ライフサイエンスコーパス: hotspot

1 entions to areas of high HIV prevalence (ie, hotspots).

2 ese Central Annamites, a global biodiversity hotspot.

3 he 3D structure, rendering it an IgE-binding hotspot.

4 a, lying in the Indo-Burma mega-biodiversity hotspot.

5 despread deficits of protection for endemism hotspots.

6 t risk of lower viral suppression within the hotspots.

7 d epigenetic environments at PRDM9-specified hotspots.

8 derstand their characteristics, and identify hotspots.

9 ation intermediate (SPO11-RI) present at all hotspots.

10 reventing removal by natural denitrification hotspots.

11 more commonly flows into rather than out of hotspots.

12 result, methylated cytosines are mutational hotspots.

13 '-can profoundly affect the allocation of WE hotspots.

14 e environments to form tropical biodiversity hotspots.

15 ogeographic regions, biomes and biodiversity hotspots.

16 rated greater risk of incident depression in hotspots.

17 o better reflect PM(2.5) spatial details and hotspots.

18 us is a powerful tool to identify mutational hotspots.

19 ive positive acceleration, help identify the hotspots.

20 tected areas in specific parrot conservation hotspots.

21 hotspots are also likely to be microplastic hotspots.

22 cilitate the discovery of global bioactivity hotspots.

23 -loops form dynamically over conserved genic hotspots.

24 ect between high-density wetland areas and N hotspots.

25 sequent outcomes, are sparsely reported from hotspots.

26 N1/gamma-secretase transiently visits ADAM10 hotspots.

27 isk of being virally unsuppressed within the hotspots.

28 educe the footprint through targeting carbon hotspots.

29 isk of being virally unsuppressed within the hotspots.

30 ncrease of land use in tropical biodiversity hotspots.

31 ield to detect infections (1.7% vs 0.6%) and hotspots (29.7% vs 12.7%), respectively.

32 uclease are coordinated by Chi recombination hotspots (5' GCTGGTGG 3') recognized during DNA unwindin

33 At Chi hotspots (5' GCTGGTGG 3'), RecB's nuclease cuts the 3'-e

34 representation occur in global biodiversity hotspots(9), including Colombia, Papua New Guinea, South

35 Anthropogenic loss hotspots across Southeast Asia and around the world have

36 Various taxonomic richness hotspots across the US represent focal regions for furth

37 ation in most mammals requires recombination hotspot activation through the action of the histone 3 L

38 nal mutations that reduced or eliminated Chi hotspot activity in each subunit and widely scattered th

39 ausing neurodevelopmental defects cluster in hotspots affecting Pol III stability and/or biogenesis,

40 wide collapse emerged in multiple geographic hotspots after 2 to 4 y of severe (>40%) and intensifyin

41 control, we assessed the extent to which HIV hotspots along Lake Victoria sustain transmission in nei

42 To address this, we developed SV-HotSpot, an automated tool that integrates SV candidates

43 d rat model, with a 9-bp deletion within the hotspot analogous to a human deletion, recapitulates hyp

44 We used optimized hotspot analysis to identify clusters of liver disease m

45 We provide a structural view of hotspot and weak driver mutations in PI3Kalpha activatio

46 ing identified a larger number of mutational hotspots and clinically significant amplifications that

47 wars often coincide with global biodiversity hotspots and have plagued the everyday reality of many c

48 Controversy surrounds the fixity of both hotspots and large low shear velocity provinces (LLSVPs)

49 urface waters and the Arctic as biodiversity hotspots and mechanistic hypotheses to explain them.

50 is is identifying mode of transmission based hotspots and population at risk of lower viral suppressi

51 preferentially occurs at somatic mutational hotspots and putative regulatory regions.

52 spatial statistics to identify global-local hotspots and regression to find population at risk of lo

53 s, and a wetland) to identify Hg methylation hotspots and seasonal differences in MeHg cycling unique

54 Alongside helping to identify hotspots and sources of microbial diversity, our study p

55 nity HIV transmissions between Lake Victoria hotspots and surrounding inland populations are infreque

56 facilitating the linking between PRDM9-bound hotspots and the nascent chromosome axis through its com

57 hlight the critical importance of lipophilic hotspots and water molecules for these peptidergic GPCR

58 e emission rates, the locations of emissions hotspots, and factors that explain spatial variability a

59 ores the possible existence of recombination hotspots, and fails to distinguish between coding and no

60 igible spatial congruence among biodiversity hotspots, and that tetrapod sampling has historically co

61 ach hotspot, supporting a model in which the hotspots apply nonlinearities at a larger spatial scale

62 nthos, suggesting that deep-sea biodiversity hotspots are also likely to be microplastic hotspots.

63 Emission hotspots are defined as segments with >=90th percentile

64 hallenge the assumption that high prevalence hotspots are drivers of transmission in regional epidemi

65 areas in eight tropical forest biodiversity hotspots are effective at retaining bird diversity.

66 Hotspots are of heterogeneous characteristics including

67 We find that the magnitude of these hotspots are related to the spatial distribution of the

68 Critical counties (high-vulnerable-hotspot) are mostly located in the southern and southwes

69 eronegative to SARS-CoV-2 infection, even in hotspot areas.

70 epidemic in Ohio were driven by the epidemic hotspot areas.

71 uided by the identification of biodiversity 'hotspots' (areas with exceptional biodiversity).

72 ormation of plasma is due to electromagnetic hotspots arising from the cooperative interaction of Mie

73 y-based fragment screening reveals a binding hotspot around the Ct-extension, where fragments interfe

74 The existence of three QTL hotspots associated with various traits across multiple

75 spatial autocorrelation to identify disease hotspots at the local community level.

76 311 indicators are capable of predicting OOE hotspots at the neighborhood-level: our results show cod

77 e SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD-ACE2 interface.

78 into the brain via anatomically specialized "hotspots" at the distal tips of ChP villi.

79 identify clusters of liver disease mortality hotspots based on the final multivariable models.

80 t white-tailed deer may have a recombination hotspot between these MHC regions similar to that found

81 ) library, we identified conserved insertion hotspots between different genetic backgrounds.

82 Many islands are biodiversity hotspots but also extinction epicenters.

83 ich promotes neighborhood-scale connectivity hotspots, but produces landscape-scale connectivity cold

84 mutations are subject to selection, and some hotspots can manifest in disease.

85 Because these hotspots can undergo fission and fusion, they have the p

86 intensified application targeting predicted hotspots, can be used to reduce malaria incidence in end

87 n the analyzed rivers was limited to certain hotspots close to wastewater treatment plants discharge

88 ion in individuals residing in food insecure hotspot communities [adjusted relative risk (aRR) = 1.13

89 ssociation between residing in food insecure hotspot communities and depression.

90 ree at baseline, residing in a food insecure hotspot community was significantly associated with high

91 Hotspots constitute the major reservoir for residual mal

92 Hotspots could therefore be an unreliable means to direc

93 To reliably identify a fleet-average hotspot, data are needed for at least 36-130 vehicles, d

94 We found a Chi hotspot-deficient mutant in the RecB helicase domain loc

95 ean island basalts (OIB) erupted at volcanic hotspots derive from deep-seated domains preserved in Ea

96 Hotspot detection improved with >=80% target population

97 rs, in many vertebrates DSBs are enriched at hotspots determined by the DNA binding activity of the r

98 , while the Middle East is a global emission hotspot due to extensive oil and gas production.

99 (PEDOT:PSS) hydrogels have become a research hotspot due to their excellent biocompatibility and stab

100 saturated wetland soils support methylation hotspots during the open water season, but subsequent ex

101 While hotspot engineering has expedited SERS development, it i

102 Furthermore, we show that in most of the hotspots examined this benefit is driven by protected ar

103 mobile marine ectotherms in a global warming hotspot, few species are fully keeping pace with climate

104 olytic cleavage of the N-terminus of PC-1, a hotspot for ADPKD mutations, produces a soluble ligand i

105 ck Mountain region of New York, a historical hotspot for atmospheric sulfur and nitrogen deposition,

106 re a unique habitat for microorganisms and a hotspot for biogeochemical cycling, including the toxic

107 The Mediterranean Sea is a hotspot for climate change, and recent studies have repo

108 Brazil is currently a hotspot for COVID-19 globally.

109 esults confirm that the Llanos de Moxos is a hotspot for early plant cultivation and demonstrate that

110 ricultural areas are considered a particular hotspot for emissions because of the large input of nitr

111 changes to the environment, is an important hotspot for malaria transmission.

112 lysis reveals that Pol gamma exo domain is a hotspot for oxidation.

113 n), encoded by exon 10 of the MPL gene, is a hotspot for somatic mutations associated with myeloproli

114 of the d(TTGGCGAA) duplex can also act as a hotspot for the formation of alternative DNA structures

115 ar dynamics simulations further identify two hotspots for cholesterol interactions.

116 ns susceptible to replication stress and are hotspots for chromosomal instability in cancer.

117 These settlements may be unique hotspots for environmental AMR transmission given: (1) t

118 We subsequently used these data to identify hotspots for gas emissions across forests of the eastern

119 Spatial analyses were used to identify hotspots for malaria incidence, as well as malaria vecto

120 on and fusion machineries colocalize to form hotspots for membrane dynamics at ER MCSs that can persi

121 The hotspots for MSMs were central DC and non-MSM in south D

122 We detected four conservation hotspots for parrots: two in the Neotropics and two in O

123 he two main airports in the region to act as hotspots for PFAS.

124 nterfacial junctions that generate localized hotspots for promoted hydride coupling and hydrogen deso

125 identifies the environmental trade-offs and hotspots for the chemically enhanced primary treatment (

126 We also show that basal mLVs are hotspots for the clearance of CSF macromolecules and tha

127 f protected areas, to determine conservation hotspots for the group, and analyze potential changes in

128 h landing beaches, and identified potential "hotspots" for disease transmission.

129 Here we studied the effects of hotspot gain-of-function mutations in Trp53 (the gene th

130 Global biodiversity hotspots (GBHs) are increasingly vulnerable to human str

131 appears inapt in p53 wild-type (WT) or other hotspot GOF mutp53 cells, our work provides a therapeuti

132 We find that migrants moving into hotspots had significantly higher HIV prevalence than mi

133 titative trait locus (eQTL) analysis detects hotspots harboring master regulators controlling importa

134 scale) variation in recombination rate, e.g. hotspots, has a small influence on the variance in reali

135 The hotspots have average emission rates 2-4 times greater,

136 tween two subgenomes, highlighted by an eQTL hotspot (Hot216) that established a genome-wide genetic

137 decreased histone trimethylation at meiotic hotspots, impaired DNA double-strand-break repair, and r

138 chemotherapeutic drugs has become a research hotspot in cancer treatment.

139 gene and define this segment as a mutational hotspot in hypertension with brachydactyly.

140 telligence algorithm identified a mutational hotspot in the sequence of S that also displays a signat

141 The variant identified is a somatic hotspot in Wilms tumors and has been identified in 2 PTC

142 The carbon footprint hotspots in China identified are the key places in which

143 ate mutagenesis and are enriched at mutation hotspots in human cancer genomes, implicating them in di

144 structural modeling to identify EE mutation hotspots in key functional domains of K(v)7.2 including

145 yse these datasets over four global isoprene hotspots in relation to model predictions, and present a

146 temperature increases >3 degrees C, primate hotspots in the Neotropics are expected to be particular

147 structure within Scandinavia, with diversity hotspots in the south and restricted gene flow within Sc

148 issense variants cluster into two mutational hotspots in the TRIO sequence, one in the seventh spectr

149 by the lack of coverage across key mutation hotspots in the vast majority of cells; this lack of cov

150 Identifying Aedes aegypti breeding hotspots in urban areas is crucial for the design of eff

151 ensitive and precise imaging of inflammatory hotspots in vivo.

152 regions of the external cuticle layers, as "hotspots" in nonkeratinous portions of the internal cort

153 g and confirmed that R-loops form over genic hotspots, including gene bodies and terminal gene region

154 tiscale computational predictions of crucial hotspot inter-atomic interactions to validation using da

155 We predict and validate inter-atomic hotspot interactions between VP monomers that are import

156 rn Africa, we find that a prominent isoprene hotspot is missing from bottom-up predictions.

157 Mode of transmission based hotspots is a smart approach to HIV mitigation yet remai

158 whether defining and conserving biodiversity hotspots is an effective conservation strategy in light

159 hat bacterial utilization of microscale DMSP hotspots is an important determinant of the fate of sulf

160 The identification of disease hotspots is an increasingly important public health prob

161 WPW1 recognition of PRDM9-bound sites at DSB hotspots is critical for synapsis, and hence fertility.

162 Detection of malaria hotspots is hampered by their heterogenous spatial distr

163 ly high biodiversity, known as biodiversity 'hotspots', is intuitive because finite resources can be

164 that dissipate power resulting in nanoscale hotspots leading to device failures.

165 k delineates global soil bacterial diversity hotspots; located mainly in climatic transition zones th

166 aptive sampling scheme optimized to identify hotspot locations where prevalence exceeds a relevant th

167 poorly explored Indo-Burma mega-biodiversity hotspot may be an extremely rich reservoir for productio

168 human genome sequencing, additional mutation hotspots, mechanistic details of their formation, and th

169 from contaminated habitats and transmission hotspots, migratory recovery due to parasite mortality,

170 ple size revealed previously uncharacterized hotspot missense mutations within the SMARCA4 helicase d

171 Other hotspots, mostly urban conglomerates such as Almaty and

172 Compared with patients with metastatic TP53 hotspot mutant solid tumors who were treated with ixazom

173 non-hotspot mutation, four a single BRAF non-hotspot mutation and fourteen carry several mutations.

174 ion was observed against tumors carrying the hotspot mutation G12D in the KRAS oncogene.

175 The R882H DNMT3A is a hotspot mutation in acute myeloid leukemia (AML) causing

176 PIK3CA hotspot mutation is well established as an oncogenic dri

177 ved in DNMs, although it was as prevalent as hotspot mutation R248Q in FMs.

178 DNM rate: 48% (23 DNMs vs. 25 FMs); and (3) hotspot mutation R248W was not observed in DNMs, althoug

179 non-hotspot mutation, one a single NRAS non-hotspot mutation, four a single BRAF non-hotspot mutatio

180 Three samples carry a single KRAS non-hotspot mutation, one a single NRAS non-hotspot mutation

181 have an elevated rate of use of less-common hotspot mutations acquired in a chronology driven in par

182 assigned using DNA polymerase epsilon (POLE) hotspot mutations and immunohistochemistry-based p53 and

183 Recurrent hotspot mutations have been found in the ENL YEATS domai

184 Collectively, our findings show that hotspot mutations in a chromatin-reader domain drive sel

185 assays, here we identified cancer-associated hotspot mutations in Arg-200 of Galpha(13) (encoded by G

186 nt of next-generation sequencing, activating hotspot mutations in G(s), G(i/o), or G(q/11) proteins h

187 ) mutants establish that naturally occurring hotspot mutations in Galpha subunits of any of the four

188 ely and to further validate the PLA, somatic hotspot mutations in genes known to be drivers of early

189 ty of resistant tumors, including those with hotspot mutations in the ligand-binding domain of ERalph

190 00 breast cancer patients identifies several hotspot mutations in the Wing2 region and a breast cance

191 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predic

192 Hotspot mutations of the oncogenes BRAF and NRas are the

193 exon and splice site recognition induced by hotspot mutations or driving "dual" phenocopies that mim

194 al" phenocopies that mimicked 2 co-occurring hotspot mutations.

195 lation history of the South Indian upwelling hotspot near Kerguelen Island, using high-resolution (14

196 eventh of the world's total population and a hotspot of aerosol loading, observes strong enhancements

197 of Mancio Lima, the main urban transmission hotspot of Brazil.

198 We find the gut as the putative hotspot of COVID-19, where a maturation correlated trans

199 gene resides on human chromosome 17p13.1, a hotspot of monoallelic deletion in human cancers.

200 mutations, each representing one mutational hotspot of the disease: T6P, F80L, R218C, and F305S.

201 d 10 ms before the end of TUS to the left M1 hotspot of the first dorsal interosseous muscle.

202 LMW DOM availability across space, revealing hotspots of biogeochemical activity for further evaluati

203 males for information exchange, thus forming hotspots of cheetah activity and presence.

204 veal the presence of 'sensory danger zones', hotspots of conservation concern where sensory pollutant

205 host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that cou

206 Significant hotspots of cystic echinococcosis were found in four reg

207 l features often characterized by biological hotspots of diversity, biomass, and abundance, though th

208 s with high human development index are also hotspots of ecological rarity, suggesting transboundary

209 serial interspersed duplications and creates hotspots of genomic instability that appear to be an anc

210 e shrinking, which is important as these are hotspots of genuine carbon sequestration.

211 s divergent clades, and that these genes are hotspots of host-pathogen conflict over deep evolutionar

212 ility in liver disease-related mortality and hotspots of liver disease mortality.

213 Several seamounts have been identified as hotspots of marine life in the Azores, acting as feeding

214 receptors at the front of cells resulted in hotspots of mitochondrial metabolism and localized ATP p

215 The CRV analysis reveals hotspots of morphological change across the delta.

216 We identify hotspots of multivariate CEs including many socio-econom

217 rtalis) and their toxic newt prey exhibiting hotspots of newt tetrodotoxin (TTX) levels and matching

218 nd conservation areas were identified as the hotspots of risk for the co-occurrence of multiple event

219 Global analyses reveal hotspots of species richness, together generating a rare

220 664 species) assembled to date, to identify hotspots of species-richness, endemism and threatened sp

221 We identified 2 hotspots of stimulation covering the midbrain ventral an

222 nding of two ligands to PDK1 reveal multiple hotspots of synergistic allostery with cumulative effect

223 targeting and point to TC motifs as activity hotspots of the cytidine deaminase used.

224 Latin America and the Caribbean have become hotspots of the novel coronavirus (COVID-19) pandemic, e

225 Protrusions act as hotspots of translation for RP-mRNAs, enhancing RP synth

226 effectiveness of interventions in persistent hotspots of transmission.

227 Our results revealed potential hotspots of triatomine species diversity in tropical and

228 We find several hotspots of variation, including the csa1 cluster encodi

229 content across long genomes and to pinpoint hotspots of well-defined RNA structures, a method that a

230 we proposed a new model, iPNHOT, to predict hotspots on both protein-DNA and protein-RNA interfaces.

231 in clusters, highlighting the small-molecule hotspots on the surface of the target protein.

232 inly with directed motility and frequenting 'hotspots' or high track-density areas that are sensitive

233 es that are forest-dependent, endemic to the hotspots, or threatened or Near Threatened, but not on o

234 nt to the appearance of very small metabolic hotspots originating from different natural isotope disc

235 In most of the cases, the hotspots overlapped with the binding sites of the intera

236 Surprisingly, we found food insecurity hotspots (p < 0.001) in high-suitability agricultural cr

237 Some villages, labeled "persistent hotspots (PHS)," fail to respond adequately in regard to

238 Four frequent 'hotspot' PIK3CA mutations (E542K, E545K, H1047R and H104

239 The "hotspotting" program created by the Camden Coalition of

240 RE1 variant lacking the CPK1 phosphorylation hotspot, promote early senescence.

241 SV-HotSpot provides a valuable resource to integrate SVs, g

242 the improved detection of infections and for hotspots (RACD events yielding >=1 additional infection)

243 d Caucasian families suggestive of a variant hotspot region rather than a founder effect.

244 relative orientation of the backbone in the "hotspot" region.

245 d, including manually drawn whole-lesion and hotspot regions of interest, histogram metrics, normaliz

246 er in the Sahel and potentially in other MCS hotspot regions of the world.

247 d visualize recurrent SVs and their targeted hotspot regions that may affect gene expression.

248 tify recurrent SVs and their targeted sites (hotspot regions), visualizes these genomic events within

249 ers, however, identified a greater number of hotspots reported in the southernmost part of the countr

250 ost "spliceosomal" mutations affect specific hotspot residues, resulting in splicing changes that pro

251 rries spliceosomal mutations that affect non-hotspot residues, whose potential functional contributio

252 rization of selected EE mutations from these hotspots revealed that L203P at S4 induces a large depol

253 Bacteria deploy rearrangement hotspot (Rhs) proteins as toxic effectors against both p

254 Using hotspot RNA mutations identified from APOBEC3A-positive

255 vertebrates remodeled genetic recombination hotspot selection from an ancestral static pattern near

256 esumed areas of higher HIV prevalence (i.e., hotspots) serve as sources of infection to neighboring a

257 Trends of viral suppression within MSM hotspots shows plateauing and among non-MSMs showed decl

258 e biogeochemistry, potentially fueling local hotspot sinks for atmospheric CO(2) by enhancing the bio

259 We identify the same hotspot somatic mutation in splicing factor 3 subunit B1

260 dules calculate feature-level and local, or "hotspot," somatic mutation enrichment statistics.

261 derlying 74 previously identified trans-eQTL hotspots spanning a variety of metabolic pathways.

262 for cleavage), characteristic of microscale hotspots such as the vicinity of phytoplankton cells.

263 nown for this species, and the more marginal hotspots, such as the Gulf of California and the Equator

264 near subunit properties associated with each hotspot, supporting a model in which the hotspots apply

265 d that 50% of the tagged genes have a single hotspot, targeted by Mu By comparing our BonnMu (B73) da

266 We show that R.RKTR is a hotspot that interacts with membrane when cRaf is monome

267 es over wild-type pol beta within a mutation hotspot that is present several times within the APC gen

268 B radiation and identifies novel UV mutation hotspots that may potentially represent founding driver

269 This analysis identified mutational hotspots that potentially disrupt gene regulatory networ

270 To understand the reliability impact of the hotspots, the device needs to be tested under the actual

271 We applied SV-HotSpot to WGS and matched transcriptome data from metas

272 ils of their formation, and the relevance of hotspots to evolution and disease are likely to be disco

273 onstitute important intracellular signalling hotspots to mediate a plethora of cellular processes, in

274 nd inferential statistics (density analysis, hotspots tools and palaeotopographic reconstruction), al

275 for the conservation of microbial diversity hotspots under global changes.

276 e quantified this synergism and ranked these hotspots using a difference in deuteration-based approac

277 s an opportunity to predict the locations of hotspots using suitable environmental and climatological

278 nts moving elsewhere, but out-migration from hotspots was geographically dispersed, contributing mini

279 ymptoms, clinical outcomes, and geographical hotspots-was launched in the United Kingdom on 24 March

280 For one hotspot, we identify a single enhancer variant ~10 kb up

281 are associated with terrestrial biodiversity hotspots well beyond (>1,000 m) their immediate colony b

282 Significant alveolar echinococcosis hotspots were detected in the Osh region (11 communities

283 onment and across both sites, three main QTL hotspots were found in chromosomal bins 2.02, 2.05-2.06,

284 Pathological hotspots were identified within the A-band and N-termina

285 alpha-, beta- and gamma-diversity hotspots were largely inconsistent with each metric rela

286 For example, some hotspots were on arterial roads with an upstream signali

287 ection and positive road grade, whereas some hotspots were on interstates with positive grade.

288 imarily originated within three evolutionary hotspots (Western Indochina, Sundaland, and East Asian)

289 nd/or transcript abundance, including 10 QTL hotspots where genetic variation at a single locus coord

290 breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K

291 Global "hotspots" where there is projected to be a significant c

292 tric field produces strong 'doubly-enhanced' hotspots which could boost measurements made using infra

293 of compromised margins based on fluorescence hotspots, which were not seen in margin-negative resecti

294 Noncovalent fragment hits revealed binding hotspots, while the covalent inhibitor structure-activit

295 uggests that targeted interventions to these hotspots will not alone control the epidemic in inland p

296 the distribution of microplastics and create hotspots with the highest concentrations reported for an

297 Ocean are identified as a major biodiversity hotspot, with more than 50 bat species.

298 Houston-are potential vaccination exemption "hotspots," with over 13% of local school systems above t

299 CPK1 phosphorylates ORE1 at a hotspot within an intrinsically disordered region.

300 Pathological hotspots within the A-band of TTN may be informative in

301 The studies found that major carbon hotspots within the examined operating theatres were ele

302 ic pathway, are proposed to be biosynthetic "hotspots" within the cell.