ライフサイエンスコーパス: hyaluronan

1 de binding to hyaluronic acid (herein termed hyaluronan).

2 to catalyze the transfer of heavy chains to hyaluronan.

3 n asymmetrical bubble collapse may break the hyaluronan.

4 es may be related to associated increases in hyaluronan.

5 compared our results to chemically sulfated hyaluronan.

6 ollagenous glycoproteins, proteoglycans, and hyaluronan.

7 ated by the recognition of leukocyte-derived hyaluronan.

8 it is used for defining functions related to hyaluronan.

9 oordinate loss in another glycosaminoglycan, hyaluronan.

10 required that did not include degrading the hyaluronan.

11 erequisite for local, cell-based turnover of hyaluronan.

12 alized more readily than high molecular mass hyaluronan.

13 mor without depletion of stromal collagen or hyaluronan.

14 for the extracellular matrix (ECM) component hyaluronan.

15 nd the other requiring the glycosaminoglycan hyaluronan.

16 ent of brain volume, is largely comprised of hyaluronan.

17 MSO), 15% human serum albumin (HSA) and 0.1% hyaluronans.

18 Hyaluronan, a high molecular mass glycosaminoglycan, has

19 mino-acid peptide of human origin that binds hyaluronan, a major macromolecular component of the eye'

20 esis is that region-specific accumulation of hyaluronan, a predominant extracellular glycosaminoglyca

21 Finally, we found that the digestion of hyaluronan, a principal extracellular matrix component,

22 ryos exhibit increased cell density, reduced hyaluronan accumulation and impaired protein glycosylati

23 Hyaluronan acts as both a scaffold of the extracellular

24 ndicating reduced confinement by neighboring hyaluronan-aggrecan complexes.

25 role but must act together with the others: hyaluronan, anchored at the outer surface of articular c

26 (ii) that heparin inhibits the intracellular hyaluronan and autophagy responses, but after completing

27 tor (TNF)-stimulated gene-6 (TSG-6) binds to hyaluronan and can reorganize/stabilize its structure, a

28 loid P, is responsible for clearing residual hyaluronan and cellular debris).

29 Further, treatment with DON decreased hyaluronan and collagen in the tumor microenvironment, l

30 ndroitin sulfate of inter-alpha-inhibitor to hyaluronan and consequently to matrix stabilization.

31 nding of the molecular mechanisms underlying hyaluronan and HAS2 regulation and the role of soluble p

32 thases; the resulting 4-N3-GlcNAc-terminated hyaluronan and heparosan were then successfully conjugat

33 er a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.

34 nd TGFbeta, downstream protumor factors, and hyaluronan and its cofactor TSG6, which all contribute t

35 an receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes/lysosomes.

36 onsidered mimetics of the repeating units of hyaluronan and keratan respectively, were achieved by S(

37 regulate secretion of essential lubricants (hyaluronan and lubricin) and cytokines from synovial fib

38 ooth muscle alpha-actin, laminin alpha1, and hyaluronan and proteoglycan link protein 1 (Hapl1) produ

39 Here, we report that hyaluronan and proteoglycan link protein 1 (HAPLN1) is p

40 matic targeting of the proteoglycan versican/hyaluronan and proteoglycan link protein 1 rich myxoid m

41 rsican and its linking protein, a vertebrate hyaluronan and proteoglycan link protein 1.

42 and living human keratinocytes, to localize hyaluronan and sialylation sites.

43 ance of rHpScs consisting of a substratum of hyaluronans and Kubota's medium (KM), a serum-free mediu

44 D-glucuronic acid (GlcA), a substructure of hyaluronan, and N-acetylneuraminic acid (NANA), the most

45 vement of disturbed flow and of neutrophils, hyaluronan, and Toll-like receptor 2 ligation in superfi

46 TSG-6 and heavy-chain protein-hyaluronan are constitutively expressed in normal skin a

47 whether the lungs of fatal Covid-19 contain hyaluronan, as it is associated with inflammation and ac

48 s the receptor for selective engagement with hyaluronan assemblages in the glycocalyx that are large

49 This is especially true in cartilage, where hyaluronan assembles into an aggregate structure with th

50 depletion leads to enhanced accumulation of hyaluronan-associated ECM in the adipose-associated stro

51 hagy in regulating angiogenesis via the HAS2-hyaluronan axis and ATG9A, a novel HAS2 binding partner.

52 Use of hyaluronan-based sperm selection for ICSI (so-called phy

53 s LYVE-1 lateral diffusion but also enhances hyaluronan-binding activity.

54 or the expansion of mouse COCs in vitro, the hyaluronan-binding function of TSG-6 does not play a maj

55 -6 mutants (with impaired transferase and/or hyaluronan-binding functions) revealed that although the

56 Proteolysis of versican generates a hyaluronan-binding G1 domain.

57 lysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated in exosom

58 HABP2 (hyaluronan-binding protein 2) is a Ca(2+)-dependent seri

59 n, we have found that the well characterized hyaluronan-binding site in the TSG-6 Link module is not

60 We discuss extracellular hyaluronan biology and the post-transcriptional and post

61 ethylumbelliferone, as a potent inhibitor of hyaluronan biosynthesis, due in part to its ability to s

62 thylumbelliferone was indeed an inhibitor of hyaluronan biosynthesis, this depletion did not give ris

63 UTP increased hyaluronan both in the pericellular matrix and in the cu

64 d reduction in IL-6 and a 5-fold decrease in hyaluronan, both linked to lung fibrosis and PH, were al

65 the extracellular proteolytic processing of hyaluronan-bound proteoglycan.

66 g region to chondroitin sulfate and sulfated hyaluronan but not to the non-sulfated hyaluronan, confi

67 ransfer of HCs from chondroitin 4-sulfate to hyaluronan by tumor necrosis factor-stimulated gene-6 pr

68 at early and late stages of NASH, involving hyaluronan-CD44 binding.

69 survival through a mechanism that depends on hyaluronan-CD44 interactions.

70 ults show that IGFBP-3 or its peptide blocks hyaluronan-CD44 signaling via a mechanism that depends o

71 of the IGFBP-3 protein, the peptide blocked hyaluronan-CD44 signaling, and more effectively inhibite

72 However, the addition of intact aggrecan to hyaluronan chains sonicated for 5 and 10 s reblocked the

73 with IL-1beta changes the structure of their hyaluronan coat by influencing the amount, post-translat

74 e1, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking o

75 -1beta turns on the monocyte adhesion of the hyaluronan coat on human keratinocytes.

76 dy demonstrates that both IalphaI and the HC-hyaluronan complex are substrates for the extracellular

77 or to hyaluronan to form heavy-chain protein-hyaluronan complexes.

78 fated hyaluronan but not to the non-sulfated hyaluronan, confirming binding specificity.

79 ost-stroke muscle stiffness, and that muscle hyaluronan content is increased in stiff muscles compare

80 ptor for the glycosaminoglycan ECM component hyaluronan, coordinates the motility and proliferative r

81 nocyte-macrophage lineage as contributors to hyaluronan degradation in bladder cancer tissue, leading

82 aluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic

83 Instead, we found that the increase in the hyaluronan-dependent monocyte binding was associated wit

84 eased monocyte binding to keratinocytes in a hyaluronan-dependent way.

85 cative of myofibroblast activity), increased hyaluronan deposition in the lung parenchyma (attributed

86 To bind hyaluronan efficiently, LYVE-1 must undergo surface clus

87 the overall size of the aggregate prevented hyaluronan endocytosis and furthermore that proteolysis

88 These data suggest that hyaluronan endocytosis is regulated in large part by the

89 a size range of aggrecan exists that permits hyaluronan endocytosis.

90 These results establish that the hyaluronan extracellular matrix surrounds developing exc

91 This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 l

92 Hyaluronan fragmentation corresponded to hypoxic inducti

93 lung hyaluronidase expression and activity, hyaluronan fragmentation, and effacement of HA from the

94 atory and proangiogenic low molecular weight hyaluronan fragments.

95 The HAS2 product hyaluronan further stimulated CD44s-mediated Akt signali

96 The extracellular matrix polysaccharide hyaluronan (HA) accumulates at sites of autoimmune infla

97 adenocarcinoma is characterized by excessive hyaluronan (HA) accumulation in the tumor microenvironme

98 cells to immunotherapy may be influenced by hyaluronan (HA) accumulation in the tumor microenvironme

99 espect to the extracellular matrix component hyaluronan (HA) and chemokine expression.

100 e an extracellular matrix (ECM), enriched in hyaluronan (HA) and its binding partner versican, which

101 Hyaluronan (HA) and its receptor CD44 may also participa

102 by accumulation of a pericellular matrix of hyaluronan (HA) and the HA-dependent co-localization of

103 ush complexes formed from the polysaccharide hyaluronan (HA) and the proteoglycan aggrecan contribute

104 r matrix changes such as the accumulation of hyaluronan (HA) and versican in the subepithelial space

105 inant human hyaluronidase (PEGPH20) degrades hyaluronan (HA) and, in combination with chemotherapy, p

106 s of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulit

107 y stimuli by synthesizing leukocyte-adhesive hyaluronan (HA) cables that remain attached to their cel

108 smembrane receptor for the glycosaminoglycan hyaluronan (HA) demonstrate a number of neurological dis

109 LYVE-1 has been implicated in both uptake of hyaluronan (HA) from tissue matrix and in facilitating t

110 The matrix polysaccharide hyaluronan (HA) has a critical role in the expansion of

111 g hyperglycemic stress abnormally synthesize hyaluronan (HA) in intracellular compartments.

112 ssels, accompanied by accumulation of low-MW hyaluronan (HA) in mouse orthotopic allografts undergoin

113 Importantly, matrix hyaluronan (HA) induces the up-regulation of stem cell m

114 Hyaluronan (HA) inhibits OPC maturation and complexes wi

115 Hyaluronan (HA) is a key component of the extracellular

116 Hyaluronan (HA) is a large (>1500 kDa) polysaccharide of

117 Hyaluronan (HA) is a major component of this structure.

118 The glycosaminoglycan hyaluronan (HA) is a major extracellular matrix componen

119 Hyaluronan (HA) is a major glycosaminoglycan component o

120 Hyaluronan (HA) is a structurally simple polysaccharide,

121 Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the

122 Hyaluronan (HA) is an abundant glycosaminoglycan within

123 Hyaluronan (HA) is associated with innate immune respons

124 During inflammation, hyaluronan (HA) is increased at sites of inflammation wh

125 Hyaluronan (HA) is one of the most prevalent glycosamino

126 Hyaluronan (HA) is present in the extracellular matrix o

127 in the interstitium of high-molecular-weight hyaluronan (HA) is principally responsible for generatin

128 Hyaluronan (HA) is required for endothelial-to-mesenchym

129 Hyaluronan (HA) is synthesized by three HA synthases (HA

130 )-dependent signaling pathway that regulates hyaluronan (HA) metabolism and drives adult fibroblasts

131 However, their role in the regulation of hyaluronan (HA) metabolism in the tumor microenvironment

132 angiogenic drug quininib was formulated into hyaluronan (HA) microneedles whose safety and efficacy w

133 d the extracellular matrix glycosaminoglycan hyaluronan (HA) on AEC2s are important for AEC2 renewal,

134 In response to tissue injury, hyaluronan (HA) polymers are cleaved by host hyaluronida

135 We present data that hyaluronan (HA) polysaccharides, about 14-86 monosacchar

136 Hyaluronan (HA) promotes transforming growth factor (TGF

137 4-Methylumbelliferone (4-MU) inhibits hyaluronan (HA) synthesis and is an approved drug used f

138 HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC.HA complexes, thereb

139 Hyaluronan (HA) turnover accelerates metastatic progress

140 to study the interaction of the GAG polymer hyaluronan (HA) with CD44, its receptor in vascular endo

141 n.SIGNIFICANCE STATEMENT We demonstrate that hyaluronan (HA) with different molecular weights produce

142 ion, however, is hindered by the presence of hyaluronan (HA), a glycosaminoglycan that is a major flu

143 ed DC culture based on their ability to bind hyaluronan (HA), a major component of the extracellular

144 Hyaluronan (HA), a ubiquitous glycosaminoglycan of the l

145 We have identified a novel role for hyaluronan (HA), an extracellular matrix polymer, in gov

146 The breakdown of the glycosaminoglycan, hyaluronan (HA), by TMEM2 within the extracellular matri

147 r inter-alpha-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA receptor binding.

148 For each class of the glycosaminoglycans-hyaluronan (HA), heparan sulfate/heparin (HS/HP), chondr

149 Our model is focused on the damage in hyaluronan (HA), which is the main structural component

150 oal of this study was to determine whether a hyaluronan (HA)-binding peptide (P15-1), via interacting

151 s study was to unravel the role of the early hyaluronan (HA)-rich ECM after I/R.

152 oocytes are surrounded by a highly hydrated hyaluronan (HA)-rich extracellular matrix with embedded

153 ular true for its main structural component, hyaluronan (HA).

154 presence or absence of a CD44-specific Ab or hyaluronan (HA).

155 Hyaluronan has a very simple structure.

156 liated apical surfaces to form a heavy chain hyaluronan (HC-HA) matrix in the absence of inflammatory

157 ccharides, including cello-oligosaccharides, hyaluronan, heparan sulfate, heparin, and chondroitin su

158 ucts were then tested for incorporation into hyaluronan, heparosan, or chondroitin using polysacchari

159 deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method

160 hondroitin sulfate and high-molecular-weight hyaluronan (HMW-HA) associated with IAIP.

161 the mechanism by which high-molecular-weight hyaluronan (HMWH) attenuates nociceptor sensitization, i

162 SIGNIFICANCE STATEMENT High-molecular-weight-hyaluronan (HMWH) is used to treat osteoarthritis and ot

163 yperalgesia induced by high molecular weight hyaluronan (HMWH).

164 Hyaluronan (hyaluronic acid; HA) instillation to the bla

165 ols, providing imaging corroboration for the hyaluronan hypothesis of muscle stiffness.

166 g synaptogenesis, we sought to determine how hyaluronan impacts the ratio of excitatory to inhibitory

167 vels or distribution of sialic acids (SA) or hyaluronan in animal cells are indicators of pathologica

168 obe, we found loss of glomerular endothelial hyaluronan in association with lesion formation in tissu

169 lso investigated the presence of endothelial hyaluronan in human kidney tissue from patients with var

170 In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tis

171 direct genetic evidence for a requirement of hyaluronan in palate development is still lacking.

172 els through selective adhesion to its ligand hyaluronan in the leukocyte surface glycocalyx.

173 g at reducing the presence and production of hyaluronan in the lungs.

174 terations in the structure and regulation of hyaluronan in the pulmonary vascular extracellular matri

175 These findings show removal of hyaluronan in the tumor microenvironment improves immune

176 hesis or increase the amount of pericellular hyaluronan in these cells.

177 Removal of hyaluronan increases the expression of excitatory synaps

178 d all sulfated GAGs, but not the nonsulfated hyaluronan, indicating that binding is specific to the p

179 ugh a mechanism preceding and independent of hyaluronan inhibition.

180 ontrolled by the affinity of individual CD44-hyaluronan interactions.

181 e aggrecan monomer was required to allow for hyaluronan internalization.

182 Glomerular endothelial hyaluronan is a previously unrecognized key component of

183 erentially bind to YKL-40 over collagen, and hyaluronan is likely the preferred physiological ligand,

184 In most extracellular matrices hyaluronan is not present as a free polysaccharide but o

185 Stainings confirmed that hyaluronan is obstructing alveoli with presence in exuda

186 Hyaluronan is organized into a cross-linked network by t

187 Hyaluronan is present from the onset of brain developmen

188 In vertebrates, hyaluronan is produced in the plasma membrane from cytos

189 urthermore, we identified that HAS2-produced hyaluronan is required for CD44V6 and TGFbetaRI co-local

190 Hyaluronan is the predominant glycosaminoglycan componen

191 tly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collaps

192 Through acute perturbation of hyaluronan levels during synaptogenesis, we sought to de

193 Decreased hyaluronan levels in peripheral blood independently pred

194 Low molecular weight hyaluronan (LMWH) acts at both peptidergic and nonpeptid

195 e mechanism of chondrocyte activation due to hyaluronan loss, a depletion method was required that di

196 Hyaluronan, lubricin and phospholipids, molecules ubiqui

197 mation of an extracellular monocyte-adhesive hyaluronan matrix after cell division was completed.

198 rmation of a monocyte-adhesive extracellular hyaluronan matrix after completing cell division; and (i

199 the formation of a larger monocyte-adhesive hyaluronan matrix.

200 c vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific

201 and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibrob

202 the previously reported rapid activation of hyaluronan metabolism in response to tissue trauma or ul

203 Altered hyaluronan metabolism may be involved in the inflammator

204 tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 sign

205 adder urothelial layer and the expression of hyaluronan-metabolizing enzymes and/or HA receptors in K

206 in gel, fibrin-Matrigel mixed gel and fibrin-hyaluronan mixed gel, were investigated to optimize the

207 that the CD44, a transmembrane receptor for hyaluronan, modulates synaptic plasticity.

208 We find that surface-anchored hyaluronan molecules complex synergistically with phosph

209 ot the mutant (K228AR230A), was able to bind hyaluronan more efficiently than the analogous sequences

210 rified aggrecan was added to FITC-conjugated hyaluronan, no internalization of hyaluronan was detecte

211 , HAS1 transfection reduced the synthesis of hyaluronan obtained by HAS2 and HAS3, suggesting functio

212 It was also determined that sonicated hyaluronan of smaller molecular size was internalized mo

213 diated by the extracellular matrix component hyaluronan of very high molecular weight (HMW-HA).

214 a, TNFalpha, LPS, fibronectin fragments, and hyaluronan oligosaccharides.

215 served as a chain termination substrate for hyaluronan or heparosan synthases; the resulting 4-N3-Gl

216 ey provide a continuous source of megadalton hyaluronan or they can be covalently-stabilized to the s

217 Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purifie

218 Together, these data indicate that hyaluronan plays a crucial intrinsic role in palatal she

219 e extracellular matrix (ECM) that is rich in hyaluronan, plays an integral role in this immune evasio

220 cheme to synthesize ultra-thick regenerating hyaluronan polymer brushes using hyaluronan synthase.

221 Modulation of hyaluronan polymer size is responsible for its control o

222 Our results suggest that chitohexaose and hyaluronan preferentially bind to YKL-40 over collagen,

223 Our results demonstrate that hyaluronan preferentially surrounds nascent excitatory s

224 was associated with an increase in bacterial hyaluronan production (mucoid colonies 200 mug per CFU a

225 program that underlies both PDAC growth and hyaluronan production.

226 , the number of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1(+)) macrophages decreased

227 Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) mediates the docking and

228 ion profiles of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), a biomarker that plays c

229 ing podoplanin, lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and cluster of different

230 ls that express lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), which include lymphatic e

231 ed with LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1), neuropilin-1 and VEGFR2 (vascula

232 ssion, and more lymphatic vessel endothelial hyaluronan receptor 1-positive vascular endothelial grow

233 arkers (LYVE-1 [lymphatic vessel endothelial hyaluronan receptor 1]: p < 0.05; PROX-1 [prospero homeo

234 In many cells hyaluronan receptor CD44 mediates the endocytosis of hya

235 We investigated the functional role of hyaluronan receptor CD44V6 (CD44 containing variable exo

236 Overexpression of the hyaluronan receptor HMMR in primary LUAD was associated

237 er of differentiation 44 (CD44), the cognate hyaluronan receptor, and intradermal administration of A

238 Sprague Dawley rats, the role of the cognate hyaluronan receptor, CD44 signaling in the antihyperalge

239 broblasts have high endogenous levels of the hyaluronan receptor, CD44V6 (CD44 variant containing exo

240 r lymphatic endothelium-the lymphatic vessel hyaluronan receptor-1 (Lyve-1).

241 ages expressing lymphatic vessel endothelial hyaluronan receptor-1 were found within peritumoral adip

242 Hyaluronan release and dispersion of the cumulus cells p

243 s experimentally depleted of cell-associated hyaluronan respond by switching to a pro-catabolic metab

244 Endothelial loss of hyaluronan results in disturbed glomerular endothelial s

245 se cells are retained around the oocyte by a hyaluronan-rich extracellular matrix synthesized before

246 nating and stabilizing the formation of this hyaluronan-rich matrix.

247 l survival, and micrometastasis expansion in hyaluronan-rich microenvironments in the lung and brain

248 Hence, cells equipped with hyaluronan-rich PCM can in principle manipulate surface

249 chanisms involves the formation of extended, hyaluronan-rich pericellular coats on local fibroblasts,

250 The hyaluronan-rich pericellular matrix (PCM) plays physical

251 The pericellular matrix is a robust, hyaluronan-rich polymer brush-like structure that contro

252 modeling and is specifically associated with hyaluronan-rich regions within the adipose stroma and fi

253 We propose that a hyaluronan-rich, relatively immobile gel-fluid phase ind

254 Hyaluronan-selected sperm have reduced levels of DNA dam

255 gical ligand, because the negatively charged hyaluronan shows enhanced affinity for YKL-40 over neutr

256 Using a hyaluronan-specific probe, we found loss of glomerular e

257 In contrast, the addition of purified hyaluronan suppresses excitatory synapse formation.

258 wn products UDP and UMP act as mediators for hyaluronan synthase (HAS) activation in human epidermal

259 brane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfe

260 We identified hyaluronan synthase 2 (Has2) as another novel downstream

261 Hyaluronan synthase 2 (HAS2) is the main hyaluronan synt

262 dothelium-specific and inducible deletion of hyaluronan synthase 2 (Has2), the enzyme that produces h

263 Furthermore, TBX4 regulated hyaluronan synthase 2 production to enable fibroblast in

264 Both Irinotecan/HAS2 (Hyaluronan synthase 2) and Bevacizumab/PGAM1 (Phosphogly

265 hibits KC proliferation and directly targets hyaluronan synthase 3 and thereby may modulate AD-associ

266 ed putative direct target genes, we verified hyaluronan synthase 3, a damage-associated positive regu

267 Hyaluronan synthase 2 (HAS2) is the main hyaluronan synthase enzyme involved in HA synthesis and

268 ice isoform CD44s promoted expression of the hyaluronan synthase HAS2 by activating the Akt signaling

269 llular UDP-glucuronic acid and inhibition of hyaluronan synthase transcription.

270 oblasts revealed induction of IL8, SERPINB2, hyaluronan synthase-2, and other genes associated with t

271 egenerating hyaluronan polymer brushes using hyaluronan synthase.

272 RNA-seq identifies hyaluronan synthase2 as a target of homo-IR, with its ex

273 egulated HAS2 expression, although the other hyaluronan synthases (HAS1, HAS3) and hyaluronidases (HY

274 In this study, we show that Has2, 1 of 3 hyaluronan synthases in mammals, plays a major role in h

275 Increased hyaluronan synthesis and CD44 expression have been detec

276 over cellular functions, and the balance of hyaluronan synthesis and degradation determines its mole

277 ecifically, we found that NOX4/ROS regulates hyaluronan synthesis and the transcription of CD44V6 via

278 nses, but after completing division, induces hyaluronan synthesis at the plasma membrane with the for

279 P sugars, and induces abnormal intracellular hyaluronan synthesis during the S phase of cell division

280 l pathways on the one hand and influence the hyaluronan synthesis in the ECM on the other.

281 synthases in mammals, plays a major role in hyaluronan synthesis in the neural crest-derived craniof

282 IL-1beta did not influence hyaluronan synthesis or increase the amount of pericellu

283 hyperglycemic medium initiate intracellular hyaluronan synthesis that induces autophagy and the cycl

284 As similar insults are known to activate hyaluronan synthesis we explored the possibility that ex

285 ntially important functional consequences on hyaluronan synthesis.

286 ovalent complex between the heavy chains and hyaluronan that can promote leukocyte invasion.

287 synthase 2 (Has2), the enzyme that produces hyaluronan, the main structural component of the endothe

288 oteins from inter-alpha-trypsin inhibitor to hyaluronan to form heavy-chain protein-hyaluronan comple

289 g of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is con

290 transfer of IalphaI heavy chains (HCs) onto hyaluronan (to form covalent HC.HA complexes that are cr

291 ation in the stroma of the glycosaminoglycan hyaluronan, together with the large gel-fluid phase and

292 Hyaluronan turnover is also increased.

293 ng rodent, produces very-high-molecular-mass hyaluronan (vHMM-HA), compared to other mammalian specie

294 o platelets previously adhered to sinusoidal hyaluronan via CD44.

295 When hyaluronan was combined with partially degraded, dansyl

296 conjugated hyaluronan, no internalization of hyaluronan was detected.

297 the interaction between CD44 and its ligand hyaluronan, we can block EHT, identifying an additional

298 whereas aggregates containing 15-s sonicated hyaluronan were internalized.

299 We also demonstrated that loss of hyaluronan, which harbors a specific binding site for an

300 reveal that Hyal-2 knockout mice accumulate hyaluronan within their bone marrow and within megakaryo