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1 f a VDRM compared with agonists by employing hydrogen/deuterium exchange.
2 ze exclusion chromatography and differential hydrogen/deuterium exchange.
3 many different phenomena lead to changes in hydrogen/deuterium exchange.
5 ral data, molecular dynamics simulation, and hydrogen-deuterium-exchange analysis, we demonstrate tha
11 acids that make up the folding core include hydrogen-deuterium exchange and Phi-value analysis and c
17 receptor chimeras, photo-affinity labeling, hydrogen-deuterium exchange, and crystallography of the
19 es a variable region, which is identified by hydrogen-deuterium exchange as the common interface for
20 ding in living red blood cells (RBCs), using hydrogen/deuterium exchange-based mass spectrometry (H/D
22 predicted structures were in agreement with hydrogen-deuterium exchange, circular dichroism, surface
26 es revealed allotype-specific differences in hydrogen-deuterium exchange, consistent with the notion
27 termination of their epitope diversity using hydrogen deuterium exchange coupled with mass spectromet
29 try, and mapped intermolecular contacts with hydrogen-deuterium exchange coupled to mass spectrometry
32 y additionally demonstrates the potential of hydrogen-deuterium exchange coupled to mass spectrometry
36 Time, temperature, and mutation dependent hydrogen-deuterium exchange coupled to mass spectrometry
37 time-resolved fluorescence spectroscopy, and hydrogen-deuterium exchange coupled to mass spectrometry
42 avirenz on CYP46A1 by using a combination of hydrogen-deuterium exchange coupled to MS, computational
43 between apoE3 and E4 functionality, we used hydrogen-deuterium exchange coupled with a fragment sepa
44 horless prion protein, PrP(C), together with hydrogen-deuterium exchange coupled with mass spectromet
46 olipid bilayer nanodiscs, subjecting them to hydrogen-deuterium exchange coupled with mass spectromet
49 nvestigated using site-directed mutagenesis, hydrogen/deuterium exchange coupled to mass spectrometry
56 tion before and after substrate binding, the hydrogen/deuterium exchange data in the L2' and 130's re
58 he most promising experimental techniques is hydrogen-deuterium exchange detected by mass spectrometr
63 assays, molecular dynamics simulations, and hydrogen-deuterium exchange experiments demonstrate that
64 ystallography, cryo-electron microscopy, and hydrogen-deuterium exchange experiments revealed that GS
65 , chemical exchange saturation transfer, and hydrogen-deuterium exchange experiments show that the va
69 her orthogonal techniques, such as gas-phase hydrogen/deuterium exchange (gHDX), MS is also capable o
71 pectrometry (IMS-MS) combined with gas-phase hydrogen-deuterium exchange has been used to characteriz
72 e method is based on early folding data from hydrogen deuterium exchange (HDX) data from NMR pulsed l
74 be a platform utilizing two methods based on hydrogen-deuterium exchange (HDX) coupled with mass spec
77 ences between each isomer by using gas-phase hydrogen-deuterium exchange (HDX) immediately after DMS
83 tivity against soluble ester substrates, and hydrogen-deuterium exchange (HDX) mass spectrometry reve
84 thermal titration calorimetry (ITC) and NMR, hydrogen-deuterium exchange (HDX) mass spectrometry, and
85 s work, we have developed a method that uses hydrogen-deuterium exchange (HDX) of C2-hydrogens of his
87 cribe the use of a combined method including hydrogen-deuterium exchange (HDX), fast photochemical ox
88 d the E2 CD81bs by electron microscopy (EM), hydrogen-deuterium exchange (HDX), molecular dynamics (M
94 -principle experiments, the use of gas-phase hydrogen/deuterium exchange (HDX) combined with IMS-MS/M
98 nly accessible database of carefully curated hydrogen/deuterium exchange (HDX) data extracted from th
105 NMR) spectroscopy, x-ray crystallography and hydrogen/deuterium exchange (HDX) mass spectrometry, her
108 tonated carbohydrate structures by gas-phase hydrogen/deuterium exchange (HDX) to discover that the e
110 structure of intact antibodies, by combining hydrogen/deuterium exchange (HDX), subzero temperature c
113 o performed mass spectrometry-detected amide hydrogen/deuterium exchange (HDXMS) experiments on Ikapp
114 the rate of trypsinolysis and the extent of hydrogen-deuterium exchange in local secondary structure
116 e hydrolysis caused significant increases in hydrogen-deuterium exchange in sub-regions of the peptid
117 assembly steps, we analyzed the patterns of hydrogen-deuterium exchange in vimentin and in four vari
118 d by substantially higher protection against hydrogen/deuterium exchange in the C-terminal region nea
120 ctions, we used mass spectrometry to monitor hydrogen/deuterium exchange in various regions of FLASH,
122 for biological mass spectrometry, including hydrogen-deuterium exchange, ion-molecule proton transfe
127 Here, we use comprehensive mutagenesis and hydrogen deuterium exchange mass spectrometry (HDX-MS) t
129 differential scanning calorimetry (DSC), and hydrogen-deuterium exchange mass spectrometry (H/D excha
131 cific chemical modifications within the CDR, hydrogen-deuterium exchange mass spectrometry (HDX MS) w
134 ns between beta2AR and beta-arrestin 1 using hydrogen-deuterium exchange mass spectrometry (HDX-MS) a
137 tructural integrity of therapeutic proteins, hydrogen-deuterium exchange mass spectrometry (HDX-MS) i
143 eport the first comprehensive application of hydrogen-deuterium exchange mass spectrometry (HDX-MS) t
144 ticle (SMALP) technology can be coupled with hydrogen-deuterium exchange mass spectrometry (HDX-MS) t
149 We describe an integrated approach of using hydrogen-deuterium exchange mass spectrometry (HDX-MS),
150 2S) has been accomplished through the use of hydrogen-deuterium exchange mass spectrometry (HDX-MS).
152 d trypsinolysis mass spectrometry (LTMS) and hydrogen-deuterium exchange mass spectrometry (HXMS) are
153 plasmon resonance, analytical rheology, and hydrogen-deuterium exchange mass spectrometry (HXMS), we
154 ensive integrated approach of cross-linking, hydrogen-deuterium exchange mass spectrometry (MS), elec
155 ck (residues 775-818) using a combination of hydrogen-deuterium exchange mass spectrometry and isothe
157 proprotein convertase 1/3 using a histidine hydrogen-deuterium exchange mass spectrometry approach.
159 lecule Forster resonance energy transfer and hydrogen-deuterium exchange mass spectrometry data with
160 ength monomeric structure of the protein, on hydrogen-deuterium exchange mass spectrometry data, and
164 tructures of the muPA:nanobody complexes and hydrogen-deuterium exchange mass spectrometry revealed m
169 titive enzyme-linked immunosorbent assay and hydrogen-deuterium exchange mass spectrometry that 7 of
170 d fluorescence polarization measurements and hydrogen-deuterium exchange mass spectrometry to define
171 use NMR, accelerated molecular dynamics and hydrogen-deuterium exchange mass spectrometry to define
174 we present a hybrid approach involving NMR, hydrogen-deuterium exchange mass spectrometry, and model
175 ystallography, small-angle X-ray scattering, hydrogen-deuterium exchange mass spectrometry, and mutat
176 ay crystallography, cryoelectron microscopy, hydrogen-deuterium exchange mass spectrometry, and mutat
177 ys11-linked diubiquitin, in combination with hydrogen-deuterium exchange mass spectrometry, enable us
178 ing calorimetry, intrinsic fluorescence, and hydrogen-deuterium exchange mass spectrometry, have thei
180 mations and lipid-binding mechanism, we used hydrogen-deuterium exchange mass spectrometry, lipoprote
181 mbined with mutational and kinetic analyses, hydrogen-deuterium exchange mass spectrometry, molecular
182 peptides, examined through crystallographic, hydrogen-deuterium exchange mass spectrometry, mutagenes
183 ective epitopes using X-ray crystallography, hydrogen-deuterium exchange mass spectrometry, mutationa
184 es, we herein apply three structural probes: hydrogen-deuterium exchange mass spectrometry, room-temp
186 using differential scanning fluorimetry and hydrogen-deuterium exchange mass spectrometry, we show h
187 hosphodiesterase8 (PDE8), monitored by amide hydrogen-deuterium exchange mass spectrometry, we show p
194 nding core of NPR4, which we validated using hydrogen-deuterium-exchange mass spectrometry analysis o
198 combined traditional analytical methods with hydrogen/deuterium exchange mass spectrometry (HDX MS),
200 f ion-mobility mass spectrometry (IM-MS) and hydrogen/deuterium exchange mass spectrometry (HDX-MS) a
201 gher-order structure information provided by hydrogen/deuterium exchange mass spectrometry (HDX-MS) i
204 ticle cryo-electron microscopy (cryo-EM) and hydrogen/deuterium exchange mass spectrometry (HDX-MS) m
206 Analysis of disulfide-bonded proteins by hydrogen/deuterium exchange mass spectrometry (HDX-MS) r
207 ody by using the complementary approaches of hydrogen/deuterium exchange mass spectrometry (HDX-MS),
208 inked IgG1 ADCs and the corresponding mAb by hydrogen/deuterium exchange mass spectrometry (HDX-MS).
211 proteolytic activity that is very useful for hydrogen/deuterium exchange mass spectrometry (HX-MS).
213 terized homotypic interactions of TcpB using hydrogen/deuterium exchange mass spectrometry and hetero
215 ions targeted by 24E9 Fab were identified by hydrogen/deuterium exchange mass spectrometry and reveal
225 isolation of neutralization escape mutants, hydrogen/deuterium exchange mass spectrometry, and X-ray
226 dynamics in the presence of substrates using hydrogen/deuterium exchange mass spectrometry, complemen
238 ion chromatography coupled with differential hydrogen-deuterium exchange-mass spectrometry experiment
242 ction based on biophysical measurements with hydrogen-deuterium exchange/mass spectrometry, surface p
245 Circular dichroism, NMR, and backbone amide hydrogen/deuterium exchange measurements as well as mole
251 tural properties of TG2 in solution by using hydrogen/deuterium exchange monitored by mass spectromet
255 -directed mutagenesis, resonance Raman (RR), hydrogen-deuterium exchange MS (HDX-MS) methods, and mol
257 usiasm in using a synergistic application of hydrogen-deuterium exchange MS (HDX-MS) with other struc
260 ollision-induced unfolding and time-resolved hydrogen-deuterium exchange MS analyses to study the con
262 Analysis of the Rab5-PI3Kbeta interaction by hydrogen-deuterium exchange MS identified p110beta pepti
267 with results from chemical cross-linking and hydrogen-deuterium exchange MS, revealed that the c.2185
275 e binding site of a bactericidal antibody by hydrogen/deuterium exchange MS shows that a protective c
277 d protein footprinting strategies, including hydrogen/deuterium exchange MS, fast photochemical oxida
278 nalytical size-exclusion chromatography, and hydrogen/deuterium exchange MS, we found that TOMM34 ass
281 hes, including small angle X-ray scattering, hydrogen-deuterium exchange-MS, circular dichroism and t
284 ve MS-based analytical method to measure the hydrogen/deuterium exchange of proteins in solution, we
285 thin non-covalent complexes as unravelled by hydrogen-deuterium exchange processes performed in the g
287 ol-2-ylidene, the so-called IDipp, catalyzes hydrogen/deuterium exchange reactions between pseudoacid
290 pray ionization mass spectrometry coupled to hydrogen-deuterium exchange studies followed by mutageni
295 er protonic species undergo room-temperature hydrogen-deuterium exchange with an alkane hydrocarbon r