ライフサイエンスコーパス: hydrolytically

1 ssociation integrated into the design of the hydrolytically activatable PF108-[SN22](2) have the pote

2 of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to p

3 mivir, a widely used anti-influenza drug, is hydrolytically activated by carboxylesterase 1 (CES1).

4 Herein, we designed and developed a hydrolytically activated oxygen-generating biomaterial i

5 Both hydrolytically active and inactive FlhF point mutants re

6 udohexamers containing different patterns of hydrolytically active and inactive subunits retain the a

7 eria-containing phagosome into an acidified, hydrolytically active compartment.

8 In the hydrolytically active complex, Met-peptide is coordinate

9 Because the increased acidity favors this hydrolytically active complex, the rate of cleavage guid

10 ATP binds to the hydrolytically active high-affinity site approximately 3

11 ver, we demonstrate that the closely related hydrolytically active macrodomain of SARS2 Nsp3, Mac1, e

12 A hydrolytically active polycarbonate backbone is used to

13 ents and restrict their differentiation into hydrolytically active vacuoles appears to correlate with

14 atic variation of active site location for a hydrolytically active ZnHis3O site contained within a de

15 ronin properties; it is structurally stable, hydrolytically active, and can bind both the co-chaperon

16 e derivatives 1 can be surprisingly unstable hydrolytically, affording, in solution, variable amounts

17 re formed in up to 88% yield and shown to be hydrolytically and configurationally stable under the re

18 requires a free 3'-hydroxyl and degrades RNA hydrolytically and distributively, releasing nucleoside

19 (TP) form, (b) an intracellular delivery of hydrolytically and enzymatically stable triphosphate der

20 tively resistant polytungstate ligands, is a hydrolytically and oxidatively stable homogeneous water

21 acid hydrolase opens the cyanuric acid ring hydrolytically and subsequent decarboxylation produces c

22 The remaining chlorine is then removed hydrolytically by a dehalogenase of the alpha/beta hydro

23 cytes exhibit ectoenzymatic activity able to hydrolytically cleave extracellular diadenosine polyphos

24 general acid/base mechanism used by BACE1 to hydrolytically cleave these substrates.

25 the phosphodiester bond of nucleic acids is hydrolytically cleaved in critical biological processes.

26 xygen to transform amines to imines that are hydrolytically cleaved to formaldehyde.

27 le, porous, crystalline materials capable of hydrolytically cleaving, and thus detoxifying, several o

28 stems mainly from B-lactamase proteins that hydrolytically deactivate the B-lactams.

29 Valyl-tRNA synthetase is unable to hydrolytically deacylate misacylated tRNA(Val) terminati

30 Adenosine deaminases acting on RNA (ADARs) hydrolytically deaminate adenosines (A) in a wide variet

31 osine deaminase (ADAR) protein family, which hydrolytically deaminates double-stranded RNA, causing a

32 o1-E109K with that of wild type Exo1 and the hydrolytically defective active site mutant Exo1-D173A.

33 ow that a protein roadblock (EcoRI(E111Q), a hydrolytically defective form of EcoRI endonuclease) pla

34 ort that N-terminal His-tagged Exo1-E109K is hydrolytically defective.

35 Hydrolytically degradable block copolymer nanoparticles

36 newable biomass(3-6) and the introduction of hydrolytically degradable bonds(7-9).

37 nerally synthesized with either disulfide or hydrolytically degradable crosslinkers, is critical to t

38 ids by covalently bonding the drug through a hydrolytically degradable ester linkage to a common hydr

39 ified with hydroxyethyl methacrylate to form hydrolytically degradable hydrogels through free-radical

40 ethylene glycol (PEG) hydrogel platform with hydrolytically degradable PEG-diester dithiol crosslinke

41 Comparative studies of bulk samples of hydrolytically degradable poly(lactic acid) (PLA) vs cor

42 d release formulations based on conventional hydrolytically degradable poly(lactic-co-glycolic acid)

43 3-dioxepane (BMDO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR

44 We present the fabrication of conformal, hydrolytically degradable thin films capable of administ

45 (CDSA) to achieve the efficient synthesis of hydrolytically degradable, highly anisotropic block copo

46 s, because these mimetics have been shown to hydrolytically degrade urea.

47 Most of these mutations occur at hydrolytically disfavoured non-methylated cytosines thro

48 on repair pathway, DNA glycosylases find and hydrolytically excise damaged bases from DNA.

49 specially attractive for synthesis, as it is hydrolytically impaired but still able to catalyze N-gly

50 ally caused by beta-lactamases, enzymes that hydrolytically inactivate the antibiotics.

51 3OC12-HSL was previously shown to be hydrolytically inactivated by the paraoxonase (PON) fami

52 the E171Q mutant of the MJ0796 ABC, which is hydrolytically inactive due to mutation of the catalytic

53 plausible xenobiological monomers, which can hydrolytically interconvert between cyclic and acyclic f

54 of guanine, but the resulting conjugates are hydrolytically labile and thus are not suitable for stru

55 SBLs neutralize beta-lactams via a hydrolytically labile covalent acyl-enzyme intermediate.

56 ate beta-lactams via a mechanism involving a hydrolytically labile covalent acyl-enzyme intermediate.

57 SBLs neutralize B-lactams via a hydrolytically labile covalent acyl-enzyme intermediate.

58 Addition of methyl groups adjacent to the hydrolytically labile ester linkage increased stability

59 BSA-bead linker was designed to incorporate hydrolytically labile fragment, which permits release of

60 examples are presented with yields of these hydrolytically labile heterocycles of up to 69%.

61 rmits the formation of either a permanent or hydrolytically labile linkage.

62 al or chemical damage to these thermally and hydrolytically labile materials was observed.

63 2 O-glycan building block and replacement of hydrolytically labile tyrosine sulfates with isosteric s

64 Hydrolytically liberated endogenous cyanide from cyanoge

65 Transitory starch of leaves is broken down hydrolytically, making maltose the predominant form of c

66 breast cancer cells prompted the search for hydrolytically more stable anthracycline-formaldehyde co

67 Dyes 2-4 are hydrolytically more stable than other chalcogenopyrylium

68 ituted disulfide (NDS) group was found to be hydrolytically much more stable.

69 probably the most common DNA damage produced hydrolytically or by glycosylase-mediated removal of mod

70 s loss to model the degradation of materials hydrolytically (PEG:dextran hydrogel) and enzymatically

71 the autophagy machinery, was demonstrated to hydrolytically process the substrate of EV71 3C(pro) and

72 The enzyme hydrolytically processes the lactyl amide bond of the 1,

73 n conformation, and isomerises easier into a hydrolytically proficient state, possibly aided by the R

74 y reported ring-expansion strategy involving hydrolytically prone imidazoline rings was thought to in

75 ting that the final elongated product is not hydrolytically released by thioesterases as observed in

76 rmed "PolyMorphine", was designed to degrade hydrolytically releasing morphine in a controlled manner

77 n, Legionella provides the protein SidD that hydrolytically reverses the covalent modification, sugge

78 ridged lactams-a class of readily available, hydrolytically robust twisted amides-are ideally suited

79 silyl enol ether of cyclohexenone produced a hydrolytically sensitive [4 + 2] adduct in good yield.

80 ormance of a nanotherapeutic encapsulating a hydrolytically sensitive docetaxel prodrug and conjugate

81 s used in medicine, especially thermally and hydrolytically sensitive polymers by themselves and in c

82 e (thio)phosphodiester linkages to form less hydrolytically stable (thio)phosphotriesters, which then

83 Treatment of H508 cells with carbachol, a hydrolytically stable acetylcholine analog, promoted H50

84 ment of new SBLi working by reaction to form hydrolytically stable acyl-enzyme complexes.

85 Two hydrolytically stable adenylate analogues, 5'-O-[N-(sali

86 ) the delta-phosph(on)ate is modified by two hydrolytically stable alkyl residues 4 and 5; (ii) the d

87 mational probe for selectin binding and as a hydrolytically stable analogue.

88 Neither PIP-199 nor its more hydrolytically stable analogues show any observable acti

89 More hydrolytically stable anchors, such as silatranes and hy

90 omiscuity of OGT, we show that S-GlcNAc is a hydrolytically stable and accurate structural mimic of O

91 d polyamide dendrimers are enzymatically and hydrolytically stable and also exhibit antimicrobial act

92 unknown family of peptidomimetics, which are hydrolytically stable and display very interesting confo

93 The anchoring group must be hydrolytically stable and oxidation resistant under a va

94 uted acenaphthene 3, affording thermally and hydrolytically stable arsanylidine-phosphorane 4 with a

95 6,6-tetramethylheptanedionate) ligand led to hydrolytically stable complex salts of type [(eta(6)-p-c

96 with molecular truncation afforded a small, hydrolytically stable dimethoxyphenyl cyanoacrylamide (D

97 The discovery of potent (2-3 microM), hydrolytically stable dipeptide derivatives, bearing onl

98 we report the construction of site specific, hydrolytically stable DPCs between 5fdC in DNA and K4 of

99 The hydrolytically stable ether can be removed by the action

100 uated 2 dental adhesives using mixtures of a hydrolytically stable ether-based monomer, triethylene g

101 , we report the deliberate construction of a hydrolytically stable fluorinated metal-organic framewor

102 er network architecture was synthesized from hydrolytically stable fluorous building blocks.

103 he design and synthesis of a novel family of hydrolytically stable glycoclusters bearing thiodigalact

104 oro-carbasugars are a particular subclass of hydrolytically stable glycomimetics that are expected to

105 ine with a similar vaccine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant

106 ADAM 4 was designed to be hydrolytically stable in blood plasma, and an investigat

107 rmed during the CuAAC reaction is robust and hydrolytically stable in both aqueous 1 M HClO(4) and 1

108 e, making these compounds substantially more hydrolytically stable in comparison to acyl-linked prodr

109 xylic acid 8a is thermally stable, and it is hydrolytically stable in water even at 40 degrees C and

110 Hydrolytically stable materials exhibiting a wide range

111 -WO(3-x)/WO3xH2O nanowhiskers dispersed in a hydrolytically stable mesoporous polycarbosilane-siloxan

112 t of the relative humidity, positioning this hydrolytically stable MOF as a prospective adsorbent for

113 ticle, we present a parametric study of nine hydrolytically stable MOFs with diverse structures for u

114 confinement in relatively narrow cavities of hydrolytically stable MOFs.

115 One of these thermally and hydrolytically stable new chemical entities (4c) complet

116 As a result, a number of hydrolytically stable NNRTIs were identified with anti-H

117 d ILs are significantly more hydrophobic and hydrolytically stable permitting them to be used in the

118 ously shown that a small peptide bearing the hydrolytically stable phosphotyrosyl (pTyr) mimetic, (di

119 While densely cross-linked and hydrolytically stable polyester networks with low solubl

120 therefore offers insight into the design of hydrolytically stable porous materials.

121 Addition of a hydrolytically stable PRPP analogue to the enzyme result

122 urated (C(10)-C(18)) FAP, headgroup-modified hydrolytically stable saturated (C(10)-C(18)) alkyl phos

123 indicate that these compounds can be used as hydrolytically stable structural and functional RNA mime

124 In this report, hydrolytically stable structural mimics of N7-guanine-co

125 the dimerization of an alpha-aminonitrile (a hydrolytically stable surrogate for its corresponding he

126 Recently, more hydrolytically stable systems incorporating the 4-aza-3-

127 ural trioxane artemisinin, the thermally and hydrolytically stable trioxane fluoroanilide 4b has been

128 TK inhibition and should find broad use as a hydrolytically stable yet thiol-reactive reversible warh

129 tation of MOFs, including highly tunable and hydrolytically stable Zr- and Hf-based frameworks, is th

130 st total synthesis of the membrane permeant, hydrolytically stable, cADPR receptor agonist 8-Br-N1-cI

131 ies of the existing ADAM lead compounds with hydrolytically stable, fused isoxazolone, isoxazole, oxa

132 anate reacts with the enzyme quickly to form hydrolytically stable, inactive forms of the enzyme that

133 an oxamic acid (compound 10) moiety leads to hydrolytically stable, monocharged ligands, with 83- and

134 hile to form an oxacarboline product that is hydrolytically stable.

135 ruction of MOFs provides a method to protect hydrolytically susceptible coordination backbones throug

136 In vitro RutB cleaves ureidoacrylate hydrolytically to release 2 mol of ammonium, malonic sem

137 rates and are inherently unstable, degrading hydrolytically under moderate conditions.

138 The hydrolytically unstable aromatic lactone is important fo

139 he resulting diazaborolidine derivatives are hydrolytically unstable but can be isolated by recrystal

140 port a polymer comprising an acid-sensitive, hydrolytically unstable enol ether backbone onto which i

141 res by selectively disassembling preprepared hydrolytically unstable frameworks and then reassembling

142 us collagen web infiltrated primarily by the hydrolytically unstable HEMA.

143 xy group as an alternative leaving group for hydrolytically unstable heteroaryl chlorides.

144 ionic framework, leading to the formation of hydrolytically unstable iminium salts.

145 sphere, enabling the incorporation of highly hydrolytically unstable M(II) centers.

146 mpounds is limited, however, as they contain hydrolytically unstable thioester linkages and have only

147 antage of their known reactivity to produce (hydrolytically unstable) anhydrides from carboxylic acid

148 ile complexes with monodentate NHCs only are hydrolytically unstable, complexes containing bidentate

149 The esters are hydrolytically unstable, generating acids and alcohols,

150 affolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytic

151 entifies protein fragments that were cleaved hydrolytically, with the output of a deconvolution algor

152 reover, the lactone ring could not be opened hydrolytically without epimerization at C alpha.

153 sis (RCM) reaction, and the core was removed hydrolytically without significant fragmentation.

154 to trimethyluric acid stoichiometrically and hydrolytically, without producing hydrogen peroxide.