ライフサイエンスコーパス: human chromosome

1 ls when a mouse carries a freely segregating human chromosome.

2 gapless, telomere-to-telomere assembly of a human chromosome.

3 romosomes show conserved synteny to a single human chromosome.

4 ent heterozygosity rates, and real data from human chromosome.

5 abeling specific repetitive DNA sequences in human chromosomes.

6 litate ongoing efforts to complete the other human chromosomes.

7 distinguish rhesus macaque chromosomes from human chromosomes.

8 required for the replication of the ends of human chromosomes.

9 eckpoint regulates origins of replication in human chromosomes.

10 e to integrate into the telomeric regions of human chromosomes.

11 izers, which occur on the short arms of five human chromosomes.

12 re-replication on single DNA molecules from human chromosomes.

13 t of 37 genes sequenced in >1,500 individual human chromosomes.

14 is of human chromosome 3, one of the largest human chromosomes.

15 atellite repeat-containing centromeres of 23 human chromosomes.

16 layed replication and condensation of entire human chromosomes.

17 rate their viral genomes in the telomeres of human chromosomes.

18 predicted in many different genes across all human chromosomes.

19 the general loop-array morphology of compact human chromosomes.

20 variations in chromatin compaction in fixed human chromosomes.

21 members hidden in pericentromeres of several human chromosomes.

22 tches of repetitive DNA vary in length among human chromosomes.

23 We find that human chromosome 1 (which does not contain BRCA1) contai

24 B gene 5'-flanking region was amplified from human chromosome 1, sequentially deleted, and cloned int

25 earching around transcription start sites in human chromosomes 1 and 2, we predicted 16 novel p53 bin

26 nd mapped ultraviolet damage hotspots across human chromosomes 1 and 6.

27 interchromosomal organization of a subset of human chromosomes (#1, 4, 11, 12, 16, 17, and 18) was ex

28 in, which lies in close proximity to pten on human chromosome 10 and encodes a 20-kDa nuclear protein

29 ial DNA secondary structure formation on the human chromosome 10 sequence, and utilize this analysis

30 ignificantly shorter than cfDNA derived from human chromosomes (103 vs 172 bp, p < 0.0001), correspon

31 ctions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the beta-globin locus a

32 s containing either the maternal or paternal human chromosome 11 showed that BORIS preferentially bin

33 moter and the ANO1 gene, lying 68 Mb away on human chromosome 11, which encodes a Ca(2+)-dependent ch

34 sing hybrid hamster cells (A(L)N) containing human chromosome 11.

35 Human chromosome-11 band-q23 translocations disrupting t

36 only G-protein-coupled receptor gene in the human chromosome 11p12-11p14.4 fragment, is the key gene

37 ich localizes within a chromosomal region on human chromosome 11p15 that is commonly lost in Wilms tu

38 f a cluster of maternally expressed genes on human chromosome 11p15.5.

39 CCDC88B maps within one IBD risk locus on human chromosome 11q13.

40 yndromic hearing loss at the DFNB63 locus on human chromosome 11q13.3-q13.4.

41 Human chromosome 11q23 translocations disrupting MLL res

42 The ALL1 (also termed MLL) gene on human chromosome 11q23 was isolated by virtue of its inv

43 66,000 CpG sites within 2,020 CpG islands on human chromosome 12, chromosome 20, and 34 selected regi

44 lycosylases encoded within a small region of human chromosome 12.

45 ive-trait locus affecting telomere length on human chromosome 12.

46 Allelic deletions on human chromosome 12q24 are frequently reported in a vari

47 in a conserved region of the VPS33A gene on human chromosome 12q24.31, occurs in Yakuts-a nomadic Tu

48 Interestingly, this region is homologous to human chromosome 13q34, and some of the same genes were

49 b region, with complete syntenic homology to human chromosome 14, that contains no genes or loci know

50 from the bacterium Staphylococcus aureus and human chromosome 14.

51 is located on distal mouse chromosome 12 and human chromosome 14.

52 olog-deiodinase, iodothyronine 3) cluster on human chromosome 14.

53 have surveyed the S/MARs in HeLa S3 cells on human chromosomes 14-18 by array comparative genomic hyb

54 phenotype matrix attached regions (MARs) on human chromosomes 14-18 were identified as a function of

55 d synteny between mouse chromosome 12aF1 and human chromosome 14q32 has enabled the use of mouse mode

56 f genes within a single imprinted cluster on human chromosome 14q32.

57 structure of the distal serpin subcluster on human chromosome 14q32.1 allow a single gene encoding al

58 Here we present a finished sequence of human chromosome 15, together with a high-quality gene c

59 gene, located in the Prader-Willi region of human chromosome 15.

60 resent alterations in the positioning of the human chromosomes 15, 18, X and Y between spermatozoa wi

61 aternally inherited and maternally inherited human chromosome 15q, respectively.

62 Human chromosome 15q11-13 is a complex locus containing

63 xpression from the imprinted gene cluster on human chromosome 15q11-q13.

64 n of paternally expressed imprinted genes on human chromosome 15q11-q13.

65 snoRNAs and their host transcript, 116HG, on human chromosome 15q11-q13.

66 Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q syndrome or Dup15

67 overed five structural configurations of the human chromosome 15q13.3 region ranging in size from 2 t

68 modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroi

69 Here we show that deletions of a sequence on human chromosome 16 that we term the intestine-critical

70 ion of the contiguous TSC2 and PKD1 genes on human chromosome 16.

71 y of intrachromosomal duplications blocks on human chromosome 16.

72 Human chromosome 16p11.2 microdeletion is among the most

73 Human chromosome 16p11.2 microdeletion is the most commo

74 member of the large protease gene cluster at human chromosome 16p13.3, which also contains the struct

75 8a, clec18b, and clec18c loci, is located in human chromosome 16q22.

76 Here we report a finished sequence for human chromosome 17, as well as a structural comparison

77 levels of PMP22, as a 1.4 Mb duplication on human chromosome 17, resulting in three copies of PMP22,

78 rotein E2C, which binds a unique sequence on human chromosome 17.

79 the 5' untranslated region of erbB-2 gene on human chromosome 17.

80 ply that the selective advantage produced by human chromosome 17p deletion reflects the combined impa

81 he peripheral myelin protein gene (PMP22) in human chromosome 17p12 are associated with neuropathy: d

82 The ALOX12 gene resides on human chromosome 17p13.1, a hotspot of monoallelic delet

83 ike protein isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk fac

84 mouse chromosome 11, syntenic with gains on human chromosome 17q.

85 C17orf37/MGC14832, a novel gene located on human chromosome 17q12 in the ERBB2 amplicon, is abundan

86 One such locus, human chromosome 17q21.31, contains a megabase-long inve

87 e3 at hundreds of loci spanning megabases on human chromosome 19 and simultaneously track genome orga

88 strate that a cluster of 5 galectin genes on human chromosome 19 emerged during primate evolution as

89 s of the highly repetitive KIR region on the Human chromosome 19.

90 n of a globin transgene in the AAVS1 site on human chromosome 19.

91 ntegrates its genome into the AAVS1 locus on human chromosome 19.

92 an evolutionarily conserved 500-kb domain in human chromosome 19q13.4 and mouse proximal chromosome 7

93 TAF12, NFYC, and RAD54L co-located on human chromosome 1p32-35.3 and mouse chromosome 4qD1-D3

94 Human chromosome 1p35-p36 has long been suspected to har

95 togen-inducible gene 6 (MIG-6) is located in human chromosome 1p36, a locus frequently associated wit

96 osome 1 in mice, and as many as four QTLs on human chromosome 1q have been implicated in human studie

97 As CRB1 is the closest gene on human chromosome 1q known to cause retinal degeneration,

98 replicated linkage peak for BP regulation on human chromosome 1q, homologous to mouse and rat quantit

99 a novel transfer RNA (tRNA) tandem repeat on human chromosome 1q23.3 that shows extensive copy number

100 An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants whi

101 Previous work has shown that the presence of human chromosome 2 increases HIV-1 production in mouse c

102 be corrected by one or more genes present on human chromosome 2 to allow production of infectious HIV

103 s may carry a nonreciprocal translocation on human chromosome 2, in which synchronized double strande

104 s and around the site of ancestral fusion in human chromosome 2.

105 Human chromosome 20q12-q13.1 has been linked to type 2 d

106 ns 14 WFDC genes organized in two subloci on human chromosome 20q13.

107 al heart disease (CHD); however, trisomy for human chromosome 21 (Hsa21) alone is insufficient to cau

108 s caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is the most common genet

109 esults from an extra copy of the long arm of human chromosome 21 (HSA21) and the increased expression

110 The genomic regions on human chromosome 21 (Hsa21) are syntenic to three region

111 functionally trisomic for approximately 120 human chromosome 21 (HSA21) classical protein-coding gen

112 Human chromosome 21 (Hsa21) contains more than 500 genes

113 Moreover, human chromosome 21 (Hsa21) encodes several negative reg

114 vealed that trisomy for only 33 orthologs of human chromosome 21 (Hsa21) genes was sufficient to coop

115 ioinformatic annotation has established that human chromosome 21 (Hsa21) harbors five microRNA (miRNA

116 Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS

117 Trisomy of human chromosome 21 (Hsa21) results in Down syndrome (DS

118 The factors on human chromosome 21 (Hsa21) that confer this predisposin

119 The Tc1 human chromosome 21 (Hsa21) transchromosomic mouse model

120 mbryonic stem cells (ESCs)) bearing an extra human chromosome 21 (HSA21)) we analyzed the early stage

121 Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of

122 Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), results in a broad range of

123 nd ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated i

124 and an isogenic control that is disomic for human chromosome 21 (HSA21).

125 ng in mice carrying a genetically rearranged Human Chromosome 21 (Hsa21).

126 The GART gene is located on human chromosome 21 and is aberrantly regulated and over

127 The underlying gene, SYNJ1, maps to human chromosome 21 and is thus a candidate for involvem

128 isorder caused by full or partial trisomy of human chromosome 21 and presents with many clinical phen

129 ndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent gen

130 ing the pathogenic role of trisomic genes on human chromosome 21 and the genotype-phenotype relations

131 The regions on human chromosome 21 are syntenically conserved in three

132 We identified a 3-megabase region on human chromosome 21 containing 6 candidate genes associa

133 This region of human chromosome 21 contains 6 candidate genes for herpe

134 ty of dentate gyrus-CA3 networks to aberrant human chromosome 21 gene expression and delineate hippoc

135 of mouse chromosome 16 that is homologous to human chromosome 21 has been triplicated.

136 tocytes were recapitulated across the entire human chromosome 21 in the mouse hepatocyte nucleus.

137 e so-called Down syndrome critical region of human chromosome 21 is an important region for this phen

138 the mouse nucleus, hundreds of locations on human chromosome 21 newly associate with activating hist

139 s of DS, involving trisomy of all or part of human chromosome 21 or orthologous mouse genomic regions

140 hich carry a duplication spanning the entire human chromosome 21 orthologous region on mouse chromoso

141 itsn1, synj/synj1, and nla/dscr1, located on human chromosome 21 play important roles in DS neurons.

142 most cases, DS results from an extra copy of human chromosome 21 producing deregulated gene expressio

143 A study in this issue of Oncogene, defines human chromosome 21 sequences that alter hematopoiesis a

144 ed a 22.9 Mb duplication spanning the entire human chromosome 21 syntenic region on mouse chromosome

145 are trisomic for approximately 56.5% of the human chromosome 21 syntenic region on mouse chromosome

146 use strain produce viable sperm and transmit human chromosome 21 to create aneuploid offspring.

147 ytes from an aneuploid mouse strain carrying human chromosome 21 to determine, on a chromosomal scale

148 transmits an almost complete single copy of human chromosome 21 via the female germline, we show tha

149 odel, the Tc1 mouse, which carries a copy of human chromosome 21 was produced in 2005.

150 syndrome is caused by a genomic imbalance of human chromosome 21 which is mainly observed as trisomy

151 ated kinase 1A (DYRK1A) gene is localized in human chromosome 21, and its overexpression has been ass

152 Down's syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of

153 Because it is located on human chromosome 21, RCAN1 has been postulated to contri

154 red with mice derived from female passage of human chromosome 21, the chromatin condensation during s

155 ly relevant published datasets that included human Chromosome 21, the human lipoprotein lipase (LPL)

156 risomic for 132 genes homologous to genes on human chromosome 21, triplication of Usp16 reduces the s

157 When applied to >23,000 transcripts from human chromosome 21, using biologically reasonable filte

158 binant region of interest on the long arm of human chromosome 21, with a multipoint logarithm of odds

159 ariations in hypermutable CpG regions across human chromosome 21.

160 lls and in rodent cells that contain part of human chromosome 21.

161 associated with a region on the long arm of human chromosome 21.

162 Down syndrome (DS) is caused by trisomy of human chromosome 21.

163 oded in the Down syndrome critical region of human chromosome 21.

164 ories of a 2-Mb-long chromatin interval from human chromosome 21.

165 etic condition caused by the triplication of human chromosome 21.

166 itulated in aneuploid mouse neurons carrying human chromosome-21, implicating promoter/enhancer seque

167 harbor a chromosomal duplication syntenic to human chromosome 21q.

168 triplication of only 31 genes orthologous to human chromosome 21q22 confers mouse progenitor B cell s

169 )A(+/-) mice, which model a microdeletion on human chromosome 22 (22q11.2) that constitutes one of th

170 We provide evidence, using alignments of human chromosome 22 against a five-species alignment fro

171 a 1.5- to 3-megabase hemizygous deletion on human chromosome 22, results in dramatically increased s

172 e of the link between hemizygous deletion of human chromosome 22q11.2 and high rates of social behavi

173 model the heterozygous deletion of genes at human chromosome 22q11.2 associated with DiGeorge/22q11.

174 Genes and a 3-Mb deletion mapping to human chromosome 22q11.2 have been implicated in 22q11.2

175 Duplication of human chromosome 22q11.2 is associated with elevated rat

176 Deletion or duplication of the human chromosome 22q11.2 is associated with many behavio

177 The human chromosome 22q11.2 region is susceptible to rearra

178 and mouse model studies on rare CNVs within human chromosome 22q11.2, we propose that alterations of

179 n maps to mouse chromosome 17, syntenic with human chromosome 2p21-22.

180 Here, we map in human chromosome 2q31 the 3D configuration of 200 kb of

181 OBSL1 is located on human chromosome 2q35 within 100 kb of SPEG, another gen

182 The GIGYF2 gene maps to human chromosome 2q37 within a region linked to familial

183 POP2 is a 294 nt single exon gene located on human chromosome 3 encoding a 97-aa protein with sequenc

184 e we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes

185 on of miR-26a located in the locus 3p21.3 of human chromosome 3.

186 emokine receptor genes of the CCR cluster on human chromosome 3p21 play important roles in humoral an

187 a novel tumor suppressor gene identified in human chromosome 3p21.3 region.

188 e new collagen VI genes at a single locus on human chromosome 3q22.1.

189 rs located on CFA34, in a region syntenic to human chromosome 3q26.

190 of synteny between macaque chromosome 5 and human chromosome 4.

191 isoforms, NHA1 and NHA2, found in tandem on human chromosome 4.

192 regions identified in autoimmune patients on human chromosomes 4q21-31, 5q31-33, 16q22-24, 17p11-q12,

193 atrial fibrillation susceptibility locus on human chromosome 4q25 in close proximity to the paired-l

194 e association studies implicated a region of human chromosome 4q25 in familial AF and AFL, approximat

195 s associated with D4Z4 repeat contraction on human chromosome 4q35.

196 lly ordered gene maps for equine homologs of human chromosome 5 (HSA5), viz., horse chromosomes 14 an

197 ndidate gene within the homologous region on human Chromosome 5, which is linked to systolic and dias

198 an interstitial deletion of the long arm of human chromosome 5.

199 C is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syn

200 mplex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of d

201 cluster of highly polymorphic genes found on human chromosome 6 and mouse chromosome 17.

202 The HLA gene complex on human chromosome 6 is one of the most polymorphic region

203 method to the 4.5-Mb extended MHC region on human chromosome 6, combining 8 assembled haplotypes, th

204 or inversion of which delayed replication of human chromosome 6.

205 The MHC on human chromosome 6p21 encodes the HLA genes that govern

206 ivator protein DRIP-130, which is encoded by human chromosome 6q16.3-q23, results in reduced KiSS-1 p

207 range haplotypes spanning a 153-Mb region of human chromosome 7 and found evidence of rare mitotic re

208 xamined 47 sequences from a 1.8-Mb region of human chromosome 7 for silencer and EB activities.

209 hypersensitive segments in the HOXA locus in human chromosome 7.

210 omosome 6qA3 with conservation of synteny to human chromosome 7q32.2.

211 lly, we suggest that aberrations that affect human chromosome 7q36, including XRCC2, correlate with g

212 enhancer of the Sonic Hedgehog (SHH) gene at human chromosome 7q36.3.

213 y number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie suscept

214 polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psorias

215 entified tumor suppressor that exists at the human chromosome 8p21.3 locus.

216 cting, telomerase inhibitor 1) is located at human chromosome 8p23, a region frequently exhibiting he

217 MCPH1 is located on human chromosome 8p23.1, where human cancers frequently

218 n studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated

219 Recently, common variants on human chromosome 8q24 were found to be associated with p

220 Defects in FAM83H on human chromosome 8q24.3 cause autosomal-dominant hypocal

221 se alterations to the locus of E-NTPDase2 on human chromosome 9 cause severe head and eye defects, in

222 This mouse QTL is syntenic with human chromosome 9p.

223 Noncoding variants at human chromosome 9p21 near CDKN2A and CDKN2B are associa

224 h 3D FISH data and known knowledge about the human chromosome and genome, such as, chromosome territo

225 R shows an average 10x speedup on any single human chromosome and has the ability to process the whol

226 oid mouse embryonic stem cells with an extra human chromosome and human induced pluripotent stem cell

227 e of centromeric epialleles on an endogenous human chromosome and suggest genomic complexities underl

228 llite DNA in pericentromeric regions of most human chromosomes and a dynamic chromatin state of gamma

229 are few rearrangements that distinguish ape-human chromosomes, and rates of single-base-pair change

230 nucleotide sequences (TTAGGG) at the end of human chromosomes, and their length is a marker of cellu

231 Human chromosomes are captured along microtubule walls (

232 KAP complex in the end-on conversion process.Human chromosomes are captured along microtubule walls a

233 presentations for the rat, the mouse and the human chromosomes at different levels of detail.

234 Human chromosomes attach initially to lateral walls of m

235 The HYDIN gene located in human chromosome band 16q22.2 is a large gene encompassi

236 urrent 1.55-1.83 Mb heterozygous deletion on human chromosome band 7q11.23.

237 andidate tumor suppressor located within the human chromosome band 7q22 that is frequently deleted in

238 within local regions spanning all autosomal human chromosomes based on Haplotype Map variation data.

239 impanzee and gorilla chromosomes differ from human chromosomes by the presence of large blocks of sub

240 chain simulations including the four largest human chromosomes (C1-C4).

241 In human chromosomes, centromeric regions comprise megabase

242 Most human chromosomes contain multiple alpha satellite array

243 terminal regions, juxtaposed to telomeres on human chromosomes, contain a high density of segmental d

244 Aberrations in human chromosome copy number and structure are common an

245 tion, we tracked the segregation of a single human chromosome during cell division by using LacI-GFP

246 Human chromosome end-capping and telomerase regulation r

247 the single-stranded G-rich DNA overhangs at human chromosome ends and suppresses unwanted DNA repair

248 Human chromosome ends are capped by shelterin, a protein

249 Human chromosome ends are protected by shelterin, an abu

250 with the Atomic Bomb Casualty Commission on human chromosomes, for which he is best known.

251 ins comprehensive annotation on 20 of the 24 human chromosomes, four whole mouse chromosomes and arou

252 (NFkappaB) to the appropriate sites on four human chromosomes generates protein clusters analogous t

253 alization of the mosaic structure of admixed human chromosomes gives results similar to another visua

254 Although most human chromosomes have a single higher-order repeat (HOR

255 At least half of all human chromosomes have two or more distinct HOR alpha sa

256 13% in COSMIC noncoding datasets across all human chromosomes, higher than previously reported.

257 m chicken chromosomes (GGA) Z and 4 and from human chromosomes (HSA) 9, 4, X, 5, and 8 were linked an

258 hromosomes, enabling us to localize specific human chromosomes in live cells.

259 Chromosome 17 is unusual among the human chromosomes in many respects.

260 Here, we examine the fate of dicentric human chromosomes in telomere crisis.

261 pecific telomeres/subtelomeres of individual human chromosomes in two embryonic stem (ES) cell lines

262 This provides a model to study human chromosome inactivation and creates a system to in

263 ntally observed higher-order architecture of human chromosomes, including average scaling properties

264 Strikingly, insertion of a human chromosome into mouse revealed that promoter-assoc

265 lts indicate that the overall structure of a human chromosome is dictated by the spatial confinement

266 rase (IN) for integration of viral cDNA into human chromosome is established, studies with IN mutants

267 Haplotyping of human chromosomes is a prerequisite for cataloguing the

268 faithful chromosome segregation for most of human chromosomes is biased in favor of centromeres with

269 iated wall-removing event, we establish that human chromosome-microtubule attachment is achieved thro

270 hod for multilocus long-range haplotyping on human chromosome molecules in vitro based on the DNA pol

271 pecific technical difficulties of assaying a human chromosome on a mouse background where highly cons

272 We find that human chromosomes operate at the border of the dense ste

273 Using the sequence data from a human chromosome, our results show that Tiger can achiev

274 Common fragile sites are regions of human chromosomes prone to breakage.

275 have re-annotated the repetitive content of human chromosomes, providing evidence for a recent expan

276 Recent studies have shown that human chromosome region maintenance 1 (hCRM1) stimulates

277 se lines showed multigenic enrichment in ten human chromosome regions linked to HLHS.

278 Genome-wide conformation maps of human chromosomes reveal that sister-chromatid pairs int

279 d variants that occur only once among the 80 human chromosomes sampled, occur preferentially at the c

280 d fluorescence-contrast images of Pt-stained human chromosome samples.

281 ano-channel arrays to analyze large terminal human chromosome segments extending from chromosome-spec

282 ated for the multiple alignment of assembled human chromosome sequences from four individuals.

283 Human chromosomes terminate in telomeres, repetitive DNA

284 ic markers in the centromere of 23 of the 24 human chromosomes that allow for rapid PCR assays capabl

285 FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluoro

286 oinformatics tool (methBLAST) for mapping to human chromosomes, the results of which indicated random

287 PURPOSE OF REVIEW: Chromosome 22, the first human chromosome to be completely sequenced, is prone to

288 genetic algorithm to construct 3D models of human chromosomes, using chromosomal contact data.

289 Coexpression of cytokeratin and human chromosome was observed at 7 and, to a lesser exte

290 omosomal spatial positionings of a subset of human chromosomes was examined in the human breast cell

291 more than 3,400 unique clones that span all human chromosomes was used for large-scale discovery exp

292 the effects of gamma radiation on an entire human chromosome, which gives some mechanistic insight i

293 As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplicat

294 rithms, we were able to optimally decode all human chromosomes with N-SCAN, which increased its accur

295 a ninefold SV bias toward the last 5 Mbp of human chromosomes with nearly 55% of all VNTRs (variable

296 phoribosyltransferase (HPRT) gene located on human chromosome X.

297 s separated by two introns and is located on human chromosome Xp11.23.

298 A familial 1.1 Mb deletion of human chromosome Xq22.1 associates with epilepsy, cleft

299 family (CT47) within an unresolved region of human chromosome Xq24.

300 proteins) to active and inactive regions of human chromosomes yields rosettes, topological domains a