ライフサイエンスコーパス: horse

1 higher GRAVY values compared to human except horse.

2 f SBR as a measure of stress in the domestic horse.

3 essed in Jeju horse compared to Thoroughbred horse.

4 igher in Jeju horse compared to Thoroughbred horse.

5 ining Iberian lines and a North African Barb Horse.

6 ACTN2, were positively selected in the Jeju horse.

7 ected and rural breeds and nine Przewalski's horses.

8 in Korea may have originated from Mongolian horses.

9 e upper respiratory tract in fully protected horses.

10 IL-31 alleviated clinical scores in affected horses.

11 domestic ungulate species: cattle, sheep and horses.

12 ), a reproductive and respiratory disease of horses.

13 was induced in both radiocarpal joints of 6 horses.

14 ted with increased behavioural reactivity in horses.

15 5 by vaccination reduces disease symptoms in horses.

16 f heterozygosity for humans, chimpanzees and horses.

17 ted 3/8 (Ab4DeltaORF2/Ab4) and 5/8 (Ab4/Ab4) horses.

18 the predominance of this haplotype in modern horses.

19 sis and function in skeletal muscle of young horses.

20 virus replication and disease progression in horses.

21 , with mortality reaching up to 95% in naive horses.

22 ion system, were determined in sera from 347 horses.

23 g IgE in sera from > 70% of the IBH-affected horses.

24 sect bite hypersensitivity (IBH) and control horses.

25 y detectable in skin lesions of IBH-affected horses.

26 a associated with white spotting patterns in horses.

27 d healthy skin from IBH-affected and healthy horses.

28 activation reported for both humans [9] and horses [10, 11].

29 he COPSAC2000 birth cohort data: (1) dog/cat/horse, (2) timothy grass/birch, (3) molds, (4) house dus

30 Severely asthmatic horses (6 horses/group) were treated with fluticasone, s

31 efense has reportedly been used against both horses [7] and humans [8].

32 In horses, a non-sense mutation in the Dmrt3 gene has major

33 Other horses acted quickly, consistently detoured in the same

34 age clinical development, utilizes a "Trojan horse" active transport mechanism to enter bacteria and

35 5% and seropositivity rates compared between horses affected with insect bite hypersensitivity (IBH)

36 es in mice, suggesting that it could protect horses against EHV-1 infection.

37 orse (PH; Equus ferus przewalskii), the only horses alive today not successfully domesticated by huma

38 Thus horses, an animal far-removed from the primate lineage,

39 As low as 0.01% of horse and 0.02% of pork DNA were detectable in binary mi

40 necroptotic signaling in human cells; while horse and pig, but not rat, MLKL can reconstitute the mo

41 ations observed in the crystal structures of horse and rat MLKL pseudokinase domains.

42 ex phenotypic traits in the small-sized Jeju horse and the novel SNPs identified will aid in designin

43 New work from the Red-Horse and Woo labs (Das et al., 2019) shows that collate

44 logy showed myofiber degeneration in 3 HERDA horses and 1 control.

45 V-2 infection for multiple species including horses and camels.

46 cross sparsely vegetated habitats, including horses and deer, evolved the severe reduction or complet

47 , we investigate the role of IL-31 in IBH of horses and developed a therapeutic vaccine against equin

48 V affects draft, thoroughbred, and companion horses and donkeys in Africa, Asia, and Europe.

49 during routine clinical work from 82 healthy horses and from 10 horses with a diagnosis of PAF.

50 r from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical

51 ding is the most fundamental use of domestic horses and has had a huge influence on the development o

52 paramyxovirus that causes deadly illness in horses and humans.

53 he Americas and that is capable of infecting horses and humans.

54 revealed an association between sEA-affected horses and IgE antibodies specific for proteins derived

55 owing intra-articular fracture in humans and horses and in human late-stage osteoarthritis; however,

56 es the major route of cortisol metabolism in horses and is up-regulated in adipose tissue in obesity

57 prior generations, proteins were taken from horses and other animals to make glues.

58 n persist and potentially infect or colonize horses and other animals.

59 BH and other eosinophil-mediated diseases in horses and other species including humans.

60 trition developed during my experiences with horses and then Angus cattle and entry into an animal sc

61 to previous untreated IBH season of the same horses and to placebo-treated horses in the same year.

62 Infected WBCs can also function as 'Trojan horses' and carry viruses into immune-sheltered spaces,

63 also obtained with heat-inactivated pus (24 horses) and blood (23 horses) spotted onto Whatman FTA c

64 world than concrete things (like spoons and horses) and happenings and acts (like running and jumpin

65 ween the two periods for both large (cattle, horse, and camel) and small livestock (sheep and goat).

66 and WNT pathways, we derived PSCs from mice, horses, and humans (designated as XPSCs) that are permis

67 Three recent case studies of cave bears, horses, and maize provide examples of the ways that pale

68 It also afflicts animals, including dogs, horses, and sheep.

69 s of GDF11/8 decline with age in mice, rats, horses, and sheep.

70 Arteriviridae and pose major threats for the horse- and swine-breeding industries worldwide.

71 acterium radiobacter K84 secretes the Trojan Horse antibiotic agrocin 84 that is selectively transpor

72 en received a conditioning regimen including horse antithymocyte globulin and aCD40/Bela.

73 actin biosynthesis inhibitors and the Trojan horse approach adopted to impair iron metabolism in myco

74 Herein we described a Trojan horse approach to therapeutic evasion of P-gp based on a

75 This study presents a "Trojan-Horse" approach to combating these tumors by using a rec

76 The findings in this group of horses are consistent with left sided demyelination and

77 is of ECG recordings of healthy Thoroughbred horses are highly dependent on the duration of analysed

78 of the disease in humans vs dogs, cats, and horses are most often caused by similar, but sometimes s

79 Most domestic horses are non-dun, a more intensely pigmented phenotype

80 Horses are often suffering from an IgE-mediated allergic

81 Horses are one of the few species, beside humans, in whi

82 We therefore suggest the horse as an alternative to rodent models to study mechan

83 ectricity overtook steam and trains overtook horses as a means of transportation, both around the yea

84 sed as a viral vector for the vaccination of horses as well as, potentially, for the vaccination of o

85 o reanalyze ancient DNA data associated with horse base coat colors.

86 All infected horses became viremic after 1 or 2 wk and viremia could

87 , we sequenced and compared the genome of 41 horses belonging to 6 breeds.

88 Such "Trojan horse" bispecific antibodies have potential as broad ant

89 th in human serum, human plasma, or sheep or horse blood.

90 toral groups in Inner Asia describe mounted, horse-borne herders sweeping across the Eurasian Steppes

91 e to MLS(B) in R. equi isolates from soil of horse-breeding farms.

92 ate northern European haplotypes, all modern horse breeds clustered together in a roughly 700-year-ol

93 h-density SNP chip for studying other native horse breeds.

94 and the relationship of the Arabian to other horse breeds.

95 ory markers were not detectable in protected horses but quickly increased in control/Ab4 horses durin

96 valid fast alternative measure of stress in horses, but the initial 'startle' response must be consi

97 e the first Y chromosome genealogy of modern horses by screening 1.46 Mb of the male-specific region

98 Furthermore, the horse can serve as a valuable model for the study of com

99 /g protein), followed by cattle, pig, sheep, horse, cat and deer: >75% was conjugated.

100 EAV preferentially infects subpopulations of horse CD14(+) monocytes expressing EqCXCL16 and that inf

101 sculi, and the bark-associated microbiota of horse chestnut (Aesculus hippocastanum) trees.

102 es from underutilized and cheap sources viz: Horse chestnut (HS), Water chestnut (WS) and Lotus stem

103 arch-based nanoparticles from three sources: horse chestnut (HSC), water chestnut (WSC) and lotus ste

104 d that the average particle size diameter of Horse chestnut starch nanoparticles (HSP), Water chestnu

105 Buds of horse-chestnut trees are covered with a viscous fluid, w

106 whisky brands: Red Label, Black Label, White Horse, Chivas Regal (12years), Ballantine's Finest, Old

107 te Bronze Age, ca. 1200 BCE - at which point horses come to dominate ritual assemblages, play a key r

108 s were also differentially expressed in Jeju horse compared to Thoroughbred horse.

109 bre content was substantially higher in Jeju horse compared to Thoroughbred horse.

110 brils with abnormal orientation in all HERDA horses compared to mild abnormalities in 2 controls.

111 ropositivity was significantly higher in IBH horses compared with controls for 25 r-allergens.

112 rgets of HIV-1 infection acting as a "Trojan horse," concealing the virus from the innate immune syst

113 Previously noninfected horses (control/Ab4) displayed clinical signs, shed larg

114 ulations and that the origins of traditional horse dairy products in eastern Eurasia are closely tied

115 st possible hacking attacks including Trojan horse, detector blinding, phase randomisation and photon

116 Upon vaccination, all horses developed reversible anti-eIL-5 auto-antibody tit

117 BMNC cultured in autologous SF or ISF (n = 8 horses) developed into macrophage-rich cultures with phe

118 tes, macrophages, and plasma cells with some horses displaying subclinical signs of hepatitis.

119 fication (RPA) for the detection of pork and horse DNA were established.

120 Horse domestication revolutionized warfare and accelerat

121 tion and have considerably changed models of horse domestication.

122 a semi-crossover design to follow vaccinated horses during a second treatment season.

123 horses but quickly increased in control/Ab4 horses during the first week after infection.

124 nocytes have also been implicated as "Trojan horses" during viral infections, carrying infectious vir

125 domesticated by humans, and herded, domestic horse (E. f. caballus) living in adjacent natural grassl

126 trated that such vesicles can act as "Trojan horses", enabling the occlusion of non-functional silica

127 constitute a perplexing group of Pleistocene horses endemic to North America.

128 ans, to have maintained a highly specialized horse-facilitated form of mobile pastoralism.

129 rval: 0.41, 0.89; P for trend < 0.01) and to horse farming (>/=20 years: hazard ratio = 0.64, 95% con

130 sociation between lung cancer and cattle and horse farming.

131 alysis of paleogenomic data from 278 ancient horses finds that this animal - crucially important to m

132 or 2 wk and viremia could be detected in two horses for several weeks followed by a delayed seroconve

133 We tested twenty-six horses for their ability to detour around symmetric and

134 Here we studied 378 Arabian horses from 12 countries using equine single nucleotide

135 cific region of the Y chromosome (MSY) in 52 horses from 21 breeds.

136 roximately 1.8 million SNP genotypes for 485 horses from 32 distinct breeds.

137 ic variation and complex ancestry in Arabian horses from the Middle East region.

138 storic controversy over the parentage of the horse 'Galopin', born in 1872.

139 n in recombination rates across the domestic horse genome.

140 ormation confirms the distinctiveness of the horse genomovar and indicates the presence of potentiall

141 e expression of mouse, rat, chimpanzee, dog, horse, goat, sheep, and human Mxra8 enables alphavirus i

142 and wild mammals, including camels, cattle, horses, goats, sheep, cats, rabbits, and pangolins, were

143 The Oriental horse group consisted of two major subclades: the Origin

144 Severely asthmatic horses (6 horses/group) were treated with fluticasone, salmeterol,

145 transportation and transforming warfare, the horse had an impact on human history with no equivalent

146 Protected horses had EHV-1-specific IgG4/7 antibodies prior to cha

147 emely low Y chromosome sequence diversity in horses has prevented the reconstruction of stallion gene

148 (e.g. ambling or pacing), so-called 'gaited' horses, have been highly valued by humans, especially fo

149 such as dogs, pigs, sheep, goats, cattle and horses, have been substantially altered during their ada

150 (weighing 1/1000th of a human heart) to the horse heart (10x heavier than the human heart).

151 ous catalyst for the efficient hydrolysis of horse heart myoglobin (HHM) in low buffer concentrations

152 he in cyto anti-HIV-1 activity of the Trojan horse heterodimers.

153 In horses, high-starch diets alter the hindgut microbiota.

154 up-regulated in adipose tissue in obesity in horses, humans and mice.

155 h viruses are associated with CNS disease in horses, humans, and mouse infection models.

156 Horses immunized with nanoparticles harboring surface gl

157 duction of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting w

158 l, our data support an origin of the Arabian horse in the Middle East, no evidence for reduced global

159 ic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with

160 on of the same horses and to placebo-treated horses in the same year.

161 Horses in their second vaccination year showed a more pr

162 e most directly related to ongoing growth of horses independent of muscle group, and training further

163 The Jeju horse, indigenous to the Jeju Island in Korea may have o

164 Horses infected with Ab4DeltaORF2 had reduced fever and

165 ins and ions) which act as a kind of 'Trojan-horse' internalization by cells.

166 The strategy was to herd horses into a pool containing electric eels, provoking t

167 admixture analyses showed that, though Jeju horse is genetically the closest to the Mongolian breeds

168 Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect

169 re, it is a zoonotic agent, and contact with horses is a known risk factor.

170 compatible with RLN in clinically unaffected horses is consistent with previous studies that identifi

171 Here we show that pigment dilution in Dun horses is due to radially asymmetric deposition of pigme

172 Characterization of a subset of horse isolates by multilocus sequence analysis (MLSA) an

173 08 Lancefield group C (n = 96) or L (n = 12) horse isolates recovered in the United States and in thr

174 mechanism of enhanced efficacy was a Trojan horse-like import of RBT, but not rifampin, through fhuE

175 and cultural origins of the modern domestic horse lineage remaining unknown.

176 he Original Arabian lineage and the Turkoman horse lineage.

177 We find that two extinct horse lineages existed during early domestication, one a

178 e show that the influence of Persian-related horse lineages increased following the Islamic conquests

179 pproach to gene therapy of NPC1 using Trojan horse liposomes (THLs), wherein the plasmid DNA is encap

180 rotein from sardine (Sardina pilchardus) and horse mackerel (Trachurus mediterraneus) was hydrolysed

181 for regular ayu fish and other fish such as horse mackerel, sardine, salmon, mackerel, codfish, and

182 ications related to Human, Arctic fox, Yakut horse, Mammoth, Polar bear, and Minke whale were chosen.

183 andinavia) at this time implies that ambling horses may have spread from Iceland and maybe also the B

184 eef meat samples spiked with only 0.5% (w/w) horse meat (levels established by the European Commissio

185 derlies colonization of the host by a Trojan horse mechanism.

186 erium Bacillus nematocida B16 uses a "Trojan horse" mechanism to kill Caenorhabditis elegans.

187 the first long-read sequence assembly of the horse MHC class II region with rigorous manual gene anno

188 ificial Chromosome (BAC) clones spanning the horse MHC class II region.

189 nstruct a reliable reference sequence of the horse MHC region.

190 by circa 3000 BC and the later emergence of horse milking at circa 1200 BC, concurrent with the firs

191 Some horses moved slowly but were more accurate in choosing t

192 e estimated the de novo mutation rate of the horse MSY and showed that various modern horse Y chromos

193 Three groups of horses (n = 8 each) were infected intranasally with Ab4D

194 which demonstrates the potential of 'Trojan horse' nanoparticles to prevent atherosclerotic cardiova

195 mon seasonal pruritic allergic dermatitis of horses occurring upon insect bites.

196 ting the telomeric repeat served as a Trojan horse on the CRISPR-dCas9 system to guide synthetic tags

197 The Arabian horse, one of the world's oldest breeds of any domestica

198 nt of the mitochondrial DNA D-loop region of horse onto the surface of magnetic microcarriers.

199 pig parasitic nematode Ascaris suum and the horse parasite Parascaris univalens.

200 Best known as a horse pathogen, R. equi is commonly isolated from other

201 olving the representatives bat (Chiroptera), horse (Perissodactyla), cow (Cetartiodactyla), and dog (

202 vestigated fecal microbiomes of Przewalski's horse (PH; Equus ferus przewalskii), the only horses ali

203 mammals, including nonhuman primates, bats, horses, pigs, and rodents, but are not associated with d

204 y within the left DCA muscle in half of this horse population and the horses with the slowest nerve c

205 By tracing ancient horse population movements and inferring the spatiotempo

206 herpesvirus 1 (EHV-1) is a viral pathogen of horse populations worldwide spread by the respiratory ro

207 r the identification of four animal species: horse, pork, beef and sheep.

208 In contrast, 5/8 or 3/8 horses previously infected with Ab4DeltaORF2 or Ab4, res

209 Horse prions produced in vitro by protein misfolding cyc

210 arrier to EqPrP(C) conversion, the resulting horse prions unexpectedly failed to cause disease upon f

211 erve no evidence for dietary exploitation of horses prior to the late Bronze Age, ca. 1200 BCE - at w

212 g cyclic amplification of mouse prions using horse PrP(C) also failed to infect TgEq but retained tro

213 baseline whereas the SBR of the non-reactive horses quickly returned to baseline.

214 Horse radish peroxidase (HRP) is one of the most common

215 , bovine serum albumin, primary antibody and Horse Radish Peroxidase (HRP) tagged secondary antibody

216 Here, we show that wheat germ agglutinin horse radish peroxidase (WGA-HRP) chemically conjugated

217 carried out using isoeugenol polymerised by horse radish peroxidase in aqueous solution.

218 by the modified tips from tryptic digests of horse radish peroxidase, chicken avidin, and human immun

219 solved fluorescence, Alexa-fluorophores, and horse radish peroxidase-based bead assays, enabling mult

220 Piperazine exhibits high selectivity 1:400 horse radish peroxidase/bovine serum albumin, sensitivit

221 odies, which then capture streptavidin-poly [horse radish peroxidase] (Poly-HRP).

222 For horses reactive to clipping, the initial reduction in SB

223 related variables in a cohort of 185 healthy horses reared in similar conditions during a period of e

224 could be maintained over two seasons and the horses remained protected against disease symptoms.

225 erlying the emergence of the modern domestic horse remains contentious.

226 Here, we examine historic horse remains for the DMRT3 SNP, tracking the origin of

227 mite, insect and mould allergens in dogs and horses, respectively.

228 ttlers selected for this comfortable mode of horse riding soon after arrival.

229 0 BC, concurrent with the first evidence for horse riding.

230 other primates) has now expanded to include horses, rodents, bats, colobus monkeys, cows, and, most

231 ly linked to their linguistic labels (spoon, horse, run, jump).

232 ich has traditionally been ubiquitous to the horse's environment in the form of riding surfaces and r

233 are a fundamental component of the athletic horse's respiratory system: as the sole abductors of the

234 inst diphtheria has been based on polyclonal horse sera directed against DT (diphtheria antitoxin; DA

235 The remaining horses shifted from a faster, directionally consistent r

236 ormation at approximately 12 Ma, generating 'horse-shoe' slab geometries.

237 n other mammals, the corresponding region in horse shows extraordinary copy number variation and diff

238 nsmitted by biting midges and causes African horse sickness in equids, with mortality reaching up to

239 African horse sickness virus (AHSV) is a lethal arbovirus of equ

240 African horse sickness virus (AHSV), an orbivirus in the Reoviri

241 African horse sickness virus is transmitted by biting midges and

242 livestock, including Bluetongue, and African Horse Sickness.

243 detected in cells expressing the equivalent horse SOD1 variant.

244 The domestication of the horse some 5,500 years ago followed those of dogs, sheep

245 nimal species, supporting the existence of a horse specific genomovar.

246 ar and indicates the presence of potentially horse-specific virulence factors.

247 Here, we report NECD behavior from horse spleen ferritin, a approximately 490 kDa protein c

248 We observed a similar metallocluster in horse spleen L-ferritin, indicating that it represents a

249 These results indicate that horses spontaneously discriminate between photographs of

250 at-inactivated pus (24 horses) and blood (23 horses) spotted onto Whatman FTA cards.

251 Such a Trojan horse strategy can also extend activity of specific Gram

252 Horses suffer from pruritic skin lesions, caused by type

253 ilar perturbations in vitro, thereby explain horses' susceptibility to certain neurodegenerative dise

254 suggested a closer relationship to caballine horses than to Asiatic asses.

255 p. zooepidemicus is an important pathogen in horses that causes severe diseases such as pneumonia and

256 ts were obtained among blood samples from 20 horses that did not exhibit clinical signs of EZL.

257 revalent degenerative disorder of the RLn in horses that predominantly affects the left side.

258 In horses, the autosomal recessive condition known as Glyco

259 Applied to horses, these technologies have provided unprecedented l

260 ding genes in cow and dog and over 13 000 in horse to date.

261 porter, and which acts as a molecular Trojan horse to deliver the enzyme to brain.

262 in themselves, but also an important Trojan horse to drive improved cancer control and care.

263 To model susceptibility of horses to prions, we produced transgenic (Tg) mice expre

264 eration stem cells are being used as 'Trojan horses' to improve the delivery of drugs and oncolytic v

265 are apparently resistant (rabbits, dogs, and horses) to the same agent.

266 of the rhino's ubiquitous near relative, the horse, to be glued together with a bespoke matrix of reg

267 gens on a cohort of IBH-affected and control horses using an allergen microarray.

268 (Electrophorus electricus) by "fishing with horses" [von Humboldt A (1807) Ann Phys 25:34-43].

269 Among domestic horses we confirmed the predominance of a young'crown ha

270 the recombination landscape in the domestic horse, we calculated population recombination rates and

271 ncy of the ambling allele in early Icelandic horses, we believe that Norse settlers selected for this

272 ooded and the other in Turkoman/Thoroughbred horses, we uncovered a third haplogroup containing Iberi

273 ng equine behaviour and cognition can inform horse welfare and management.

274 Nine months after the initial infection, all horses were challenged intranasally with Ab4.

275 At 144 h, horses were euthanatized, joints were evaluated, and syn

276 Following establishment of infection, the horses were euthanized and the endometrial surfaces were

277 researchers to rethink the process by which horses were first domesticated and then diversified into

278 Horses were i.v. injected with NPHV containing plasma.

279 Thirty Icelandic horses were immunized with 300 mug of eIL-5-CuMV(TT) wit

280 Importantly, after a primary NPHV infection, horses were protected against rechallenge with the homol

281 Eighteen IBH-affected horses were recruited and immunized with 300 mug of eIL-

282 Five HERDA and 5 control horses were studied.

283 opods) and an accidental host, a symptomatic horse, were also tested with similar improvement in dete

284 highly conserved across mammals, except the horse, which naturally carries the (dog mutant) K40 resi

285 e community of bacteria compared to domestic horses, which is likely partly explained by different pl

286 ask may reflect distinct cognitive styles in horses, which vary among individuals, and could be linke

287 to attack by pressing themselves against the horses while discharging.

288 local harsh environment have conferred Jeju horse with unique traits such as small-sized body, stock

289 ical work from 82 healthy horses and from 10 horses with a diagnosis of PAF.

290 lergens could diagnose > 90% of IBH-affected horses with a specificity of > 95%.

291 ied fine-scaled Y-chromosomal haplotyping in horses with biallelic markers and demonstrate the potent

292 rastructural findings of myodural bridges in horses with hereditary equine regional dermal asthenia (

293 re taken, along with blood from a further 20 horses with no cutaneous EZL lesions.

294 rent laryngeal nerves (RLn) was conducted in horses with normal laryngeal function.

295 This allows identification of horses with PAF from sinus-rhythm ECGs with high accurac

296 Twenty-nine horses with signs of EZL from different climatic regions

297 Therefore, horses with the ability to perform comfortable gaits (e.

298 cle in half of this horse population and the horses with the slowest nerve conduction velocities.

299 the horse MSY and showed that various modern horse Y chromosome lineages split much later than the do

300 Twenty-four Quarter Horse yearlings were randomly assigned to either submaxi