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1 syltransferases (e.g. cellulose, chitin, and hyaluronan synthases).
2  a novel mouse gene which encodes a putative hyaluronan synthase.
3 human homolog of a recently described murine hyaluronan synthase.
4 egenerating hyaluronan polymer brushes using hyaluronan synthase.
5 that the recombinant protein is an authentic hyaluronan synthase.
6 ding frame, A98R, with similarity to several hyaluronan synthases.
7               TGF-beta also strongly induced hyaluronan synthase 1 (HAS1) and HAS2 mRNA levels, which
8 rs contained a c-Maf binding site, including hyaluronan synthase 1 (HAS1).
9 f Hyaluronidase 2 and CD44, and no change of Hyaluronan synthase 1 and Hyaluronidases 1, 3, 4 or 5.
10  further observed that the expression of the Hyaluronan synthase 1, 2 and 3, and the Hyaluronidase 3
11 brane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfe
12 1 and UGDH with specific siRNAs also lowered hyaluronan synthase-1 (HAS-1) and HAS-2 levels and reduc
13  Soluble hyaluronan levels and expression of hyaluronan synthase-1 were increased in TNFDeltaARE mice
14 creased HA secretion resulted from increased hyaluronan synthase 2 (HAS2) activity localized to sphin
15 STAT3 pathway, which regulates expression of hyaluronan synthase 2 (HAS2) and subsequent hyaluronan s
16                                We identified hyaluronan synthase 2 (Has2) as another novel downstream
17             Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in
18                                              Hyaluronan synthase 2 (HAS2) is the main hyaluronan synt
19         Here, we report that upregulation of hyaluronan synthase 2 (HAS2) occurs in highly metastatic
20     In addition, we found that expression of hyaluronan synthase 2 (Has2) was elevated by a loss of S
21 tures induced a specific, rapid induction of hyaluronan synthase 2 (HAS2), and an increase of hyaluro
22 latelet-derived growth factor-B (PDGFB), and hyaluronan synthase 2 (HAS2), as well as the EMT transcr
23 ntricular canal marker genes, such as tbx2b, hyaluronan synthase 2 (has2), notch1b and bmp4, are chan
24 dothelium-specific and inducible deletion of hyaluronan synthase 2 (Has2), the enzyme that produces h
25 A-degrading enzymes and a unique sequence of hyaluronan synthase 2 (HAS2).
26  enhanced thrombin-induced HA synthesis, and hyaluronan synthase 2 expression in VSMC.
27 ynovial cells, and condyles displayed higher Hyaluronan synthase 2 expression.
28 ticoid receptor chromatin occupancy to drive hyaluronan synthase 2 gene expression and increase extra
29 ytes demonstrated overexpression of SAA3 and hyaluronan synthase 2 in vitro and in vivo in diet-induc
30 e consistent with the possibility that while Hyaluronan synthase 2 increases the levels, the Hyaluron
31 g hyaluronan production by overexpression of hyaluronan synthase 2 or emmprin causes elevated ErbB2 p
32                  Furthermore, TBX4 regulated hyaluronan synthase 2 production to enable fibroblast in
33 dentification of a natural antisense mRNA of hyaluronan synthase 2 that we have chosen to designate a
34                    Therefore, we generated a Hyaluronan Synthase 2 transgenic mouse line, driven by a
35                        Both Irinotecan/HAS2 (Hyaluronan synthase 2) and Bevacizumab/PGAM1 (Phosphogly
36 d-glucosaminyl 3-O-sulfotransferase 3A1, and hyaluronan synthase 2) that have direct or indirect role
37 expression of CD44 exon 19 and CD44 exon 20, hyaluronan synthase 2, aggrecan, and GAPDH messenger RNA
38 suppressive factors, checkpoint ligands, and hyaluronan synthase 2, all of which drive T cell dysfunc
39  d-glucosaminyl 3-O-sulfotransferase 3A1 and hyaluronan synthase 2, are also potentially important me
40                              myCAF-expressed hyaluronan synthase 2, but not type I collagen, promotes
41                          This group included hyaluronan synthase 2, nephroblastoma-overexpressed gene
42  accompanied by increased gene expression of Hyaluronan synthase 2, reduced expression of Hyaluronida
43 actor signaling, including cyclooxygenase 2, hyaluronan synthase 2, tumor necrosis factor-stimulated
44 ression of hyaluronan (HA) and activation of hyaluronan synthase-2 (Has2) are also enhanced upon PN/I
45                                We identified hyaluronan synthase-2 (Has2) as a likely source of hyalu
46                     Targeted deletion of the hyaluronan synthase-2 (Has2) gene in mice results in an
47    The aim of this study was to characterize hyaluronan synthase-2 (HAS2)-driven HA synthesis and det
48                          Cells infected with hyaluronan synthase-2 adenovirus also acquired mesenchym
49 , we have shown that increased expression of hyaluronan synthase-2 induces malignant cell properties,
50 oblasts revealed induction of IL8, SERPINB2, hyaluronan synthase-2, and other genes associated with t
51   Using recombinant adenoviral expression of hyaluronan synthase-2, we show that increased hyaluronan
52 e identified a common SNP, rs2232228, in the hyaluronan synthase 3 (HAS3) gene that exerts a modifyin
53                                              Hyaluronan synthase 3 (HAS3) is responsible for the prod
54 dine 5'-diphosphate dehydrogenase (ugdh) and hyaluronan synthase 3 (has3), drives canal morphogenesis
55 hibits KC proliferation and directly targets hyaluronan synthase 3 and thereby may modulate AD-associ
56 (bicuculline methiodide model) and in vitro (hyaluronan synthase 3 knock-out, picrotoxin, bicuculline
57 ed putative direct target genes, we verified hyaluronan synthase 3, a damage-associated positive regu
58 on is dependent on de novo synthesis through hyaluronan synthase 3, and plays a role in the inflammat
59 aluronan induced by high VT was dependent on hyaluronan synthase 3, and was associated with ventilato
60 hereas adenoviral-mediated overexpression of hyaluronan synthase 3, which stimulated endogenous hyalu
61 high VT ventilation in C57BL/6 wild-type and hyaluronan synthase-3 knockout mice were compared.
62 hese reactions were significantly reduced in hyaluronan synthase-3 knockout mice, except the capillar
63 nthase-3 mRNA, neither of which was found in hyaluronan synthase-3 knockout mice.
64 sues and concomitant increased expression of hyaluronan synthase-3 mRNA, neither of which was found i
65 s, and was accompanied by an upregulation of hyaluronan synthase-3 mRNA.
66                          In analogy to known hyaluronan synthases, a single polypeptide species, pmCS
67 hree homologous genes encoding proteins with hyaluronan synthase activity (Has1-3), all producing an
68 revious reports indicate that hasA, encoding hyaluronan synthase, and hasB, encoding UDP-glucose 6-de
69 gest that there are three putative mammalian hyaluronan synthases encoded by three separate but relat
70     Hyaluronan synthase 2 (HAS2) is the main hyaluronan synthase enzyme involved in HA synthesis and
71                                     mRNA for hyaluronan synthase enzymes HAS1 and HAS2 increased >10-
72 ion, but the depletion of versican decreased hyaluronan synthase expression and decreased the retenti
73 ereas CD44 is expressed in tumor epithelium, hyaluronan synthase expression is restricted to stromal-
74 ant cDNAs included S10-40-H5, members of the Hyaluronan synthase family, Xvent-2 and XFD2/FoxI1.
75  for a virus, e.g., ornithine decarboxylase, hyaluronan synthase, GDP-D-mannose 4,6 dehydratase, and
76 nt was studied using knock-out mice of three hyaluronan synthase genes (Has1, Has2, and Has3).
77 ization studies, in combination with a novel hyaluronan synthase-GFP transgenic mouse, show a restric
78  Collagen I (COL1A1), collagen III (COL3A1), hyaluronan synthase (HAS) 2, and fibronectin expression
79 wn products UDP and UMP act as mediators for hyaluronan synthase (HAS) activation in human epidermal
80 ERK) signaling, and their role in regulating hyaluronan synthase (HAS) activity in human ovarian tumo
81     Subcutaneous injection of SCID mice with hyaluronan synthase (HAS) antisense-transfected cells pr
82 a functional glycosaminoglycan synthase, the hyaluronan synthase (HAS) from Group A Streptococcus pyo
83  the role of HA in this disease, we examined hyaluronan synthase (Has) gene expression and HA product
84 but related genes which comprise a mammalian hyaluronan synthase (HAS) gene family.
85                          The three mammalian hyaluronan synthase (HAS) genes and the related Xenopus
86                                              Hyaluronan synthase (HAS) utilizes UDP-GlcUA and UDP-Glc
87 ane-embedded processive glycosyltransferase, hyaluronan synthase (HAS), which catalyses the synthesis
88 f the cell membrane by the membrane-embedded hyaluronan synthase (HAS).
89 aluronan and its three synthesizing enzymes, hyaluronan synthases (Has 1, 2, and 3), also participate
90                      To dissect the roles of hyaluronan synthases (HAS) and Hyal1 in tumorigenesis an
91         In monolayer cultures, UVB increased hyaluronan synthase Has1 mRNA already 4 h postexposure,
92 egulated HAS2 expression, although the other hyaluronan synthases (HAS1, HAS3) and hyaluronidases (HY
93                                              Hyaluronan synthases (HAS1-3) are unique in that they ar
94 ice isoform CD44s promoted expression of the hyaluronan synthase HAS2 by activating the Akt signaling
95 r cells express 20-fold higher levels of the hyaluronan synthase HAS3, but the mechanistic relevance
96 lation of a cDNA encoding the third putative hyaluronan synthase, HAS3.
97 an cDNA that is related to the Streptococcus hyaluronan synthase (HasA) and the Xenopus developmental
98                                              Hyaluronan synthases (HASs) are essential enzymes for hy
99                                              Hyaluronan synthases (HASs) are glycosyltransferases tha
100 be a sensitive assay for detection of active hyaluronan synthases (HASs) capable of synthesizing hyal
101  different conclusions about whether class I hyaluronan synthases (HASs) elongate hyaluronic acid (HA
102                                      The two hyaluronan synthases (HASs) from Streptococcus pyogenes
103 he functional sizes of the two streptococcal hyaluronan synthases (HASs) were determined by radiation
104                                      A human hyaluronan synthase (HuHAS1) cDNA was isolated by a func
105     In this study, we show that Has2, 1 of 3 hyaluronan synthases in mammals, plays a major role in h
106            Cps1p also shares similarity with hyaluronan synthase of higher eukaryotes.
107 lusively attributed to the ubiquitous hasABC hyaluronan synthase operon, which is highly conserved ac
108                    The Pasteurella multocida hyaluronan synthase (PmHAS) catalyzes the polymerization
109 e nucleotide and the amino acid level to the hyaluronan synthase, pmHAS, from P. multocida Type A.
110 with the mouse HAS protein, another putative hyaluronan synthase recently reported by Itano and Kimat
111 mbranes expressing Streptococcus equisimilis hyaluronan synthase (seHAS) demonstrated an inherent art
112 onstrated that the Streptococcus equisimilis hyaluronan synthase (seHAS) is phospholipid-dependent an
113 ne domains (MD) of Streptococcus equisimilis hyaluronan synthase (seHAS), Lys48 in MD2 and Glu327 in
114  protein is a crucial component of the human hyaluronan synthase system.
115  the Pasteurella multocida Type A PmHAS, the hyaluronan synthase that makes the alternating (-beta3-G
116 llular UDP-glucuronic acid and inhibition of hyaluronan synthase transcription.
117 ion is only partially PKC dependent; and (3) hyaluronan synthase turnover time is >6 h in vivo, which
118           To identify the putative mammalian hyaluronan synthase, we cloned a human cDNA that is rela
119                  The prototypical vertebrate hyaluronan synthase, xlHAS1 (or DG42) from Xenopus laevi

 
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