ライフサイエンスコーパス: human lung

1 ovides a single-cell atlas of the developing human lung.

2 both the proximal and distal portions of the human lung.

3 nse to re-exposure to M. tuberculosis in the human lung.

4 acteria, while establishing infection in the human lung.

5 gE-mediated bronchoconstriction in slices of human lung.

6 tection of pathogens in situ in an explanted human lung.

7 cterize the major NK cell populations in the human lung.

8 tively little is known about NK cells in the human lung.

9 ch, we create an extensive cell atlas of the human lung.

10 CE2), the SARS-CoV-2 receptor, in rodent and human lungs.

11 dy innate interactions between S. aureus and human lungs.

12 NA sequencing on HLA-DR(+) cells sorted from human lungs.

13 of lung size, using a computational model of human lungs.

14 ery in small (rodent) and large (porcine and human) lungs.

15 This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu and systemi

16 f engineered nanoparticles (NPs) on cultured human lung A549 cells directly from the gas phase.

17 ges in the synthesis of specific proteins in human lung adenocarcinoma (A549) cells in which eEF2K ha

18 COX6B2 is expressed in human lung adenocarcinoma (LUAD) and expression correlat

19 , Madin-Darby canine kidney subclone II, and human lung adenocarcinoma [Calu-3] cells).

20 e cell-lethal phenotype of ADAR1 deletion in human lung adenocarcinoma A549 cells is rescued by CRISP

21 d a high level of expression of miR-155 in a human lung adenocarcinoma A549R cell line that is highly

22 a from OPA to previously published data from human lung adenocarcinoma and found a large degree of ov

23 del and invasion and replication assays with human lung adenocarcinoma cell line A549.

24 Using a human lung adenocarcinoma cell line, we show pharmacolog

25 ge and apoptotic responses across a panel of human lung adenocarcinoma cell lines.

26 Huh7 human hepatocarcinoma cells and HCC4006 human lung adenocarcinoma cells.

27 Human lung adenocarcinoma exhibits a propensity for de-d

28 D1/integrin beta3 axis, was also detected in human lung adenocarcinoma specimens.

29 s on syngeneic mouse lung adenocarcinoma and human lung adenocarcinoma xenografts.

30 in-modifying genes are frequently mutated in human lung adenocarcinoma, but the functional impact of

31 first show, using primary cell cultures from human lung adenocarcinoma, that the effectors of the Hip

32 aluable naturally occurring animal model for human lung adenocarcinoma.

33 athways may cooperate in the pathogenesis of human lung adenocarcinoma.

34 similarities and differences between OPA and human lung adenocarcinoma.

35 of this naturally occurring animal model for human lung adenocarcinoma.IMPORTANCE Ovine pulmonary ade

36 potential impact of 19 well-defined DCAFs in human lung adenocarcinomas (LuADCs) using integrative om

37 examined in a subset of surgically resected human lung adenocarcinomas by multispectral imaging, whi

38 rcinoma (Kras(LA1)), here we postulated that human lung adenocarcinomas containing Thy-1(+) CAFs have

39 initiating oncogenic event in almost half of human lung adenocarcinomas is still unknown, a fact that

40 xamined the location of Thy-1(+) CAFs within human lung adenocarcinomas.

41 ogenesis in vitro, including exposure of the human lung airway to fresh whole cigarette smoke (WCS) u

42 O- and glycosphingolipid-glycans from total human lungs, along with histological analyses of IAV bin

43 is the cause of a present pandemic, infects human lung alveolar type 2 (hAT2) cells.

44 ation of miR-221 in total RNA extracted from human lung and breast cancer cell lines, discriminating

45 Pac 1 significantly inhibited the growth of human lung and breast xenograft tumors in mice with no t

46 In human lung and colorectal tumors, RAS pathway activation

47 onstruction map on a radiological image of a human lung and forms an interactive resource for the sci

48 roduction, bioactions, and mechanisms in the human lung and in patients with experimental allergic ai

49 Efficient growth in primary human lung and intestinal cells implicate SADS-CoV as a

50 s control the deposition of particles in the human lung and likely their toxicity; in addition, they

51 In addition, we found that normal human lung and mammary epithelial cells were less sensit

52 duced caspase-mediated apoptosis against the human lung and melanoma cancer cells which were well sup

53 ALK, ROS1, RET, and NTRK1 act as drivers in human lung and other cancers.

54 y eradicate highly aggressive drug-resistant human lung and pancreas cancers in mice, but also to pre

55 ectively in RAS mutant but not RAS wild-type human lung and pancreas carcinomas.

56 The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease are poorly

57 ication and characterization of LAM cells in human lung and uterus using a single-cell approach.Metho

58 circulation of whole blood between explanted human lungs and a Yorkshire swine.

59 e of c-KIT(+) ECs was conserved in mouse and human lungs and enriched in FOXF1-regulated transcriptio

60 platform to study S. aureus interaction with human lungs and to define virulence factors that incapac

61 l Ag-presentation molecule HLA-DR within the human lung, and that this expression can be recapitulate

62 ata are available on NiV pathogenesis in the human lung, and the relative contribution of the innate

63 Glycans within human lungs are recognized by many pathogens such as inf

64 te that our designed peptides perturb TJs in human lung as well as human and murine skin epithelium,

65 We examined RGS4 expression in human lung biopsies by immunohistochemistry.

66 its of which we showcase for the exemplar of human lung biopsy specimens.

67 has been validated by a preliminary test on human lung biopsy, which has confirmed the ex-vivo CK17

68 pecialization is conserved between mouse and human lungs but is not found in alligator or turtle lung

69 nvolvement of these T cells during TB in the human lung by global TCR sequencing.

70 s one of the most common driver mutations in human lung cancer and correlates with aggressive disease

71 ensity and distribution between TC and IM in human lung cancer and TAM associations with overall surv

72 Human lung cancer biopsies expressed higher levels of Nr

73 RNA-seq analysis in human lung cancer cell line H1299 reveals that downregul

74 exhibited strong cytotoxicity toward various human lung cancer cell lines, as well as chemotherapeuti

75 Here, using several human lung cancer cell lines, siRNA-mediated gene silenc

76 nhanced MET or c-Src signaling, including in human lung cancer cell lines.

77 ansition (EMT) and migration in both primary human lung cancer cells and cell lines.

78 enic radiation-resistant and -sensitive A549 human lung cancer cells and human head and neck squamous

79 sis preferentially impedes tumorigenicity of human lung cancer cells bearing KMT2D-inactivating mutat

80 resses immune rejection and allows growth of human lung cancer cells in lal(-/-) mice.

81 A 10-min exposure of A549 human lung cancer cells to sequential 50- and 385-Hz osc

82 Depletion of endogenous Mcl-1 from human lung cancer cells using CRISPR/Cas9 or Mcl-1 shRNA

83 rimary PH vascular cells, and in a subset of human lung cancer cells.

84 onmuscle myosin IIA-dependent trafficking in human lung cancer cells.

85 5-induced growth inhibition and apoptosis in human lung cancer cells.

86 To interrogate a human lung cancer database for the presence of Thy-1(+)

87 Furthermore, a case study on human lung cancer dataset was performed and we provided

88 Analysis of human lung cancer datasets showed that GLI1 mRNA was hig

89 formed a transcriptome analysis of the major human lung cancer entities.

90 sis and irreversibly blocks proliferation of human lung cancer H460, H520, H1299, HCC827, and H1703 c

91 of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and

92 We investigated human lung cancer metabolomics from 93 paired tissue-ser

93 ith the transcriptional changes occurring in human lung cancer revealed important similarities and di

94 In human lung cancer specimens, while FBXW2 levels are inve

95 lation of Th9 and Th17 cells was detected in human lung cancer tissue and correlated with poor surviv

96 Here, using human lung cancer tissue microarrays and fresh frozen ti

97 vitro cocultures, in vivo mouse models, and human lung cancer tissue.

98 expression, which was later corroborated in human lung cancer tissues and immortalized lung cancer c

99 Remarkably, human lung cancer tissues can only be distinguished from

100 tly, NatD is commonly upregulated in primary human lung cancer tissues where its expression level cor

101 More importantly, CDK20 is overexpressed in human lung cancer tissues, as determined by immunostaini

102 ofoundly between cancer cell lines and fresh human lung cancer tissues; the latter preferred glucose

103 A novel immunodeficient rat model supports human lung cancer xenografts.

104 While PDLIM2 is epigenetically repressed in human lung cancer, associating with therapeutic resistan

105 have comparative relevance for understanding human lung cancer.

106 is a valuable animal model for some forms of human lung cancer.

107 SRP), an ARE-BP, is robustly up-regulated in human lung cancer.

108 n that adversely impacts clinical outcome in human lung cancer.

109 e report that HACE1 is frequently mutated in human lung cancer.

110 Approximately 30% of human lung cancers acquire mutations in either Keap1 or

111 Tissue microarrays of human lung cancers indicated the expression of PIERCE1 i

112 In human lung cancers, high NFATc2 expression predicted poo

113 Although silica is a confirmed human lung carcinogen, little is known regarding the can

114 ion induced a significant increase of ROS in human lung carcinoma A549 cells.

115 ome-wide CRISPR-Cas9-mediated screen using a human lung carcinoma cell line and identify semaphorin (

116 veness in targeting c-Myc for degradation in human lung carcinoma.

117 Here we assembled a healthy human lung cell atlas meta-analysis with ~ 130,000 publi

118 NAVETTA is a novel option for mimicking human lung cell exposure to NPs, complementing existing

119 eLa cells to levels comparable to those in a human lung cell line.

120 xposure, which deserves to be tested also on human lung cell lines.

121 ted efficiently in several different primary human lung cell types, as well as primary human intestin

122 uggest resveratrol may enhance resistance of human lung cells (e.g., SAEC) to air pollutants (e.g. DE

123 anism employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-null) lung

124 on biomarkers of exposure after treatment of human lung cells and zebrafish to benzo[a]pyrene (BAP).

125 s as potential regulators of BAP toxicity in human lung cells associated with cell migration, cell co

126 tective effect of resveratrol on DEP-exposed human lung cells in a factorial experimental design.

127 Exposing human lung cells to particulate matter smaller than 10 m

128 Human lung cells were exposed at an air-liquid interface

129 s more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered per

130 ensional organotypic coculture using primary human lung cells, precision-cut lung slices (PCLS), and

131 sampled and subsequently exposed to cultured human lung cells.

132 fficient to induce severe adverse effects in human lung cells.

133 n of human gut cells but is unable to infect human lung cells.

134 increased accumulation of ILC subsets in the human lung, coinciding with a robust transcriptional res

135 Immunofluorescence of human lungs confirmed our in vivo data and showed an inc

136 The N-glycome of human lung contains extremely large complex-type N-glyca

137 We investigated 1) the levels of human lung CYP2A mRNA in smokers versus nonsmokers and 2

138 ainties in risk assessment for NA is whether human lung CYP2A13 and CYP2F1 can mediate NA's respirato

139 t smoking was associated with a reduction in human lung CYP2A13, CYP2A6, and CYP2A7 mRNA, consistent

140 Here we demonstrate that acutely injured human lungs declined for transplantation, including a lu

141 Finally, fibrotic human lungs demonstrate altered BMP activation in the me

142 TF antiserum inhibited bacterial adhesion to human lung derived epithelial cells, indicating that TF

143 s can now be used to study hidden aspects of human lung development and pediatric lung disease.

144 To elucidate the pathogenetics of human lung development, we studied a unique collection o

145 g pathways in proximodistal specification in human lung development.

146 del epithelial-mesenchymal cross-talk during human lung development.

147 ight into proximodistal specification during human lung development.

148 c mouse lung is a widely used substitute for human lung development.

149 lungs in large animals to enable modeling of human lung disease as well as cell-based therapeutic int

150 y disease (COPD) and asthma remain prevalent human lung diseases.

151 Twenty-nine human lung DNA samples resulted in 20 positive measureme

152 mes from bronchoalveolar lavage samples from human lung donors.

153 ns revealed that the exposures of the NPs to human lung due to the abrasion of the textiles were lowe

154 We sought to understand AM ontogeny in human lung during healthy aging and after transplant.

155 del in which the majority of NK cells in the human lung dynamically move between blood and the lung r

156 An immortalized primary human lung EC (HPMEC-im) line was generated by SV40 tran

157 Human lungs enable efficient gas exchange and form an in

158 created a microdevice for culturing primary human lung endothelial cells under physiological flow co

159 tool is demonstrated using biological (e.g. human lung endothelial cells) and environmental (e.g. pe

160 IL-13 stimulation decreased miR-1 levels in human lung endothelium.

161 duces Moraxella adherence to and invasion of human lung epithelial A549 cells.

162 etone, cause the same deleterious effects in human lung epithelial and bladder urothelial cells.

163 se peptides transiently disrupted TJs in the human lung epithelial cell line 16HBE and delayed TJ for

164 rounding and detachment of cells of the A549 human lung epithelial cell line as well as the Xps-media

165 Human postmortem lung tissue and human lung epithelial cell line BEAS-2B.

166 Human lung epithelial cells (BEAS-2B) were used to study

167 found that it enhances viral replication in human lung epithelial cells and primary human airway tis

168 factor, to the neoplastic-like properties of human lung epithelial cells chronically exposed to a low

169 death, improved viability, and protection of human lung epithelial cells in vitro.

170 Here, we show that infection of human lung epithelial cells with influenza A virus (IAV)

171 In human lung epithelial cells, GSK3008348 induces rapid in

172 higher level of apoptosis upon infection of human lung epithelial cells, indicating that a T4SS effe

173 itro action of TGFbeta1-mim was evaluated in human lung epithelial cells, Jurkat cells, and rat basop

174 has profound effects upon gene expression in human lung epithelial cells, some of which are epigeneti

175 In human lung epithelial cells, the microRNA-150 (miR-150)

176 equences and live influenza A virus (IAV) in human lung epithelial cells.

177 and activities of cGAS, STING, and PYHINs in human lung epithelial cells.

178 ig on the micro RNA (miRNA) transcriptome in human lung epithelial cells.

179 aspase-8 and induces apoptotic cell death in human lung epithelial cells.

180 he proximo-distal differentiation pattern of human lung epithelial cells.

181 e of a multi-cellular model representing the human lung epithelial tissue barrier via multi-colour fl

182 demonstrated antiviral efficacy in a primary human lung explant model.

183 x vivo human bronchial epithelial cell (BEC)/human lung fibroblast (HLF) coculture model.

184 nts are enriched in regulatory features in a human lung fibroblast cell line and contribute to DLC1 e

185 esolution whole-genome Hi-C data from IMR90 (human lung fibroblast), and (iii) budding yeast whole-ge

186 V infection of human airway epithelial cell, human lung fibroblast, and U937 monocyte cocultures (at

187 brotic TGFbeta signaling, TGFbeta stimulated-human lung fibroblast-derived PD-L1 into extracellular v

188 tumor cells + mesenchymal stem cells (MSCs)/human lung fibroblasts (HLFs)/HUVECs) and the extracellu

189 We evaluated the response of normal human lung fibroblasts (NHLFs) to stimulation with mtDNA

190 Correspondingly, human lung fibroblasts and bronchial epithelial cells we

191 ed for cytotoxicity with the MTT assay using human lung fibroblasts and epithelial cells.

192 L33 protein segments and variants in primary human lung fibroblasts and HEK293T cells, we show that F

193 ulators of proliferation and inflammation in human lung fibroblasts and that these might mediate the

194 brotic TGF-beta activity in murine cells and human lung fibroblasts as well as in vivo with no demons

195 These results indicate a novel role for human lung fibroblasts in contributing to responses agai

196 ivation in a PI3K-dependent manner in normal human lung fibroblasts in vitro Mechanistically, TRPV4 m

197 Analysis of human lung tissues and primary human lung fibroblasts indicates that this fate switchin

198 ir proximity in tissue, we hypothesized that human lung fibroblasts play an important role in modulat

199 kel cell polyomavirus-large tumor antigen in human lung fibroblasts resulted in upregulation of SPTLC

200 aling induced HK2 accumulation in murine and human lung fibroblasts through induction of the transcri

201 modest induction of Ralpha2 in normal adult human lung fibroblasts, but found that prostaglandin E(2

202 TGF-beta(1) stimulated collagen synthesis in human lung fibroblasts, whereas canonical PI3K/Akt signa

203 ion and bystander effect on individual IMR90 human lung fibroblasts.

204 ted in decreased TGFB2 expression in primary human lung fibroblasts.

205 g factor for collagen enhancer activation in human lung fibroblasts.

206 -to-myofibroblast differentiation in primary human lung fibroblasts.

207 fferentiation potential compared with normal human lung fibroblasts.

208 endent models of lung injury and persists in human lung fibrosis, creating a distinct cell-cell commu

209 d a single-cell mRNA sequencing atlas of the human lung from 11.5 to 21 weeks of development, which r

210 on of the microbial and chemical makeup of a human lung from a cystic fibrosis patient.

211 nary macrophages were defined in nondiseased human lungs from smokers and nonsmokers.

212 Human lung gene expression and single nucleotide polymor

213 T cells formed aggregates in rejection-free human lung grafts and accumulated within induced bronchu

214 show that NiV-B replicated to high titers in human lung grafts and caused similar cytopathic effects

215 Using human lung grafts in a human immune system-reconstituted

216 showed that NiV replicates to high titers in human lung grafts in NOD-SCID/gamma mice, resulting in a

217 lls made up the vast majority of NK cells in human lungs, had a more differentiated phenotype, and mo

218 d with high resolution imaging in the distal human lung has the potential to provide new insights and

219 ted clearance of persistent Mtb infection in human lungs has not been established.Objectives: Using a

220 natomic locations they occupy in the healthy human lung have not been quantified.Objectives: To deter

221 es and have been described in the developing human lung; however, the mechanisms controlling human bu

222 the EVLP platform to study miR signature in human lungs in response to CI/EVR.

223 to examine the changes in miR expression in human lungs in response to cold ischemia and ex vivo rep

224 ical locations of 58 cell populations in the human lung, including 41 out of 45 previously known cell

225 led many potential regulators of ACE2 in the human lung, including genes related to histone modificat

226 Single-cell RNA-sequencing of human lungs, including those from idiopathic pulmonary f

227 Data from in-vitro, animal, and human lung injury models suggest that keratinocyte growt

228 y time of flight (CyTOF), we identified that human lung IRF5 expression was highest in cells of the m

229 syncytial virus (RSV) infection in mouse and human lung is associated with oxidative injury and patho

230 id that exhibits characteristics of a normal human lung is developed to study the biology of metastat

231 Human lung mast cells readily recover from a desensitize

232 ation of IgE-mediated histamine release from human lung mast cells was explored by methods that parti

233 Within the human lung, mast cells typically reside adjacent to the

234 that mouse models can be used to interrogate human lung metabolome changes.

235 ty, but they have been little studied in the human lung.METHODSHealthy adult volunteers were inoculat

236 d IHC to enable 3D mathematical modelling of human lung microfluidics at micrometre resolution.

237 coding a single guide RNA (sgRNA) in primary human lung microvascular ECs (HLMVECs) disrupted the exp

238 of heme-mediated intracellular signaling of human lung microvascular endothelial cells (HLMVECs).

239 disease lungs and CS extract-exposed primary human lung microvascular endothelial cells (HLMVECs).

240 rhage model, increased miR-19b expression in human lung microvascular endothelial cells, leading to a

241 evealed a high degree of heterogeneity among human lung myeloid cells.

242 h demonstrated strong expression of TRPA1 in human lung myofibroblasts, human airway smooth muscle ce

243 omposition, differentiation, and function of human lung NK cells is critical to better understand the

244 Despite this, human lung NK cells were hyporesponsive toward target ce

245 raffin-embedded tissues from fresh explanted human lungs of patients with PVOD (n = 19), PAH (n = 20)

246 10-FGFR2 epithelial-mesenchymal signaling in human lung organogenesis and help to explain the histopa

247 g disease can be targeted and corrected in a human lung organoid model in vitro.

248 their applications in developmental biology, human lung organoids and bud tip progenitor organoids ma

249 urther into two distinct types of organoids: human lung organoids and bud tip progenitor organoids.

250 Human lung organoids can be generated from hPSCs in 50-8

251 ploring epithelial fate decisions, while the human lung organoids can be used to model epithelial-mes

252 The resulting human lung organoids possess cell types and structures t

253 in lung epithelial cells and viral entry in human lung organoids.

254 est impact on host viability in the cells of human lung origin.

255 On human lung parenchymal explants, chloroquine concentrati

256 glycans that may serve as binding sites for human lung pathogens.

257 lung development are expressed in primordial human lung progenitors and revealed a CD47hiCD26lo cell

258 In this study, we used human lung samples and a hypoxia-induced mouse model of

259 gy was tested in model systems and unrelated human lung samples.

260 High-fidelity, 3D computational models of human lungs, scaled to various sizes representative of n

261 howed that GLI1 mRNA was highly expressed in human lung SCC and portended a poor prognosis.

262 but low H3K27me3 mark, is also prevalent in human lung SCC and SCC regions within ADSCC tumours.

263 Inhibition of GLI1 in human lung SCC cell lines suppressed tumor cell clonogen

264 structures, and core modifications; and the human lung shotgun glycan microarray.

265 ly 'breathes' WCS through microchannels of a human lung small airway microfluidic culture device, mim

266 thoroughly tested for their toxicity in the human lung.Solid-state emissions from coal burning remai

267 pression quantitative trait locus effects in human lung specimens and blood, as well as associations

268 ession profiling to analyze TLS formation in human lung squamous cell carcinoma (LSCC) and in an expe

269 Although reported to be present in the human lung, their specific presence and functional orien

270 limitations in acquiring cells from healthy human lung, these subsets remain poorly characterized tr

271 Explanted small bronchi isolated from human lung tissue and human airway smooth muscle cells w

272 echnique for hAT2 cells derived from primary human lung tissue and investigate infection response to

273 lveolar epithelial cells can be derived from human lung tissue but the quality of these cells is high

274 r BI2536 on influenza virus replication in a human lung tissue culture model and observed strong inhi

275 an S8mAb can inhibit mast cell activation in human lung tissue ex vivo.

276 bited TRAP activity in murine macrophage and human lung tissue extracts.

277 eter, 0.5-2 mm) from macroscopically healthy human lung tissue were obtained from 48 patients and mou

278 alleled by increased TrkB gene expression in human lung tissue, and SNPs in the NTRK2 [TrkB] and BDNF

279 This vector also transduces human lung tissue, demonstrating its potential for clini

280 Here, we show that implantation of human lung tissue, which contains up to 40 cell types, i

281 e pathogen does not grow in non-hAM cells of human lung tissue.

282 human alveolar macrophages (hAMs) in ex vivo human lung tissue.

283 y the ion at m/z 885.6 as a marker of PAH in human lung tissue.

284 Analysis of human lung tissues and primary human lung fibroblasts in

285 mised approach for fibroblast isolation from human lung tissues.

286 ributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly

287 donor-derived CD4 T cells in 21 consecutive human lung transplant recipients, with 3 patterns of chi

288 levels of histone deacetylase 11 (HDAC11) in human lung tumor tissues correlate with poor patient out

289 Human lung tumors exhibit robust and complex mitochondri

290 derlies this sensitivity was also present in human lung tumors, indicating that this therapeutic appr

291 ing of the interactions between cells within human lung tumors, we perform RNA-seq profiling of flow-

292 1 activation is found in non-KRAS-associated human lung tumors.

293 on between loss of IPO11 and PTEN protein in human lung tumors.

294 d CD8(+) T cell subpopulations in murine and human lung tumors.

295 o been identified in a subset of KRAS-driven human lung tumours.

296 Human lungs were assessed by using immunohistochemistry

297 t the most abundant cysteinyl LMs in healthy human lungs were MCTRs, whereas CysLTs were most prevale

298 Twenty-four human lungs were perfused in cellular EVLP system for 2

299 s allows the bacteria to be inhaled into the human lung, where L. pneumophila can be phagocytosed by

300 These dynamic environments include the human lung, which is the first exposure site for these o