ライフサイエンスコーパス: hot

1 focuses on the characterization of the Mcl-1 hot-spots which are related to four hydrophobic pockets

2 cluding seasons with extreme drought (2012), hot and dry conditions (2013 and 2015) and extreme preci

3 Across the flora of Java, we identify 26 "hot clades" with plant species providing a high probabil

4 count rates loaded with a lung insert and 6 hot spheres with a 12:1 target-to-background ratio of (1

5 0.43; - 0.21], p < 0.001, Cohen's d = 0.86), hot flush frequency (- 1.12 [- 1.81; - 0.43], p = 0.02,

6 lar populations in the member galaxies and a hot, metal-rich gas composing the intracluster medium.

7 1 eV, suggesting the carbon also serves as a hot-spot for the dissociation of water molecules in wate

8 , extracellular vesicles (EVs) have become a hot topic.

9 ic cell by actively tuning the gap between a hot-emitter (T(E) ~ 880 K) and the cold photodetector (T

10 e institutions, two in a region considered a hot spot (area of high prevalence) for COVID-19.

11 by weak van der Waals forces are currently a hot research topic.

12 energy, color and intensity, emitted from a hot object at thermal equilibrium.

13 from a Thermoproteales host isolated from a hot spring in Yellowstone National Park (USA).

14 ght, at 13.5 nm wavelength, is produced in a hot and dense laser-driven tin plasma.

15 ery simulations of similar complexities in a hot and in a normothermic operating room.

16 arid Middle East, the ability to thrive in a hot, dry environment.

17 n approach to converting the PDAC TME into a hot TME, thereby empowering immunotherapeutic strategies

18 The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose ca

19 ble and user-friendly sensing platforms is a hot topic in the field of analytical chemistry.

20 te along two pathways: After population of a hot (3) MLCT state, from the initially excited (1) MLCT

21 rimetric breath sensing system composed of a hot-film senor in the center and two calorimetric sensor

22 e recovered following up to five cycles of a hot-press reprocessing technique (1 h/100 degrees C).

23 nthesis of phosphorene nanosheets is still a hot topic, including the shaping of its two-dimensional

24 ions, transport the suspended cells toward a hot-spot site of the chip, for rapid concentrating and p

25 The iDES were manufactured using a hot melt extrusion process with accurate irinotecan drug

26 ned within a titanium device equipped with a hot and cold jacket connected to two water baths.

27 haeota, a symbiotic archaean found in acidic hot springs of Yellowstone National Park, USA.

28 , we explored virus diversity in the acidic, hot spring Umi Jigoku in Beppu, Japan.

29 antom study, the diameter of the most active hot spot was reduced by 24% in the dual gated images com

30 ce-enhanced Raman spectroscopy (SERS) active hot spots associated with gold nanoparticle oligomers is

31 gies increases in the vicinity of the active hot and cold walls for all cases considered here.

32 ntionally druggable, but reaching additional hot spots enables improved pharmaceutical properties.

33 Although hot air (HA) is a conventional roasting medium for coffe

34 reas the regions in the vicinity of cold and hot walls, in particular in the boundary layers, are fou

35 emperature, with a greater effect in dry and hot conditions, and decline toward wet and cool conditio

36 Far infrared radiation (FIR) and hot air drying (HA) were applied to unpolished and polis

37 ool semi-arid Rwanda, hot subhumid Ghana and hot semi-arid Mali and Benin using an ensemble of 25 mai

38 gh spawning abundance, heavy fall rains, and hot, dry summers may have contributed to the recent popu

39 as (GHG) fluxes, also known as hot spots and hot moments.

40 cantly during washing/cutting, squeezing and hot pack canning (>55% loss).

41 oparticle-bacterial cellulose substrate and "hot spot"-normalized surface-enhanced Raman scattering (

42 Also conserved to varying extents are hot spots for interactions with hydrophobic ligands, lip

43 However, only the minority of tumors are hot, and a limited proportion of patients benefit from i

44 dicating that these sequence elements act as hot spots for the formation of CNVs.

45 stern Russia, Europe, and the WUS emerged as hot spots for snow droughts, experiencing ~2, 16, and 28

46 f greenhouse gas (GHG) fluxes, also known as hot spots and hot moments.

47 e River, further confirming these regions as hot spots for biodiversity in Europe, where successful l

48 ocesses and fabrication technologies such as hot forging, machining and casting.

49 technologies have established themselves as hot research areas, where the target recognition, respon

50 However, only a few cells work as 'hot spots' on the sorption of Pb NPs.

51 experimentally interrogate cancer-associated hot-spot mutations localizing within the endogenous huma

52 stone modifications and DNA accessibility at hot spots.

53 PRDM9 function together to open chromatin at hot spots and provide access for the DNA double-strand b

54 ry that noble-transition alloys can excel at hot-carrier generation reveals a new material platform f

55 Initiation of chemical reactions occurs at hot spots due to energy localization at sites of porosit

56 For eight of nine species tested at hot and cold marginal temperatures, we observed substant

57 anets found in and near the typically barren hot-Neptune 'desert'(1,2) (a region in mass-radius space

58 ctic tundra-glacier region (ArcTG) have been hot subjects under extensive investigations.

59 fill with water at 80 degrees C (fire-bent + hot water), were trialed in triplicate.

60 microsecond timescales with dynamics beyond hot Brownian motion and superheated water states persist

61 binding and whether other nucleosome binding hot-spots exist remain unclear.

62 However, metals that offer both hot-carrier generation in the near-infrared and sufficie

63 -up influences such as stress, training both hot and cool EF skills, and adding a reflective, metacog

64 e Magadi, a hypersaline alkaline lake fed by hot springs in the semi-arid southern Kenya Rift Valley.

65 were melt-blended and formed into a film by hot press forming.

66 of its lignin and hemicellulose, followed by hot-pressing.

67 o 1.2-kilometer-deep and up to 120 degrees C hot sediments in the Nankai Trough subduction zone.

68 ctrode-temperature modulation, which we call hot square wave voltammetry (Hot-SWV).

69 iensis from the Rhynie and Windyfield cherts hot spring complex in Scotland, reveals details of head

70 s observed latitudinal gradients and coastal hot spots of [Formula: see text]O flux and reveals a vig

71 However, past and future changes in compound hot extremes as well as their underlying drivers and soc

72 ared to individual hot days/nights, compound hot extremes that combine daytime and nighttime heat are

73 degrees C decade(-1)) of summertime compound hot extremes arise primarily from summer-mean warming.

74 d growth in intensity of summertime compound hot extremes by 2100 (relative to 2012), given uncurbed

75 d-of-century population exposure to compound hot extremes is projected to be four to eight times the

76 The devices were created with controllable hot and cold regions.

77 However, in the conventional hot-wall CVD system, CVD-derived graphene films suffer f

78 cal use of cannabis derivatives is a current hot topic and it is unknown whether phytocannabinoids ma

79 K CRISPR cells we found that one deleterious hot-spot mutation increased chromosome instability in a

80 Here, we create a three-dimensional hot electron gas through two-photon photoemission from a

81 PepNats derived from the iNOS DINNN hot loop and the AGRP RFF hot spot sequence yielded nove

82 promellose processing include spray draying, hot-melt extrusion, 3D printing, and electrospinning.

83 ibe electron-phonon interactions which drive hot carrier cooling and nonradiative recombination ( k(n

84 eutical technologies including spray drying, hot-melt extrusion, 3D printing, nanoprecipitation and e

85 ing processes, using TG/DTG/DTA, TG-MS, DSC, hot stage microscopy and DRX analysis.

86 ened historical anthropogenic warming during hot days, with particularly strong effects over South As

87 nt-resistance mutations occur in the dynamic hot spots recently identified to be responsible for imat

88 nanoscale deformations can form 'electrical hot spots' in the sensing channel which reduce the charg

89 on identified as potential electrocatalytic "hot spots".

90 tein-ligand interactions in three energetic "hot spots" identified by fragment screening.

91 Above-equilibrium "hot"-carrier generation in metals is a promising route t

92 ing the degradation machinery at specific ER hot spots to enable efficient protein quality control.

93 affects climate conditions - and especially hot extremes - in various regions across the globe.

94 a 20-fold increase in the number of ~0.8 eV hot holes, compared to Au, and a threefold increase in t

95 t field ionization and the outward expanding hot electron current as the cause of the radial expansio

96 carrier PSCs as it is capable of extracting hot carriers generated throughout the early time scales

97 tant factor mediating responses to extremely hot or dry weeks; residents and short-distance migrants

98 We used freeze drying (FD), hot-air drying (HD) at 50 degrees C and sun drying (SD).

99 ons, which generate a strong electric field, hot carriers, and heat through the excitation and decay

100 r polyps 1 to 10 mm and 10 to 20 mm, IRR for hot and cold snare removal of polyps 1 to 10 mm and 10 t

101 The IRR for hot snare removal of polyps 1 to 10 mm was 14.2% (95% CI

102 Together, these data provide a model for hot spot activation in which HELLS and PRDM9 form a pion

103 dopsins in cultivated bacteria isolated from hot and arid ecological niches.

104 anol, benzonitrile, and benzyl nitrile, from hot tub water.

105 rtunity for metal sulfide precipitation from hot acidic metallurgical streams, avoiding costly coolin

106 The luciferin, partially purified from hot extracts by a combination of anion exchange chromato

107 abundance of these proteins in strains from hot and arid habitats was not reported previously.

108 ess, the exact function of plasmon-generated hot holes in regulating the morphology of nanostructures

109 s and subsequently in terrestrial geothermal hot springs, the Nanoarchaeota species that have been de

110 hicken, ground beef, ground pork, hamburger, hot dog, ice cream, liver, luncheon meat, margarine, mea

111 during the initiation stage of the Hawaiian hot spot, the fate of this plateau is unclear.

112 nal convergence of hydrophobic alpha-helical hot spots was revealed by analyzing alpha-helix-mediated

113 ing mode of the side chains of alpha-helical hot spots, offering a new class of small-molecule alpha-

114 and contributes to enlarging a "hydrophobic hot spot" region on the WW1 domain.

115 mplex, with strong dependence on hydrophobic hot spots and networks of water-mediated hydrogen bonds.

116 s revealed that it fits into the hydrophobic hot spot region of the accessible surface of WW1.

117 s dominated over oxyanions in many Icelandic hot springs.

118 In some Icelandic hot springs, arsenic was nearly quantitatively thiolated

119 and by hospital referral region to identify hot spots.

120 Identifying hot spots or areas of high environmental contributions u

121 ing more recently than subclones from immune hot regions.

122 d by policymakers when identifying important hot spots for the conservation of biodiversity in the Am

123 t climates, with the latter more abundant in hot, dry regions, we also investigated the effects of wa

124 rapidly improve this crop for agriculture in hot and dry environments.

125 , we corroborate that C(60) is applicable in hot carrier PSCs as it is capable of extracting hot carr

126 nd provides a means of maintaining growth in hot, water-limited environments.

127 oaded with organic molecules by immersion in hot melts, providing single crystals suitable for X-ray

128 ently benefit from this dampened increase in hot extremes because irrigation massively expanded throu

129 the fluctuations of mean solar radiation in hot arid regions.

130 us storage conditions simulating shipping in hot or cold climates.

131 tial-volume effects (PVEs) degrade signal in hot-spot imaging techniques such as amyloid PET.

132 e examples of life's resilience, thriving in hot springs at boiling temperatures, in brine lakes satu

133 Criticality is known to occur in "hot" Fermi pockets with a high density of states close t

134 been observed within this outflow, including hot highly ionized(3,4) (temperatures of about 10(6) kel

135 ted than others to cope with an increasingly hot and sour sea.

136 ntial fine-scale heterogeneity at individual hot spots.

137 Compared to individual hot days/nights, compound hot extremes that combine dayt

138 Photothermal heating, light-induced hot electron-driven charge transfer, and direct electron

139 Patients with immune-infiltrated "hot" tumors demonstrate higher treatment response rates

140 diment composition, and vegetation influence hot spots of P retention throughout small agricultural s

141 show that the same scattering mechanism into hot electrons that are instead localized near a 2D van H

142 three [6%]) patients had 50% lesser hot flushes.

143 ynthetic gene clusters are embedded in local hot spots of 3D contacts that segregate cluster regions

144 provided the only means to survive the long, hot dry season.

145 ricting structural elements into macrocyclic hot loop-derived peptides.

146 ed Volatile Organic Compound (VOC), the main hot spot is noticed over the city Atyrau, the oil capita

147 Regarding SO(2) the major hot spots relate to regions with high population and lar

148 label placebo (OLP) treatment for menopausal hot flushes.

149 n effective, safe alternative for menopausal hot flushes.

150 al sweet red peppers dried by three methods (hot air, intermittent microwave and infrared) were studi

151 es based on different heat transfer methods (hot air and infrared), differently affect the protein so

152 ir remarkable thermal conductivity minimizes hot spots and thermal gradients.

153 ted in emotionally neutral contexts to more "hot" EF skills needed for the reversal of motivationally

154 Here, we present a multimodal hot-spot imaging approach using an innovative high-densi

155 This led to our discovery of a mutational hot spot at HBoV1 capsid position 590 that accumulated i

156 idue belongs to 1 of the 2 mosaic mutational hot spots that face each other in the core of the NLRP3

157 We describe a new hot loop mimicking modality, termed PepNats, in which na

158 dic epitopes enables identification of novel hot loop mimics with conformationally constrained and bi

159 y high reproducibility due to the absence of hot spots, high durability due to no oxidization, and hi

160 The spatial patterns and temporal changes of hot, dry, and windy events (HDWs) for two time periods,

161 OD improved color of hot-air dried apricot compared to UOD pretreatment.

162 ropose, given the low host cell densities of hot spring environments, that the TSPV1 filaments serve

163 tion of steady-state energy distributions of hot carriers in nanostructures has so far been lacking.

164 XLSSC 122, thus confirming the existence of hot intracluster gas, while deep imaging spectroscopy fr

165 the projected future increasing frequency of hot and dry conditions, but the role of parasitic plants

166 ividual group members against the impacts of hot and dry conditions, which are expected to increase i

167 d by the extraction of Mg in the infusion of hot water.

168 metals concerning generation and lifetime of hot carriers when excited in the near-infrared.

169 e global warming increases the likelihood of hot extremes almost globally, irrigation can regionally

170 amping is the dominant physical mechanism of hot-carrier generation in nanoscale systems with strong

171 decreases with an increase in the number of hot school days.

172 Problem rating of hot flushes and subdomains of quality of life did not im

173 arger scales, which show that a reduction of hot extremes with deforestation - as simulated in a numb

174 In this study, a range of stoichiometries of hot-pressed ZrC(1-x) were examined by SEM, XRD, Raman sp

175 d full cream milk), increased temperature of hot drinks, and decreased variation in diet (PFalse Disc

176 hnique will enable a better understanding of hot electron driven reactions at electrochemical interfa

177 ntially reduced human exposure to warming of hot extremes but question whether this benefit will cont

178 The demonstration of 'hot' and universal quantum logic in a semiconductor plat

179 durability due to its strong dependence on "hot spots", large photothermal heat generation, and easy

180 arge, "cold" Fermi surfaces scatter into one hot and one cold electron renders the ostensibly noncrit

181 ared classical encoding matrices, namely one-hot, VHSE8 and BLOSUM62, to end-to-end learning of amino

182 ill define the intensity of CO(2) outgassing hot moments.

183 racterized by either an overrepresentation ("hot clades") or an underrepresentation ("cold clades") o

184 distributed among Yellowstone National Park hot springs.

185 A particular hot spot for such oxidative attack on chromosome 15 has

186 In particular, hot spots of charge storage are identified.

187 Higher tolerance of Phusion hot start DNA polymerase to PCR inhibitors and its compa

188 ive tumor cells within a subjectively picked hot-spot.

189 ial location of molecules within a plasmonic hot spot.

190 work will enable quantification of plasmonic hot-carrier distributions in nanophotonic and plasmonic

191 that can provide quantification of plasmonic hot-carrier distributions.

192 f white-bread, butter, jam, and 2% milk plus hot cereal [Cream of Rice (CR), or instant-oatmeal plus

193 Being in a pool/hot tub/sauna within 24 h or taking a shower/bath within

194 Turkish coffee is a popular hot beverage owing to its delicious taste and pleasant a

195 roaches; here, we predict the binding poses, hot-spot residues, and binding affinity differences of a

196 terminants of ASFV variability are potential hot-spots for recombination.

197 tional model, iPNHOT, to effectively predict hot spot residues on protein-nucleic acids interfaces.

198 timized and validated a modified pressurized hot water extraction (PHWE) method for the simultaneous

199 ch and two adjacent surfaces are the primary hot-spots for nucleosome disk interactions, whereas near

200 We show that SRSF2 Pro95 hot spot mutations elicit enhanced mRNA decay, which is

201 Due to the laser-produced hot electrons with energies of mega-electron volts, cold

202 involving intraband excitation that produces hot electrons (HEs).

203 rticularly abundant in ocean N(2)O-producing hot spots.

204 Aotearoa New Zealand Ross Ice Shelf Program hot water drill borehole melted in the central region of

205 O(2) emissions, and presented more prominent hot moments in soil CO(2) outgassing.

206 o-scale simulations are required to quantify hot spot ignition and growth and to develop models for m

207 Recombination hot spots are decorated by a unique combination of histo

208 high frequency of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and in the G

209 high frequency of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and the GP2

210 s concentrated as interlineage recombination hot spots.

211 Intralineage recombination hot spots were not as concentrated as interlineage recom

212 Also, intralineage recombination hot spots were scattered across the genome between Chine

213 for the determination of these recombination hot spots.

214 oorly understood, is access to recombination hot spots during meiosis.

215 Macrocyclic PepNats representing hot loops of inducible nitric oxide synthase (iNOS) and

216 The research hot spots in the period from 1976 to 2016 were identifie

217 sistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV

218 rom the iNOS DINNN hot loop and the AGRP RFF hot spot sequence yielded novel and potent ligands of th

219 Little is known about life in the boron-rich hot springs of Trans-Himalayas.

220 states, and thioantimonates, in sulfide-rich hot springs from Yellowstone National Park and Iceland i

221 ol subhumid Ethiopia, cool semi-arid Rwanda, hot subhumid Ghana and hot semi-arid Mali and Benin usin

222 t two or three decades of research have seen hot debates about what features of population tuning and

223 he AgNPs and inducing the formation of SERS "hot spots" responsible for SO(2) signals enhancement.

224 Women with at least five moderate or severe hot flushes per day were allocated to receive four weeks

225 erarchies on microsequence motifs (i.e., SHM hot/cold spots) are mostly consistent between different

226 Herein, we describe a straightforward single hot injection procedure revolving around In(I)Cl as the

227 g is used to detect specific binding sites ("hot spots") for cholesterol on K(+) channels with charac

228 Litter bags and soil hot water extracts (HWE) have frequently been used to st

229 lly determine the role of diverse structural hot spots in conferring host cell binding and ligand bin

230 uggest that variation of numerous structural hot spots in the ligand binding pocket of Epa proteins i

231 ng several conserved and variable structural hot spots, which were implicated in mediating functional

232 semiconductor materials, realization of such hot-carrier schemes is complicated by extremely fast int

233 Subseafloor mixing of high-temperature hot-spring fluids with cold seawater creates intermediat

234 We find that hot electrons in the metal contact transfer their energy

235 Specifically, it is found that hot holes stabilized by surface adsorbed iodide enable t

236 early ocean hydrothermal environment is that hot temperatures, large pH gradients, high salinity and

237 Sensory analysis revealed that hot air-dried samples were least preferred.

238 ce tension to round these objects before the hot (and so relatively low viscosity) silicate melt cool

239 f the Snowy Mountains, where they endure the hot summer in the cool climate of alpine caves.

240 0-mm sphere) to 83.9% (22-mm sphere) for the hot spheres, and between 81.4% (28-mm sphere) and 87% (3

241 an electron microprobe could account for the hot spots.

242 e, which corotates with the planet, from the hot ring current/plasma sheet outside.

243 and-edge anisotropy is also reflected in the hot carrier decay rate, which is a factor of two slower

244 Perceived workload was higher in the hot condition.

245 uid rotation and is expected to occur in the hot quark-gluon fluid (the "subatomic swirl") created in

246 sition behaviors from being isotropic in the hot state to perpendicular to the surface in the trapped

247 ral selection was particularly strong in the hot-dry location in Spain, where 63% of lines were kille

248 hot spots on protein-protein interfaces, the hot spot residues within protein-nucleic acids interface

249 ts of a radiant cooling system that made the hot and humid tropical climate of Singapore feel cool an

250 with the time-evolving magnetization of the hot electron sheath.

251 hieved by controlling the temperature of the hot electrons through the Joule heating.

252 hedron cube or platelet shape in most of the hot injection reactions.

253 d to suboptimal filling, particularly of the hot rod section, in 5 sites.

254 Compared to the extensive studies of the hot spots on protein-protein interfaces, the hot spot re

255 The prediction of the hot-spot residues within the target peptide through comp

256 ocial-ecological indicators, focusing on the hot dry season, and applying the risk framework of the I

257 tional theory calculations revealed that the hot carriers are transferred to the antibonding (pai*) o

258 We show that the hot carriers in Cu-THQ generated after photoexcitation a

259 sing aridity from the cool-wet forest to the hot-dry Sahel, from south to north in Nigeria.

260 th and empty channel) were obtained with the hot region maintained at 70 degrees C and the cold regio

261 osis, and cell death ultimately renders them hot targets in cancer therapy.

262 We show that while these hot pockets occupy a small fraction of the Brillouin zon

263 of the energy transport associated with this hot-electron injection remains unclear.

264 Herein, we discover that those hot holes work with surface adsorbates collectively to c

265 entified in 277 patients revealed that those hot spots account for 68.5% of patients (37 of 54) with

266 radicalization (e.g., rigidity of thoughts, hot-cognitive defense of cultural worldviews, and violen

267 We identified three hot spots and obtained 6 X-ray co-structures, giving a h

268 Refine the Treatment (SMART) of CRC through hot and cold homogenization approach.

269 osures, potentially enabling transit through hot crustal fluids.

270 Middle East and Africa, they are adapted to hot dry and semi-dry areas, in contrast to their wild an

271 ase in GPP/SIF from cold-and-wet climates to hot-and-dry climates.

272 how to convert the liver tumors from cold to hot and responsive, which may rely on in-depth mechanist

273 that photothermal processes, in contrast to hot carriers, are the main contributor to the observed c

274 e scenarios are common in species exposed to hot environments, with heat avoidance more common in spe

275 However, we also found that exposure to hot-dry stress is increasing faster than mean annual tem

276 inistered to mice, SR-17018 does not lead to hot plate antinociceptive tolerance, receptor desensitiz

277 ilable from triplet energy transfer leads to hot and nonstatistical dynamics in the rearrangement.

278 mation for studies aiming to adapt plants to hot and dry environments by modifying leaf physiology fo

279 HELLS is recruited to hot spots by PRDM9 and is necessary for both histone mod

280 in sub-Saharan Africa, that is resilient to hot and drought-prone environments.

281 ed) or was even cost saving for travelers to hot spots, especially if travelers were previously unvac

282 uscular, injection converts "cold" tumors to hot, generates systemic CD8(+) T cell-mediated antitumor

283 e resident in, an oil reservoir normally too hot for germination and growth, explaining observations

284 to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater deg

285 o-treatment, OLP reduced the log-transformed hot flush composite score (frequency x intensity) (mean

286 Innovative approaches that make tumors hot can have immediate impact particularly if they repur

287 y as turning immunologically 'cold' tumours 'hot'.

288 (4) grasses to outcompete C(3) species under hot, dry conditions explains previous observations suppo

289 ntrol the thermal radiation of an underlying hot body with different emissivity features.

290 ounds was observed in the first seconds upon hot water addition ("aroma burst"), followed by subseque

291 th no difference in density between the very hot (May to August) and warm season (September to April)

292 al conditions characteristic of the volcanic hot springs in which these archaeal extremophiles reside

293 There is no difference in IRRs of cold vs hot snares for polyps 1 to 10 mm.

294 In this work, we introduce a wearable hot-film/calorimetric breath sensing system composed of

295 ng, Shanggao, Jing'an and Gao'an county were hot spots areas.

296 ommonly reported grade 3 adverse events were hot flushes (20 [1%] of 2801 patients in the POAI group

297 xtremely dry and wet events accompanied with hot days have been more frequent in Amazonia due to clim

298 ain and forage crop in areas frequented with hot and dry weather, and high temperature.

299 n images, images of a cylindric phantom with hot and cold spots, and a mix of the first two.

300 AID deamination occurs predominantly at WRC hot spots (where W is A or T and R is A or G) and that t