ライフサイエンスコーパス: human skin

1 he human immune response to infection in the human skin.

2 (+) fibroblasts to modulate wound healing in human skin.

3 d functional features are found in mouse and human skin.

4 ip and the depth distribution of proteins in human skin.

5 ingested by mosquitoes taking a bloodmeal on human skin.

6 suppressing mosquito biting behavior on live human skin.

7 es, plasma cells reside in healthy mouse and human skin.

8 or the detection and monitoring of drugs via human skin.

9 he intimate contact between novel fibers and human skin.

10 studies comparing their relative efficacy in human skin.

11 PVs activated CD8(+) T cells from unaffected human skin.

12 h MCPyV virions being continuously shed from human skin.

13 as well as in a model of bacterial insult in human skin.

14 ssment of the presence of drugs directly via human skin.

15 res were not active at the levels emitted by human skin.

16 ignancy can also occur in PIPs within normal human skin.

17 ith aging in a tissue-specific manner and in human skin.

18 the time-consuming purification of LCs from human skin.

19 elivery and subsequent expression of pDNA in human skin.

20 (pCMVbeta and pEGFP-N1) into viable excised human skin.

21 rent wavelengths for producing vitamin D3 in human skin.

22 taxa, represented by a core archaeome of the human skin.

23 or mass transfer from environmental media to human skin.

24 olation of primary fibroblasts and LECs from human skin.

25 types, including cells of the target tissue-human skin.

26 s in paired samples of normal and irradiated human skin.

27 moduli increased with body mass, except for human skin.

28 ions of dietary treatments in both mouse and human skin.

29 onomy of APC subsets found in both mouse and human skin.

30 onally distinct fibroblast subpopulations in human skin.

31 2A (p16(ink4)) expression in organ-cultured human skin.

32 2 response is operational in acute wounds of human skin.

33 expression level of heparan sulfate (HS) in human skin.

34 ar chemical agents are irritating or not for human skin.

35 ify Il22 mRNA and IL-22 protein in mouse and human skin.

36 el eukaryote genomes, including one from the human skin.

37 lly-resolved quantitative proteomic atlas of human skin.

38 allergic and irritant contact dermatitis in human skin.

39 ility by fast ex vivo and in vivo imaging of human skin.

40 s is selectively increased after wounding of human skin.

41 ic landscapes of individual melanocytes from human skin.

42 of ES closely resembled that of non-inflamed human skin.

43 three-dimensional (3D) skin equivalents, and human skin.

44 These spines were also present in intact human skin.

45 unctional profiles of T cells found in fresh human skin.

46 the liver (dual-soft) while being stable in human skin.

47 n, is elevated in dermal fibroblasts in aged human skin.

48 y far above the basal levels of autophagy in human skin, a major site of VZV assembly.

49 As demonstrated before, human skin actually contains two different memristor typ

50 ress the senescence marker p16(INK4A) during human skin ageing.

51 keratinocyte function and act as drivers of human skin ageing.

52 Understanding human skin aging requires in-depth knowledge of the mole

53 provide a single-cell molecular framework of human skin aging, providing a rich resource for developi

54 ifferent studies expand our understanding of human skin aging.

55 e phosphate buffered saline-treated animals, human skin allografts were infiltrated with lymphocytes

56 h blood vessel networks, over 8 mm x 8 mm of human skin and 5 mm x 5 mm of human areola.

57 phenotypic differences between the mouse and human skin and broadly informs on the prevailing princip

58 one of the most common bacterial species on human skin and can promote the common disease acne vulga

59 n transducers that are not conformal to soft human skin and cannot function under stretched states.

60 with abundant Cutibacteria acnes on healthy human skin and does not typically form a biofilm in this

61 ials to process capability, for their use in human skin and eye-interfaced health monitoring systems

62 Human skin and eyes contain specific carotenoid species

63 locus analysis, utilizing RNA-seq data from human skin and found that LCE3B/C-del was associated wit

64 tively expressed in the epidermis of healthy human skin and has been found to be upregulated in chron

65 Here, we introduce the human Skin and Immune System (hSIS)-humanized NOD-scid I

66 The co-engraftment of these human skin and immune system components into a single hu

67 se commensurate with the level released from human skin and in the ratio produced by subject A, the a

68 ased soft sensor is fabricated and tested on human skin and in vivo in mice.

69 ranscriptomic analysis on acutely UV-exposed human skin and integrated those findings with datasets f

70 Furthermore, human skin and its appendages can be used as highly acce

71 ermidis is normally a commensal colonizer of human skin and mucus membranes, but, due to its ability

72 Us to compare to transcriptional profiles of human skin and oral acute wounds, oral as a model of "id

73 It has been shown that human skin and other biological tissues are memristors.

74 from 20% to 165% of that expressed in normal human skin and persisted for 3 months.

75 hway maintains the structure and function of human skin and provide 3D epidermal models wherein SCC p

76 c receptor, was expressed on nerve fibers in human skin and sensory neurons in dorsal root ganglia.

77 -induced mutations in habitually sun-exposed human skin and subsequent development of actinic keratos

78 Using a bioinformatics approach of human skin and vascular tissue, we determined IFN-gamma

79 is the most prominent inflammasome sensor in human skin, and all pathogenic NLRP1 mutations are gain-

80 Scratching upregulated IL13 expression in human skin, and IL-13 suppressed the capacity of LPS-sti

81 ed peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in prima

82 fold higher than that of miR-146b in healthy human skin, and it was more strongly induced by stimulat

83 ics (such as reversibility and stability) of human skin are affected by the external stimuli, as well

84 established that different sites in healthy human skin are colonized by distinct microbial communiti

85 ge-related changes in the immune function of human skin are unclear.

86 an antimicrobial fatty acid produced only by human skin, arrested growth without recovery in WT, Delt

87 Using human skin as a microvascular model, we hypothesized tha

88 Since human skin as well as ambient air is a poor conductor of

89 , we showed HCMV successfully grows in adult human skin, as does VZV.

90 d significant similarities between swine and human skin, as previously published.

91 d significant similarities between swine and human skin, as previously published.

92 and an increase in the relative abundance of human skin-associated fungi and bacteria in houses.

93 Successful co-engraftment of human skin, autologous lymphoid tissues, and autologous

94 rminal differentiation and were disrupted by human skin barrier disease-associated mutations.

95 RNA aptamers can permeate across the intact human skin barrier to therapeutically relevant levels in

96 hat the effects of air pollutant exposure on human skin be investigated.

97 involved immunological players and pathways, human skin biopsies were taken at 0, 2, 48, and 96 hours

98 e light electron microscopy was performed on human skin biopsies.

99 scopy have been used to identify features in human skin biopsy samples diagnosed for basal cell carci

100 ct of lidocaine, a local anesthetic used for human skin biopsy, on B. burgdorferi presence was measur

101 tic skin biopsy specimens, as well as normal human skin, blood, and primary cells, were used to inves

102 ical impact, a biological system such as the human skin, brain, or liver is rapidly accelerated, whic

103 ve fibroblast population that is abundant in human skin but not in gingiva may drive the profibrotic

104 pDCs are not readily detectable in healthy human skin, but have been suggested to accumulate in wou

105 NAM has anti-aging activity on human skin, but the underlying mechanisms of action are

106 Analyzing digested normal human skin by single-cell RNA sequencing, we explored di

107 Our findings suggest that human skin can be successfully cultured for pharmacodyna

108 a from an ultraviolet radiation (UV)-induced human skin cancer and from a mouse model of urethane-ind

109 cant reduction in viral activity and load in human skin cancer compared with the adjacent healthy ski

110 ial therapeutic target for the prevention of human skin cancer given that it is a major negative regu

111 radiated XP-V cells is highly similar to the human skin cancer profile, revealing how studies involvi

112 rcinoma (MCC), a rare but aggressive form of human skin cancer, strongly suggesting that this virus i

113 murine tumors are similar to those found in human skin cancers, and PMA promotes proliferation of hu

114 mulus-dependent manner and was detectable in human skin cancers.

115 ydroxylumisterols inhibited proliferation of human skin cells in a cell type-dependent fashion with p

116 wavelengths, the responsiveness of different human skin cells, the magnitude of inter-individual diff

117 n cancers, and PMA promotes proliferation of human skin cells.

118 ROS/RNS and effectively tune the behavior of human skin cells.

119 The wide range in human skin color results from varying levels of the pigm

120 2 ratio was associated with CD4+ cells in AD human skin compared with those in healthy controls.

121 Human skin consists of multiple cell types, including ep

122 Human skin contains a population of memory T cells that

123 Human skin contains an abundant and diverse population o

124 In an ex vivo human model of BP, normal human skin cryosections were incubated with purified hum

125 13 suppressed the capacity of LPS-stimulated human skin DCs to express IL-12 and promote IFN-gamma se

126 We examined mature human skin-derived MCs using flow cytometry for expressi

127 marrow-derived cultured mast cells (MCs) and human skin-derived MCs.

128 l provide a foundation for future studies of human skin development, disease modelling and reconstruc

129 as been proposed to contribute to the common human skin disease acne vulgaris.

130 olar fibroblasts, we demonstrate that in the human skin disease lichen simplex chronicus, WNT5a and K

131 Widlund of the Brigham and Women's Hospital, Human Skin Disease Resource Center, Harvard Medical Scho

132 e palmoplantar keratoderma type 1 (PPKP1), a human skin disease.

133 dventitial fibroblast states in inflammatory human skin diseases and relate these states to perivascu

134 of differentiation genes that are altered in human skin diseases, including keratins 1 and 10, filagg

135 Mutations in K1/K10 are associated with human skin diseases.

136 We investigated 322 healthy human skin DNA methylomes associated with total body nev

137 its effectiveness for producing vitamin D in human skin due to the shorter exposure time.

138 -6+ DCs (ASDC), was also found to infiltrate human skin during wounding.

139 of female Ae. aegypti to 103 compounds from human skin emanations.

140 ma cleavage, induced psoriasiform changes in human skin-equivalent models.

141 past the epidermis was observed in cultured human skin equivalents and in mice but was found to be i

142 d can drive pro-inflammatory processes in 3D human skin equivalents supporting a role for this target

143 planted normal and SSc fibroblasts and in 3D human skin equivalents, in part by attenuating focal adh

144 stem cell genes result in severe thinning of human skin equivalents, validating their essential role

145 ce that carried in vivo-generated engineered human skin (ES).

146 relevant quantities of peptide to mouse and human skin even with hydrophobic peptides.

147 onse to study the puncturing and recovery of human skin ex vivo and in vivo after discretised punctur

148 its roles in the UVB DNA damage response in human skin ex vivo and indicate that SP may increase UVB

149 ble electronics puts batteries closer to the human skin, exacerbating the need for battery materials

150 Invertebrates molt, furry mammals shed, and human skin exfoliates.

151 By doing so, we found that human skin exhibits non-volatile memory and that analogu

152 Here we describe an ex vivo cultured human skin explant model in which we have characterized

153 oduct development, in a clinically relevant, human skin explant model.

154 lipoplex-delivered RNA in resident cells in human skin explants and, we explore a more modular deliv

155 al burn injury to keratinocytes in vitro and human skin explants ex vivo, and mice in vivo generate m

156 DCs migrated out of human skin explants upon inoculation of the skin with B.

157 We studied the dynamics of DENV infection in human skin explants using quantitative in situ imaging.

158 h after intradermal injections into primary, human, skin explants.

159 most of the bactericidal activity present in human skin exudates is chemerin-dependent, just how chem

160 -dose and fractionated irradiation in normal human skin fibroblast cells (AGO1522) and human prostate

161 of the biosensor was tested by using normal human skin-fibroblast.

162 ypothesized that CD26 is highly expressed by human skin fibroblasts (SFBLs), and this associates with

163 We analysed primary human skin fibroblasts and induced neurons from heterozy

164 Focusing on transdifferentiation of primary human skin fibroblasts by forced expression of myogenic

165 a potent ROS scavenging efficacy in cultured human skin fibroblasts derived from healthy donors and f

166 Thus, we reprogramed human skin fibroblasts from cognitively normal individua

167 in mouse, rat, and rabbit skin wounds and in human skin fibroblasts in culture, while a miR-29 inhibi

168 ficantly, ectopic expression of vU1 genes in human skin fibroblasts leads to increases in levels of k

169 human isoform lacking exon 5 is expressed in human skin fibroblasts, HEK293 cells, and murine heart a

170 Using UV-exposed human skin fibroblasts, we found that, at the dose used,

171 In this study, we irradiated human skin fibroblasts-AG01522B cells with laser-acceler

172 ion of caveoli and reduce dorsal ruffling in human skin fibroblasts.

173 rotection was conferred by mouse tail tip or human skin fibroblasts.

174 /c IL2rgammaRag2 mice were transplanted with human skin followed by adoptive transfer of human alloge

175 m, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively.

176 resulted in blistering skin, reminiscent of human skin fragility syndromes.

177 Using human skin from contact dermatitis patients and a mouse

178 Adult human skin from reduction mammoplasties was prepared for

179 iTE cells did not result in toxicity against human skin grafts in vivo.

180 target the skin are generated by introducing human skin grafts to immunocompromised rodent strains.

181 Human skin has different types of tactile receptors that

182 The natural topographical microchannels in human skin have recently been shown to be capable of gui

183 his model has broad utility in many areas of human skin immunology research, including the study of i

184 chine interfaces, and realistic imitation of human skin in robotics and prosthetics.

185 ns relevant to AD, experimental challenge of human skin in vivo, tissue culture models, integration o

186 irculating pool of T cells into non-inflamed human skin in vivo.

187 be exploited to accelerate wound closure of human skin in vivo.

188 egration of wearable electronic devices with human skin in ways that bypass the mechanical and therma

189 udy, we performed IVPT studies using excised human skin (in vitro) and harmonized in vivo human serum

190 The first design mimics the pores in human skin, in which pre-cut flaps open to produce pores

191 These models also support human skin infection following intradermal inoculation w

192 To recapitulate the various types of human skin infections, many different mouse models have

193 model could provide a platform for studying human skin infections.

194 roviding a resource for the further study of human skin inflammation.

195 The human skin is a promising conduit for genetic engineerin

196 The human skin is a significant barrier for protection again

197 Adult human skin is an appropriate model for these viruses bec

198 n of physiological and physical signals from human skin is crucial for health monitoring, disease pre

199 Human skin is equipped with slow adapting (SA) and fast

200 hypothesis that the abundance of archaea on human skin is influenced by human age and skin physiolog

201 ure of glucocorticoids and their receptor in human skin is largely unknown.

202 tic system's response to inflammation within human skin is monitored throughout an acne lesion develo

203 ed in the upper pilosebaceous unit of normal human skin, is down-regulated in acne.

204 knowledge that pollutants can interact with human skin, it is now of even greater importance that th

205 ns were noticed in lewisite-treated cultured human skin keratinocytes.

206 tions represent a subset of RNAs detected in human skin lesions which mapped to homologs of numerous

207 nity and suppress inflammation to persist in human skin lesions.IMPORTANCE Poxviruses adapt to specif

208 The human skin-like multimodal receptor array, called multim

209 evels of CD33 were consistently expressed on human skin mast cells and that the antigenic liposomes w

210 We demonstrate an important role for human skin mast cells in DENV infection and identify a n

211 ell proteins by proteome analysis of primary human skin mast cells.

212 imulatory effect was consistent in mouse and human skin mast cells.

213 vant piRNAs involved in disease processes in human skin may provide new clues for therapeutic targets

214 Dynamics of the human skin mediator lipidome in response to dietary omeg

215 dentified genes implicated in sensitivity of human skin melanocytes and fibroblasts to BRAF(V600E) ov

216 ghts into how within-individual evolution of human skin microbes shapes their functional diversificat

217 ghts into the complexity and biogeography of human skin microbes.

218 The human skin microbiome acts as an important barrier prote

219 suggests an integral interaction between the human skin microbiome and ADSCs.

220 Overall, these data show how a member of the human skin microbiome can be useful as a biotherapy for

221 Although the healthy human skin microbiome has been the subject of recent stu

222 Studies of the human skin microbiome suggest that Propionibacterium acn

223 us epidermidis, a commensal bacterium in the human skin microbiome, produces short-chain fatty acids

224 onstant but highly variable component of the human skin microbiome, yet factors that determine their

225 structural and functional composition of the human skin microbiome.

226 rate that cutaneous leishmaniasis alters the human skin microbiota.

227 ed fetal tissue; here, we developed an adult human skin model to study VZV and HCMV in culture and in

228 t, performed on an in vitro reconstructed 3D human skin model, indicated that MB was safe for long-te

229 after 24 h of Ca(2+) chelation in an ex vivo human skin model, suggesting that desmosomal cadherins m

230 RNA knockdown of CAPN12 in three-dimensional human skin models was associated with acanthosis, disorg

231 demonstrated using in vivo mouse and ex vivo human skin models.

232 olic hydroxyethyl cellulose gel into ex vivo human skin, murine skin, and RHS.

233 Malassezia is the dominant fungus in the human skin mycobiome and is associated with common skin

234 olved in humans; thus, the impact of nACD on human skin needs to be further elucidated.

235 Here, we report that the human skin odour profile is affected by malaria infectio

236 Xenotransplantation of human skin onto immunocompromised animals can overcome t

237 hrough gain- and loss-of-function studies in human skin organoids as a model of tissue injury, we dem

238 BD-3 transcription in experimentally wounded human skin (P = .003).

239 Additionally, ex vivo human skin permeation studies using confocal microscopy

240 er when M. sympodialis is cultured at normal human skin pH versus the elevated pH present on the skin

241 eview focuses on how neurohormones impact on human skin physiology and pathology.

242 In addition, since human skin proteins were also identified, this method of

243 Human skin provides both physical integrity and immunolo

244 melanocytes and fibroblasts isolated from 36 human skins ranging from neonates to 86 years old.

245 rgue that greater emphasis on neuroendocrine human skin research will foster the development of novel

246 iptome, of imiquimod-induced inflammation in human skin resembles acute contact dermatitis rather tha

247 Human skin responds to numerous neurohormones, neuropept

248 These results enhance our understanding of human skin response to CL caused by L. tropica.

249 Whereas touching the roots with soil or human skin resulted in odor detection, agitating the roo

250 7 response was stimulated in freshly excised human skin resulting in significantly upregulated IL-17f

251 mediated recruitment of CD14(+) monocytes in human skin results in the reduction of epidermal LCs wit

252 The present study reports the piRNome of human skin, revealing that all but one of the piRNAs exa

253 opical drug delivery relies on reconstructed human skin (RHS) in addition to ex vivo human and animal

254 skin can be successfully used as a model for human skin RNA studies.

255 The optimal strategy for extracting human skin RNA was to collect, store and homogenize the

256 ing in dynamical settings, closer to natural human skin's behaviour.

257 onize lipids is exploited in the analysis of human skin samples from sufferers of HS.

258 four most promising workflows were tested on human skin samples.

259 rganotypic skin, and immunohistochemistry of human skin samples.

260 reduces tumor growth in a xenograft model of human skin SCC.

261 xpression is increased on senescent cells in human skin sections from old individuals, when compared

262 Mimicking human skin sensation such as spontaneous multimodal perc

263 compounds also decrease RyR1 Ca(2+) leak in human skinned skeletal muscle fibers.

264 small (<24 mm(2) for mice and <12 mm(2) for humans) skin specimens that can be readily obtained from

265 mestic pig skin is applicable as a model for human skin studies.

266 on changes in cultured melanocytes, modified human skin substitutes, and ex vivo skin.

267 ing the microbiome community distribution on human skin, supporting the importance of indirect contac

268 al data obtained from amplicon sequencing of human skin swab specimens and oral rinses from healthy i

269 es more efficient in producing vitamin D3 in human skin than the sun in less than 1/60(th) the time.

270 When coated on human skin, they are capable of slowing water evaporatio

271 rcome this obstacle in the context of normal human skin, thus offering a glimpse into the genomic lan

272 rehensive analysis of live or resected thick human skin tissue.

273 ntially differentiating healthy and diseased human skin tissues based on changes in detected neutral

274 acids [L-SNAs]), which are able to penetrate human skin to knock down cutaneous gene targets.

275 inflammatory processes is essential for the human skin to maintain homeostasis in the presence of th

276 Human skin tolerates a surprisingly high burden of oncog

277 Here we show that in both mouse and human skin, topical application of a mitochondrially tar

278 is is the first study to globally assess the human skin transcriptional response during early Lyme di

279 Our validated bioinformatics analysis of human skin transcriptome induced by topical glucocortico

280 ctric coolers demonstrated here can cool the human skin up to 8.2 degrees C below the ambient tempera

281 etration of the aptamer into freshly excised human skin using two different fluorescent labels.

282 e gene expression of exogenous naked pDNA in human skin using volumes that are considered to be stand

283 velength ultraviolet radiation (UVA) damages human skin via reactive oxygen species (ROS).

284 RELM family member Resistin was expressed in human skin, was induced by vitamin A analogs, and killed

285 in healthy as well as tape-stripped ex vivo human skin, we model the penetration of the antiinflamma

286 f the antiinflammatory drug dexamethasone in human skin, we model the time-dependent drug penetration

287 umulation, whereas in newborn mice and adult human skin, we report LC3 puncta coincident with misshap

288 skin surface (a suitable model representing human skin) were successfully detected by the DNA sensor

289 tics and markedly improved DFO delivery into human skin when compared to other topical application te

290 ave the potential to better interface to the human skin, whereas silicon-based electronics are extrem

291 formed non-linear electrical measurements on human skin with applied direct current (DC) voltage puls

292 olecular contrast for macroscopic imaging of human skin with microscopic resolution.

293 omic analysis that P450 27C1 is localized to human skin, with two proteins of different sizes present

294 Using both in vitro and ex vivo models of human skin wound closure, we found that hair follicle de

295 ling in diabetic mice and accelerate ex vivo human skin wound healing.

296 +CD123int DC subset that rapidly infiltrates human skin wounds and comprises a major DC population.

297 scuss how humanized mouse models such as the human skin xenograft on immunocompromised mice might be

298 In a human skin xenograft transplant model, adoptive transfer

299 f these observations during VZV infection of human skin xenografts in the SCID mouse model of VZV pat

300 c mutant gB[Y881F] is severely attenuated in human skin xenografts.