ライフサイエンスコーパス: hydrophobic group

1 cial about the ability of urea to solubilize hydrophobic groups.

2 icative of a substantial solvent exposure of hydrophobic groups.

3 f collapsed states with local clusterings of hydrophobic groups.

4 lly disordered solvent shells around exposed hydrophobic groups.

5 that they disrupt phase separation driven by hydrophobic groups.

6 ut poorly understood phospholipid with three hydrophobic groups.

7 lymeric backbone but differ in the number of hydrophobic groups.

8 and interactions as well as by burial of its hydrophobic groups.

9 y involving the burying of otherwise-exposed hydrophobic groups.

10 ductive substrate containing hydrophilic and hydrophobic groups.

11 t-range interactions among the polar and the hydrophobic groups.

12 basic nitrogen center flanked by aromatic or hydrophobic groups.

13 igned to template positions randomly, within hydrophobic groups.

14 rophobic effect and encouraging solvation of hydrophobic groups.

15 two hydrogen bond acceptors (HBAs) and three hydrophobic groups.

16 onic acid, a fluorescent probe that binds to hydrophobic groups.

17 by the molecules used in this study, are two hydrophobic groups 16.5 A apart and two hydrogen-bond-ac

18 d are better catalysts than those with small hydrophobic groups (1a is 43.5 times faster than 1f).

19 went randomization; 365 were assigned to the hydrophobic group, 365 to the chlorhexidine group, and 3

20 Using a ligand bearing a bulky hydrophobic group, a "shish kabob" of nanocages, has bee

21 ed ensembles in water despite the absence of hydrophobic groups--a result that holds for polypeptide

22 /L2302C) and a second variant with a bulkier hydrophobic group (A108I) to better occupy a cavity betw

23 onnecting 4,4'-dimethylbipyridine to a bulky hydrophobic group (adamantane, 1), a heme ligand (imidaz

24 etween molecules containing both charged and hydrophobic groups and are shown to provide valuable new

25 the 2-substituted moieties and prefers small hydrophobic groups and hydrogen bonding functionalities.

26 % after subunit dissociation, which exposed hydrophobic groups and loosened the structure.

27 Results strongly suggest that, while hydrophobic groups and presumably an intact helix B are

28 positions in (R)-1 can accommodate nonbulky, hydrophobic groups and still retain pronounced anticonvu

29 arly differentiates between structure-making hydrophobic groups and structure-breaking hydrophilic gr

30 correlates with interactions between ligand hydrophobic groups and the C-terminal lid region that is

31 no acid, and O is an amino acid with a bulky hydrophobic group), and to the di-leucine (or LL) motif.

32 ite and projects an aminopyridine, a central hydrophobic group, and an aryl group, into the S1, S2, a

33 ometre striations of alternating anionic and hydrophobic groups, and the other coated with the same m

34 ble pharmacophore features (carboxylate, two hydrophobic groups, and three NH groups) and wrote a com

35 nucleotides that contain pi-electron and/or hydrophobic groups are incorporated opposite the non-nat

36 tive potency against stromelysin when larger hydrophobic groups are used.

37 In the hydrophobic group as compared with the standard-polyuret

38 4-CmC analogs containing a single hydrophobic group at either the 3- or 4-position as well

39 contribute a large favorable enthalpy, (2) a hydrophobic group at P2' can contribute a favorable entr

40 (3) The potential importance of the hydrophobic group at position R3 as illustrated by its a

41 is required for activation of RyR1 and that hydrophobic groups at the 3,4- and 5-positions are prefe

42 Substitution of hydrophobic groups at the 3-position enhanced bioactivit

43 ure drug design in terms of extending planar hydrophobic groups at the C2 position of PBDs to maximiz

44 to demonstrate that the hydrogen-bonding and hydrophobic groups at the ice-binding site of the antifr

45 that while calpain I tolerates a variety of hydrophobic groups at the P1 site, Leu at P2 is preferre

46 emonstrated that introduction of appropriate hydrophobic groups at the phenyl ring and a gem-dimethyl

47 butions of specific cationic side chains and hydrophobic groups at the rim of the alpha beta-barrel t

48 FIV PR exhibited strong preference for small hydrophobic groups at the S3 and S3' subsites.

49 aromatic portion of the molecule as well as hydrophobic groups at the vicinity of this aromatic regi

50 that isatins (indole-2,3-diones), containing hydrophobic groups attached at a variety of positions wi

51 phorothioate (PS) backbone modifications and hydrophobic group conjugations have been used to enhance

52 t water cage formation and breakage near the hydrophobic groups control the fusion dynamics and aggre

53 he orientational entropy of waters hydrating hydrophobic groups decreases during pulling of the molec

54 Notably, the chemical structures of the hydrophobic groups do not appear to play a role in overa

55 An examination of solvent density near hydrophobic groups during folding suggests that in the c

56 designed within collagen peptides, including hydrophobic groups, electrostatic interactions, and meta

57 n state for dimerization has a high level of hydrophobic group exposure, indicating that gross confor

58 s is largely set by the balance of polar and hydrophobic groups flanking a conserved carboxylic side

59 mportance of a long side chain capped with a hydrophobic group for optimal potency, consistent with a

60 established that the cationic center and the hydrophobic group found in JN430 and MLA are important f

61 Nanopores lined with hydrophobic groups function as switches for water and al

62 Replacing the 5'-methyl group with other hydrophobic groups gave 17 transition state analogue inh

63 been made by either deleting or substituting hydrophobic groups, hydrophilic groups, aromatic amino a

64 e COOH-terminal half of the core recognize a hydrophobic group in glibenclamide, adjacent to the sulf

65 e presence of a conformationally constrained hydrophobic group in position 6 in complementary topolog

66 etic compounds, containing aromatic or other hydrophobic groups in combination with two carboxylate g

67 In addition, the hydrophobic groups in ILV form "specific" hydrophobic in

68 ften limited because of the relative lack of hydrophobic groups in nucleic acids.

69 ting substituents in the salicyloyl ring and hydrophobic groups in the anilide moiety for optimal act

70 sulfoxide suggest that interactions between hydrophobic groups in the distal regions may play a sign

71 demonstration of the involvement of the same hydrophobic groups in the high affinity binding of CaM t

72 tween the dry region in the receptor and the hydrophobic groups in the ligands.

73 2-Anilino groups with small hydrophobic groups in the meta or para position enhanced

74 Bulky hydrophobic groups in the side chain of residue 3 turned

75 idence for an increase in solvent accessible hydrophobic groups in the transition state.

76 tify interactions between ions and molecular hydrophobic groups in water.

77 s of pressure on the pairwise interaction of hydrophobic groups in water.

78 vatives of 4-hydroxyproline with a series of hydrophobic groups in well-defined orientations have bee

79 t occurred in 77 participants (21.5%) in the hydrophobic group, in 140 (38.6%) in the chlorhexidine g

80 rred in 21 of 358 participants (5.9%) in the hydrophobic group, in 36 of 363 (9.9%) in the chlorhexid

81 istic interplay between hydrogen bonding and hydrophobic groups, in stark contrast to their bare Au c

82 ors (6a, 6b, 6d, and 6e) with flexible bulky hydrophobic groups instead of the rigid polyheterocyclic

83 The presence of a hydrophobic group interacting with multiple receptor res

84 Addition of phenyl or butyl hydrophobic groups into guanidine-oxanorbornene polymers

85 The counterintuitive behavior of the hydrophobic group is ascribed to a tendency to maximize

86 The nature of the hydrophobic group is likely a discriminator for super- v

87 Layer packing of hydrophobic groups is compared for possible combinations

88 nts: one involving replacement of the highly hydrophobic groups, Leu404, Phe408, and Phe412, all with

89 Substitution of long-chain or bulky hydrophobic groups (leucines or phenylalanines) for isol

90 that direct the distribution of the leading hydrophobic groups (LHG).

91 An aryl ring at position 7 or a hydrophobic group linked to the 8-position through an am

92 taLg native conformation causing exposure of hydrophobic groups, lower thermal stability and also, sh

93 isomerization from trans to cis exposes more hydrophobic groups, making the cis bilayers more hydroph

94 This work suggests that the bulky hydrophobic groups may locally influence the formation o

95 Despite the presence of a hydrophobic group, MG often solvates with both the keton

96 However, when a large hydrophobic group occupies position -1, Arg47 adopts a n

97 en a GSH conjugate with a sufficiently large hydrophobic group occupies the H-site, Tyr-9 is fully pr

98 ced by a polar group of similar size or by a hydrophobic group of smaller size.

99 nd the size of the side chain instead of the hydrophobic group of W207 regulates the transition betwe

100 emains poorly understood how hydrophilic and hydrophobic groups of the binding site contribute to the

101 The replacement by hydrophobic groups of the homologous residues of the bra

102 complexes, accommodating the diverse, rigid hydrophobic groups of the inhibitors.

103 ved inhibitor potency by introducing a small hydrophobic group on the adenine ring.

104 rogen on the quinoline group, and (iii) of a hydrophobic group on the quinazoline.

105 Modifications of the hydrophobic group on the terminal urea produced substant

106 P1 substrate preference including basic and hydrophobic groups on either side of the scissile bond.

107 unds 1 and 3, was conceived to allow the new hydrophobic groups on the lactone to engage in specific

108 The effect of introducing hydrophobic groups onto the disaccharide portion of the

109 ative refinement of the CSP model identified hydrophobic groups other than the traditional phenylalan

110 ensin-induced unfolding promoted exposure of hydrophobic groups otherwise confined to the core of the

111 vity based on the addition of multiple small hydrophobic groups positioned away from the cationic cen

112 The defatting process exposes the hydrophobic groups present within the YLPI, which increa

113 Likewise, 4-CmC analogs with hydrophobic groups substituted into the 4-position enhan

114 A hydrophobic group such as isobutyl or isopropoxyl was fo

115 crystallization of molecules with polar and hydrophobic groups, such as ionic amphiphiles and protei

116 with the modification; the bulkier and more hydrophobic groups (tert-butyl and phenyl) exhibited low

117 ese data indicate that Cys-168 contributes a hydrophobic group that influences the structure and ulti

118 ization of such parameters as the density of hydrophobic groups, the number of carbon atoms and their

119 hat would allow a number of both charged and hydrophobic groups to be presented to fibronectin for hi

120 phyrin moieties, and are functionalized with hydrophobic groups to facilitate their incorporation int

121 inate catalytic zinc ion/s, and a variety of hydrophobic groups to probe the S1' pockets of the four

122 ipid modification involves the attachment of hydrophobic groups to proteins via ester, thioester, ami

123 ar groups from and near-complete exposure of hydrophobic groups to solvent, in a manner resembling a

124 The addition of specific bulky hydrophobic groups to the insulin molecule provides it w

125 e structure which favors the partitioning of hydrophobic groups to the surface of ice.

126 five-point pharmacophores (carboxylate + two hydrophobic groups + two NH groups) for the three compou

127 atured state while increasing the density of hydrophobic groups, two effects that also contribute to

128 rs at mildly acidic pH following loss of the hydrophobic groups upon acetal hydrolysis.

129 e the azido group to attach different, large hydrophobic groups via click chemistry.

130 One compound with a bulky hydrophobic group (VPC12249) was a dual LPA1/LPA3 compet

131 Those data demonstrated that a C-terminal hydrophobic group was an important determinant for elici

132 This hydrophobic group was designed to mimic the hydrophobic

133 To achieve that, a fluorophore with bulky hydrophobic groups was encapsulated in the nanoparticles

134 ysine or polyester dendron were prepared and hydrophobic groups were attached to the dendrimer periph

135 0P) derived from thalidomide by insertion of hydrophobic groups were evaluated for anti-inflammatory

136 eous urea solution unfolds a chain of purely hydrophobic groups which otherwise adopts a compact stru

137 modifying hydrophilic PSs with a variety of hydrophobic groups, which allow the constructs to self-a

138 Spherical hydrophobic groups, which assemble via shape complementa

139 nd interior volume available for packing the hydrophobic groups, which is reflected in different aggr

140 ent to the surface or a strongly interacting hydrophobic group with the surface; and (3) lockdown of

141 lidinedione-based peptide hybrids containing hydrophobic groups with Ki values between 1.5 and 1.8 mu

142 Hydrophobic groups within Nt17 become sequestered in int