ライフサイエンスコーパス: hydrolase

1 ETase, cytochrome P450, and organophosphorus hydrolase).

2 site of stalk PG synthesis, but SpmX is a PG hydrolase.

3 syltransferases, and one family 16 glycoside hydrolase.

4 nd ePD inhibited LTB(4) production by LTA(4) hydrolase.

5 inducing overexpression of fatty acid amide hydrolase.

6 with the gene TGL2 encoding a neutral lipid hydrolase.

7 ol lipase (MAGL) but not by fatty acid amide hydrolase.

8 ond intracellular N-acyl amino acid synthase/hydrolase.

9 through the activity of the enzyme bile salt hydrolase.

10 a unique and abundantly secreted alpha/beta hydrolase.

11 hereby enhancing the efficiency of glycoside hydrolases.

12 ined activity of peptidoglycan synthases and hydrolases.

13 tivity is unique to MTH1 among related NUDIX hydrolases.

14 he spatiotemporal action of PG synthases and hydrolases.

15 ein NlpI as a general adaptor protein for PG hydrolases.

16 in both family 127 and 129 of the glycoside hydrolases.

17 o be protected from degradation by glycoside hydrolases.

18 tivity and subsite specificities of chitosan hydrolases.

19 ew of the different families of (ADP-ribosyl)hydrolases.

20 ith unimpaired activity of cognate lysosomal hydrolases.

21 n center of the cell, are filled with acidic hydrolases.

22 o examine the unique specificity of glycosyl hydrolases.

23 ontrols transcription of distinct sets of PG hydrolases.

24 00-fold selectivity relative to other serine hydrolases.

25 ding the activity of resident acid-activated hydrolases.

26 r activities of autophagy and some lysosomal hydrolases.

27 embers of the RsbQ-like family of alpha,beta-hydrolases.

28 ptidase II (GCPII), coded by the gene folate hydrolase 1 (FOLH1), regulates the amount of NAAG in the

29 we identified and characterized a glycoside hydrolase 109 (GH109) that is active on blood type A-ant

30 a new CAZyme family, classified as glycoside hydrolase 138 (GH138).

31 are part of the large and diverse glycoside hydrolase 16 (GH16) family and are often lipoproteins, i

32 ) that is distantly related to the glycoside hydrolase 16 (GH16) family beta-agarases and beta-porphy

33 These enzymes include serine hydrolases(2,3) (encoded by one per cent of human genes,

34 rrounded acidic organelles contain around 70 hydrolases, 200 membrane proteins, and numerous accessor

35 beta-Mannanases from the glycoside hydrolase 26 (GH26) family are retaining hydrolases that

36 nucleoside diphosphate linked moiety X]-type hydrolase 3) in vitro.

37 gen, along with a new subfamily of glycoside hydrolase 31 (GH31) that specifically cleaves the initia

38 xo-beta-1,3-galactosidases from the glycosyl hydrolase 43 (GH43) family in Arabidopsis thaliana GH43

39 -binding pockets characteristic of glycoside hydrolase 70 (GH70) glucansucrases that are known to be

40 ase activity of M. thermoresistibile epoxide hydrolase A (Mth-EphA) and report its crystal structure

41 For glycosyl hydrolases a variety of sensitive and quantitative spect

42 rces of biotechnologically relevant glycosyl hydrolases, a putative GH10 endo-beta-1,4-xylanase, Xyl1

43 tion pathway, dependent on the mitochondrial hydrolase ABHD11, that signals changes in mitochondrial

44 o, we present a case example of urine serine hydrolase ABPP in kidney transplant rejection to illustr

45 amidases via its interaction with the murein hydrolase activator, EnvC.

46 regulation by demonstrating that NUDT16 has hydrolase activities that remove ADP-ribosylation of 53B

47 Targeting nucleoside triphosphate hydrolase activity (CD39) toward activated platelets is

48 revealed several transcripts related to the hydrolase activity (e.g. NAD+ diphosphatase), which were

49 d that SidI possesses GDP-dependent glycosyl hydrolase activity and that this activity is regulated b

50 BiuHs revealed residues critical to triuret hydrolase activity but no single mutant evolved more biu

51 sepsis, agents with nucleoside triphosphate hydrolase activity decreased platelet-leukocyte-endothel

52 Although PNPLA3 has TG hydrolase activity in vitro, inactivation or overexpress

53 We identify the ATP hydrolase activity of Hsp104 disaggregase as the critica

54 Here, we demonstrate epoxide hydrolase activity of M. thermoresistibile epoxide hydro

55 uated, which targets nucleoside triphosphate hydrolase activity toward activated platelets via a reco

56 hown to exhibit diverse functions, including hydrolase activity toward amides, esters, and thioesters

57 Faecal bile salt hydrolase activity was measured using a precipitation as

58 Bile salt hydrolase activity was reduced in women with low Bactero

59 Moreover, NUDT16's catalytic hydrolase activity was required for 53BP1 de-ADP-ribosyl

60 membrane system" (PICALM, STX4, and LRP10), "hydrolase activity" (NCSTN and XRCC6), "protein binding"

61 xon death molecule dSarm, but not its NAD(+) hydrolase activity, was required cell autonomously for t

62 ed platelet targeted nucleoside triphosphate hydrolase activity, we employed a potato apyrase in vitr

63 These demonstrate high bile salt hydrolase activity, which deconjugates bile acids enabli

64 imes to yield a truncated enzyme with serine hydrolase activity, yet little is known about the mechan

65 ocessing, ribosome binding, GTP binding, and hydrolase activity.

66 es, Asp87 and His88, are required for MBLAC2 hydrolase activity.

67 idic polysaccharide's pH microenvironment on hydrolase activity.

68 alkaline phosphatase (AP), an important DOP hydrolase, although extracellular hydrolysis is involved

69 show that a Staphylococcus aureus cell wall hydrolase and a membrane protein that contains eight tra

70 lly caused by a deficiency in a soluble acid hydrolase and are characterized by the accumulation of u

71 O-linked beta-N-acetylglucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activitie

72 R family having 2 unrelated functions (Nudix hydrolase and DNA binding), S. suis 2 retains a single r

73 s, clustered with biuH, which encodes biuret hydrolase and has close protein sequence homology.

74 Here, using glycoside hydrolase and kinase assays and immunoprecipitation and

75 esis activity and a shift in soluble epoxide hydrolase and lipoxygenase activity.

76 ctones perception by the D14 alpha/beta-fold hydrolase and MAX2.

77 e first instance of an FMN-binding glycoside hydrolase and suggest a potential link between FMN and c

78 sisting of the EutD ectoine/5-hydroxyectoine hydrolase and the EutE deacetylase degrades both ectoine

79 KAI2 (KARRIKIN INSENSITIVE) alpha/beta-fold hydrolase and the MAX2 (MORE AXILLARY GROWTH 2) F-box le

80 chieved by a balance of glycosyltransferase, hydrolase and transglycosylase activities.

81 NlpI binds to different classes of hydrolases and can specifically form complexes with vari

82 Peptidoglycan hydrolases and cell wall-tailoring enzymes that regulate

83 iculum (ER) and Golgi apparatus by glycoside hydrolases and glycosyltransferases.

84 s facilitated by peptidoglycan synthases and hydrolases and is potentially modulated by components of

85 CI-M6PR required for maturation of lysosomal hydrolases and lysosomal function.

86 Glycoside hydrolases and phosphorylases are two major classes of e

87 tive signals to regulate the import of H(+), hydrolases, and endocytic and autophagic cargos, as well

88 l and functional activities of peptidoglycan hydrolases, and highlight recently developed methods to

89 the polymer films by extracellular microbial hydrolases, and subsequent microbial assimilation and ut

90 creasingly compelling view that (ADP-ribosyl)hydrolases are a vital element within ADP-ribosyl signal

91 ctively, these results demonstrate lysosomal hydrolases are not required for C. burnetii survival and

92 Cell wall hydrolases are required to enlarge this covalently close

93 ture has been recently solved, but bacterial hydrolases are still widely used as structural homologue

94 foods using the plant-origin gamma-glutamyl hydrolase as part of the extraction procedure.

95 and linkages that correspond to the glycosyl hydrolases associated with the microbial community.

96 , a specific sulfatase (BF3086) and glycosyl hydrolase (BF3134) were highly induced in mucus and tiss

97 ppressing microbes associated with bile-salt hydrolase (BSH) activity.

98 The gut bacterial bile salt hydrolase (BSH) plays a critical role in host lipid meta

99 Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid

100 secretion and subsequent uptake of lysosomal hydrolases by adjacent cells, often referred to as "cros

101 any attempts have been made to obtain active hydrolases by introducing a Ser -> Cys exchange at the r

102 ly monitors changes in the activity of these hydrolases by sensing the cleavage products generated by

103 n provide clues to the specificity of serine hydrolases by using a panel of neutral lipase inhibitors

104 ellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 (peptidase M20 domain containing

105 ese drugs requires the activity of cell wall hydrolases called autolysins, but how penicillins misact

106 pha-galactosidase Aga (a family 36 glycoside hydrolase), can cleave alpha-(1->3)-linked galactose uni

107 fic gene families belonging to the glycoside hydrolase category reflected contrasting ecological stra

108 yer III projection neurons contain lysosomal hydrolase cathepsin D (CatD), a marker of neurons vulner

109 Here we utilize the peptidoglycan hydrolase CbpD that targets the septum of S. pneumoniae

110 (moeB, nifU-like domain protein, alpha/beta hydrolase), chemotaxis (cheB, luxR) and stress response

111 Formyltransferase/hydrolase complex (Fhc) generates formate from formyl-H(

112 d acyltransferase (PLAAT) family of cysteine hydrolases consists of five members, which are involved

113 PI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in both genetic

114 ability, including but not limited to serine hydrolases, cysteine proteases, matrix metalloproteases,

115 s excluded a transcriptional contribution to hydrolase declines.

116 3-HIB-forming enzyme 3-hydroxyisobutyryl-CoA hydrolase decreases release of 3-HIB and lipid accumulat

117 ivered to hepatocytes in fumarylacetoacetate hydrolase-deficient mice at the time of liver injury via

118 toxic liver injury using fumarylacetoacetate hydrolase-deficient mice.

119 C. burnetii does not require by-products of hydrolase degradation to survive and grow in the CCV.

120 epresent a new subtype within the alpha/beta hydrolase dehalogenases.

121 unced proteolytic impairment compounded with hydrolase depletion, enhanced membrane damage, and defec

122 inactivation domain (RID), and an alpha/beta hydrolase domain (ABH)-to suppress innate immunity and e

123 ugh the physiological role of the C-terminal hydrolase domain is well-investigated, little is known a

124 the crystal structure of Kti12's nucleotide hydrolase domain trapped in a transition state of ATP hy

125 Its newest member, alpha/beta-hydrolase domain-containing 6 (ABHD6), has emerged as a

126 loring the role of one such gene, alpha/beta-hydrolase domain-containing 6 (ABHD6), in regulation of

127 Here we show that ABHD17a (alpha/beta-hydrolase domain-containing protein 17a) deacylates the

128 he P-loop containing nucleoside triphosphate hydrolases domain (P-loop).

129 icatalytic enzymes contain several glycoside hydrolase domains and one or more carbohydrate-binding m

130 We hypothesized that the hydrolase domains of Sph3 and PelA (Sph3(h) and PelA(h),

131 ases (PRO) frequently double up as ubiquitin hydrolases (DUB), thus interfering with cellular process

132 atal faeces indicated that bacterial epoxide hydrolase (EH) genes are more abundant in the gut microb

133 erculosis has six putative genes for epoxide hydrolases (EH) of the alpha/beta-hydrolase family with

134 lly high structural similarity to alpha/beta-hydrolase EHs.

135 istance gene with a self-cleaving cis-acting hydrolase element (CHYSEL) 2A peptide.

136 upon co-administration of a soluble epoxide hydrolase (EPHX2) inhibitor in males, and/or were associ

137 across three diverse protein targets: sEH (a hydrolase), ERalpha (a nuclear receptor), and c-KIT (a k

138 molecular identification of fatty acid amide hydrolase (FAAH) as a second intracellular N-acyl amino

139 Fatty acid amide hydrolase (FAAH) controls brain anandamide levels; howev

140 Fatty acid amide hydrolase (FAAH) degrades 2 major classes of bioactive f

141 damide due to inhibition of fatty acid amide hydrolase (FAAH) facilitates fear extinction and protect

142 e signal-terminating enzyme fatty acid amide hydrolase (FAAH) from Arabidopsis in its apo and ligand-

143 Fatty acid amide hydrolase (FAAH) hydrolyzes the endocannabinoid anandami

144 ion of its catabolic enzyme fatty acid amide hydrolase (FAAH) in the basolateral complex of amygdala

145 armacological inhibition of fatty acid amide hydrolase (FAAH) produces elevated levels of anandamide

146 tress-induced activation of fatty acid amide hydrolase (FAAH) reduces AEA, we confirmed that oral adm

147 targets a specific amidase, fatty acid amide hydrolase (FAAH), an enzyme with enriched expression in

148 nandamide-degrading enzyme, fatty acid amide hydrolase (FAAH), prolongs the regulatory effects of end

149 of its degradative enzyme, fatty acid amide hydrolase (FAAH), restored both synaptic and behavioral

150 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degrada

151 id signalling by inhibiting fatty acid amide hydrolase (FAAH), the enzyme that degrades the endocanna

152 es, which are terminated by fatty acid amide hydrolase (FAAH).

153 ally inherited variation in fatty acid amide hydrolase (FAAH, C385A), which metabolizes the cannabis-

154 ons in the gene encoding fumarylacetoacetate hydrolase (FAH) cause hereditary tyrosinemia type I (HT1

155 Fumarylacetoacetate hydrolase (FAH) is the last enzyme in tyrosine catabolis

156 ored splicing, generated fumarylacetoacetate hydrolase (FAH)-positive hepatocytes in the liver, and r

157 Glycoside hydrolase family (GH) 16 comprises a large and taxonomic

158 1,4-galactosaminidase belonging to glycoside hydrolase family 114 (GH114).

159 expansin (exlx) gene adjacent to a glycoside hydrolase family 5 (gh5) gene.

160 Glycoside hydrolase family 7 (GH7) cellulases are some of the most

161 al alpha-glucans produced by GH70 (glycoside hydrolase family 70) glucansucrases are gaining importan

162 Glycoside hydrolase family 74 (GH74) is a historically important f

163 The insert carried a glycoside hydrolase family 9 (GH9) catalytic domain with sequence

164 echanism of acetyl transfer in the SGNH/GDSL hydrolase family and highlight important evolutionary di

165 e also upregulated, including the alpha/beta-hydrolase family gene PLIP1, which encodes a plastid-loc

166 We identified genes from Glycoside Hydrolase family GH131 as commonly expressed during plan

167 or epoxide hydrolases (EH) of the alpha/beta-hydrolase family with little known about their individua

168 of the formyltransferase (FhcD) and metallo-hydrolase (FhcA).

169 trated with three different human nucleotide hydrolases (Fhit, DcpS, and cNIIIB).

170 evealed that this OatA domain adopts an SGNH-hydrolase fold and possesses a canonical catalytic triad

171 having substitutions in the core alpha/beta hydrolase-fold domain and the hairpin, exhibited hormone

172 ite, with identification of 21 active serine hydrolases from alpha/beta hydrolase, patatin, and rhomb

173 that is processed by a variety of glycoside hydrolases from different families.

174 to properly localize the presumed cell wall hydrolase, GbpB.

175 nation for the genetic repertoire of epoxide hydrolase genes in M. tuberculosis.

176 y analysis of 513 pyranoside-bound glycoside hydrolase (GH) crystal structures, we determine that mos

177 sequence space has revealed a new glycoside hydrolase (GH) family (GH164) of putative mannosidases.

178 is study we characterize a family 3 glycosyl hydrolase (GH3) beta-glucosidase (Bgl) produced by Malbr

179 Family 45 glycoside hydrolases (GH45) are endoglucanases that are integral t

180 Glycoside hydrolases (GHs) catalyze hydrolyses of glycoconjugates

181 Focusing on Glycoside Hydrolases (GHs) we found that, across samples, 58.3% of

182 GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity h

183 ons in GBA1, the gene encoding the lysosomal hydrolase glucocerebrosidase (GCase), are a risk factor

184 at provide protection from endogenous murein hydrolases governing cell division and from bacteriocins

185 oxidase, xanthine dehydrogenase, nucleoside hydrolases, guanosine deaminase, and hypoxanthine guanin

186 Some glycoside hydrolases have broad specificity for hydrolysis of glyc

187 monstrate that this 5'-hydroxyl dinucleotide hydrolase (HDH) activity for DXO is higher than the subs

188 rphisms in the region of the trimeric serine hydrolase high-temperature requirement 1 (HTRA1) are ass

189 study the kinetics of human soluble epoxide hydrolase (hsEH), an enzyme involved in cardiovascular h

190 ganglioside oligosaccharides by the glycosyl hydrolase human neuraminidase 3 served to validate the r

191 ate, tannase (TA) - is a type of tannin acyl-hydrolase hydrolyzing HTs, CT monomer gallates and depsi

192 AIG1 and ADTRP as the first endogenous FAHFA hydrolases identified and provide critical genetic and c

193 TrtA is a member of the isochorismatase-like hydrolase (IHL) protein family, similarly to BiuH, and h

194 This study suggests functions for triuret hydrolase in certain eukaryotic intermediary processes a

195 ha-Gal epitope can be processed by glycoside hydrolases in family GH110, whereas the presence of gene

196 provided a detailed census of active serine hydrolases in the asexual parasite, with identification

197 photoswitchable inhibitors for other serine hydrolases, including lipases, peptidases, and proteases

198 s as a novel class of photoswitchable serine hydrolase inhibitors and present a chemoproteomic platfo

199 of the binding properties of covalent serine hydrolase inhibitors is expected to aid in the discovery

200 tidyl peptidase 3 (DPP3) is a zinc-dependent hydrolase involved in degrading oligopeptides with 4-12

201 se (MANEA) is the sole endo-acting glycoside hydrolase involved in N-glycan trimming and is located w

202 articular a strong upregulation of glycoside hydrolases involved in mannan degradation.

203 escribed: An incomplete catalytic triad in a hydrolase is rescued by a chloride ion (Fig.

204 However, the regulation of PG hydrolases is less well understood, with only regulators

205 ctivation of cathepsin D and other lysosomal hydrolases known to be unstable or less active when lyso

206 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and en

207 of tau protein, ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), neurofilament light (NF-L), and g

208 Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a deubiquitylating enzyme that i

209 Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiqui

210 obe labels active ubiquitin carboxy-terminal hydrolase L1 (UCHL1), also known as neuron-specific prot

211 neuronal injury (Ubiquitin Carboxy-terminal Hydrolase L1 [UCH-L1]), microglial/macrophage activation

212 VII, 8.8-fold increase; ubiquitin C-terminal hydrolase L1, 2.5-fold increase; AII spectrin fragments,

213 deubiquitinating enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) is required for the maintenance of

214 rillary acidic protein, ubiquitin c-terminal hydrolase-L1, S100 calcium binding protein B, alpha-II-s

215 y, mutations affecting a predicted cell wall hydrolase lead to alterations in lipooligosaccharide syn

216 iplasmic domains of two YejM homologues with hydrolases like arylsulfatases, no enzymatic activity ha

217 e further uncovered that VdtD, an alpha/beta hydrolase-like protein lacking the catalytic serine, dir

218 Sucrase-isomaltase (SI), lactase-phlorizin hydrolase (LPH), and neutral Aminopeptidase N (ApN) were

219 The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is an essential lipid A biosynthetic enzy

220 Activation of the leukotriene A(4) hydrolase (LTA(4)H) aminopeptidase (AP) activity with 4-

221 ng to poorer outcomes and (2) leukotriene A4 hydrolase (LTA4H) genotype influenced the clinical impac

222 classified as oxidoreductases, transferases, hydrolases, lyases, and ligases.

223 Xyloglucan endotransglycosylases/hydrolases may have a role in coleorhiza reinforcement t

224 HETase follows the canonical two-step serine hydrolase mechanism.

225 es are major sites for intracellular, acidic hydrolase-mediated proteolysis and cellular degradation.

226 rolyzed to diols by human microsomal epoxide hydrolase (mEH).

227 alpha-Galactoside hydrolases mostly show a preference for the second most

228 In addition, we show that hydrolase NahA (also known as YvcI) efficiently produces

229 probe targeting the cancer-associated serine hydrolase NCEH1.

230 alian cells and a role for DXO and the Nudix hydrolase Nudt12 in decapping NAD-capped RNAs (deNADding

231 Here, we report that the Nudix hydrolase NUDT16, a TIRR homolog, regulates 53BP1 stabil

232 hiamet G (TMG), an inhibitor of the O-GlcNAc hydrolase O-GlcNAcase, exhibited enhanced retinal protei

233 of such a reaction intermediate in glycoside hydrolases operating via substrate-assisted catalysis.

234 ay relies on unmodified and organophosphorus hydrolase (OPH) enzyme-modified carbon paste (CP) micron

235 ymer, the bioavailability of organophosphate hydrolase (OPH) was significantly increased from 5% to 5

236 line phosphatase or enzyme (organophosphorus hydrolase, OPH)) catalyzed reaction.

237 er MAGL expression (but not fatty-acid amide hydrolase or FAAH) were more vulnerable to cortical thin

238 (lukA, IC(50) 0.4-25 muM) and glycerol ester hydrolase or lipase (gehB, IC(50) 1.5-25 muM).

239 21 active serine hydrolases from alpha/beta hydrolase, patatin, and rhomboid protease families.

240 ylsulfatases (ASs) and phosphonate monoester hydrolases (PMHs).

241 other enzyme encoded in the same operon, Ppt hydrolase (PptH), that undoes the PptT reaction.

242 cid amidase (NAAA) is an N-terminal cysteine hydrolase primarily found in the endosomal-lysosomal com

243 d in pregnancy because of elevated bile salt hydrolase-producing Bacteroidetes.

244 eptor complex comprising the alpha/beta-fold hydrolase receptor KARRIKIN INSENSITIVE 2 (KAI2) and the

245 and via a S-P-S motif to the pseudoglycoside hydrolase region (site 2).

246 Several peptidoglycan synthases and hydrolases require activation by outer-membrane-anchored

247 Thioglycosides are hydrolase-resistant mimics of O-linked glycosides that c

248 lly difficult for the Escherichia coli Nudix hydrolase RppH, which triggers 5'-end-dependent RNA degr

249 r role in the context of PG expansion or the hydrolase(s) capable of catalyzing their cleavage is not

250 al bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal b

251 A soluble epoxide hydrolase (Se-sEH) of S. exigua was predicted and showed

252 Herein, using the human soluble epoxide hydrolase (sEH) as a model analyte, we found that both t

253 olism by cytochrome P450 and soluble epoxide hydrolase (sEH) enzymes affects retinal angiogenesis and

254 Soluble epoxide hydrolase (sEH) inhibitors, which increase endogenous ep

255 rging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two

256 cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) pathways prevented the debris-induced su

257 f 5-lipoxygenase (5-LOX) and soluble epoxide hydrolase (sEH) pharmacophores led to the discovery of a

258 harmacological inhibition of soluble epoxide hydrolase (sEH) reduces inflammatory diseases, including

259 s identified oxamide 2b as a soluble epoxide hydrolase (sEH) stable replacement but unsuitable for in

260 , which are converted by the soluble epoxide hydrolase (sEH) to dihydroxylethersatrienoic acids (DHET

261 es cyclooxygenase-2 (COX-2), soluble epoxide hydrolase (sEH), ER stress-response genes including BiP,

262 nases (CYPs) and degraded by soluble epoxide hydrolase (sEH).

263 harmacological inhibition of soluble epoxide hydrolase (sEH, EPHX2).

264 Serine hydrolases (SHs) are a large, diverse family of enzymes

265 l the active lipases, including other Serine hydrolases (SHs), expressed during seed germination in r

266 families with various types of peptidoglycan hydrolases suggests that this secretion pathway evolved

267 4 putative fucoidanases, including glycoside hydrolases, sulfatases and carbohydrate esterases, which

268 ytically by a dehalogenase of the alpha/beta hydrolase superfamily (BbdC).

269 Enzymes of the serine hydrolase superfamily are ubiquitous, highly versatile c

270 roles of the 56-member P. falciparum serine hydrolase superfamily in the asexual erythrocytic stage

271 panel of sequences from the carbon-nitrogen hydrolase superfamily that represent possible green cata

272 ich is in turn part of the larger alpha/beta-hydrolase superfamily.

273 pid discovery of optically controlled serine hydrolase targets in complex proteomes.

274 ir receptor, DWARF14 (D14), is an alpha/beta-hydrolase that can cleave SLs.

275 identified as a divisome-localized glycosyl hydrolase that cleaves peptide-free PG glycans.

276 ediately adjacent to lytN, which specifies a hydrolase that cleaves the bond between the fifth glycin

277 that recombinant Ega3 is an active glycoside hydrolase that disrupts GAG-dependent A. fumigatus and P

278 osomal acid lipase (LAL) is a critical lipid hydrolase that generates free fatty acids and cholestero

279 Acid ceramidase (AC) is a cysteine hydrolase that plays a crucial role in the metabolism of

280 Recently, mutations in the ARH3 (ADPRHL2) hydrolase that removes ADP-ribose from proteins have bee

281 ide hydrolase 26 (GH26) family are retaining hydrolases that are active on complex heteromannans and

282 action of autolysins-essential peptidoglycan hydrolases that are required for remodelling of the cell

283 They contain various hydrolases that degrade extracellular and intracellular

284 ising exosomes with unique cargo and soluble hydrolases that degrade the extracellular matrix, can pr

285 pic data, our studies define a set of serine hydrolases that likely mediate critical metabolic reacti

286 sine triphosphatase, and a ubiquitin protein hydrolase) that function in disparate biochemical pathwa

287 armacological inhibition of fatty acid amide hydrolase to elevate levels of the endocannabinoid anand

288 hows that the membrane protein scaffolds the hydrolase to orient its active site for cleaving the gly

289 This leads to the decreased sorting of hydrolases to lysosomes and reduces the autophagic degra

290 hosphate receptor, which normally sorts acid hydrolases to lysosomes.

291 tes into membranes to preferentially promote hydrolase trafficking and enhance cellular clearance.

292 Ubiquitin carboxyl-terminal hydrolases (UCHs) belong to an enzymatic subclass of DUB

293 We identified the ubiquitin hydrolase USP9X as a novel ERG transcriptional target th

294 ence of the improper processing of lysosomal hydrolases, which is dependent on the trafficking of the

295 Carboxylesterase 3 (Ces3) is a hydrolase with a wide range of activities in liver and a

296 y inhibited a cysteine protease and a serine hydrolase with nanomolar potency and exceptional specifi

297 35%, DP(w) = 905) using recombinant chitosan hydrolases with distinct substrate and cleavage specific

298 eading to the identification of seven serine hydrolases with potential lipolytic activity.

299 recombinant xyloglucan endotransglucosylase/hydrolases (XTHs) from Fragaria vesca, FvXTH9 and FvXTH6

300 cipation of xyloglucan endo-transglycosylase/hydrolases (XTHs).