ライフサイエンスコーパス: hydrophobic residue

1 N-terminal methionine if it is followed by a hydrophobic residue.

2 found at a position typically occupied by a hydrophobic residue.

3 related with the decrease in the size of the hydrophobic residue.

4 epresented regions rich in proline and other hydrophobic residues.

5 us amino acid sequences containing basic and hydrophobic residues.

6 e region of Eis (residues 28-37) bearing key hydrophobic residues.

7 D access tunnel and are exposed to multiple hydrophobic residues.

8 positively charged residues intercalated by hydrophobic residues.

9 endent on an ordered sequence of charged and hydrophobic residues.

10 tact the phospholipid bilayer with basic and hydrophobic residues.

11 mer interface is formed by a small number of hydrophobic residues.

12 by binding sites characterized by acidic and hydrophobic residues.

13 Pro-392, and Thr-396, were mutated to small hydrophobic residues.

14 kelihood, medium/long-range contacts between hydrophobic residues.

15 and the subsequent re-packing of the N-lobe hydrophobic residues.

16 ction between multiple aligned ion pairs and hydrophobic residues.

17 re both the N-terminal and the 48 C-terminal hydrophobic residues.

18 bordered a drug-binding cavity dominated by hydrophobic residues.

19 phobicity equivalent to that of 5 contiguous hydrophobic residues.

20 cious binding locus lined with predominantly hydrophobic residues.

21 .3 that is based on two consecutive pairs of hydrophobic residues.

22 he protein collapse, mainly by burying their hydrophobic residues.

23 spanning channel to minimize the exposure of hydrophobic residues.

24 ly of AT1R homomers with a specific focus on hydrophobic residues.

25 a central cavity containing highly conserved hydrophobic residues.

26 e barrel core is fastened by three layers of hydrophobic residues.

27 with a cationic carboxy terminus depleted in hydrophobic residues.

28 eractions with the RGD motif plus downstream hydrophobic residues.

29 activity and substrate cleavage upstream of hydrophobic residues.

30 -cage's interior and the hydration of buried hydrophobic residues.

31 vesicle surface through its regularly spaced hydrophobic residues.

32 ed in glutamines/asparagines and depleted in hydrophobic residues.

33 n is the result of the membrane insertion of hydrophobic residues adjacent to the PI(3)P binding site

34 ng from the active site consisting mostly of hydrophobic residues, an environment well suited for fat

35 sequence, a spacer amino acid followed by a hydrophobic residue and a C-terminal vicinal disulfide m

36 pare peptide mixtures containing one type of hydrophobic residue and one type of cationic residue.

37 ng a narrow stretch of highly conserved gp41-hydrophobic residues and a critical arginine or lysine j

38 synergistic combination of both charged and hydrophobic residues and achieves the best binding metal

39 t Abeta42 oligomer has a minimal exposure of hydrophobic residues and is further stabilized by the E2

40 en-binding pocket, architecturally important hydrophobic residues and the hydrogen-bonding network ar

41 which become more favorable as the number of hydrophobic residues and thus van der Waals interactions

42 c side of the carrier is closed by conserved hydrophobic residues, and a salt bridge network, braced

43 ane pore, closed by three rings of conserved hydrophobic residues, and has a cytoplasmic cavern with

44 These hydrophobic residues appear to become ordered, thus enca

45 the carbohydrate-binding pockets, aliphatic hydrophobic residues are disfavored, whereas aromatic si

46 r the reactive residues, we find that nearby hydrophobic residues are essential, suggesting that the

47 Leu in their S1 pockets, while Glu and large hydrophobic residues are not accepted.

48 Hydrophobic residues are present in analogous positions

49 ues adopt interfacial positions, and several hydrophobic residues are within the membrane interior.

50 the first two residue sidechains complement hydrophobic residues around the active site, while the t

51 e adsorption of peripheral proteins that use hydrophobic residues as membrane anchors.

52 We examined the ratio of cationic to hydrophobic residues as well as the type of hydrophobic

53 ith a glutamine residue at position +1 and a hydrophobic residue at position -1, thus elucidating the

54 A hydrophobic residue at position 34 in the beta1 strand w

55 AR-containing proteins (ARPs) with a hydrophobic residue at the 13th position of two consecut

56 Binding to C-terminal sequences with a hydrophobic residue at the P-2 position plus an acidic r

57 -terminally (i.e., at the P1 position) and a hydrophobic residue at the second position following the

58 teractions, with dominant contributions from hydrophobic residues at a and d heptad positions.

59 Incorporation of hydrophobic residues at evolutionarily permissive positi

60 ependent accessibility is delineated by four hydrophobic residues at homologous positions in each dom

61 P4, tryptophan or leucine at P2, arginine or hydrophobic residues at P1, and alanine or asparagine at

62 receptors containing each of four different hydrophobic residues at position 195 served as input dat

63 Hydrophobic residues at residue 39 appear to stabilize t

64 We show that variations in hydrophobic residues at the active site of class D SBLs

65 and P7 positions and a preference for small hydrophobic residues at the C terminus (POmega).

66 nnel conformation involving a single ring of hydrophobic residues at the center of the pore.

67 Three hydrophobic residues at the channel's exit appear to hav

68 he HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the Env-gp41 s

69 peptidase with a preference for cysteine and hydrophobic residues at the N terminus of the hydrolyzed

70 The preference for hydrophobic residues at the P1 and P1' position was conf

71 s, including thermolysin, ZMPSTE24 preferred hydrophobic residues at the P1' position (Leu647), but i

72 ng affinity derives from burial of preferred hydrophobic residues at the P1, P4, and P2' positions of

73 s, the likely presence of adjacent polar and hydrophobic residues at the protein-membrane interface.

74 ing and transmembrane regions push conserved hydrophobic residues at the substrate entry site towards

75 Consolidation of hydrophobic residues at the tip of FLs may be a common r

76 Consequently, mutating the crucial hydrophobic residues at this key loop abrogates KGA acti

77 o1 are required for activation of Pdr1, with hydrophobic residues being critical for activity.

78 Moreover, swapping two hydrophobic residues between these D-sites switches the

79 Modification of the size of two hydrophobic residues by site-specific mutagenesis in SLO

80 bly arise from the introduction of two bulky hydrophobic residues by the substitutions Gln226Leu and

81 Along with hydrophobic residues, charged residues in the N terminus

82 celle interaction include the anchoring of a hydrophobic residue cluster into gaps in the reverse mic

83 Consistent with a specificity for exposed hydrophobic residues, competition from native BSA only w

84 ility along an internal conduit of conserved hydrophobic residues, connecting the domain interface wi

85 Y-shaped, 18-20 A in length and comprised of hydrophobic residues, connecting the protein surface wit

86 ffer-Edmundson helical wheel representation, hydrophobic residues consisting of leucine were all foun

87 ining hydrogen-bonding networks, whereas the hydrophobic residues constrain the positioning of the ca

88 ing this short motif by inserting additional hydrophobic residues creates very powerful ADs that bind

89 analyses) to identify conserved networks of hydrophobic residues critical for clamp stability and ri

90 Hydrophobic residues critical for interaction with Pdr1

91 ermediate proteasomes fail to cleave between hydrophobic residues, despite a higher chymotrypsin-like

92 molecules at the interface between some key hydrophobic residues (e.g. Trp-64) and MoS2 surface also

93 Once hydrophobic residues especially from C-terminus are lock

94 y 4G8, suggesting that the chaperone shields hydrophobic residues exposed on the oligomeric assemblie

95 Further analyses of mutants with hydrophobic residues (F or Y) found that interactions wi

96 vage pattern but shows a weak preference for hydrophobic residues (F/L) at the P1 position.

97 Mutation of hydrophobic residues (F2A, I22T, V25T, F29A) perturbs se

98 We show that each of the hydrophobic residues F438 and F461, which are located on

99 tivation gate, which is established by three hydrophobic residues, F518, Y563 and I612, in the middle

100 Mutation of hydrophobic residues (F793A, L797A, L814A, and L818A) fl

101 data support a model in which small neutral hydrophobic residues facilitate the post-translational c

102 ence of typical CXC pattern, with X being an hydrophobic residue facing towards the hydrophobic cavit

103 Our findings show the importance of hydrophobic residues for antiviral activity and show tha

104 revealed a cis-prenyl transferase fold with hydrophobic residues for isoprenoid binding and a second

105 monstrate the importance of highly conserved hydrophobic residues for tetramer stability.

106 homologs, predicted the importance of three hydrophobic residues forming a patch on the surface of I

107 ure of an Atg7(NTD)-Atg3(FR) complex reveals hydrophobic residues from Atg3 engaging a conserved groo

108 Here, we have mutated several hydrophobic residues from I360 to F370 in the S4 segment

109 The signal involves a stretch of hydrophobic residues from the C-terminal region that for

110 tagenesis analysis shows that four conserved hydrophobic residues from the identified binding motif a

111 We identified key hydrophobic residues from the lambda5-UR as crucial for

112 s also revealed the presence of a cluster of hydrophobic residues from transmembrane domains 2, 3, an

113 mulations, suggesting that I364 and adjacent hydrophobic residues function as a hydrophobic gate that

114 acement of Gly(332) and Leu(336) with larger hydrophobic residues (G332A and L336F) selectively augme

115 It preferred Ala and hydrophobic residues, had no activity toward Pro at the

116 , where the buried positions are composed of hydrophobic residues, Hec1 possessed an unusual distribu

117 s and (ii) an increased exposition of buried hydrophobic residues, however it was observed a decrease

118 ch helps position the side chains of two key hydrophobic residues (I170 and L230), over the carboxyla

119 ue W61 of one subunit packs into a pocket of hydrophobic residues I366 and W410 of the adjacent subun

120 NCE In this study, we identified an aromatic hydrophobic residue in foot-and-mouth disease virus (FMD

121 pocket between TM-III and TM-V and that the hydrophobic residue in position III:16 constitutes a gat

122 Mutation of this hydrophobic residue in the C(2)B domain (I420), on the o

123 A hydrophobic residue in the prodomain binds to a pocket a

124 Our previous studies identified a single hydrophobic residue in trans-membrane domain 7 of class

125 The higher solvent-exposure of hydrophobic residues in Abeta42 oligomers contributes to

126 These results suggest that critical hydrophobic residues in both fusion loops may be involve

127 or in spindle and spindle matrix depends on hydrophobic residues in BuGZ.

128 this configuration, MutY, surprisingly, uses hydrophobic residues in combination with hydrophilic res

129 Several hydrophobic residues in helix 1 and helix 4 of Atg17 and

130 Asymmetry in the distribution of hydrophobic residues in intrinsically unstructured prote

131 ma membrane through an interface enriched in hydrophobic residues in its C-terminal domain.

132 10E8 indeed binds lipid bilayers through two hydrophobic residues in its CDR H3 (third heavy-chain co

133 By burying hydrophobic residues in its core, the client's affinity

134 This allows recognition of scattered hydrophobic residues in late folding intermediates that

135 id profiles indicated a higher proportion of hydrophobic residues in OD-FPH and hydrophilic residues

136 Several aromatic and hydrophobic residues in pore helix 1, helices S5 and S6,

137 (R(h)>/=30 A) and contains local clusters of hydrophobic residues in regions that correspond to the f

138 ology of the two domains, a network of large hydrophobic residues in RRM2 provides a possible explana

139 While all Nek kinases strongly select for hydrophobic residues in the -3 position, the family sepa

140 on between WhiB1 and sigmaA4 is dominated by hydrophobic residues in the [4Fe-4S] cluster binding poc

141 is 235 degrees , which results in burial of hydrophobic residues in the bilayer.

142 Responsiveness to Vpu involves bulky hydrophobic residues in the C-terminal region of the BST

143 Mutagenesis studies confirm that hydrophobic residues in the centre of the three-helix bu

144 ctric charge of the filaments, the number of hydrophobic residues in the constituent keratin polypept

145 In total, eight hydrophobic residues in the core of DSD were replaced by

146 at is driven by interactions of cationic and hydrophobic residues in the first EF-hand sequence.

147 mined by variations among a set of basic and hydrophobic residues in the gamma-subunit types.

148 Thus, the contribution of hydrophobic residues in the H segment is not simply addi

149 over, site-directed mutagenesis of conserved hydrophobic residues in the JD (F363A/I364A, L356A, and

150 ic domain form a latch-like interaction with hydrophobic residues in the lid.

151 diates, each with a nonnative arrangement of hydrophobic residues in the MDM2 binding cleft, control

152 roteins, and that the position of acidic and hydrophobic residues in the motif plays the most importa

153 hase are induced by a unique motif featuring hydrophobic residues in the N1 and N2 positions adjacent

154 2-P2' region, demonstrating a preference for hydrophobic residues in the non-prime and hydrophilic re

155 Computational docking suggests hydrophobic residues in the pocket are involved in steri

156 Substitution of basic for hydrophobic residues in the region that overlays with ph

157 showing predicted molecular interactions of hydrophobic residues in the S4 segment in disulfide-lock

158 The additional hydrophobic residues in the synthetic ADs likely allow m

159 nd increased non-native self-interactions of hydrophobic residues in the urea/GdmCl mixture.

160 Reversion of hydrophobic residues in these patches to their hydrophil

161 ominent hydrophobic patch; reversion of four hydrophobic residues in this patch to their hydrophilic

162 Changing just 1 or 2 key hydrophobic residues in this submotif is sufficient to t

163 Alanine substitutions of the hydrophobic residues in those aggregation-prone beta-str

164 state is locked between the backbone and two hydrophobic residues in transmembrane (TM)-III, upon act

165 nt mutants has mapped the dimer interface to hydrophobic residues in transmembrane helix 4.

166 to peptides primarily composed of basic and hydrophobic residues in vitro.

167 tal structure near the A-cluster, defined by hydrophobic residues including F229, forms a cage surrou

168 rface charges and increased accessibility of hydrophobic residues (including the nuclear export seque

169 er surface and packs into its core conserved hydrophobic residues, including the Ile at position 181

170 domain bound sequences enriched in basic and hydrophobic residues, indicating that PTN conforms to th

171 and charge distribution, with predominantly hydrophobic residues, interspersed by some uncharged pol

172 e partitioning is driven by the insertion of hydrophobic residues into large packing defects that are

173 he Rop sequence to combine a specific set of hydrophobic residues into strikingly different hydrophob

174 an intracellular gate composed of a ring of hydrophobic residues is not only responsible for regulat

175 tein involving conservative substitutions of hydrophobic residues, key positions have been identified

176 ains a hydrophobic patch formed by conserved hydrophobic residues (L253, I257, and W258).

177 ing interact with a complementary cluster of hydrophobic residues (L302, I364, and L393) in the beta-

178 conjugation to PTT and increased exposure of hydrophobic residues led to a significant increase in it

179 Successive substitutions with hydrophobic residues led to the formation of ThT-negativ

180 the substrate and product and identify four hydrophobic residues-Leu120, Leu144, Phe182, and Leu193-

181 Helix unwinding at the C-terminus allows key hydrophobic residues (Leu383 and Phe385) to make more ex

182 Several additional hydrophobic residues lie in close proximity to GP-F88, i

183 eed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.

184 A crevice of hydrophobic residues linking the polar edge of KAR1 and

185 w the functional role of a highly conserved, hydrophobic residue located at the tip of each of the tw

186 s been attributed to the presence of a bulky hydrophobic residue located directly below the cofactor.

187 Mutational studies of conserved hydrophobic residues located in the identified beta-stra

188 ne was determined, suggesting that burial of hydrophobic residues may be a driving force for assembly

189 this localization is mediated by a conserved hydrophobic residue motif.

190 Folding measurements for hydrophobic residue mutations of hisactophilin and atomi

191 rong acidic ADs contain multiple clusters of hydrophobic residues near acidic side chains, explaining

192 Resveratrol and curcumin bind only to the hydrophobic residues near peptide termini.

193 We identified three hydrophobic residues near the active site of OCBS, corre

194 path (global); and repacking of a cluster of hydrophobic residues near the extracellular vestibule (l

195 ) consensus motif (PsiKX(D/E, where Psi is a hydrophobic residue)) near the scaffolding domain and th

196 g Leu(29) is similar to that of a C-terminal hydrophobic residue of HNP1, Trp(26).

197 on with new interactions between neutral and hydrophobic residues of about the same size: D231L/K178V

198 behaviour that depended on three C-terminal hydrophobic residues of AS2.

199 (iv) Surface hydrophobic residues of CD1 are involved in heterogeneou

200 (ii) Multiple surface hydrophobic residues of CD1 mediate the HMW complex asse

201 ability of ERdj3 to mask the solvent-exposed hydrophobic residues of CTA1.

202 addition, Nfs1 was found to require the same hydrophobic residues of Isu for binding, as does Jac1, s

203 -directed mutagenesis on the surface-exposed hydrophobic residues of pvLAAD INS, and we found that th

204 sical analysis demonstrates that the central hydrophobic residues of the cap are essential to allow a

205 as well as by van der Waals interactions to hydrophobic residues of the catalytic pocket.

206 o the known requirements of the aromatic and hydrophobic residues of the core motif, we found the int

207 from the inner leaflet and is coordinated by hydrophobic residues of the M and E transmembrane helice

208 ctions between the I4897 residue and several hydrophobic residues of the neighboring subunit.

209 ion loop and alphaC-helix and an ensemble of hydrophobic residues of the Regulatory spine and Shell.

210 rane-proximal external region aromatics with hydrophobic residues of the transmembrane domain, and co

211 This protects the hydrophobic residues on both domains and keeps the SH3 d

212 s indicate methionine oxidation perturbs key hydrophobic residues on one face of helix-C as follows:

213 and immunoprecipitation analyses implicated hydrophobic residues on one face of the M2AP galectin fo

214 ar contacts involving two acidic patches and hydrophobic residues on Spt2C.

215 Three layers of hydrophobic residues on the carboxy-terminal half of the

216 ted system similar to a polymer network with hydrophobic residues on the external surface.

217 affecting the relative placing of charged or hydrophobic residues on the helix severely impacted the

218 by fumarate on one face and tight packing by hydrophobic residues on the other face and sides.

219 substituent on the isocoumarin inhibitor and hydrophobic residues on the protease reflect S' subsite

220 econfiguration rate is slow enough to expose hydrophobic residues on the same time scale that bimolec

221 econfiguration rate is slow enough to expose hydrophobic residues on the same time scale that bimolec

222 required for Rap1A activation and identified hydrophobic residues on the surface of the RA2 domain th

223 Our data suggest a model in which hydrophobic residues on TM3 and TM7 form a broad ligand-

224 face residues, whereas basic and hydrophilic/hydrophobic residues only mildly modify its density.

225 A preference for either a hydrophobic residue or an acidic residue following the a

226 were obtained by modification of individual hydrophobic residues or a predicted salt bridge, suggest

227 , we replaced putative HG residues with less hydrophobic residues or acidic Asp.

228 h the binding interfaces feature clusters of hydrophobic residues, overall, the protein-protein assoc

229 These hydrophobic residues pack together and form the structur

230 When the hydrophobic residue Phe is labeled, however, the spin-la

231 , and E-III (the FVYL pocket, comprising the hydrophobic residues Phe-1012, Val-1025, Tyr-1089, and L

232 Two hydrophobic residues, Phe-198 and Met-134, frequently be

233 t for membrane binding, whereas the flanking hydrophobic residues play a lesser role.

234 affinity by distinct mechanisms; mutation of hydrophobic residues primarily alters association rate c

235 d TM-V into a tight pocket generated by five hydrophobic residues protruding from TM-III and TM-V.

236 d to strongly discourage the exposure of any hydrophobic residues, providing an enhanced hydrophobic

237 negatively charged, positively charged, and hydrophobic residues, respectively, together forming a u

238 the H protein, we identified two neighboring hydrophobic residues responsible for severe F-to-H bindi

239 Most changes of the conserved hydrophobic residues resulted in >10(7)-fold decrease in

240 hanges and possible burial of some antigenic hydrophobic residues resulted in reduction of antigenici

241 e, we characterized 26 Ala mutants of buried hydrophobic residues, spanning the three helices of the

242 volutionarily conserved pattern of polar and hydrophobic residues specifying recognition of discrete

243 In contrast, nonaromatic hydrophobic residues strongly promote prion formation bu

244 pendent accessibility is demarcated by an S6 hydrophobic residue; substituted cysteines above this si

245 Through the attachment of hydrophobic residues such as linear alkyl chains on the

246 Hydrophobic residues, such as propyl or butyl in the par

247 mbly of LC domains that are nearly devoid of hydrophobic residues, such as the 214-residue LC domain

248 ls an ~160- angstrom long channel lined with hydrophobic residues suitable for solubilizing multiple

249 Residues P193 and W222 comprise a series of hydrophobic residues surrounding the cofactor binding si

250 of high negative charge density and aromatic/hydrophobic residues that are distributed across the pro

251 ll interface residues, we identified several hydrophobic residues that are important for AHR dimeriza

252 erve that, although mutation of four surface hydrophobic residues that are unique to RelB does not af

253 es of 8-15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CR

254 tions in hydrated powders, whereas it is the hydrophobic residues that experience the more pronounced

255 The m04 interior was packed by a myriad of hydrophobic residues that form distinct clusters around

256 s, we identified two acidic residues and two hydrophobic residues that form the peptide ligand bindin

257 the ATP binding cleft contained a number of hydrophobic residues that occlude ATP binding as expecte

258 n IRF-7 derives from a unique combination of hydrophobic residues that pack against the protein core.

259 l egress as cellular assays demonstrate that hydrophobic residues that penetrate deeply into the plas

260 sensus sequence motif of AOPXW (where O is a hydrophobic residue) that is highly conserved in the maj

261 not with the sign of the charges, while for hydrophobic residues, the surface densities are uncorrel

262 Mutation of five conserved hydrophobic residues to alanines within the amphipathic

263 In the negative peptides, two changes of hydrophobic residues to glycine were especially abundant

264 sis revealed strict segregation of polar and hydrophobic residues to opposite faces of a predicted al

265 atic interactions, which further facilitates hydrophobic residues to reside on the bilayer.

266 ture activation is driven by the exposure of hydrophobic residues to solvent.

267 l pulling expose an increasing amount of the hydrophobic residues to the solvent molecules, and the u

268 between TM segments in the closed state pull hydrophobic residues together to form a hydrophobic plug

269 esidue 375 mutations that mimic the bulky or hydrophobic residues typically found in simian immunodef

270 r deducing a rule for SLC6 family members: a hydrophobic residue (Tyr or Val) in the +2 position spec

271 sting that, for peptide-CPP chimeras, distal hydrophobic residues upstream of the CPP sequence can ha

272 ment analysis demonstrates that a cluster of hydrophobic residues (V101, L104, and V162) within the C

273 Replacement of Leu(336) with smaller hydrophobic residues (Val, Ala, and Gly) shifted the oxy

274 roles of the platform His115-Arg127 and the hydrophobic residues Val120 and Leu123 in dG:dGTP misinc

275 tion by site-directed mutagenesis of barrier hydrophobic residues (Val50, Leu54, Leu170, Leu174) to a

276 together within a capsomer, where the E-loop hydrophobic residue W61 of one subunit packs into a pock

277 fundamentally differentiates it from purely hydrophobic residues, we have used in vitro cellular exp

278 s on newly exposed protein surfaces, several hydrophobic residues were mutated, two polypeptide segme

279 hobic interaction between the side chains of hydrophobic residues were still partly retained, imparti

280 nus side of the HA PCS (P2 position) avoided hydrophobic residues, whereas the P3 position avoided hy

281 side chains of Tyr-131 and Ala-134 with core hydrophobic residues, whereas the reactive center loop h

282 cognized conserved motif, PXGG (X is a large hydrophobic residue), which is in a hydrophobic region p

283 es in four pockets by contributing different hydrophobic residues, which are spread along the subunit

284 embrane-binding domain composed of basic and hydrophobic residues, which is necessary and sufficient

285 These results further show that a hydrophobic residue with a strong preference for tryptop

286 Replacement of the central hydrophobic residue with Gly (L83G) also conferred no et

287 s simultaneous substitution of four aromatic/hydrophobic residues with Ala dramatically impairs both

288 This study suggests that the conserved hydrophobic residue within the intracellular loop 2 of t

289 ted into a low-affinity one by mutation of a hydrophobic residue within the motif.

290 structs containing substitutions of the most hydrophobic residues within each of the two fusion loops

291 These centrally localized hydrophobic residues within fairly charged patches may f

292 orroborates mutagenesis implicating multiple hydrophobic residues within the AI segment that contribu

293 ulations, here we identified single aromatic/hydrophobic residues within the amyloid core IAPP region

294 directed mutagenesis was used to explore the hydrophobic residues within the MD-2 binding pocket as t

295 We identify a set of hydrophobic residues within the oligomerization helix th

296 site-directed mutagenesis of outward-facing hydrophobic residues within the transmembrane region of

297 Specific hydrophobic residues within this sequence that are known

298 s demonstrate that mutations in a cluster of hydrophobic residues within transmembrane domain 1 affec

299 is governed by an HbYX motif (where Hb is a hydrophobic residue, Y is tyrosine, and X is any amino a

300 There are three hydrophobic residues (Y161, F164, and F287) which form s