ライフサイエンスコーパス: humoral immunity

1 elp and are crucial for generating long-term humoral immunity.

2 essary for affinity maturation and effective humoral immunity.

3 endosomal toll-like receptors and antiviral humoral immunity.

4 s provide new insight into the regulation of humoral immunity.

5 ibody/effector cell interaction in mediating humoral immunity.

6 of immune cell subsets involved in antiviral humoral immunity.

7 y, especially for protection against EBV and humoral immunity.

8 r understanding disease mechanisms involving humoral immunity.

9 ress GC B cell responses and anti-Plasmodium humoral immunity.

10 mechanisms collaborate to provide protective humoral immunity.

11 mulatory receptor that enhances cellular and humoral immunity.

12 f strategies that elicit effective antiviral humoral immunity.

13 that IL-10 is essential for anti-Plasmodium humoral immunity.

14 infection and the need for early functional humoral immunity.

15 ultiple Ags and generate robust cellular and humoral immunity.

16 elper T (Tfh) cells, which are essential for humoral immunity.

17 served peptide sequences from recognition by humoral immunity.

18 activation and the development of long-lived humoral immunity.

19 of soluble BAFF, which in turn up-regulated humoral immunity.

20 then tested as adults for cell-mediated and humoral immunity.

21 barrier to their participation in protective humoral immunity.

22 comparable mucosal and systemic cellular and humoral immunity.

23 s and is a key component of HIV evasion from humoral immunity.

24 Cs in humans that contribute to long-lasting humoral immunity.

25 , B lymphocytes are an indispensable part of humoral immunity.

26 ered in pathophysiological states, modulates humoral immunity.

27 melanization, and antibacterial activity for humoral immunity.

28 on and sustained expansion of GC B cells for humoral immunity.

29 lymphocytes that promote the development of humoral immunity.

30 CD4(+) T cell subset critical for long-lived humoral immunity.

31 act with B cells, and foster tumor-promoting humoral immunity.

32 ration and as such are vitally important for humoral immunity.

33 ay contribute to long-term cell-mediated and humoral immunity.

34 ction or vaccination to assess durability of humoral immunity.

35 es are superior at generating stalk-specific humoral immunity.

36 t-population turnover and individual loss of humoral immunity.

37 L-21 and IFN-gamma, with IL-21 being key for humoral immunity.

38 ts and strategies to improve anti-Plasmodium humoral immunity.

39 evels of viral replication and dysregulating humoral immunity.

40 nd will provide insight into the kinetics of humoral immunity.

41 als, ART does not fully restore cellular and humoral immunity.

42 for optimal GC-Tfh cell differentiation and humoral immunity.

43 h cells, germinal centers, and Tfh-dependent humoral immunity.

44 e is known about functional abnormalities in humoral immunity.

45 sis of cellular immunity and quantitation of humoral immunity.

46 ng, which is known to facilitate T-dependent humoral immunity.

47 ells in CD4(+) T-cell responses that support humoral immunity.

48 SARS-CoV-2 proteins, we detected preexisting humoral immunity.

49 cells) regulate the quantity and quality of humoral immunity.

50 tion in the germinal center is a hallmark of humoral immunity.

51 Tfr, and Treg cells, which together control humoral immunity.

52 in the generation of protective cellular and humoral immunity.

53 r certain conditions PEGylated lipids induce humoral immunity.

54 bers of circulating B cells suggest impaired humoral immunity.

55 ection is thought to be conferred in part by humoral immunity.

56 ions in LPA levels likely influence adaptive humoral immunity.

57 al development rather than disease-enhancing humoral immunity.

58 regulation of CD1d in normal B cells and in humoral immunity.

59 stand the outcome of vaccine trials based on humoral immunity.

60 d bone marrow-resident plasma cells maintain humoral immunity.

61 or CD20 in B cell activation and T-dependent humoral immunity.

62 CBCs) are critical for generating long-lived humoral immunity.

63 ell response declines, resulting in impaired humoral immunity.

64 ot included a detailed analysis of meningeal humoral immunity.

65 B cells (MBCs) are essential for long-lived humoral immunity.

66 innate lymphoid cells (ILC2s) in regulating humoral immunity.

67 secrete antibodies and form a cornerstone of humoral immunity.

68 d the generation of increased sensitivity to humoral immunity.

69 e from in vitro studies that HCMVs can evade humoral immunity.

70 cell interactions required for induction of humoral immunity.

71 ferent mechanisms may drive infant and adult humoral immunity.

72 t the parasite's ability to evade anti-PvDBP humoral immunity.

73 protein Env, contributing to the evasion of humoral immunity.

74 e in circulation and providing newborns with humoral immunity.

75 riment to assess the nature and longevity of humoral immunity after a single primary influenza infect

76 The longevity of protective humoral immunity after influenza infection has important

77 lity and immune determinants of induction of humoral immunity after primary influenza infection remai

78 The generation of protective humoral immunity after vaccination relies on the product

79 way serves as a key node in the induction of humoral immunity against AAV serotypes.

80 Vaccines to generate durable humoral immunity against antigenically evolving pathogen

81 ugh prophylactic vaccines provide protective humoral immunity against infectious agents, vaccines tha

82 B cells mediate humoral immunity against pathogens but also direct CD4(+

83 the development of long-lived and effective humoral immunity against Plasmodium takes many years and

84 4 costimulation are essential for productive humoral immunity against T-dependent Ags.

85 profile in the context of both cellular and humoral immunity against the major outer membrane protei

86 ses for long-lived cellular and neutralizing humoral immunity against the viral hemagglutinin.

87 ses for long-lived cellular and neutralizing humoral immunity against the viral hemagglutinin.

88 However, our knowledge of pre-existing humoral immunity against various AAV serotypes in cats i

89 Notably, only humoral immunity and activated B cell frequency in the a

90 Specific serum antibodies mediating humoral immunity and autoimmunity are provided by mature

91 However, the role of A2aR in humoral immunity and B cell differentiation is unknown.

92 en CD4(+) T cells and B cells are needed for humoral immunity and CD4(+) T cell memory.

93 Since both humoral immunity and cell-mediated immunity are essentia

94 tly limits helper T cell-mediated support of humoral immunity and decreases parasite control.

95 ibutions of donor and recipient to antiviral humoral immunity and evaluate longitudinal changes.

96 The duration and quality of humoral immunity and generation of immunological memory

97 l activation, germinal center reactions, and humoral immunity and how impaired responses to, or produ

98 FH) responses to elicitation of SIV-specific humoral immunity and implicate their participation in SI

99 glucosphingolipid-mediated dysregulation of humoral immunity and increased risk of B-cell malignancy

100 ent with the VSL#3 probiotic on cellular and humoral immunity and inflammation in healthy macaques.

101 a TFR cell effector molecule that regulates humoral immunity and limits systemic autoimmunity.

102 of allergic sensitization, the generation of humoral immunity and memory remains to be elucidated.

103 ght impair the TFH cell-dependent control of humoral immunity and might lead to the development of ab

104 purified donor-strain nT-regs inhibited host humoral immunity and prolonged allograft survival, and m

105 B cells promoted restoration of cellular and humoral immunity and protection against opportunistic in

106 Humoral immunity and resident-memory T cells notwithstan

107 s that may be targeted to promote long-lived humoral immunity and resistance to malaria.

108 nct commensal bacteria by multiple layers of humoral immunity and reveal a specialized function of th

109 We performed a comprehensive evaluation of humoral immunity and secondary lymphoid tissues in an es

110 offer some protection, due to cross-reactive humoral immunity and T cell immunity between common coro

111 y target cells of rapamycin for the impaired humoral immunity and that reduced Tfh formation in rapam

112 ious variable major proteins (VMPs) to evade humoral immunity and that VMPs are antigenic in humans.

113 Waning humoral immunity and the circulation of divergent wild-t

114 e formation of the cells that provide stable humoral immunity and therefore have implications for aut

115 tion and selection to both provide effective humoral immunity and to protect against genomic instabil

116 ycoproteins C (gC2) and D (gD2) to stimulate humoral immunity and UL19 (capsid protein VP5) and UL47

117 culate antigens, with broad implications for humoral immunity and vaccine design.

118 e is critical for the rescue of host natural humoral immunity and vaccine development.

119 Germinal centres (GCs) promote humoral immunity and vaccine efficacy.

120 cell responses in vivo However, the role of humoral immunity and viral modulation of anti-CMV antibo

121 able infants were eligible for assessment of humoral immunity, and eight studies with 4254 infants we

122 of intestinal immunity, induction of durable humoral immunity, and low cost.

123 Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in

124 gnaling enhances helper CD4 T cell activity, humoral immunity, and parasite clearance in rodents.

125 resulted in both MOMP-specific cellular and humoral immunity, and while there was a slight enhanceme

126 (LLPC) are essential for durable protective humoral immunity, and, conversely, in disease are a majo

127 orbent assays (gpELISAs) were used to assess humoral immunity; anti-varicella virus T-cell responses

128 haematopoiesis, although their functions in humoral immunity are difficult to decipher as a result o

129 However, whether and how mTOR regulates humoral immunity are not well understood.

130 s underlying the maintenance of long-lasting humoral immunity are not well understood.

131 However, mechanisms that regulate TI humoral immunity are poorly defined.

132 Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective anti

133 ed with defective CTL functions and impaired humoral immunity as indicated by reduced germinal center

134 Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen

135 The elderly have reduced humoral immunity, as manifested by increased susceptibil

136 in-depth understanding of both cellular and humoral immunity, as well as the intrinsic balances of t

137 ppreciated that in addition to their role in humoral immunity, B cells also exert regulatory mechanis

138 ymphoid tissues to vaccine antigens promotes humoral immunity, but traditional bolus immunizations le

139 fh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper s

140 ontribute to the development of long-lasting humoral immunity by germinal center formation.

141 We found that CXCL13 expression promoted humoral immunity by recruiting Tfh and GC B cells, facil

142 entify a mechanism by which IL-21 reinforces humoral immunity by restricting Tfr cell proliferation.

143 IL-10 also indirectly supports humoral immunity by suppressing excessive IFN-gamma, whi

144 Humoral immunity can help protect against atherosclerosi

145 Pre-existing humoral immunity can impact immune responses to heterolo

146 ice have shown that components of B cell and humoral immunity can modulate the immune responses again

147 tation, and highlights relationships between humoral immunity, cellular immunity and nonadherence.

148 Humoral immunity consists of pre-existing antibodies exp

149 Both cellular and humoral immunity contribute to this complication, with i

150 Humoral immunity depends on efficient activation of B ce

151 Long-lived humoral immunity depends on help provided by Tfh cells,

152 Immunization induced humoral immunity depends on rapid B cell proliferation a

153 ot affect the development of anti-Bordetella humoral immunity, did not contribute to disease severity

154 strategies that focus on the development of humoral immunity directed against the stalk domains of t

155 Unexpectedly, loss of FRCs also attenuated humoral immunity due to impaired B cell viability and fo

156 ow and blood, perhaps as a means to optimize humoral immunity during diurnal periods of activity.

157 s are essential for generation of protective humoral immunity during influenza infection.

158 1 regulatory (Tr1) cells, and restriction of humoral immunity during malaria blood stage infection.

159 dentifies a multi-signal relay of organismal humoral immunity, establishing adult Drosophila as model

160 in mice and nonhuman primates induces strong humoral immunity even in the absence of adjuvant, a proc

161 immunodeficiencies characterized by impaired humoral immunity following infection or vaccination.

162 ls are necessary for promotion of protective humoral immunity following pathogen challenge, but when

163 clones remained as important contributors to humoral immunity following their initial establishment d

164 hylaxis (PEP) requires rapid vaccine-induced humoral immunity for protection.

165 ng rise to novel viruses that can escape the humoral immunity generated by current influenza virus va

166 Driving robust humoral immunity has been a challenge given preexisting,

167 moniae infections, and underscore the effect humoral immunity has on evolving drug resistance.

168 ecent attempts to target these components of humoral immunity have failed.

169 g T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL

170 eature has been associated with avoidance of humoral immunity, i.e., B cell activation and antibody n

171 bda light chain, thus potentially minimizing humoral immunity impairment.

172 n the presence of natural or vaccine-induced humoral immunity.IMPORTANCE Rhesus cytomegalovirus (RhCM

173 add to the understanding of anti-ebolavirus humoral immunity.IMPORTANCE This study describes the gen

174 its established role in B cells, to promote humoral immunity in a variety of contexts.

175 ith correlation of CMV-specific cellular and humoral immunity in all subjects.

176 both reduced neutralization activity against humoral immunity in antisera of patients and healthy adu

177 ry of contradictory evidence for the role of humoral immunity in defense against tuberculosis.

178 esearchers to gain a better understanding of humoral immunity in HCV infection.

179 To explore PC longevity and humoral immunity in humans, we investigated the fate of

180 s a significant threat due to the absence of humoral immunity in individuals under the age of 50.

181 a tool to distinguish the differences in HIV humoral immunity in infants versus adults.

182 n ER-negative disease, suggesting a role for humoral immunity in mediating response to cytotoxic ther

183 BAFF) is critical for B cell development and humoral immunity in mice and humans.

184 cells in vitro and augments vaccine-induced humoral immunity in mice, leading to the development of

185 rized the molecular features of the elicited humoral immunity in mice.

186 cells in vitro and augments vaccine-induced humoral immunity in mice.IMPORTANCE MVA is an attractive

187 cicept suggests that the role of B cells and humoral immunity in multiple sclerosis is complex.

188 e clearance of B. burgdorferi is mediated by humoral immunity in NZW rabbits, the previously reported

189 on to understand decline in T cell-dependent humoral immunity in older age.

190 is in Rb1(+/-) mice and corrected decline in humoral immunity in older mice following immunization wi

191 nical course of disease suggesting a role of humoral immunity in S. aureus clearance.

192 ent understanding of how TRIM21 orchestrates humoral immunity in the cytosolic environment.

193 ell defects, and induced robust cellular and humoral immunity in the periphery.

194 Although the contributory role of humoral immunity in the protection against Mtb infection

195 Cs and elicitation of prolonged Env-specific humoral immunity in the rectal mucosa.

196 o manipulate these cells to not only improve humoral immunity in the setting of primary immunodeficie

197 r specific contribution to the regulation of humoral immunity in the spleen.

198 ell differentiation in the regulation of gut humoral immunity in vivo has never been directly shown.

199 T cell help in humoral immunity includes interactions of B cells with a

200 ile malaria but did not increase with age as humoral immunity is acquired or correlate with protectio

201 Impaired humoral immunity is also common.

202 Humoral immunity is an essential component of the protec

203 Humoral immunity is an essential correlate of protection

204 Humoral immunity is complemented by a cellular immune re

205 Development of long-lived humoral immunity is dependent on CXCR5-expressing T foll

206 The establishment of protective humoral immunity is dependent on the ability of mature B

207 from malaria in animal models but protective humoral immunity is difficult to induce in humans.

208 ivation after transplantation and found that humoral immunity is essential for preventing viral recru

209 Humoral immunity is generated and maintained by antigen-

210 elative importance of mucosal, cellular, and humoral immunity is important in developing vaccine stra

211 ng of how persistent viral infection impacts humoral immunity is incomplete.

212 our current knowledge on the role of ILCs in humoral immunity is limited.

213 sistently infect humans, but how HCMV avoids humoral immunity is not clear.

214 results show that induction of antibacterial humoral immunity is only partially effective in protecti

215 gainst severe respiratory viral disease when humoral immunity is overcome.

216 The cornerstone of humoral immunity is the differentiation of B cells into

217 roles in cardiovascular disease, the role of humoral immunity is unknown.

218 helper T cell (T(FH)), a critical player in humoral immunity, is associated with disease severity an

219 or B-T-cell interactions because the loss of humoral immunity leads to a smaller but less stable plaq

220 of cattle to colonization generally focus on humoral immunity, leaving the role of cellular immunity

221 creased interest in the role of Tfr cells in humoral immunity, many fundamental aspects of their biol

222 indicate that the escape of HIV-1 from host humoral immunity may play a direct role in TF in long-te

223 Such cross-reactive humoral immunity may provide vital first-line defense ag

224 reg cells play a critical role in regulating humoral immunity mediated by CD4(+)CXCR5(+)PD-1(+) folli

225 esting that targeting both cell-mediated and humoral immunity might optimally protect against seconda

226 one, as assessed by the primary endpoints of humoral immunity (neutralising antibodies-ie, seroconver

227 ew exceptions, the development of protective humoral immunity of more than a year is the norm.

228 lts highlight the importance of neutralizing humoral immunity on disease progression and the need to

229 The influence of humoral immunity on the prevention of primary cytomegalo

230 n the critical contribution of complement to humoral immunity, our observations provide new mechanist

231 dentify mechanisms underlying persistent IgE humoral immunity over almost the entire lifespan of the

232 own whether these changes continue to affect humoral immunity postpartum or how quickly they resolve.

233 al fatty acid status is a factor influencing humoral immunity, potentially through an SPM-mediated me

234 Plasma cells (PCs) as effectors of humoral immunity produce Igs to match pathogenic insult.

235 was not explained by changes in cellular or humoral immunity, reduced transmigration of leukocytes i

236 ion, a discriminatory or protective role for humoral immunity remains unclear.

237 Humoral immunity requires B cells to respond to multiple

238 Humoral immunity requires cross-talk between T follicula

239 ntibody production, development of long-term humoral immunity requires T-dependent B cell responses.

240 While humoral immunity seems to be central for protection agai

241 ion to impairing CD8(+) T cell responses and humoral immunity, STING N153S also promoted the replicat

242 mechanism used by Plasmodium vivax to escape humoral immunity targeting PvDBP, the key ligand involve

243 lts establish PTIP as a licensing factor for humoral immunity that acts at several junctures of B lin

244 wever, we also identified characteristics of humoral immunity that differed across species.

245 most critically, to identify the features of humoral immunity that distinguish protective from non-pr

246 ls has shed new light on pathways regulating humoral immunity that enable potent and specific respons

247 l-intrinsic, role for IDO1 as a regulator of humoral immunity that has implications for both vaccine

248 onse in combination with IgG1/IgG3-dominated humoral immunity that increase with age.

249 HA) effectively induces rapid and sustained humoral immunity that is protective against lethal chall

250 in humans, thereby supporting the long-lived humoral immunity that is required for effective vaccines

251 The BCR recognizes foreign Ags to initiate humoral immunity that needs isotype-switched Abs generat

252 though TFH cells are important in anti-viral humoral immunity, the contribution of TH1 cells to a pro

253 IgA are poorly characterized and the type of humoral immunity they elicit remains elusive.

254 allele was also associated with up-regulated humoral immunity through increased levels of soluble BAF

255 support that mTORi is a potent inhibitor of humoral immunity through suppression of alloprimed B cel

256 Generating durable humoral immunity through vaccination depends upon effect

257 Remarkably, rVSV(GP) escapes humoral immunity, thus, for the first time, allowing rep

258 Humoral immunity to a virus is achieved through the dual

259 al importance of functional antigen-specific humoral immunity to guide patient care and vaccine devel

260 3BNC117-mediated immunotherapy enhances host humoral immunity to HIV-1.

261 Tfh cell generation and prevented protective humoral immunity to intestinal helminth infection.

262 e studies provide guidance for comparison of humoral immunity to LASV of distinct lineages following

263 , for example, the placenta, enhancing fetal humoral immunity to levels similar to their mothers'.

264 Natural infection-induced humoral immunity to matrix protein 2 (M2) of influenza A

265 fection and gastric inflammation may enhance humoral immunity to oral attenuated S. Typhi vaccine.

266 nce factors as well as the analysis of human humoral immunity to pathogenic glycans.

267 Humoral immunity to pathogens and other environmental ch

268 Elderly humans show decreased humoral immunity to pathogens and vaccines, yet the effe

269 of a diverse antibody repertoire, providing humoral immunity to pathogens, requires the participatio

270 gen presenting cells to improve cellular and humoral immunity to plasmid-coded antigen.

271 didates suggests that both cell-mediated and humoral immunity to pre-erythrocytic parasite stages can

272 sociated with interindividual differences in humoral immunity to rubella virus.

273 le of the pathogen are shedding light on how humoral immunity to Salmonella operates.

274 thorough understanding of the mechanisms of humoral immunity to SARS-CoV-2(4).

275 lly infected animals, immunizations enhanced humoral immunity to sequences located in the putative Tp

276 anslatable approach to significantly improve humoral immunity to subunit vaccines using a clinical ad

277 e a practical means to substantially enhance humoral immunity to subunit vaccines.

278 yte trafficking was accompanied by defective humoral immunity to T-cell-dependent antigens.

279 SS provides the potential to elicit humoral immunity to target Plasmodium at multiple stages

280 s to examine the contribution of B cells and humoral immunity to the control of TB in nonhuman primat

281 e relative contribution of cell-mediated and humoral immunity to the vaccine-induced protection in a

282 ile progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little

283 e in vivo, B cell responses to model Ags and humoral immunity upon influenza infection were enhanced.

284 ICOSL and ICOS in a mouse model of increased humoral immunity using B6(mir146a-/-) mice and a model o

285 es a novel role for Eos in the regulation of humoral immunity via their impact on B cell homeostasis

286 r whether it will occur more frequently when humoral immunity wanes following primary infection.

287 Humoral immunity was associated with viral load at prese

288 ptide-specific Phl p 1- and Bet v 1-specific humoral immunity was demonstrated in subjects undergoing

289 Humoral immunity was dominated by IgG1 and IgG3, whereas

290 Humoral immunity was identified as the correlate of prot

291 We found that impairment of humoral immunity was most outspoken in the first year af

292 In contrast, renal humoral immunity was unaffected in BL5923-treated mice,

293 Therefore, to fully define protective humoral immunity, we dissected the early evolution of th

294 2 months of the HSCT, and both cellular and humoral immunity were re-established within a year of th

295 ole of GS protein-coupled A2aR in regulating humoral immunity, which may be pharmacologically targete

296 revealed significant boosting (by 4-fold) of humoral immunity, which occurred only in subjects (10 of

297 ess vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig,

298 microneedle patch induced a potent, balanced humoral immunity with an increased memory response compa

299 IV vaccine design has been that cellular and humoral immunity work together to provide the strongest

300 rofound impact on CD4(+) T cell function and humoral immunity, yet the impact of aging on antigen spe