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1 ing protein of KCNH2-encoded K(v)11.1 (HERG [human Ether-a-go-go-related gene]).
10 ucleotide polymorphism 2660 G-->A within the human ether-a-go-go-related gene 1 coding sequence, whic
12 ingle-nucleotide polymorphisms (SNPs) in the human ether-a-go-go-related gene 1, hERG1, are associate
14 ts of mutations in the S4-S5 linker of HERG (human ether-a-go-go-related gene), a human delayed recti
15 an cardiac K(+) channel alpha subunits HERG (human ether-a-go-go-related gene) and KCNQ1 by suppressi
16 me ion channels and in particular, the hERG (human Ether-a'-go-go-Related Gene) cardiac potassium cha
17 nonrodent species, had no cytochrome P450 or human ether-a-go-go related gene channel issues, and was
18 limiting to a defined range of cLogP avoided human ether-a-go-go-related gene channel inhibition.
19 is of our previous studies of a mutant HERG (human ether-a-go-go-related gene) channel, we hypothesiz
21 unintentional blockade of the Kv11.1 (hERG [human ether-a-go-go-related gene]) channel are a major s
22 n K(+) (K(2P)) channels, voltage-gated hERG (human ether-a-go-go-related gene) channels and calcium (
23 with cardiac ion channels, notably the hERG (human ether-a-go-go-related gene) channels that generate
24 overexpression of the human K+ channel HERG (human ether-a-go-go-related gene) could enhance repolari
29 ll-derived cardiomyocytes (hESC-CMs) and the human ether-a-go-go-related gene expressing human embryo
31 yndrome type 2 is caused by mutations in the human ether a go-go-related gene (hERG) potassium channe
32 alters cardiac excitability by inhibition of human ether a-go-go related gene (hERG) trafficking and
35 k demonstrates that heterologously expressed human ether a-go-go-related gene (hERG) 1a/1b channels,
41 tage sensor movement to the S6 domain in the human ether-a'-go-go-related gene (hERG) K+ channel.
42 ding activity but also significantly reduced human ether-a-go-go related gene (hERG) and sodium chann
44 inking beta-adrenergic signaling and altered human ether-a-go-go related gene (HERG) channel activity
47 e compounds, they displayed affinity for the human ether-a-go-go related gene (hERG) ion channel.
48 The cardiac potassium channel encoded by the human ether-a-go-go related gene (HERG) is blocked by a
49 eric assembly of two isoforms encoded by the human ether-a-go-go related gene (hERG) is essential for
53 seizure (sei), the Drosophila homolog of the human Ether-a-go-go Related Gene (hERG) potassium channe
54 often due to the off-target blockade of the human ether-a-go-go related gene (hERG) potassium channe
55 ly express wild-type (WT) and mutant (G601S) human ether-a-go-go related gene (hERG) potassium channe
56 onist with a high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channe
58 +)(o)) and extracellular Na(+) (Na(+)(o)) in human ether-a-go-go related gene (HERG)-encoded K(+) cha
60 ividuals harbor mutations in either KCNQ1 or human ether-a-go-go related genes (hERG), which encode t
61 o-EM structures of two of them, K(V)10.1 and human ether-a-go-go-related gene (hERG or K(V)11.1), hav
64 ort that alternate mRNA transcripts encoding human ether-a-go-go-related gene (hERG) 1a and 1b subuni
65 expression of the cardiac potassium channel human ether-a-go-go-related gene (HERG) at clinically re
66 irect block of the cardiac potassium channel human ether-a-go-go-related gene (hERG) but via disrupti
71 T syndromes associated with loss and gain of human ether-a-go-go-related gene (hERG) channel activity
72 III antiarrhythmic compound that blocks the Human Ether-a-go-go-Related Gene (HERG) channel and its
74 patch-clamp electrophysiology to measure the human ether-a-go-go-related gene (hERG) channel block (t
75 silico approaches are widely used to predict human ether-a-go-go-related gene (hERG) channel blockade
76 uoromethyl-phenyl)-urea [NS1643 (NS)] on the human ether-a-go-go-related gene (hERG) channel expresse
84 tifier K(+) current that is conducted by the human ether-a-go-go-related gene (hERG) encoded channel.
85 unctional effects of extracellular Cd(2+) on human ether-a-go-go-related gene (HERG) encoded K(+) cha
100 of the human voltage-dependent K(+) channel human ether-a-go-go-related gene (hERG) in myeloid leuke
105 prolongation directly target and inhibit the human ether-a-go-go-related gene (HERG) K(+) channel at
106 with QTc prolongation on the ECG target the human ether-a-go-go-related gene (HERG) K(+) channel by
107 Defective functional PM expression of the human ether-a-go-go-related gene (hERG) K(+) channel lea
108 of prolonged alpha1A-AR and PKC activity on human ether-a-go-go-related gene (HERG) K(+) channels (K
112 0.5,act)) and inactivation (V(0.5,inact)) of human ether-a-go-go-related gene (hERG) K(+) channels.
113 (NS1643) is a newly discovered activator of human ether-a-go-go-related gene (hERG) K(+) channels.
114 clic nucleotide binding domain (CNBD) of the human ether-a-go-go-related gene (HERG) K+ channel are a
116 t RFFL and the core-glycosylated form of the human ether-a-go-go-related gene (hERG) potassium channe
117 T prolongation is usually caused by block of human ether-a-go-go-related gene (HERG) potassium channe
118 The molecular determinants of high-affinity human ether-a-go-go-related gene (HERG) potassium channe
119 diac ion channels including Na(V)1.5 and the human ether-a-go-go-related gene (hERG) potassium channe
120 quently used antiarrhythmic drug that blocks human ether-a-go-go-related gene (hERG) potassium channe
123 emistry data demonstrate that RNF207 and the human ether-a-go-go-related gene (HERG) potassium channe
126 es displayed a low propensity to inhibit the human ether-a-go-go-related gene (hERG) potassium ion ch
128 yndrome (LQT2) is caused by mutations in the human ether-a-go-go-related gene (HERG) that encodes the
129 ties in luciferase folding and repression of human ether-a-go-go-related gene (HERG) trafficking that
130 caused by loss-of-function mutations in the human ether-a-go-go-related gene (hERG) voltage-gated po
132 ryonic kidney cell line 293 cells expressing human ether-a-go-go-Related gene (hERG), a Food and Drug
133 with LQT, we identified a novel mutation in human ether-a-go-go-related gene (HERG), a voltage-gated
135 -rectifier K(+)-current (IKr) encoded by the human ether-a-go-go-related gene (hERG), is therefore re
136 HERG USO, a C-terminal splice variant of the human ether-a-go-go-related gene (HERG), the gene encodi
137 om mutations in several genes, including the human ether-a-go-go-related gene (HERG), which encodes a
138 channel, cause the disease, Mutations in the human ether-a-go-go-related gene (HERG), which encodes a
139 ctifier K(+) channel (IKr) is encoded by the human ether-a-go-go-related gene (hERG), which is import
140 en illustrated with the cloning of zebrafish human ether-a-go-go-related gene (HERG), which shows nea
142 e the mechanism and site of action whereby a human ether-a-go-go-related gene (HERG)-specific scorpio
149 n the trafficking of subunits encoded by the human ether-a-go-go-related gene (hERG1) can lead to cat
153 ntended block of the promiscuous drug target human ether-a-go-go-related gene (hERG1), the pore-formi
154 lead compound 3, which had off-target hERG (human ether-a-go-go related gene) inhibition activity, l
157 the functional role of the C-terminus of the human ether-a-go-go-related gene K(+) channel HERG was i
158 hypothesis that anti-Ro Abs target the HERG (human ether-a-go-go-related gene) K(+) channel, which co
159 )) located in the S4-S5 linker endowed HERG (human ether-a-go-go-related gene) K(+) channels with the
160 report here inhibition by 4-AP of HERG (the human ether-a-go-go-related gene) K+ channels expressed
161 voltage-gated potassium channel subtype 11.1 human ether-a-go-go related gene (Kv11.1) (hERG) channel
162 lectivity over the serotonin 2A receptor and human ether-a-go-go-related gene potassium ion channel.
164 Drug-induced block of the cardiac hERG (human Ether-a-go-go-Related Gene) potassium channel dela
167 n that the unusually long S5-P linker lining human ether a-go-go related gene's (hERG's) outer vestib
168 responses more accurately than the standard human ether-a-go-go-related gene test or healthy control
171 The toxin had no effect on hKv1.4, hKv1.5, human ether-a-go-go-related gene type 1 (hERG1), or huma
172 g3 (Rg3) is a steroid glycoside that induces human ether-a-go-go-related gene type 1 (hERG1, Kv11.1)
173 , LQT2, results from mutations in HERG1, the human ether-a-go-go-related gene, which encodes a voltag