ライフサイエンスコーパス: humanized mice

1 viral evolution in the plasma compartment in humanized mice.

2 r 20 hr after termination of NA exposure, in humanized mice.

3 d antiretroviral responses in HIV-1-infected humanized mice.

4 fgs-null, CYP2A13-humanized, and CYP2A13/2F1-humanized mice.

5 ity to deplete target cells in FcgammaR/FcRn humanized mice.

6 ining their capacity to engraft in vivo into humanized mice.

7 ss early HIV-1 spread in lymphoid tissues in humanized mice.

8 ophages in the skin and lymphatic tissues of humanized mice.

9 nsfer of treated lymphocytes into uninfected humanized mice.

10 vivo therapeutic activity in HIV-1-infected humanized mice.

11 vely assessed after severe burn injury using humanized mice.

12 ervoir, both in vitro and in patient-derived humanized mice.

13 ed long-lived protection in conventional and humanized mice.

14 , and for anti-tumor efficacy in xenografted humanized mice.

15 l models of intestinal injury and the use of humanized mice.

16 reduced circulating levels of vemurafenib in humanized mice.

17 DC) in the blood, spleen, and bone marrow of humanized mice.

18 ups of patients replicated in culture and in humanized mice.

19 erent genotypes, both in cell culture and in humanized mice.

20 red HCV RNA from the circulation of infected humanized mice.

21 maRs and assessed their activity in FcgammaR-humanized mice.

22 efficiently blocked by an anti-SR-BI mAb in humanized mice.

23 tured primary neurons from the brains of the humanized mice.

24 nt and maintenance of the HIV-1 reservoir in humanized mice.

25 immunity to lymphotropic virus infections in humanized mice.

26 ected cells from the liver of HLA-transgenic humanized mice.

27 tro and in an antibody therapy experiment in humanized mice.

28 s- but not bacillus Calmette-Guerin-infected humanized mice.

29 oving human intrahepatic immune responses in humanized mice.

30 f HIV-infected T cells in the lymph nodes of humanized mice.

31 m in a comparable range of concentrations in humanized mice.

32 or the poor human platelet reconstitution in humanized mice.

33 ginal transmission of RPV-resistant HIV-1 in humanized mice.

34 mphoid and nonlymphoid tissues of humans and humanized mice.

35 as a therapeutic modality in HIV-1-infected humanized mice.

36 ed by expression of human GM-CSF and IL-4 in humanized mice.

37 ttern of iAs metabolism in the wild-type and humanized mice.

38 ts were obtained in ART-treated HIV-infected humanized mice.

39 ent of IgG receptors (FcgammaRs) in FcgammaR-humanized mice.

40 st, and chronic phases of HIV-1 infection in humanized mice.

41 tent infectious reservoirs in HIV-1 infected humanized mice.

42 lowing therapy interruption in immune system-humanized mice.

43 and abolish ethanol-induced liver disease in humanized mice.

44 vitro by using flow cytometry and in vivo in humanized mice.

45 ogenesis in bone marrow, liver, thymus (BLT) humanized mice.

46 nfiltration and rejection by immune cells in humanized mice.

47 ensitive to pegIFNalpha in immunocompromised humanized mice.

48 ival was confirmed in a huMoDC reconstituted humanized mice.

49 Using humanized mice, a preclinical model relevant to human ph

50 nulomas of bacillus Calmette-Guerin-infected humanized mice administered with a TNF-neutralizing TNF

51 Single bNAbs protected humanized mice against infection but selected for resist

52 broadly neutralizing antibody b12 protected humanized mice against repetitive intravaginal infection

53 A new generation of humanized mice aims to tighten the gap between mouse and

54 Generation of C1q humanized mice allowed for demonstration of the efficacy

55 f HCV replication in vitro and in coinfected humanized mice also reduced interferon signaling and, co

56 because in vivo neutralization of IL-17A in humanized mice ameliorated hepatic and intestinal damage

57 the patient tumor than to those grown in non-humanized mice-an effect partially facilitated by human

58 d virus load substantially in HIV-1-infected humanized mice and also provided complete protection whe

59 ere, we describe parallel efforts using both humanized mice and convalescent patients to generate ant

60 Thus, we have identified defects in humanized mice and devised approaches to correct these d

61 mise for modelling haematopoietic disease in humanized mice and for therapeutic strategies in genetic

62 e analyzed human myeloid cell development in humanized mice and found that it was blocked at the prom

63 ecent progress in the development and use of humanized mice and highlights their utility for the stud

64 pleen, bone marrow, and peritoneal cavity of humanized mice and included distinct populations display

65 r, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred.

66 lpha (pegIFNalpha) against HEV infections in humanized mice and modelled intrahepatic interferon stim

67 n prevent infection and suppress viraemia in humanized mice and nonhuman primates, but their potentia

68 ing on the two most promising model systems: humanized mice and nonhuman primates.

69 ee independent experiments in HIV-1-infected humanized mice and one pivotal experiment in simian-huma

70 chronic HCV infection in the livers of both humanized mice and patients, and direct-acting antiviral

71 s against P. falciparum asexual infection in humanized mice and prevented transmission to mosquitoes.

72 tial genetic drift seen after passage on non-humanized mice and provide a more accurate tumor model t

73 onocyte/macrophage development is blocked in humanized mice and reveals overlapping and distinct func

74 RT-suppressed bone-marrow-liver-thymus (BLT) humanized mice and rhesus macaques infected with HIV and

75 ong-term hematopoietic repopulating cells in humanized mice and rhesus macaques.

76 wever, anti-HA protects against infection in humanized mice and strongly selects for nnAb-resistant v

77 al human ILC3s develop in lymphoid organs of humanized mice and that persistent HIV-1 infection in th

78 dy treatments for Ebola-one from genetically humanized mice and the other from a human survivor.

79 ent pathogenetic mechanisms in wild-type and humanized mice and the possible benefit of including hum

80 developed a murine skin transplant model in humanized mice and used it to test human monoclonal anti

81 , (3) migration toward CXCL8 in vitro and in humanized mice, and (4) CXCR1, CXCR2, and CXCR4 expressi

82 g-like receptor B1 (LILRB1) transgenic mice, humanized mice, and genetically engineered HLA-G dimer,

83 genous IL-21 limits early HIV-1 infection in humanized mice, and lower viremia in vivo is associated

84 can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeut

85 nd early postnatal life can be reproduced in humanized mice, and they suggest that onset of human thy

86 Humanized mice are a powerful tool for the study of huma

87 Although all DC subsets in humanized mice are efficient at presenting peptide to CD

88 Humanized mice are permitting significant progress in st

89 subsets generated after FLT3-L treatment of humanized mice are phenotypically and functionally simil

90 In this way, humanized mice are providing a powerful small animal mod

91 Humanized mice are versatile tools for the study of HIV

92 s study support the use of hematopoietically humanized mice as an in vivo model for screening of radi

93 -alpha3NC1 autoantibodies injected into FCRN-humanized mice as effectively as genetic ablation of FcR

94 ved macrophages, primary CD4(+) T cells, and humanized mice at a level comparable to that for the wil

95 , virus carrying this mutation replicated in humanized mice at levels indistinguishable from those of

96 In this study, we show that in humanized mice, B cells are immature, and there is a com

97 zing plasma concentrations in HIV-1-infected humanized mice but elicited CD4-binding site mutations t

98 as recently reported to establish latency in humanized mice but not cause tumors.

99 lungs from bacillus Calmette-Guerin-infected humanized mice but not in nonhumanized infected controls

100 2) were differentially expressed between the humanized mice, but circadian clock genes were not.

101 t drugs in inhibiting vascular thrombosis in humanized mice, but neither causes serious bleeding, est

102 Our data indicate that humanized mice can be used as a model to study the forma

103 Our results demonstrate that humanized mice can be used as a small-animal model to st

104 Humanized mice can be used to better understand how the

105 This study provides "proof of concept" that humanized mice can be used to examine the effects of imm

106 These results indicate that humanized mice can be used to study HHV-6A in vivo infec

107 Combined with single-cell genomics, humanized mice can facilitate functional precision medic

108 The data support the idea that humanized mice can provide a means to examine the multif

109 Here we found that humanized mice carrying the 118GG allele (h/mOPRM1-118GG

110 We generated humanized mice carrying the respective human OPRM1 A118G

111 Here we show that this also applies to humanized mice coexpressing both human P2X7R variants.

112 In humanized mice, combinations of monoclonal antibodies ha

113 dependency of viral particles isolated from humanized mice compared to cell culture-produced virus.

114 ylococcus aureus infection was aggravated in humanized mice, compared with wild-type or nonengrafted

115 ng maternal-fetal transport in FcgammaR/FcRn humanized mice confirmed that only FcRn contributed to t

116 ral variants with greater fitness.IMPORTANCE Humanized mice constitute a useful model for studying th

117 Paradoxically, humanized mice contained higher mycobacterial numbers in

118 er of TCR-grafted T cells into HBV-infected, humanized mice controlled HBV infection and virological

119 h CEA-TCB/CEA-4-1BBL in MKN-45 tumor-bearing humanized mice correlated with intratumoral CD8(+) T-cel

120 to cross the interspecies barrier to infect humanized mice correlates with their phylogenetic distan

121 evious metabolomics studies, indicating that humanized mice could be a highly relevant small-animal m

122 We demonstrate that such minimally humanized mice develop normally, express the modified ge

123 ockout, bone marrow, liver, thymus (TKO-BLT) humanized mice develop organized lymphoid tissues includ

124 Humanized mice developing functional human T cells endog

125 Based on studies in humanized mice, diet can affect GI transit through micro

126 In addition, the humanized mice display abnormal erythropoiesis, which wa

127 The humanized mice display prolonged and increased responses

128 Humanized mice displayed a more pronounced AHR and bronc

129 The humanized mice displayed a significantly reduced surviva

130 However, these humanized mice do not make any significant level of IgG

131 Studies in humanized mice document an interaction between estrus cy

132 ore, we analyzed human antiviral immunity in humanized mice during a hepatotropic adenovirus infectio

133 eatment reactivated HIV-1 gene expression in humanized mice during suppressive cART.

134 Humanized mice engrafted with human hematopoietic stem c

135 fective to human hepatocytes in vitro and to humanized mice engrafted with human hepatocytes in vivo

136 Both murine transplant models and humanized mice engrafted with LV-modified HSCs show high

137 markedly inhibited acute HIV-1 infection in humanized mice, even when activation of NK cells by IL-1

138 cell population, and engrafted B-1 cells in humanized mice exhibit an Ig-usage pattern comparable to

139 ges at the sites of infection, M-CSF-treated humanized mice exhibited an enhanced protection against

140 RNase 7 humanized mice exhibited marked protection from UPEC.

141 BV infection and assessed tumor formation in humanized mice exposed to wild-type virus and a viral mu

142 CD141(+) DC in humanized mice express C-type lectin-like receptor 9A, X

143 Notably, the humanized mice expressed both the full-length AS3MT that

144 We showed that humanized mice expressing HLA-DR4 (DR0401) molecules and

145 lass II molecules, we studied the ability of humanized mice expressing human HLA class II molecules t

146 Humanized mice expressing Human Leukocyte Antigen (HLA)

147 al treated, virus-free animals to uninfected humanized mice fails to produce infectious progeny virus

148 Analysis of gut motility revealed that humanized mice fed a standard polysaccharide-rich diet h

149 g wild-type, Cyp2abfgs-null, and CYP2A13/2F1-humanized mice following inhalation exposure at an occup

150 unctionality of monocytes/macrophages in the humanized mice following M-CSF expression provide a supe

151 the first to demonstrate the suitability of humanized mice for injury research.

152 nd T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy.

153 n the bone marrow and suggest the utility of humanized mice for studying human hematopoiesis.

154 la infections and demonstrate the utility of humanized mice for understanding the pathogenesis of a h

155 tope in the viral E2 glycoprotein to protect humanized mice from a patient-derived HCV challenge.

156 orm, human lymphocyte apoptosis, and rescued humanized mice from CLP-induced mortality.

157 emonstrate that VIP is capable of protecting humanized mice from intravenous as well as vaginal chall

158 om a single injection of VRC01 mRNA protects humanized mice from intravenous HIV-1 challenge, demonst

159 As a patient-derived xenograft (PDX) model, humanized mice functionally correlate putative mechanism

160 d-derived MSCs (hUC-MSCs) on tumor growth in humanized mice generated by the human adoptive transfer

161 Replicate humanized mice generated diverse and highly divergent re

162 However, newer versions of humanized mice generated in severely immunodeficient mic

163 In this study, we show that these humanized mice had extremely low levels of human platele

164 Humanized mice have emerged as a promising model to stud

165 Humanized mice have emerged as a testing platform for HI

166 In particular, humanized mice have enabled studies of the pathogenesis

167 cy.IMPORTANCE Advances in the development of humanized mice have raised the possibility of a small-an

168 is effort and bone marrow-liver-thymus (BLT) humanized mice have recently emerged as a powerful small

169 Studies in humanized mice have shown that HIV-1 lacking Vif express

170 functional human cells and tissues, that is, humanized mice, have become increasingly important as sm

171 Humanized mice historically have not been good models of

172 Humanized mice (HM) allow researchers to examine xenogra

173 Recent advances in the development of humanized mice hold great promise to advance our underst

174 s observed in Cyp2abfgs-null and CYP2A13/2F1-humanized mice; however, the extent of NA-induced lung i

175 Here, we optimized humanized mice (Hu-mice) reconstituted with a functional

176 IFN-alpha/beta receptor (IFNAR) signaling in humanized mice (hu-mice) that were persistently infected

177 We have developed a humanized mice (Hu-mice) tuberculosis model system to in

178 In humanized mice (hu-mice), control of viremia can be achi

179 estigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV o

180 serum metabolic profiling from a model using humanized mice (humice) with DENV serotype 2 infection a

181 Here, we show that humanized mice, i.e., animals engrafted with components

182 FcRn-null and -humanized mice immunized with alpha3NC1 developed no alb

183 We previously showed that humanized mice immunized with long-lived induced-dendrit

184 d mice and the possible benefit of including humanized mice in future studies involving S. aureus as

185 n vivo model of ART in BM/liver/thymus (BLT) humanized mice in order to better understand the ability

186 cently begun to use MP-IVM in lymph nodes of humanized mice in order to examine HIV infectious spread

187 The optimal parameters for using humanized mice in preclinical CNS injury models need to

188 ted HIV-1 reservoirs under effective cART in humanized mice in vivo Interestingly, I-BET151 during su

189 We have used humanized mice, in which human immune cells differentiat

190 lar to those of tumor-derived lines from the humanized mice, including reduced CXCL10 secretion.

191 ion of HIV in almost all tissues analysed in humanized mice, including the lymph nodes, thymus, bone

192 rom cytometry by time-of-flight analysis and humanized mice indicating that human CD49e(-) NK cells a

193 CD4(-) cells, were significantly modified in humanized mice infected by cell-associated transmission.

194 od, Tezuka et al report the establishment of humanized mice infected by human T-cell leukemia virus t

195 Blunting antiviral immunity in genetically humanized mice infected with HCV results in measurable v

196 preventative and postexposure setting, that humanized mice infected with HCV variants exhibiting inc

197 In humanized mice, INK128 decreased plasma HIV RNA by >2 lo

198 ncreasingly permissive, and progress towards humanized mice is advancing rapidly.

199 Recent progress in developing genetically humanized mice is exciting, but these models only permit

200 the development of immune-disease specific "humanized" mice is that optimal adaptive immune response

201 In humanized mice, lethal disease develops, characterized b

202 Liver-humanized mice (LHM) are considered a promising model to

203 n incorporated into bone marrow/liver/thymus humanized mice, lung implants are repopulated with autol

204 o prevent and treat lentivirus infections in humanized mice, macaques, and humans.

205 Humanized mice may be useful for understanding the mecha

206 Ultimately, use of humanized mice may lead to the implementation of truly p

207 These new humanized mice may offer attractive models to study immu

208 hese results suggest that the development of humanized mice may provide a framework to assess the con

209 e, humoral, and cellular immune responses in humanized mice (mice with a human immune system [HIS mic

210 of multiple clones of low abundance in these humanized mice mirrors the early phase of HTLV-1 infecti

211 us NS3-expressing adenovirus, HLA-transgenic humanized mice mounted an HLA-A*0201-restricted hepatiti

212 As heterologous Ag in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse I

213 In macrophage cultures derived from TNF humanized mice MYSTI could capture the secreted hTNF, li

214 Additionally, as evaluated in TNF humanized mice, MYSTI was superior to an otherwise analo

215 a graft-versus-host disease (GvHD) model of humanized mice (NOD/SCID/IL-2Rgammac(-/-) [NSG] mice).

216 As a result, these cytokine-treated humanized mice produced significant levels of Ag-specifi

217 These results show that CLP in humanized mice provides a model to study human sepsis, H

218 Humanized mice receiving a SCI before or after stable en

219 Humanized mice reconstituted with a human immune system

220 anded human cord blood-derived NK cells into humanized mice reconstituted with autologous human cord

221 y studying Borrelia burgdorferi infection in humanized mice reconstituted with human hematopoietic st

222 dies administered to infected individuals or humanized mice reported poor control of virus replicatio

223 Humanized mice represent a novel lethal model for studie

224 injection of hUC-MSCs in immune-deficient or humanized mice, respectively.

225 ort hairpin (sh)RNA in B cells developing in humanized mice resulted in a failure to remove autoreact

226 CYP2A13/2F1-humanized mice showed greater sensitivity to NA than Cyp

227 Recently, partial transmissions to humanized mice showed that the zoonotic potential of scr

228 -only mice and bone marrow/liver/thymus-lung humanized mice substantially increase the number of huma

229 Promising early results from studies in humanized mice suggest great potential and enthusiasm fo

230 so detected in the serum from HIV-1-infected humanized mice suggesting that TAR RNA may be stable in

231 Moreover, administration of 25HC in humanized mice suppressed HIV replication and reversed T

232 Administrating SF12 to HIV-1-infected humanized mice suppressed viremia and selected for virus

233 for HCV research owing to the development of humanized mice susceptible to HCV infection.

234 r in the terminal bronchioles of CYP2A13/2F1-humanized mice than in Cyp2abfgs-null mice.

235 cation of iAs was much less efficient in the humanized mice than in wild-type mice.

236 By combining human RBC supplementation and humanized mice that are optimized for human immune cell

237 n in the bone marrow of the cytokine-treated humanized mice that express both NK cell marker CD56 and

238 Humanized mice that express the entire UGT1 locus (hUGT1

239 ant induces an "abortive" lytic infection in humanized mice that is compatible with continued cell gr

240 Here we show by intravital microscopy in humanized mice that perturbation of the actin cytoskelet

241 We therefore created humanized mice that transgenically express the entire 16

242 Using humanized mice that were colonized with bacteria from th

243 against HIV-1 in vitro We now demonstrate in humanized mice that, when delivered at the same high cli

244 Here we show, in humanized mice, that the TLR-7-mediated response of huma

245 In humanized mice, the acquisition of ILC1 features by ILC3

246 When administrated in immune-humanized mice, the covalent PD-1(FSY) exhibited strikin

247 absence of the human Vlambda locus in these humanized mice, the dominance of Vlambda pairing with hu

248 lyzed, by using lung tissues from humans and humanized mice, the role of human CD1c(+) and CD141(+) D

249 luding recent advances in the development of humanized mice, the trafficking of human immune cells fo

250 n overview of some of the emerging models of humanized mice, their use in the study of infectious dis

251 Here, we utilized bone marrow/liver/thymus humanized mice to evaluate the in vivo HIV-inhibitory ac

252 This study sought to use humanized mice to extend these results to humans.

253 an optimal experimental framework for using humanized mice to help translate promising preclinical t

254 Karlinsey et al. (2019) combine TraDIS with humanized mice to identify genes required for early repl

255 Here, we describe the capacity of BLT humanized mice to mount broadly directed HIV-1-specific

256 Here, we genetically humanized mice to permit the growth of primary human pre

257 These findings validate the use of humanized mice to study acute and persistent HAdV infect

258 Here we review the growing ability of humanized mice to support the study of human humoral imm

259 ssion of in vivo HIV-1 infection observed in humanized mice treated with the IL-15 superagonist, demo

260 We have found that reconstituted "humanized" mice treated with anti-CTLA-4 Ab (ipilimumab)

261 Finally, in liver chimeric humanized mice, TROS antagonizes inflammation in a model

262 o prevent intravenous transmission of HIV in humanized mice using broadly neutralizing antibodies.

263 In humanized mice, viral replication was less evident, but

264 CNS disease in humanized mice was characterized by gliosis, meningitis,

265 Using FcgammaR-humanized mice, we demonstrate that anti-tumor human (h)

266 Using HIV-infected humanized mice, we demonstrated that in vivo blockade of

267 In female humanized mice, we found that RPV LA inhibited vaginal t

268 In our humanized mice, we have shown downregulation of eukaryot

269 In addition, using COL7-humanized mice, we provide in vivo evidence of pathogeni

270 Using humanized mice, we show that broadly neutralizing antibo

271 PPARalpha-humanized mice were also protected, whereas Ppara-null m

272 In some cases, humanized mice were also treated with activating anti-CD

273 mens from HEV-infected and ribavirin-treated humanized mice were analyzed using HEV antigen-specific

274 ed metabolites in tissues and excreta of the humanized mice were consistent with those reported in hu

275 mine these mechanisms, NOD/SCID IL-2 RG(-/-) humanized mice were either directly infected with HIV(AD

276 Humanized mice were infected with isogenic HIV molecular

277 Humanized mice were previously reported as a model for t

278 activities in OM and lung of the CYP2A13/2F1-humanized mice were primarily contributed by, respective

279 r, peripheral T cells developed in the FOXP3-humanized mice were quantitatively reduced and hyporespo

280 All humanized mice were stably colonized with O. formigenes

281 In this study, humanized mice were treated with Smoothened Agonist (SAG

282 While humanized mice were unaffected in their behavioral reper

283 A matured HMAb protected humanized mice when challenged with an infectious HCV hu

284 ibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing

285 P2F1 are active toward NA in the CYP2A13/2F1-humanized mice, where they play significant roles in NA-

286 Humanized mice, which contain a human immune system, can

287 BLT (bone marrow-liver-thymus) humanized mice, which reconstitute a functional human im

288 pping grafted human classical monocytes into humanized mice, which were able to differentiate sequent

289 The use of humanized mice will allow us to use our knowledge of HIV

290 sis of plasma virus, that treatment of these humanized mice with a broadly neutralizing antibody, 10-

291 Finally, treatment of humanized mice with anti-Siglec antibody led to robust d

292 regs were depleted by denileukin diftitox in humanized mice with chronic HIV-1 infection.

293 a serum metabolomics study on a model using humanized mice with dengue infection that had significan

294 Humanized mice with faster transit due to administration

295 r-derived particles were infectious in liver-humanized mice with high RNA copy numbers detectable in

296 We immunized IgH- and Igkappa-humanized mice with the AE.A244 gp120 Env.

297 t viral escape mutants in HIV-1YU-2-infected humanized mice, with viremic control exhibited when a th

298 ymphoma models and against human lymphoma in humanized mice without any detectable toxic side effects

299 survive and possibly proliferate in vivo in humanized mice without exogenous cytokine administration

300 e fully suppressed viremia in HIV-1-infected humanized mice without selecting for resistant viral var