ライフサイエンスコーパス: hydrogen atom abstraction

1 enable remote C-H functionalization via 1,5-hydrogen atom abstraction.

2 ps that include a solvent-dependent step and hydrogen atom abstraction.

3 allosteric effects were seen on diffusion or hydrogen atom abstraction.

4 xy radical, which is a selective reagent for hydrogen atom abstraction.

5 l reactions, but the addition even more than hydrogen atom abstraction.

6 H bonding orbital in the best trajectory for hydrogen atom abstraction.

7 substrate radical intermediate is formed by hydrogen atom abstraction.

8 tivity of formation of a C4 radical by a 1,5-hydrogen atom abstraction.

9 t dioxygenase) oxidize alkanes by an initial hydrogen atom abstraction.

10 ficult chemical transformations initiated by hydrogen atom abstraction.

11 tion steps happen through a rate-determining hydrogen atom abstraction.

12 al is formed from the hypophosphite anion by hydrogen atom abstraction.

13 hat is enabled by catalytic enantioselective hydrogen atom abstraction.

14 mphor skeleton at C8 using an intramolecular hydrogen atom abstraction.

15 investigate the kinetic significance of the hydrogen atom abstraction.

16 h initiates opposite strand cleavage via C4'-hydrogen atom abstraction.

17 nitiates enzymatic transformations requiring hydrogen atom abstraction.

18 cohols is achieved by thiyl radical mediated hydrogen-atom abstraction.

19 ransition-metal phosphinidene synthesized by hydrogen-atom abstraction.

20 n rate, establishing that ABLM is capable of hydrogen-atom abstraction.

21 lorine radicals promoted the degradation via hydrogen-atom abstraction.

22 that an oxo-Mn(V) species is responsible for hydrogen-atom abstraction.

23 ure-inspired pathway of high- and low-energy hydrogen atom abstractions.

24 lized mixed valency and greatly enhances the hydrogen atom abstraction activity of the bridging oxyge

25 Hydrogen-atom abstraction affords an achiral benzylic ra

26 complex, with the highest reactivity toward hydrogen-atom abstraction among the three, has the stron

27 ively), and with the nucleoside thymidine by hydrogen atom abstraction and addition at C5 in the base

28 benzaldehyde dialkyl acetal is activated via hydrogen atom abstraction and beta-scission via a bromin

29 te a copper-bound radical anion, followed by hydrogen atom abstraction and collapse to products, with

30 molecular dynamics confirmed that the 1beta-hydrogen atom abstraction and deformylation or decarbony

31 the thermodynamic unfavorability of both its hydrogen atom abstraction and oligomerization reactions

32 Finally, the hydrogen atom abstraction and proton coupled electron tr

33 substrates in a manner most consistent with hydrogen atom abstraction and provides chemical preceden

34 inglet oxygen scavenging, electron transfer, hydrogen atom abstraction and radical adduct formation.

35 The capability of LCuF to perform both hydrogen atom abstraction and radical capture was levera

36 elf-decay by rate-determining intramolecular hydrogen atom abstraction and subsequent formation of a

37 the reaction is not concerted but occurs via hydrogen atom abstraction and subsequent radical rebound

38 s in ((iPr)PDI)Mo(NH3)2(eta(2)-C2H4) enabled hydrogen atom abstraction and synthesis of a terminal ni

39 reacts with acetaldehyde and pivaldehyde by hydrogen atom abstraction and, in the presence of O(2),

40 kinetic control, through sequential steps of hydrogen-atom abstraction and hydrogen-atom donation med

41 Both the radical (hydrogen atom abstraction) and nonradical (NH(2) abstrac

42 Hence, the regioselectivity of hydrogen atom abstraction appears to be independent of t

43 nstants for reaction with organic compounds (hydrogen atom abstraction) approach the diffusion-contro

44 molecular isotope effects, that the rates of hydrogen atom abstraction are masked.

45 xperimental data seems to support the direct hydrogen atom abstraction as evidenced by the break in l

46 be expected if the mechanism of MMO involves hydrogen atom abstraction as indicated by many previous

47 ry is at play, rather than classical Norrish hydrogen atom abstraction as initially conceived.

48 The rate constant for hydrogen atom abstraction at 298 K by benzyl radical fro

49 Hydrogen atom abstraction at other sites of the deoxyrib

50 xquisitely selective tertiary amine-mediated hydrogen-atom abstraction at the N6-methyl group to form

51 gma*z(2) excitation energy, which raises the hydrogen atom abstraction barrier above that found for t

52 We show that the hydrogen atom abstraction barrier of substrate hydroxyla

53 ever, that are associated with variations in hydrogen-atom abstraction barrier heights and tunneling

54 Thus, replacement of C-H by C-D raises the hydrogen atom abstraction barriers and enables a regiose

55 No evidence for internucleotidyl hydrogen atom abstraction by 1 was detected.

56 limination of the 3'-phosphate following C2'-hydrogen atom abstraction by 1.

57 occurs via beta-fragmentation following C2'-hydrogen atom abstraction by 1.

58 Rate constants for hydrogen atom abstraction by [Mn(2)(O)(2)](3+) and [Mn(2

59 This value is consistent with hydrogen atom abstraction by an electrophilic Fe(O) cent

60 adical clock is based on competition between hydrogen atom abstraction by an intermediate peroxyl rad

61 trapping of alkyl radicals generated through hydrogen atom abstraction by arylsulfonyl-based SOMO-phi

62 ed by determination of a rate expression for hydrogen atom abstraction by benzyl radical from 1 (log(

63 re-dependent rate data are also reported for hydrogen atom abstraction by benzyl radical from thiophe

64 idea that PFL-AE accesses Gly-734 for direct hydrogen atom abstraction by binding to the Gly-734 loop

65 ptides has been used to identify the site of hydrogen atom abstraction by hydroxyl radical.

66 lation sequence which are initiated by 1beta-hydrogen atom abstraction by P450 compound I are conside

67 A basis rate expression for hydrogen atom abstraction by sec-phenethyl alcohol, PhC*

68 This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and ad

69 graphy; and deuterium isotope effects on the hydrogen atom abstraction by the adenosyl radical were u

70 ct is believed to result from intramolecular hydrogen atom abstraction by the C6-peroxyl radical (14)

71 onstants for the chain propagation reactions:hydrogen atom abstraction by the methoxy radical and ele

72 ), a hypothetical product resulting from C1'-hydrogen atom abstraction by the peroxyl radical, could

73 Hydrogen atom abstraction by the resulting methoxy radic

74 m, forming an alkoxy radical which undergoes hydrogen atom abstraction by the tyrosine-cysteine pheno

75 The percentage yield of hydrogen atom abstraction by these radicals was found to

76 te hexahydrate is described as a convenient, hydrogen atom abstraction catalyst that can mediate fluo

77 onsted basic carboxylates that become potent hydrogen atom abstraction catalysts upon visible light i

78 While the regiochemistry of the hydrogen atom abstraction catalyzed by AprD4 has been es

79 es suggest that thiolate coordination favors hydrogen-atom abstraction chemistry over oxygen-atom tra

80 on mechanism at elevated temperatures, while hydrogen atom abstraction dominates below 100 K despite

81 photocatalysts for the requisite high-energy hydrogen atom abstraction event.

82 irst example of ammonia oxidation via triple hydrogen atom abstraction facilitated by a metal-free sy

83 lytic step, which can be summarized by 1beta-hydrogen atom abstraction followed by gem-diol deprotona

84 udies reveal that catalysis proceeds through hydrogen atom abstraction followed by radical rebound, a

85 Both results are consistent with 5'-hydrogen atom abstraction for initiation of the site-sel

86 omplished by measuring the rate constants of hydrogen atom abstraction for novel, charged dehydroquin

87 The data indicate a mechanism of initial hydrogen-atom abstraction forming radicals that dimerize

88 by computations, show that the position for hydrogen atom abstraction from 2,5-DAPn and 2,4-DAB by t

89 thyl groups in 3, followed by intermolecular hydrogen atom abstraction from 2-MeTHF solvent.

90 the adenosine nucleotide of the substrate by hydrogen atom abstraction from an amidine carbon, the 5'

91 an that of 1, possibly due to intramolecular hydrogen atom abstraction from benzylic methyl groups in

92 mation of the bicyclic intermediate involves hydrogen atom abstraction from both C2' and C4' in the s

93 e that TPZ-mediated strand damage arises via hydrogen atom abstraction from both the most hindered (C

94 radical generator, which initiates repair by hydrogen atom abstraction from C-6 of SP.

95 Hydrogen atom abstraction from C2' in DNA under aerobic

96 lysed ring contraction reaction initiated by hydrogen atom abstraction from C2'.

97 DPS-catalyzed cyclization likely proceeds by hydrogen atom abstraction from C7', oxidation of the ben

98 initial cleavage of H(2)O(2) and subsequent hydrogen atom abstraction from chitin by the copper-oxyl

99 ion of dG(N1-H)(.) via dG(N2-H)(.) following hydrogen atom abstraction from dG is unlikely to be a ma

100 rmal conditions, the benzyl radicals undergo hydrogen atom abstraction from dibenzyl ketone and para-

101 uces vinyl radical intermediates that affect hydrogen atom abstraction from DNA, leading to the forma

102 Transition states for 1beta-hydrogen atom abstraction from enolized substrates in th

103 These radicals can affect hydrogen atom abstraction from methanol and acetone.

104 n its chemistry than previously anticipated: hydrogen atom abstraction from Nalpha-cyclopropyltryptop

105 Hydrogen atom abstraction from NHC-BH(2)Ar groups produc

106 oxime esters 2d and 2e to dC. and subsequent hydrogen atom abstraction from organic solvents.

107 Moreover, a Hammett analysis of hydrogen atom abstraction from para-X-benzyl alcohol rev

108 bled the realization of catalytic reactions: hydrogen atom abstraction from phenols and room temperat

109 hygromycin B consistent with metal-catalyzed hydrogen atom abstraction from substrate.

110 1beta-Hydrogen atom abstraction from substrates in the presenc

111 vity trends observed for these radicals upon hydrogen atom abstraction from tetrahydrofuran and 2-met

112 in this reaction was determined to occur by hydrogen atom abstraction from the 4'- and 5'-positions

113 xyuridin-6-yl involve pi-bond addition to or hydrogen atom abstraction from the adjacent nucleotides

114 sotopically labeled amino acids, we rule out hydrogen atom abstraction from the alpha-carbon as the i

115 oxidation of the carboxylate of I3A or (2) a hydrogen atom abstraction from the alpha-carbon of I3A t

116 perimental observation with rate-determining hydrogen atom abstraction from the C(4)-H position, foll

117 The tandem lesion (17) resulting from hydrogen atom abstraction from the C1' position of the a

118 Hydrogen atom abstraction from the C5'-position of nucle

119 Hydrogen atom abstraction from the C5'-position of nucle

120 xyl radicals, a species responsible for both hydrogen atom abstraction from the CH reagent and the se

121 idence suggests DNA cleavage is initiated by hydrogen atom abstraction from the deoxyribose backbone.

122 directly cause DNA strand scission after C4' hydrogen atom abstraction from the deoxyribose moiety.

123 This paper provides support for 5'-hydrogen atom abstraction from the deoxyribose ring as t

124 hanisms as well as the proposal that initial hydrogen atom abstraction from the fatty acid is the fir

125 henyl radical and HO(*), but mainly react by hydrogen atom abstraction from the methyl group (some ad

126 ransfer from one SAM equivalent, followed by hydrogen atom abstraction from the methyl group by a 5'-

127 specific dehydrogenation of 3MI via initial hydrogen atom abstraction from the methyl group.

128 ion of HO(.) with dG was proposed to involve hydrogen atom abstraction from the N2-amine.

129 eration of the purine radical resulting from hydrogen atom abstraction from the N6-amine of 2'-deoxya

130 activated oxygen species thought to mediate hydrogen atom abstraction from the nearest substrate car

131 were located wherein the copper facilitates hydrogen atom abstraction from the NH-sulfoximine and th

132 Formal hydrogen atom abstraction from the nitrogen-hydrogen bon

133 determining step is generally accepted to be hydrogen atom abstraction from the pentadiene subunit of

134 determining step is generally accepted to be hydrogen atom abstraction from the pentadiene subunit of

135 a proton to DMDS, which is then followed by hydrogen atom abstraction from the protonated sulfur ato

136 s favored by approximately 4-5-fold over C1'-hydrogen atom abstraction from the respective deoxyribos

137 lding the transient CH(3) radical capable of hydrogen atom abstraction from the S-H bond in coenzyme

138 are the corresponding triamines, suggesting hydrogen atom abstraction from the solvent as the primar

139 orresponding tetraamine, suggesting that the hydrogen atom abstraction from the solvent is primarily

140 ggest that Co-C bond homolysis is coupled to hydrogen atom abstraction from the substrate and that th

141 active intermediate that results from formal hydrogen atom abstraction from the thymine methyl group.

142 d Ni-C(sp(2)) bond homolysis are involved in hydrogen atom abstraction from trialkylamines.

143 equently, the radical intermediate undergoes hydrogen atom abstraction from vicinal methylene by a co

144 Fe(IV), kH2O/kD2O = 2.8, is consistent with hydrogen atom abstraction from water.

145 In recent computational studies of hydrogen-atom abstraction from amino acid derivatives, t

146 Hydrogen-atom abstraction from M-E(H) to generate M hori

147 Hydrogen-atom abstraction from nickel(I) phosphide and a

148 nlike prior systems, this amination involves hydrogen-atom abstraction from O-H bonds.

149 iates play a major role and are generated by hydrogen-atom abstraction from substrate C-H bonds or in

150 ate detected prior to DNA cleavage following hydrogen-atom abstraction from the C-4' of a deoxyribose

151 gue show that DNA cleavage occurs through 4'-hydrogen-atom abstraction from the DNA backbone and oxid

152 dicals during catalysis and their subsequent hydrogen-atom abstraction from the THF solvent to genera

153 lkaloid-derived catalyst, enantiodetermining hydrogen atom abstraction generates a desymmetrized kety

154 sp(3))-H halogenation sequence by sequential hydrogen atom abstraction (HAA) and radical capture.

155 The catalytic pathway involves key steps of hydrogen atom abstraction (HAA) and radical substitution

156 Hydrogen atom abstraction (HAA) from 1,4-cyclohexadiene

157 This gap arises because hydrogen atom abstraction (HAA) of protic C-H bonds by e

158 -NH)(mu-N(3)) (5) formed from intermolecular hydrogen atom abstraction (HAA) of strong C-H bonds (BDE

159 ters that enables 1e(-) activation of O2 for hydrogen atom abstraction (HAA) of substrate C-H bonds a

160 Four different pathways were considered: (1) hydrogen atom abstraction (HAA) of the Pd-H bond by mole

161 ll demonstrated to undergo both 1,5- and 1,6-hydrogen atom abstraction (HAA) reactions, 1,4-HAA is ty

162 The hydrogen atom abstraction (HAA) reactivity of these inte

163 Cu-S bond which also possesses demonstrated hydrogen atom abstraction (HAA) reactivity.

164 d by coupling H(+) and e(-) transfers as net hydrogen atom abstraction (HAA) steps using the 2,4,6-tr

165 e decomposition via intra- or intermolecular hydrogen-atom abstraction (HAA) from an imido aryl ortho

166 understanding the basis for the high rate of hydrogen atom abstraction (HAT) from dihydroanthracene (

167 Radical coupling and hydrogen atom abstraction (HAT) reactions have been expl

168 ts on the thermodynamics and kinetics of its hydrogen-atom abstraction (HAT) reactions.

169 hetic potential of catalysts able to perform hydrogen atom abstraction in a stereoselective manner.

170 the broad synthetic potential of harnessing hydrogen atom abstraction in an enantioselective manner.

171 xperimental/theoretical study suggested that hydrogen atom abstraction in TAA by DPPH was located on

172 The reaction involves hydrogen atom abstraction in the transition state, and t

173 es of an apparent preference for alternative hydrogen-atom abstractions in which complexes 1 and 7/8

174 Hydrogen atom abstraction is an important elementary che

175 Hydrogen atom abstraction is another plausible pathway b

176 Internucleotidyl hydrogen atom abstraction is effected selectively by the

177 et up that explains how the rate constant of hydrogen atom abstraction is proportional to the differe

178 A new transition state model for hydrogen atom abstraction is proposed.

179 AA and LA as substrate, is large indicating hydrogen atom abstraction is the principle rate-determin

180 Hydrogen-atom abstraction is selective, preferentially p

181 retro-Bergman ring opening predominates over hydrogen atom abstraction (k-1 > k2) for 6,7-diethynylqu

182 energies, rather than pK(a)'s, suggesting a hydrogen atom abstraction mechanism.

183 ransfer step preceding deprotonation or to a hydrogen atom abstraction mechanism.

184 We probed their hydrogen atom abstraction mechanisms and regiochemical p

185 The fact that hydrogen atom abstraction occurs at C-3 also sheds light

186 ensity functional theory calculations on the hydrogen atom abstraction of propene by a range of diffe

187 of iron and oxygen mediate DNA damage by 4'-hydrogen atom abstraction of pyrimidines 3' to guanines.

188 Mechanistic studies are consistent with the hydrogen atom abstraction of the C-H bond by the copper-

189 Subsequent hydrogen atom abstraction, often from the solvent, produ

190 alyst that operates through enantioselective hydrogen atom abstraction, once oxidized by an excited p

191 be intercepted at the 5-exo stage via either hydrogen atom abstraction or C-S bond scission or allowe

192 The generated radicals undergo reduction via hydrogen atom abstraction or reductive cyclization.

193 oyl radicals, which can be formed via direct hydrogen atom abstraction or via an electron-transfer-pr

194 s the origin of the reactivity preference of hydrogen-atom abstraction over nucleophilic addition.

195 lyze the origin of this unexpected selective hydrogen atom abstraction pathway and find that the alte

196 react with hydrocarbon substrates through a hydrogen atom abstraction pathway and raise the intrigui

197 yl radicals deriving from lactones through a hydrogen atom abstraction process mediated by tetrabutyl

198 )-superoxo species are capable of performing hydrogen atom abstraction processes.

199 ethoxypyridinium cations, in addition to the hydrogen atom abstraction product.

200 tent with the amination proceeding through a hydrogen atom abstraction, radical rebound type mechanis

201 unctionalize strong C-H bonds via a two-step hydrogen atom abstraction-radical rebound mechanism that

202 )(hp)(4)Cl]-promoted C-H amination involving hydrogen-atom abstraction/radical recombination and the

203 The hydrogen atom abstraction rate constant (k(H)) was obser

204 10(3) M(-1) s(-1), respectively, both having hydrogen atom abstraction rate constants orders of magni

205 nism for the reaction that is initiated by a hydrogen atom abstraction reaction, which enables a keto

206 igh (D)k value is consistent with an initial hydrogen atom abstraction reaction.

207 rizability change and barrier height for the hydrogen atom abstraction reaction.

208 teraction poses a conundrum for the proposed hydrogen-atom abstraction reaction because the >6 A dist

209 vealed a logarithmic correlation between the hydrogen-atom abstraction reaction efficiencies and the

210 No correlation was found between the hydrogen-atom abstraction reaction efficiencies and the

211 ogarithmic correlation was found between the hydrogen-atom abstraction reaction efficiencies and the

212 Hydrogen-atom abstraction reaction efficiencies for two

213 Thus, the hydrogen-atom abstraction reaction efficiency for an ary

214 onal potential energy surface for the direct hydrogen-atom abstraction reaction of the deoxyribose 4'

215 A time-resolved kinetic study of the hydrogen atom abstraction reactions from phenol by the c

216 ) enzyme superfamily has widespread roles in hydrogen atom abstraction reactions of crucial biologica

217 more, the ferric complex is shown to undergo hydrogen atom abstraction reactions with O-H and C-H bon

218 ability to perform oxygen atom transfer and hydrogen atom abstraction reactions.

219 ; however, the reverse trend is obtained for hydrogen atom abstraction reactions.

220 Manganese(III)-peroxo can react through hydrogen-atom abstraction reactions instead of the commo

221 Examination of the hydrogen-atom abstraction reactions of 29 different aryl

222 tein-folds vs the QMT factors, in modulating hydrogen-atom abstraction reactivity, in two distinct me

223 t the critical role of the photocatalyst and hydrogen atom abstraction reagents for productive cataly

224 ) to other coordination complexes capable of hydrogen atom abstraction shows that, although a strong

225 ducing ofloxacin desaturation via sequential hydrogen atom abstraction, single electron transfer and

226 llowing order of radical stabilities for the hydrogen atom abstractions: sp2 centers > heteroatom sp3

227 oes not proceed through the rate-determining hydrogen atom abstraction step that occurs in alcohol ox

228 nd anti isomers of adduct 7b showed that the hydrogen atom abstraction step was significantly more st

229 protein environment catalyzes the substrate hydrogen atom abstraction step with a remarkably low fre

230 results reveal that the enzyme catalyzes the hydrogen-atom abstraction step with a remarkably low fre

231 This intermediate reacts via an initial hydrogen-atom abstraction step, performing subsequent ha

232 s generally proceeds through two consecutive hydrogen atom abstraction steps from two adjacent carbon

233 We show that the order of the hydrogen atom abstraction steps, however, is opposite of

234 On this basis, we developed a hydrogen-atom abstraction strategy that allows for a con

235 for acetol formation reflects rate-limiting hydrogen atom abstraction; the lower isotope effect for

236 tone or an alkene changes the chemistry from hydrogen atom abstraction to double bond addition.

237 At higher energies, spin-allowed hydrogen atom abstraction to form FeOH(+) predominates.

238 een explored by determination of kinetics of hydrogen atom abstraction to form the radical Cp*Mo(mu-S

239 or a Norrish type II mechanism involving 1,5-hydrogen atom abstraction to generate an aci-nitro speci

240 HmaS performs hydrogen-atom abstraction to yield benzylic hydroxylated

241 ar radical intermediates accessed by neutral hydrogen atom abstraction under visible light-mediated p

242 electivity switch from aliphatic to aldehyde hydrogen atom abstraction upon deuteration of the substr

243 ent reactivities exhibited by these enzymes (hydrogen-atom abstraction vs. aromatic electrophilic att

244 Hydrogen atom abstraction was the only reaction observed

245 P450s to catalyze amine N-dealkylations via hydrogen atom abstraction when such a course is electron

246 beta-scission reactions are faster than 1,5-hydrogen atom abstractions when the incipient carbon rad

247 reactive radicals are most selective toward hydrogen atom abstraction, while the most reactive radic

248 theta = 2.303RT, was determined by competing hydrogen atom abstraction with radical self-termination.

249 lic radicals react with sugars via exclusive hydrogen atom abstraction, with adenine and uracil almos

250 alization of the alcohol, taking place via a hydrogen atom abstraction, with the simultaneous formati

251 pathway and find that the alternative C(3)-H hydrogen atom abstraction would be followed by a low-ene