ライフサイエンスコーパス: host immunity

1 cells but also affect the gut microbiota and host immunity.

2 ey role in various cell processes related to host immunity.

3 ens secrete numerous effectors to manipulate host immunity.

4 hanism by which bacterial pathogens modulate host immunity.

5 al egress and allows infected cells to evade host immunity.

6 es its antileishmanial activity by promoting host immunity.

7 than EsxN cause increased susceptibility to host immunity.

8 es alter bacterial gene expression to affect host immunity.

9 mmalian cytokines and chemokines to suppress host immunity.

10 tide, which in turn blocks PLCPs to modulate host immunity.

11 variety of mechanisms, including effects on host immunity.

12 expression and contributes to inhibition of host immunity.

13 s virus (LCMV), and schistosomiasis to evade host immunity.

14 hey live in the host's bloodstream and alter host immunity.

15 ty to withstand numerous stresses imposed by host immunity.

16 GAS) and an antigenically variable target of host immunity.

17 ack this machinery, thereby interfering with host immunity.

18 lf by host immune receptors and activate non-host immunity.

19 their diversity, and how they interact with host immunity.

20 cells affects their function and influences host immunity.

21 may improve the ability of a virus to evade host immunity.

22 erstand how this virus replicates and evades host immunity.

23 tes are predicted to circumvent and overcome host immunity.

24 tly inhibit the growth of GBS independent of host immunity.

25 nologists discover targets and mechanisms of host immunity.

26 tuning NOD2 signalling to promote protective host immunity.

27 rns that stimulate protective or detrimental host immunity.

28 tside (apoplastic) plant cells to neutralize host immunity.

29 classical apoptosis that can shape long-term host immunity.

30 at this ascovirus protein helps evade innate host immunity.

31 ease their infectious potential and suppress host immunity.

32 or preventing perturbations in this facet of host immunity.

33 arriage and virulence traits, and evasion of host immunity.

34 mechanism used by an arbovirus to manipulate host immunity.

35 luence their intracellular survival or evade host immunity.

36 as evolved sophisticated mechanisms to evade host immunity.

37 esting a broader role beyond deregulation of host immunity.

38 both positive and negative consequences for host immunity.

39 and promoting survival under high levels of host immunity.

40 defined microbial virulence as a function of host immunity.

41 on (IFN)-alpha-based treatment is related to host immunity.

42 , translation, ligand-substrate binding, and host immunity.

43 evolutionary process in their co-option for host immunity.

44 h an eventual outcome that mainly depends on host immunity.

45 ent and is a promising approach to stimulate host immunity.

46 ent natural infection in priming or boosting host immunity.

47 ope, raising the possibility of selection by host immunity.

48 perturbations to the commensal microbiota or host immunity.

49 obial diseases in addition to its effects on host immunity.

50 ans by which Gram-negative bacteria modulate host immunity.

51 re a strategy deployed by pathogens to evade host immunity.

52 s linked insights into its pathogenicity and host immunity.

53 overexpression sensitizes M. tuberculosis to host immunity.

54 vergent and tissue-specific roles of IRF8 in host immunity.

55 re tightly linked to its ability to modulate host immunity.

56 ppressive cytokine IL-10 and MMTV evasion of host immunity.

57 hether TNF inhibitors in clinical use reduce host immunity.

58 ral commensal might help cancer cells escape host immunity.

59 rm multiple protective functions for evading host immunity.

60 mpact this may have on treatment success and host immunity.

61 prominence due to their ability to modulate host immunity.

62 ting fungal-virulence traits, and modulating host immunity.

63 thymocytes in mice, thus likely suppressing host immunity.

64 eflective of molecular processes rather than host immunity.

65 a novel means by which bacteriophages thwart host immunity.

66 rb multiple macrophage functions for evading host immunity.

67 a and developed multiple mechanisms to evade host immunity.

68 t bacteria is part of this symbiosis shaping host immunity.

69 of the bacterial phages in the modulation of host immunity.

70 f CD4 T cells, with a progressive decline of host immunity.

71 h its target organs, accordingly evading the host immunity.

72 oping pathogenic mechanisms of resistance to host immunity.

73 B lymphocytes play a central role in host immunity.

74 and the interaction of related pathogens via host immunity.

75 y of Plasmodium and other parasites to evade host immunity.

76 l death induced by TaLOL2, thus compromising host immunity.

77 he mechanisms viruses have evolved to escape host immunity.

78 sites, implying that it is largely driven by host immunity.

79 tes, which employ RXLR effectors to suppress host immunity, a carbohydrate-binding module family 1 (C

80 iologically pivotal role for SIX proteins in host immunity, a human SIX1 transgene suppressed inflamm

81 c evolution allowing mutant viruses to evade host immunity acquired to previous virus strains.

82 ng-lived IgM plasma cells provide protective host immunity against a lethal virus challenge.

83 Host immunity against bacteria typically involves antibo

84 members IL-12p70 and IL-23 are important for host immunity against Candida spp.

85 the critical role of 4-1BB costimulation in host immunity against EBV infection.

86 d parasitic infections; however, its role in host immunity against fungal pathogens, including the ma

87 Helminth infections inhibit host immunity against microbial pathogens, which has lar

88 hether the RLR family has broader effects on host immunity against other pathogen families remains to

89 ytosis pathway is intimately associated with host immunity against pathogens.

90 dress the specific role of CD20 depletion in host immunity against Pneumocystis, we examined a murine

91 host-directed therapy aimed at manipulating host immunity against TB.

92 rotein for RIG-I like receptor in regulating host immunity against the live attenuated West Nile viru

93 rotein for RIG-I-like receptor in regulating host immunity against the NS4B-P38G vaccine.

94 h may represent an early warning to activate host immunity against the pathogen.

95 Restoring host immunity against the virus is the cornerstone of tr

96 ificantly improve our knowledge of effective host immunity and accelerate the HIV cure agenda.

97 ng our understanding of the roles of IRF8 in host immunity and autoimmunity.

98 ommunities (the microbiota) is influenced by host immunity and can have a profound impact on host phy

99 um tuberculosis (Mtb) defends itself against host immunity and chemotherapy at several levels, includ

100 apacity for evolutionary adaptation to evade host immunity and develop drug resistance.

101 develop inside another insect by regulating host immunity and development via maternal factors injec

102 trategies that EBV uses to subvert and evade host immunity and discuss the implications for the devel

103 a number of effector molecules that inhibit host immunity and facilitate pathogen transmission.

104 LR crosstalk pathways in ways that undermine host immunity and favor their persistence.

105 Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact

106 bial peptides and metabolites that influence host immunity and immune response to allergens.

107 tal evidence for parasite down-regulation of host immunity and immunopathology, in allergy and other

108 erived metabolites in the intestine regulate host immunity and impact disease pathophysiology in vari

109 s for the gut mycobiota in the regulation of host immunity and in the development and progression of

110 and highlight the importance of considering host immunity and infection history for vaccine design.

111 suggests the commensal microbiome regulates host immunity and influences brain function; findings th

112 Gut commensals profoundly affect host immunity and intestinal homeostasis, but the impact

113 TNF blockade compromises host immunity and may cause reactivation of latent infec

114 Helminthic infections modulate host immunity and may protect people in less-developed c

115 Helminthic infections modulate host immunity and may protect their hosts from developin

116 t microbiota, with a profound impact on both host immunity and metabolic potential.

117 obiome may play an important role in shaping host immunity and modifying the risk of respiratory infe

118 ish homodimer activity contributes to proper host immunity and organismal health.

119 Understanding how viruses subvert host immunity and persist is essential for developing st

120 gnaling, and features profound influences on host immunity and physiology, including the endocrine, m

121 Sir2 during growth in rice cells, triggering host immunity and preventing infection.

122 eds of effectors into plant cells to subvert host immunity and promote pathogenicity on their host pl

123 variety of cell surface proteins to disrupt host immunity and promote the viral replication cycle.

124 veals a previously undefined role of LGP2 in host immunity and provides a new strategy to improve the

125 k explores the role of central regulators of host immunity and stress resistance, employing qPCR and

126 ted to better understand how hormones impact host immunity and susceptibility factors important for H

127 elucidate the role of SP110b in controlling host immunity and susceptibility to tuberculosis (TB), a

128 al interface have broad, systemic effects on host immunity and the development of chronic inflammator

129 es that M. tuberculosis utilizes to modulate host immunity and thereby persist in host lungs.

130 leukin-22 (IL-22) plays an important role in host immunity and tissue homeostasis in infectious and i

131 ntersections between OM lipid regulation and host immunity and to provide working models for how bact

132 dynamics of MRSA persistence in the face of host immunity and typical antibiotic regimens, we develo

133 tion networks and how these networks control host immunity and viral infection remain to be elucidate

134 ants, however, the functions of autophagy in host immunity and viral pathogenesis are poorly understo

135 (SUMO) proteins regulate multiple aspects of host immunity and viral replication.

136 asitic diseases through metabolic effects on host immunity and/or the parasite.

137 antly associated with the level and stage of host immunity and/or were temporally restricted to devel

138 ow these structures enable bacteria to evade host immunity, and current and developing strategies for

139 ucial role in influencing the development of host immunity, and in turn the immune system also acts t

140 central regulators of pathogen recognition, host immunity, and inflammation with utmost importance i

141 mmunities, adhere tightly to surfaces, evade host immunity, and resist antibiotics.

142 y which EPEC colonizes the intestine, evades host immunity, and spreads from person to person.

143 It secretes molecules to dampen host immunity, and the recently identified adenosine is

144 anisms by which these microbes interact with host immunity, and their functional effects on the patho

145 Micronutrients are known to modulate host immunity, and there is limited literature on this a

146 sses including embryogenesis, wound healing, host immunity, and tumor suppression.

147 However, the mechanisms of host immunity are complex and often combinatorial.

148 Extrinsic factors such as diet and host immunity are insufficient to explain the constituen

149 r mechanisms that underlie symbiont-mediated host immunity are largely unknown.

150 functional mechanisms by which it regulates host immunity are only now beginning to be elucidated.

151 may be a viable model for HCV and implicate host immunity as a potential species-specific barrier to

152 asopharynx, biofilm formation and evasion of host immunity as previously demonstrated.

153 HpasRNA-targeted plant genes contributed to host immunity, as Arabidopsis gene knockout mutants disp

154 increasingly recognised for its influence on host immunity, as well as therapeutic responses to cance

155 zema formation, and highlight the microbiota-host immunity axis as a possible target for future thera

156 ges, which we illustrate by developing a new host immunity-based platform for detection of infections

157 and its usefulness as a target of protective host immunity blocking the transmission of B. burgdorfer

158 ion is consistent with intraseason waning of host immunity, but bias or residual confounding could ex

159 perceived by resistance proteins to trigger host immunity, but our understanding of the demographic

160 the synergy of both bacterial predation and host immunity, but that in vivo predation contributes si

161 One helps with host immunity, but the other can cause immunopathology.

162 We evaluated the impact of host immunity by comparing M. tuberculosis and human gen

163 We created variation in host immunity by experimentally inoculating wild-caught,

164 ell as an examination of viral adaptation to host immunity by Gag sequencing.

165 ritic cells (cDCs) play an essential role in host immunity by initiating adaptive T cell responses an

166 nfection models allow researchers to examine host immunity by investigating the timing, inoculum, rou

167 eal an unprecedented mechanism of modulating host immunity by modifying a key ubiquitination enzyme b

168 our results show that P. infestans subverts host immunity by repressing the AS of positive regulator

169 has emerged as an important regulator of the host immunity by the induction, functional modulation, o

170 counter defense, P. syringae pathovars evade host immunity by using BGAL1-resistant O-glycans or by p

171 oil-transmitted helminth infections, and yet host immunity can also influence the impact of warming o

172 nt transmission rates would suggest and that host immunity can extinguish subsequent infection foci.

173 Influenza A viruses evolve rapidly to escape host immunity, causing reinfection.

174 loss of F-MLV infectivity, independently of host immunity, challenging whether associations exist be

175 Host immunity controls the development of colorectal can

176 infect keratinocytes and successfully evade host immunity despite the fact that keratinocytes are we

177 eased aggregation, could be offset by better host immunity due to improved nutrition.

178 eractions of CDT with TLR2 and the impact on host immunity during CDI.

179 h the importance of alveolar macrophages for host immunity during early Streptococcus pneumoniae lung

180 mia after trauma is, in part, consequence of host immunity failure and may not be completely preventa

181 o-dodecanoyl) homoserine lactone to suppress host immunity for its own better survival; conversely, b

182 production plays a pivotal role in elevating host immunity for viral clearance and cancer immune surv

183 RNAs (Bc-sRNAs) into plant cells to silence host immunity genes.

184 This broad-spectrum modulation of host immunity has intended and unintended consequences,

185 esistance, the impact of BRAFi resistance on host immunity has not been explored.

186 olecular patterns that are recognized by the host immunity; however, little is known about whether an

187 tic resistance and bacterial defense against host immunity; however, there is little knowledge on how

188 transfer to the host roots causes a loss of host immunity (i.e. decreased HR and increased parasite

189 nce of adaptive T-cell and antibody-mediated host immunity.IMPORTANCE In this study, we constructed a

190 lination due to loss of protective antiviral host immunity.IMPORTANCE The current trend in CNS diseas

191 PS limits IFN-gamma production by modulating host immunity in a Toll-like receptor 4 (TLR4)-dependent

192 ence that beneficial microbes cooperate with host immunity in an effort to shut out pathogens.

193 ng pathogen clearance via the restoration of host immunity in an interferon regulatory factor 3-depen

194 The nervous system regulates host immunity in complex ways.

195 ing the interaction between cancer cells and host immunity in microgravity.

196 Restoring host immunity in order to improve outcomes and potential

197 with a role for these T cells in protective host immunity in TB.

198 The involvement of host immunity in the gut microbiota-mediated colonizatio

199 s exhibiting signatures typical for adaptive host immunity in the latter.

200 Yet, the role of host immunity in this process remains poorly understood.

201 use CD4(+) T cells are known contributors to host immunity, including cytokine production, help for C

202 Host immunity influences the impact of radiotherapy (RT)

203 se-causing T cells while keeping the overall host immunity intact.

204 extreme form of antigenic variation to evade host immunity, involving the switching of expressed vari

205 The ability of HPV to evade host immunity is a critical component of its ability to

206 Thus, it has become a truism that host immunity is a major driver and determinant of the a

207 avoidance of flagella-mediated activation of host immunity is advantageous for the wildtype bacteria.

208 population in sputum and reveal that reduced host immunity is associated with lower prevalence of CF-

209 complex combination of oxidants generated by host immunity is difficult to accurately recapitulate in

210 hrough the combined action of commensals and host immunity is far from inevitable.

211 s of the interplay between the cell wall and host immunity is fundamental to combatting Aspergillus d

212 entification of the full complement by which host immunity is inhibited.

213 nces where pathogen concentrations are high, host immunity is low, or exposure to small-diameter aero

214 A central enigma is that host immunity is necessary to control disease yet promot

215 rred at transplantation, but their impact on host immunity is unclear.

216 role of the protein's functional domains in host immunity is unknown.

217 accurately assessed the functional state of host immunity, lack dynamic range, and are more reflecti

218 The model comprises host immunity, M. tuberculosis metabolism, M. tuberculos

219 Host immunity may act on microbiome diversity through to

220 immune profile and environmental effects on host immunity may influence the risk of BV, as well as t

221 The study suggests that inherited host immunity may play an important role in MPM developm

222 ng drug-resistant pathogens, where improving host immunity may prove to be the ultimate resource.

223 stages of development coincide with altered host immunity mechanisms and amyloidosis in a murine mod

224 hogens secrete effector proteins to suppress host immunity, mediate nutrient uptake and subsequently

225 oids inject venoms into the host to modulate host immunity, metabolism and development.

226 The microbiome is a regulator of host immunity, metabolism, neurodevelopment, and behavio

227 Tennessee, United States, were surveyed for host immunity, microbiome and pathogen dynamics.

228 a complex interaction between host genetics, host immunity, microbiome, and environmental exposures.

229 therapeutic approaches, such as, to enhance host immunity, mitigate destructive inflammation, or cou

230 Host immunity often targets the motility of tissue-migra

231 We investigated the effects of host immunity on the efficacy of phage therapy for acute

232 hat incorporates the two opposing effects of host immunity on the virus population can explain this c

233 We conclude that suppression of host immunity or further viral adaptation may allow robu

234 This may occur through a host immunity pathway that involves intestinal secretory

235 of H. pylori to understand how they modulate host immunity, persist lifelong, and contribute to tumor

236 eloping febrile episodes and suggesting that host immunity plays a prominent role in mediating this p

237 bly, despite the increasing recognition that host immunity plays a role in microbial pathogenesis, th

238 on in response to changing oxygen levels and host immunity pressures.

239 Our results show that incomplete host immunity produced by low-level prior exposure can c

240 tition reveals that the selection imposed by host immunity promotes the persistence of these modules.

241 The triad of virus, vaccine, and host immunity provides a framework to examine contributi

242 alistic symbiosis between gut microbiota and host immunity raises the possibility that dysbiosis of t

243 ascended to prominence as key modulators of host immunity, raising the possibility that they could i

244 estinal disease, but the mechanisms by which host immunity regulates pathogen virulence are largely u

245 s by which Mycobacterium tuberculosis evades host immunity remain enigmatic.

246 t the mechanisms by which these TLRs mediate host immunity remain incompletely understood.

247 VID-19 pandemic remains a global threat, and host immunity remains the main mechanism of protection a

248 ATT) is toxic, lengthy, and severely impairs host immunity, resulting in posttreatment vulnerability

249 However, it remains puzzling how host immunity selects for antigenic diversity at the lev

250 Host immunity shapes intestinal microbiota composition,

251 To bypass host immunity, SHIV-A was rapidly passaged in naive maca

252 Alterations in host immunity, stress, resident microbiota, and other fa

253 role(s) in the regulation and development of host immunity, subsequent studies revealed important rol

254 -life changes may have long-range effects on host immunity that manifest later in time as disease pat

255 ected in the gastrointestinal tract, but the host immunity that regulates chlamydial colonization in

256 candidiasis, as well as in the modulation of host immunity through augmentation of leukocyte infiltra

257 Immunomodulatory commensal bacteria modify host immunity through delivery of regulatory microbial-d

258 s cancers grow within host tissues and evade host immunity through immune-editing and immunosuppressi

259 nd contributes to pathogenesis by modulating host immunity through interactions with the human chemok

260 ells (ILC1) serve an essential early role in host immunity through rapid production of interferon (IF

261 ants need to evade or suppress detection and host immunity to access nutrients.

262 el approaches to target viral life cycle and host immunity to achieve a functional cure.

263 ia and represent an important determinant of host immunity to bacterial pathogens.

264 In this study, we aimed to characterize host immunity to CF5 and M68, two genetically well-defin

265 ever, the specific roles of IL-1 elements in host immunity to cutaneous viral infection remain elusiv

266 ltiple chaperones could work in concert with host immunity to disable Mtb.

267 Commensal microbes profoundly impact host immunity to enteric viral infections(1).

268 ion for further understanding how HCV evades host immunity to establish persistence.

269 Much less is understood about effective host immunity to fungi than is generally known about imm

270 an understanding of their functional role in host immunity to infection is just emerging.

271 igated the role of Semaphorin 3E (Sema3E) in host immunity to Leishmania major infection in mice.

272 We identify multiple compounds that modulate host immunity to limit mycobacterial disease, including

273 rther investigate the effect of vitamin D on host immunity to M. tuberculosis in the context of the g

274 efore, in this study we investigated whether host immunity to M. tuberculosis infection would be modu

275 PR-Cas pathway in prokaryotes for developing host immunity to mobile genetic elements.

276 evealed that Th17 cells are also critical in host immunity to mucocutaneous candida infections and St

277 d platelet activation compromises protective host immunity to mycobacterial infection.

278 ions: These data provide novel insights into host immunity to Mycobacterium tuberculosis-related cavi

279 sicaceae, and cause infections that suppress host immunity to other pathogens.

280 Host immunity to parasitic nematodes requires the genera

281 le of the commensal microbiota in regulating host immunity to pathogens, it is not surprising that mi

282 killer (NK) cells are critical mediators of host immunity to pathogens.

283 rophage migration inhibitory factor regulate host immunity to promote parasite persistence.

284 nd produce immune complexes that can enhance host immunity to the virus.

285 mostly focusing on pathogenetic aspects and host immunity to the virus.

286 ), suggesting that a deeper understanding of host immunity to these viruses may lead to enhanced stra

287 echanisms of immunotherapy that activate the host immunity to treat cancers, unconventional immune-re

288 onic inflammatory conditions but compromises host immunity to tuberculosis.

289 cient mice exhibited protective T cell-based host immunity to tumors in association with a decline in

290 as both positive and negative regulators of host immunity to virus infection.

291 bition of PD-L1 and PD-1 binding can restore host immunity towards tumor killing, and many new drugs

292 al pathogen Legionella pneumophila modulates host immunity using effectors translocated by its Dot/Ic

293 ting to investigate whether CLEC18 modulates host immunity via binding to glycolipids, and are also i

294 iated with protective CD8+- and CD4+-related host immunity via the glucocorticoid receptor.

295 To study the role of viral genotype and host immunity, we characterized oral HSV-1 shedding rate

296 attenuation and the potential modulation of host immunity, we conducted transcriptional profiling of

297 ta to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilita

298 We noted an induction of host immunity when experimentally treating bacterially d

299 ctions (phagocytic synapses) that impinge on host immunity, with a main emphasis on tolerance and can

300 nts were more vulnerable to be eliminated by host immunity, without the accumulation of immunity-rela