S)-beta(2)-homoserine, (S) and (R)-beta(3)-homocysteine, and (2R,3R

283 g a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of l

284 The conversion of homoserine to aspartic acid in the glycopeptide was succ

285 enzyme nucleophile, followed by transfer to homoserine to form O-succinylhomoserine.

286 yme performs gamma-elimination of O-acetyl-l-homoserine to generate the vinylglycine ketimine, which

287 he homoserine transacetylase MetX converts L-homoserine to O-acetyl-L-homoserine at the committed ste

288 r homoserine transsuccinylase (HTS, metA) or homoserine transacetylase (HTA; met2) for the biosynthes

289 The homoserine transacetylase MetX converts L-homoserine to

290 A comparison of homoserine transacetylases from other bacterial and fung

291 Bacteria and yeast rely on either homoserine transsuccinylase (HTS, metA) or homoserine tr

292 rovide the first detailed description of the homoserine transsuccinylase active site and provide a fr

293 Homoserine transsuccinylase catalyzes the succinylation

294 eems to result from destabilization of MetA (homoserine transsuccinylase), the first enzyme in methio

295 he protein catalyzes the transacetylation of homoserine using acetyl-CoA.

296 hway leads to direct formation of O-ureido-L-homoserine via a reactive thiouronium intermediate.

297 ine is transferred to the terminal carbon of homoserine via its sulfhydryl group to form cystathionin

298 ne, methionine, cystathionine, cysteine, and homoserine were quantified by liquid chromatography-posi

299 Bacillus cereus metA protein in complex with homoserine, which provides the first view of a ligand bo

300 ccessfully prepared poly(L-phosphorylcholine homoserine) with controlled chain lengths and found thes