ライフサイエンスコーパス: humanized monoclonal antibody

1 in that has a tissue targeting peptide and a humanized monoclonal antibody.

2 mmunoprophylaxis of high-risk infants with a humanized monoclonal antibody.

3 Pertuzumab, a recombinant humanized monoclonal antibody (2C4), binds to extracellu

4 Alemtuzumab (Campath-1H) is a humanized monoclonal antibody (Ab) directed against CD52

5 Treatment with recombinant humanized monoclonal antibodies against CD20 (rituximab)

6 e first strategy involves the development of humanized monoclonal antibodies against the nonconserved

7 nitial validation experiments with mouse and humanized monoclonal antibodies against the S. aureus au

8 Natalizumab, a humanized monoclonal antibody against alpha4 integrin, i

9 Whether treatment with litifilimab, a humanized monoclonal antibody against BDCA2, would be ef

10 open label baseline-to-treatment trial of a humanized monoclonal antibody against CD25 (daclizumab)

11 rch of the mechanisms by which daclizumab, a humanized monoclonal antibody against CD25, inhibits bra

12 We studied the effects of a nonactivating humanized monoclonal antibody against CD3--hOKT3gamma1(A

13 Hu5F9-G4 (magrolimab), a humanized monoclonal antibody against CD47, blocks CD47'

14 a potential benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF-A

15 Magrolimab is a first-in-class humanized monoclonal antibody against cluster of differe

16 Bexmarilimab is a new humanized monoclonal antibody against common lymphatic e

17 Eculizumab, a humanized monoclonal antibody against complement protein

18 Trastuzumab, a humanized monoclonal antibody against HER2, is cytostati

19 eosinophilia of 2% or more were treated with humanized monoclonal antibody against IgE (omalizumab) (

20 Omalizumab, a humanized monoclonal antibody against IgE, is clinically

21 RPC4046, a recombinant humanized monoclonal antibody against IL13, prevents its

22 ents were assigned to receive mepolizumab, a humanized monoclonal antibody against interleukin-5, whi

23 his binding can be prevented by MORAb-009, a humanized monoclonal antibody against mesothelin current

24 ve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated

25 and preliminary efficacy of crizanlizumab, a humanized monoclonal antibody against P-selectin approve

26 RO5323441, a humanized monoclonal antibody against PlGF, showed antit

27 Denosumab, a humanized monoclonal antibody against receptor activator

28 Etrolizumab is a humanized monoclonal antibody against the beta7 integrin

29 Since the approval of trastuzumab, a humanized monoclonal antibody against the extracellular

30 A study of a humanized monoclonal antibody against the high-affinity

31 Trastuzumab is a humanized monoclonal antibody against the human epiderma

32 Tocilizumab is a recombinant humanized monoclonal antibody against the IL-6 receptor

33 cell-anergizing therapy using tocilizumab, a humanized monoclonal antibody against the IL-6 receptor,

34 Daclizumab is a humanized monoclonal antibody against the interleukin 2

35 Daclizumab, a humanized monoclonal antibody against the interleukin-2

36 carcinoma were treated with spartalizumab, a humanized monoclonal antibody against the programmed dea

37 Bevacizumab, a humanized monoclonal antibody against vascular endotheli

38 Bevacizumab, a recombinant humanized monoclonal antibody against vascular endotheli

39 anted accelerated approval of bevacizumab, a humanized monoclonal antibody against vascular endotheli

40 Combination therapy with bevacizumab, the humanized monoclonal antibody against vascular endotheli

41 efore 6 and 48 h after, three infusions of a humanized, monoclonal antibody against IL-5 (mepolizumab

42 iple sclerosis with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath [regi

43 rials revealed that the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath-1H) i

44 proaches to block RSV replication, including humanized monoclonal antibodies and nucleic acid-based s

45 bB2 antibodies, including (i) trastuzumab, a humanized monoclonal antibody, and (ii) pAb, rabbit poly

46 Here, we describe ponezumab, a humanized monoclonal antibody, and show how it binds spe

47 Immunotherapy with effector cells alone or a humanized monoclonal antibody anti-p185(HER2) (4D5-8) re

48 Initial attempts to block VEGF by using a humanized monoclonal antibody are beginning to show prom

49 ti-vascular endothelial growth factor (VEGF) humanized, monoclonal antibody, bevacizumab, and/or its

50 Efalizumab, a humanized monoclonal antibody, binds to the alpha subuni

51 Inhibition of TNF-alpha by a chimeric humanized monoclonal antibody, cA2, was investigated in

52 The conditioning regimen consisted of the humanized monoclonal antibody CAMPATH-1H, fludarabine, a

53 To test this theory, a humanized monoclonal antibody capable of neutralizing hu

54 mechanism of TcdB neutralization by PA41, a humanized monoclonal antibody capable of neutralizing Tc

55 Birtamimab is an investigational humanized monoclonal antibody designed to neutralize tox

56 Humanized monoclonal antibodies directed against specifi

57 We evaluated the efficacy of MEDI-507 (a humanized monoclonal antibody directed against CD2) alon

58 A recently developed, humanized monoclonal antibody directed against complemen

59 Trastuzumab (Herceptin) is a recombinant humanized monoclonal antibody directed against HER-2.

60 Trastuzumab, a humanized monoclonal antibody directed against Her2, rep

61 Trastuzumab is a humanized monoclonal antibody directed against human epi

62 A recombinant humanized monoclonal antibody directed against IgE has p

63 clizumab (Zenapax, Roche Pharmaceuticals), a humanized monoclonal antibody directed against the alpha

64 we investigated the effects of daclizumab, a humanized monoclonal antibody directed against the alpha

65 Trastuzumab, a humanized monoclonal antibody directed against the extra

66 cacy and safety of intravenous Lu AG09222, a humanized monoclonal antibody directed against the PACAP

67 tive effect can be overcome by a recombinant humanized monoclonal antibody directed against VEGF in b

68 such as 2- methoxyestradiol and recombinant humanized monoclonal antibody directed against VEGF may

69 completely inhibited by coincubation with a humanized monoclonal antibody directed at human CD154 (h

70 d the efficacy of Campath-1H (alemtuzumab; a humanized monoclonal antibody directed to CD52), alone a

71 Here, we assessed the efficacy of the humanized monoclonal antibody eculizumab, which blocks t

72 nical cardiac tolerability of trastuzumab, a humanized monoclonal antibody effective in the treatment

73 Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all

74 We compared ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all

75 is, Genentech, South San Francisco, CA) is a humanized monoclonal antibody fragment designed to bind

76 ecific reversing agents include the approved humanized monoclonal antibody fragment idarucizumab for

77 study the antigen-binding site of Fab2C4, a humanized monoclonal antibody fragment that binds to the

78 Idarucizumab, a humanized monoclonal antibody fragment, reverses dabigat

79 es, including tyrosine kinase inhibitors and humanized monoclonal antibodies, have increased the comp

80 Treatment of lung epithelial cells with a humanized monoclonal antibody (hMAb159) selected for its

81 Conjugates of the anti-CanAg humanized monoclonal antibody huC242 with the microtubul

82 A humanized monoclonal antibody (huMAb 4D5) directed again

83 his report, we describe the development of a humanized monoclonal antibody, ICT01, with subnanomolar

84 ly quantified the levels of deamidation of a humanized monoclonal antibody in cynomolgus monkeys over

85 d pharmacokinetics of epratuzumab (anti-CD22 humanized monoclonal antibody) in patients with recurren

86 ety and efficacy of Campath-1H, an anti-CD52 humanized monoclonal antibody, in previously treated T-p

87 atients with cancer cachexia, ponsegromab, a humanized monoclonal antibody inhibiting GDF-15, was ass

88 GS-5745, a potent, highly selective humanized monoclonal antibody inhibitor of MMP9, has sho

89 phylaxis with hyperimmune globulin or with a humanized monoclonal antibody is expensive, limited to c

90 Humanized monoclonal antibody KD-247 targets the Gly(312

91 Pharmacological inhibition of ITGA5 with humanized monoclonal antibody M200 (volociximab) recapit

92 Murine and humanized monoclonal antibodies (mAb) have emerged as an

93 ent, which has led to the development of two humanized monoclonal antibodies (mAb) pertuzumab and bev

94 We have developed a humanized monoclonal antibody (mAb hu2c) that completely

95 Natalizumab, a humanized monoclonal antibody (mAb) against a4-integrin,

96 violet (UV) light irradiation in MEDI-493, a humanized monoclonal antibody (MAb) against respiratory

97 doses of RSHZ19 (also known as SB 209763), a humanized monoclonal antibody (MAb) directed to the fusi

98 Targeting Flower protein with humanized monoclonal antibody (mAb) in mice significantl

99 Tanezumab, a humanized monoclonal antibody (mAb) specific for NGF, is

100 mediate hemolysis in vivo was inhibited by a humanized monoclonal antibody (mAb) that blocks IgG bind

101 uated whether a potent neutralizing anti-WNV humanized monoclonal antibody (MAb), hE16, could improve

102 Recently, a recombinant, humanized, monoclonal antibody (mAb) that binds to and n

103 These three Fabs and derived humanized monoclonal antibodies (MAbs) exhibited high ne

104 Two humanized monoclonal antibodies, MEDI-493 and RSHZ19, we

105 This study describes the generation of a humanized monoclonal antibody, MEDI-493, that recognizes

106 post hoc analyses to evaluate the effect of humanized monoclonal antibody mepolizumab in patients wi

107 rolled trial of the alpha4 integrin-specific humanized monoclonal antibody natalizumab in 248 patient

108 Intravenous administration of a humanized monoclonal antibody of IgE (E25) attenuates th

109 only specific treatment available today is a humanized monoclonal antibody (Palivizumab) directed aga

110 ns within 4 months time, paving the way to a humanized monoclonal antibody platform and additional hu

111 Solanezumab, a humanized monoclonal antibody, preferentially binds solu

112 A humanized monoclonal antibody raised against human ovari

113 In this study, we examined the efficacy of a humanized monoclonal antibody recognizing interleukin-2

114 During the characterization of a recombinant humanized monoclonal antibody (referred to as rhuMAb), e

115 These chimeric or humanized monoclonal antibodies, respectively, act by bi

116 sing concentrations of anti-HER2 recombinant humanized monoclonal antibody (rhuMAb) 2C4.

117 The recombinant humanized monoclonal antibody (rhuMAb) HER2 has high aff

118 The glycated form of a basic recombinant humanized monoclonal antibody (rhuMAb) was separated and

119 A recombinant humanized monoclonal antibody (rhuMAb-E25) forms complex

120 verexpression of HER-2 receptor, recombinant humanized monoclonal antibodies (rhuMAbs) to HER-2 recep

121 Humanized monoclonal antibodies selectively targeting th

122 a on prostate cancer cells utilizing a novel humanized monoclonal antibody -- soon to undergo phase-I

123 xamined whether treatment with daclizumab, a humanized monoclonal antibody specific for the interleuk

124 n-10 is an attractive therapeutic target for humanized monoclonal antibody strategies.

125 Neutralization of VEGF using humanized monoclonal antibodies such as Avastin, effecti

126 Ocrelizumab, a humanized monoclonal antibody targeted against CD20+ B c

127 te the efficacy and safety of trastuzumab, a humanized monoclonal antibody targeted against the human

128 ellular retention of radiolabeled murine and humanized monoclonal antibodies targeting the CD33 antig

129 Natalizumab, a humanized monoclonal antibody targeting alpha4 integrin,

130 ration and evaluation of (124)I-MORAb-004, a humanized monoclonal antibody targeting an extracellular

131 Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-

132 Pembrolizumab is a humanized monoclonal antibody targeting programmed cell

133 Bococizumab, a humanized monoclonal antibody targeting proprotein conve

134 uvic et al demonstrate that mogamulizumab, a humanized monoclonal antibody targeting the chemokine re

135 Olokizumab, a humanized monoclonal antibody targeting the interleukin-

136 , combining bevacizumab (BV)--a recombinant, humanized, monoclonal antibody targeting vascular endoth

137 Humanized monoclonal antibodies that recognize the alpha

138 d pertuzumab (Omnitarg, 2C4) are recombinant humanized monoclonal antibodies that target different ex

139 Solanezumab, a humanized monoclonal antibody that binds amyloid, failed

140 afety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits ne

141 is effectively controlled with eculizumab, a humanized monoclonal antibody that binds complement prot

142 Ibalizumab is a humanized monoclonal antibody that binds human CD4, the

143 Ibalizumab is a humanized monoclonal antibody that binds human CD4--a ke

144 LT1009 (also known as sonepcizumab) is a humanized monoclonal antibody that binds S1P with high a

145 Mepolizumab, a humanized monoclonal antibody that binds to and inactiva

146 Mepolizumab is a humanized monoclonal antibody that binds to and neutrali

147 and efficacy of subcutaneous litifilimab, a humanized monoclonal antibody that binds to BDCA2, in pa

148 an entry portal for HIV-1, and PRO 140 is a humanized monoclonal antibody that binds to CCR5 and pot

149 Daclizumab high-yield process (HYP) is a humanized monoclonal antibody that binds to CD25 (alpha

150 ppression regimen consisted of daclizumab, a humanized monoclonal antibody that binds to the alpha ch

151 CSL346 is a novel humanized monoclonal antibody that binds VEGF-B with hig

152 HuN901 is a humanized monoclonal antibody that binds with high affin

153 Pembrolizumab is a humanized monoclonal antibody that blocks interaction be

154 Alemtuzumab is a humanized monoclonal antibody that causes an immediate d

155 exelimab is an investigational, bifunctional humanized monoclonal antibody that inhibits B-lineage ce

156 Axatilimab is a humanized monoclonal antibody that inhibits CSF-1R signa

157 Pertuzumab is a humanized monoclonal antibody that inhibits human epider

158 Bococizumab is a humanized monoclonal antibody that inhibits proprotein c

159 Pertuzumab, an anti-HER2 humanized monoclonal antibody that inhibits receptor dim

160 ng to the availability of burosumab, a fully humanized monoclonal antibody that neutralizes circulati

161 Mepolizumab, a humanized monoclonal antibody that neutralizes IL-5 and

162 important driver of AMR, and clazakizumab, a humanized monoclonal antibody that neutralizes interleuk

163 Bevacizumab is a recombinant humanized monoclonal antibody that neutralizes vascular

164 sts of interleukin-2 molecularly linked to a humanized monoclonal antibody that recognizes the GD2 di

165 Ocrelizumab is a humanized monoclonal antibody that selectively depletes

166 We studied ocrelizumab, a humanized monoclonal antibody that selectively depletes

167 eration classical complement inhibitor, is a humanized monoclonal antibody that selectively inhibits

168 Mepolizumab is a humanized monoclonal antibody that targets interleukin-5

169 Tanezumab, which is a late-stage development humanized monoclonal antibody that targets NGF.

170 udy, we report the development of IPH4102, a humanized monoclonal antibody that targets the immune re

171 We evaluated the addition of bevacizumab, a humanized monoclonal antibody that targets vascular endo

172 Bevacizumab is a humanized monoclonal antibody that targets vascular endo

173 y and efficacy of natalizumab, a recombinant humanized monoclonal antibody to alpha4 integrin, in pat

174 s of short-term administration of Vitaxin, a humanized monoclonal antibody to alphavbeta3, on the res

175 Galcanezumab, a humanized monoclonal antibody to calcitonin gene-related

176 Teplizumab, a humanized monoclonal antibody to CD3 on T cells, is appr

177 Alemtuzumab is a humanized monoclonal antibody to CD52 and has activity i

178 We hypothesized that crizanlizumab, a humanized monoclonal antibody to P-selectin, would reduc

179 e to HIT plasma or 5B9, a recently developed humanized monoclonal antibody to PF4/heparin.

180 , a radiotracer for PET derived from a fully humanized monoclonal antibody to STEAP1 in preclinical P

181 iangiogenic agent bevacizumab, a recombinant humanized monoclonal antibody to vascular endothelial gr

182 Bevacizumab, a recombinant humanized monoclonal antibody to VEGF, is being used cli

183 Bevacizumab, a recombinant humanized monoclonal antibody to VEGF, was administered

184 ne the safety and efficacy of a recombinant, humanized, monoclonal antibody to the CD18 subunit of th

185 ponse to B-cell-anergizing therapy using the humanized monoclonal antibody tocilizumab directed again

186 The humanized monoclonal antibody trastuzumab (Herceptin) wa

187 Treatment with the anti-ERBB2 humanized monoclonal antibody trastuzumab and chemothera

188 Targeted therapy with the humanized monoclonal antibody trastuzumab has become a m

189 an epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody trastuzumab improves the o

190 Moreover, the SGN-70 humanized monoclonal antibody, which binds to CD70 (the

191 s an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human t