ライフサイエンスコーパス: homotetrameric

1 Asp142 in the homotetrameric ADP-glucose pyrophosphorylase (ADP-Glc PP

2 Lysine (Lys)-195 in the homotetrameric ADP-glucose pyrophosphorylase (ADPGlc PPa

3 omologous to those of bacterial and archaeal homotetrameric alcohol dehydrogenases (ADHs) and also to

4 e (Zea mays) rf2a and rf2b genes both encode homotetrameric aldehyde dehydrogenases (ALDHs).

5 esence of secretable and functionally active homotetrameric alpha- and beta-tryptases in transfected

6 -scale monomeric units of these polymers are homotetrameric, alpha-helical bundles of low-molecular-w

7 isoforms HCN1-4 assemble to form functional homotetrameric and heterotetrameric hyperpolarization-ac

8 The four active sites of the homotetrameric apoenzyme appear to divide into two numer

9 herichia coli MgsA is described, revealing a homotetrameric arrangement for the protein that distingu

10 ined by both the direct DNA contacts and the homotetrameric arrangement of the Cre monomers.

11 functional CRAC channel pore is formed by a homotetrameric assembly of Orai1 subunits.

12 on, including an unexpected asymmetry in the homotetrameric assembly.

13 rate that Kir 2.2 channels are formed by the homotetrameric association of Kir 2.2 subunits and do no

14 alcium selectivity filter constructed in the homotetrameric bacterial NaV channel NaVAb.

15 t differences between D. radiodurans SSB and homotetrameric bacterial SSB proteins may confer a selec

16 ly showed that Escherichia coli (Eco) SSB, a homotetrameric bacterial SSB, undergoes not only rapid s

17 biochemical analyses, we identified a single homotetrameric bifunctional ammonia-lyase (PTAL) among e

18 Here we report that KRP130, a homotetrameric BimC-related kinesin purified from Drosop

19 Each pore-forming alpha subunit of the homotetrameric BK(Ca) channel is expected to contain two

20 dimeric by gel filtration chromatography and homotetrameric by dynamic light scattering and to contai

21 tome is the ryanodine receptor (RyR), a huge homotetrameric Ca(2+) release channel (~2.3 MDa) of the

22 the cold receptor that forms a nonselective homotetrameric cation channel.

23 toreceptors, can by itself form a functional homotetrameric channel and has been used as the model sy

24 n two adjacent hERG1 subunits, and, hence, a homotetrameric channel has four identical RPR binding si

25 in the fully assembled, membrane-associated, homotetrameric channel protein.

26 of Kir3.1/Kir3.4 heterotetrameric and Kir3.4 homotetrameric channel subunits, is one of the best vali

27 of the influenza virus M(2) protein forms a homotetrameric channel that transports protons.

28 e of the complex shows the drug bound in the homotetrameric channel, threaded between the side chains

29 er) and increase the open probability of the homotetrameric channel.

30 ind that each of hBest1, 2, 3, and 4 forms a homotetrameric channel.

31 module between two adjacent subunits of the homotetrameric channel.

32 in tobacco mesophyll protoplasts: KAT2 forms homotetrameric channels active at the plasma membrane, w

33 gion, preventing surface expression of Kv1.1 homotetrameric channels and of heteromeric Kv1 channels

34 eases surface expression of functional Kv1.1 homotetrameric channels and support a model whereby a DT

35 When expressed alone ex vivo, ORco forms homotetrameric channels gated by ORco-specific ligands a

36 tance at femtosiemens resolution of all four homotetrameric channels of the mouse, mHCN1-4.

37 mutation is permissive for the expression of homotetrameric channels that are nonselective for cation

38 e compared this pH-dependence with that from homotetrameric channels with four copies of the mutation

39 However, L18A/L25A channels failed to form homotetrameric channels, as assessed by Co-IP, suggestin

40 inity (K(d) values 7-21 nM) to each of these homotetrameric channels.

41 itary conductance values with respect to the homotetrameric channels.

42 yl-tRNA synthetase, operates as well in this homotetrameric class II tRNA synthetase.

43 ess at least two distinct PEPC enzyme-forms, homotetrameric Class-1 and heteromeric Class-2, that dif

44 in inside-out macropatches containing either homotetrameric (CNGA2), heterotetrameric (CNGA2:CNGA4:CN

45 he Kv1.1 outward current when expressed as a homotetrameric complex (EC(50) = 0.34 nM).

46 at RECQ1 can form what appears to be a flat, homotetrameric complex and propose that RECQ1 tetramers

47 l muscle (RyR1) receptor isoforms, RyR3 is a homotetrameric complex comprising two main components, a

48 mass of 270 kDa, compatible with its being a homotetrameric complex of the approximately 64-kDa subun

49 pure SNAP-23N crystallizes as a coiled-coil homotetrameric complex.

50 nges that drive the function of this 240 kDa homotetrameric complex.

51 tracellular superoxide dismutase (SOD3) is a homotetrameric copper- and zinc-containing glycoprotein

52 nformational ensembles of the D2 -symmetric, homotetrameric copper-sensitive operon repressor (CsoR)

53 Structural studies of ACLY reveal a central homotetrameric core citrate synthase homology (CSH) modu

54 Cys-504-Cys-504 dithiol-disulfide switch in homotetrameric CRMP2.

55 Homotetrameric Cys10 TTR variants, including TTR-Cys, TT

56 The homotetrameric DnaD protein is essential in low G+C cont

57 o-electron microscopy structure of the NiV G homotetrameric ectodomain in complex with the nAH1.3 bro

58 otubule gliding at a rate similar to that of homotetrameric Eg5 in vitro.

59 onucleases, thought to have evolved from the homotetrameric endonucleases.

60 +)-dependent enzyme, GCYH-IB is a bimodular, homotetrameric enzyme activated by a variety of divalent

61 of ATP binds at the subunit interface of the homotetrameric enzyme and that the majority of the ATP-e

62 Each chain of this homotetrameric enzyme consists of 330 residues.

63 This homotetrameric enzyme exhibits strong cooperativity towa

64 a reduction in the overall dimensions of the homotetrameric enzyme following substrate binding and ox

65 e synthase revealed four active sites of the homotetrameric enzyme located within deep tunnels.

66 tes reside in different subunits of a single homotetrameric enzyme molecule.

67 olecule FRET to monitor the dynamics of this homotetrameric enzyme on RNA.

68 This homotetrameric enzyme possesses 222 symmetry, which impo

69 The homotetrameric enzyme provides a unique environment for

70 The homotetrameric enzyme required NADPH, flavin mononucleot

71 PAAS is a cytosolic homotetrameric enzyme that belongs to group II pyridoxal

72 yl-acyl carrier protein (ACP) reductase is a homotetrameric enzyme that catalyzes the last reductive

73 Pyruvate decarboxylase is a homotetrameric enzyme which crystallizes with two subuni

74 ate dehydrogenase from Escherichia coli is a homotetrameric enzyme which is allosterically regulated

75 manganese superoxide dismutase (MnSOD) is a homotetrameric enzyme which protects mitochondria agains

76 Using the homotetrameric enzyme, lactate oxidase (LOx), as a label

77 i pyruvate oxidase (PoxB), a lipid-activated homotetrameric enzyme, upon substrate binding.

78 cts the active sites on the subunits of this homotetrameric enzyme.

79 utamate at residue 487 in the 500 amino acid homotetrameric enzyme.

80 , supporting the conclusion that ACAT-1 is a homotetrameric enzyme.

81 sessed just 16-18% activity of the glutamate homotetrameric enzyme.

82 The homotetrameric enzymes belong to the type I family of ex

83 The homotetrameric Escherichia coli single-stranded DNA bind

84 The homotetrameric Escherichia coli single-stranded DNA-bind

85 The kinetic mechanism of transfer of the homotetrameric Escherichia coli SSB protein between ssDN

86 or DrSSB that strongly resemble those of the homotetrameric Escherichia coli SSB, further supporting

87 ned the kinetic mechanism for binding of the homotetrameric Escherichia coliSSB protein to single-str

88 We demonstrate our approach on the yeast homotetrameric FBP1 complex, the rate-limiting enzyme in

89 dehydrogenase (IVD) is an intramitochondrial homotetrameric flavoenzyme that catalyzes the conversion

90 ort chain acyl-CoA dehydrogenase (SCAD) is a homotetrameric flavoenzyme that catalyzes the first intr

91 7.3 +/- 1.1 mum(2).s(-1), consistent with a homotetrameric form of Kaede.

92 ition, it has not been demonstrated that the homotetrameric form of these proteins is essential for t

93 ntisense response, due to the formation of a homotetrameric G quartet structure.

94 In fluorescently labelled homotetrameric GIRK1 channels and in the heterotetrameri

95 ocytes, expression of Ggamma alone activated homotetrameric GIRK1* and heterotetrameric GIRK1/3 chann

96 ive Xenopus oocytes, Gbetagamma affinity for homotetrameric GIRK2 ranges from 4-30 uM.

97 similar to the distal (B/D) subunits in the homotetrameric GluA2 alpha-amino-3-hydroxy-5-methyl-4-is

98 aracterize the structure and sequence of the homotetrameric glycoprotein avidin.

99 heterodimer of Gc and the Gn head and of the homotetrameric Gn base.

100 In this study, we expressed homotetrameric HCN2 channels in Xenopus oocytes and perf

101 x cooperative interaction of the subunits in homotetrameric HCN2 pacemaker channels.

102 hese studies to investigate formation of the homotetrameric hemoglobin H, whose formation in vivo is

103 onding enzyme from Saccharomyces uvarum, the homotetrameric holoenzyme assembly has approximate 222 s

104 on equilibrium analysis indicates an alpha 4 homotetrameric holoenzyme structure (4 x 38,861 Da).

105 The structure of homotetrameric htADH is highly homologous to those of ba

106 the same family, kappaM-RIIIK, inhibits the homotetrameric human Kv1.2 channels.

107 Glu162 in homotetrameric human MnSOD spans a dimeric interface and

108 The homotetrameric influenza A M2 channel (AM2) is an acid-a

109 Ryanodine receptors are homotetrameric intracellular calcium release channels.

110 .0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into pot

111 Polycystin subunits can form hetero- and homotetrameric ion channels in the membranes of various

112 Nematostella Shaker genes express functional homotetrameric K(+) channels in vitro.

113 s with high affinity to membranes expressing homotetrameric K(v)1.3 channels, and high affinity diTC

114 KIF11 is a homotetrameric kinesin that peaks in protein expression

115 The dynamic behavior of homotetrameric kinesin-5 during mitosis is poorly unders

116 ind that spindle turbulence is driven by the homotetrameric kinesin-5 Eg5, and that acute Eg5 inhibit

117 Eg5 or KSP is a homotetrameric Kinesin-5 involved in centrosome separati

118 Eg5 is a homotetrameric kinesin-5 motor protein that generates ou

119 Homotetrameric kinesin-5 motors are essential for chromo

120 ulations to dissect the various roles of the homotetrameric kinesin-5, KLP61F, in astral, centrosome-

121 Eg5/KSP is a homotetrameric, Kinesin-5 family member whose ability to

122 Homotetrameric Kv1.1 channels were localized to endoplas

123 sented in this report, we postulate that all homotetrameric L-asparaginases from mesophilic bacteria

124 y of tRNA(Met)i The crystal structure of the homotetrameric m1A58 tRNA Mtase from Mycobacterium tuber

125 heart of the H+ conductance mechanism in the homotetrameric M2 H+ channel from influenza A is a set o

126 The homotetrameric M2 integral membrane protein of influenza

127 in the influenza virus His37 cluster in the homotetrameric M2 proton channel and block the proton cu

128 The homotetrameric M2 proton channel of influenza A plays a

129 The system for this study is the homotetrameric M2 proton channel protein from the influe

130 removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD).

131 This report investigates the homotetrameric membrane protein structure of the S31N M2

132 otein from influenza A virus is a 97-residue homotetrameric membrane protein that functions as a prot

133 Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric mitochondrial flavoenzyme which catalyzes

134 -CoA dehydrogenase (IVD), a nucleus-encoded, homotetrameric, mitochondrial flavoenzyme that catalyzes

135 al analyses of drug binding to the bacterial homotetrameric model CaV channel CaVAb, which is inhibit

136 Homotetrameric models of three mammalian Kir channels (K

137 Kinesin-5 is a slow homotetrameric motor protein best known for its essentia

138 Kinesin-5 (also called Eg5 or kif11) is a homotetrameric motor protein that functions by modulatin

139 Kinesin-5 is a homotetrameric motor protein that interacts with adjacen

140 The crystal structure of the homotetrameric MtbThyX was determined in the presence of

141 a concatenated channel as that observed for homotetrameric mutant channels.

142 quaternary structure, a potato small subunit homotetrameric mutant, TG-15, was subjected to iteration

143 Despite its versatility, the homotetrameric nature of streptavidin (Sav) and the nonc

144 Escherichia coli NikR is a homotetrameric Ni(2+)- and DNA-binding protein that func

145 NikR is a homotetrameric nickel regulatory protein whose binding t

146 ial ion channel family and can function as a homotetrameric nonselective cation channel.

147 ristletail(4) Machilis hrabei assembles as a homotetrameric odorant-gated ion channel with broad chem

148 ent, an intrinsic RNA kinase activity, and a homotetrameric or homodimeric quaternary structure, that

149 s are the largest known ion channels, with a homotetrameric organization and approximately 5,000 resi

150 5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dime

151 Homotetrameric P. falciparum aldolase (PfALDO) crystalli

152 The influenza A virus M2 protein (A/M2) is a homotetrameric pH-activated proton transporter/channel t

153 Homotetrameric polycystin channels are voltage- and calc

154 His-37 from symmetry-related monomers of the homotetrameric pore converge to form a coordination site

155 KCNA2 encodes KV1.2 subunits, which form homotetrameric potassium channels and participate in het

156 ed that the principal functional unit of the homotetrameric PPK is a dimer.

157 at the MGAT2 enzyme primarily functions as a homotetrameric protein and as a tetrameric protein.

158 ACAT1 is a homotetrameric protein and contains nine transmembrane d

159 to cobalt and nickel regulator) is a 40-kDa homotetrameric protein and metalloregulator that control

160 igand interaction between biotin (B) and the homotetrameric protein complex streptavidin (S(4)) in th

161 In the crystal structure each subunit of the homotetrameric protein contains one substrate-binding si

162 Aldolase (E.C. 4.1.2.13), a homotetrameric protein encoded by the ALDOA gene, conver

163 Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyl

164 of the transmembrane-spanning region of the homotetrameric protein in the presence and absence of th

165 Transthyretin (TTR) is an homotetrameric protein involved in the transport of thyr

166 transthyretin (TTR), a human beta-sheet-rich homotetrameric protein that must undergo rate-limiting t

167 67 dihydrofolate reductase (DHFR) is a novel homotetrameric protein that possesses 222 symmetry and a

168 It is a homotetrameric protein that spans the membrane multiple

169 The amyloidogenic homotetrameric protein transthyretin (TTR) must undergo

170 The homotetrameric protein transthyretin (TTR) must undergo

171 The subunit size of this homotetrameric protein was 55 kDa, which is about half t

172 This is the case of transthyretin (TTR), a homotetrameric protein whose dissociation into its monom

173 The ryanodine receptor (RyR) is a large homotetrameric protein with a hydrophobic domain at the

174 Streptavidin, a homotetrameric protein with extremely tight biotin bindi

175 This study shows that MHPCO is a homotetrameric protein with one flavin adenine dinucleot

176 This homotetrameric protein wraps ssDNA in multiple distinct

177 chondrial ssDNA-binding protein (mtSSB) is a homotetrameric protein, involved in mtDNA replication an

178 of symmetry at the dimer interfaces in this homotetrameric protein, suggesting that the quaternary s

179 Transthyretin (TTR) is a homotetrameric protein.

180 o a cleft formed by adjacent subunits of the homotetrameric protein.

181 a dimer of dimer quaternary structure of the homotetrameric protein.

182 Homotetrameric proteins can assemble by several differen

183 and that selective pressure may have caused homotetrameric proteins to evolve to assemble by a singl

184 ent members of the AQP family, the signature homotetrameric quaternary structure is conserved.

185 A recent crystal structure of active, homotetrameric R67 DHFR indicates that a single active s

186 olate and NADPH by approximately 100-fold in homotetrameric R67 DHFR.

187 wild-type and Lys --> Gln or Glu site mutant homotetrameric rabbit cytosolic SHMTs identified lysine

188 Here, we report a structure of a homotetrameric rat GluA2 receptor in complex with partia

189 4-isoxazole propionic acid (AMPA)-sensitive, homotetrameric, rat GluA2 receptor at 3.6 A resolution i

190 Unlike the homotetrameric recombinant GluR2, the native heterotetra

191 We next find that axis core proteins form homotetrameric (Red1) or heterotetrameric (SYCP2:SYCP3 a

192 -contraction coupling involves activation of homotetrameric ryanodine receptor ion channels (RyR1s),

193 s of the square-shaped cytoplasmic region of homotetrameric RyR3.

194 Human lung tryptase, a homotetrameric serine protease unique to mast cell secre

195 beta-Tryptase, a homotetrameric serine protease, has four identical activ

196 Transthyretin (TTR) is an abundant homotetrameric serum protein and was selected here for e

197 in the last transmembrane region (S6) of the homotetrameric Shaker K+ channel creates metal binding s

198 We showed that the homotetrameric species exchanged dimers, because when th

199 tein is the adduct of the G26C mutant of the homotetrameric SSB from Escherichia coli and a diethylam

200 many of the same reactions catalyzed by the homotetrameric SSB of bacteria, but its origin, subunit

201 ing properties of these two highly conserved homotetrameric SSB proteins, and these differences might

202 In contrast to homotetrameric SSB proteins, asymmetry exists between th

203 Escherichia coli SSB, a representative homotetrameric SSB, binds to ssDNA by wrapping the DNA u

204 results extend our previous observations on homotetrameric SSBs to homodimeric SSBs, indicating that

205 DrSSB that are analogous to those mapped in homotetrameric SSBs, although there are distinct contact

206 nylated Cp*Ir moiety (Cp* = C5Me5(-)) within homotetrameric streptavidin (Sav) (referred to as Cp*Ir(

207 The purified DAHP synthase displays a homotetrameric structure and exhibits maximal activity a

208 ce the inactive enzyme while maintaining its homotetrameric structure and interaction with PC-TP.

209 ar mass of 185 +/- 35 kDa, consistent with a homotetrameric structure for the native enzyme.

210 The homotetrameric structure of ES* was solved by MAD phasin

211 The homotetrameric structure of the ryanodine-sensitive intr

212 This homotetrameric structure reveals a novel KaiB interface

213 tes at each protein-protein interface in the homotetrameric structure with binding constants relative

214 Previous studies demonstrated a specialized homotetrameric structure with two pairs of catalytic dom

215 ristics of mammalian class 1 ALDHs include a homotetrameric structure, high expression in liver, sens

216 se product of ca. 50,000 Da assembles into a homotetrameric structure.

217 tuber LS and, in turn, enabling it to form a homotetrameric structure.

218 The building block structure consists of a homotetrameric subunit complex with three unique supramo

219 The pseudo-fourfold homotetrameric synapse formed by Cre protein and target

220 thods to dissect the domain structure of the homotetrameric T4 Pnk protein and to localize essential

221 arE adopts a global structure resembling the homotetrameric TDO, it features a simplified alpha6 heli

222 The homotetrameric thermosensitive transient receptor potent

223 te editing status, in an otherwise identical homotetrameric TMD.

224 The p53 tumor suppressor gene encodes a homotetrameric transcription factor which is activated i

225 Common to both viruses is the M2 protein, a homotetrameric transmembrane proton channel that acidifi

226 Transthyretin (TTR) is a homotetrameric transport protein, assembled from monomer

227 single subunit of the previously determined homotetrameric tRNA splicing endonuclease from Methanoco

228 The homotetrameric TTR contains two identical thyroxine bind

229 p53 is a homotetrameric tumor suppressor protein that is found to

230 scorpion toxin, Charybdotoxin (CTX), blocks homotetrameric, voltage-gated K(+) channels by binding n

231 Thus eubacterial SSBs are homotetrameric whilst the eucaryal RPA protein is a hete