ライフサイエンスコーパス: hydroxy group

1 with a predetermined stereochemistry of the hydroxy group.

2 here incorporate ribose mimics missing the 2-hydroxy group.

3 ses, C2 in ketoses), which has a more acidic hydroxy group.

4 anomeric hydroxy group is cis to an adjacent hydroxy group.

5 not as active as the compounds without the 1-hydroxy group.

6 f Arg9 forms an intra-hydrogen bond with the hydroxy group.

7 nalized and isolated by the acylation of the hydroxy group.

8 the steric hindrance in the vicinity of the hydroxy group.

9 n metals and aromatic carbonyl with an ortho-hydroxy group.

10 unable by easy modifications on the phenolic hydroxy group.

11 s, accelerating the arylation of an adjacent hydroxy group.

12 bly faster than O-acylation of the primary 6-hydroxy group.

13 s resulted in an in situ protection of the o-hydroxy group.

14 red spectroscopy confirmed the presence of a hydroxy group.

15 rescent PIP(2) derivatives modified at the 6-hydroxy group.

16 three-methylene unit, and an alkylamino or a hydroxy group.

17 at undergo transesterification with residual hydroxy groups.

18 l depend upon the number and location of the hydroxy groups.

19 an iCTC-like skeleton bearing two additional hydroxy groups.

20 earing multiple chiral centers and protected hydroxy groups.

21 differentiate between differently positioned hydroxy groups.

22 on between aryl fluorosulfates and silylated hydroxy groups.

23 alkyl groups (e.g., propyl groups) onto the hydroxy groups.

24 me steps of protecting/deprotecting amino or hydroxy groups.

25 hydrogen bonds for the two binding sites via hydroxy groups 3-OH and 4-OH and hydrophobic contact by

26 l) derivatives, introduction of the 17 alpha-hydroxy group (4b) and 16 alpha,17 alpha-epoxide group (

27 ve acceptorless dehydrogenation of the gamma-hydroxy group, a subsequent retro-aldol reaction that cl

28 le them to cross the cell membrane, the free hydroxy group also was esterified with a long hydrocarbo

29 Key H-bonding partners with the 17-hydroxy group and 3-keto group of testosterone are Asn70

30 e conversion of dimethyl(phenyl)silyl to the hydroxy group and a Swern oxidation of the alcohol 30 to

31 a strong hydrogen bond between an ionized 2-hydroxy group and Ser195 of factor Xa.

32 d dimethyl(phenyl)silyl moiety as a "masked" hydroxy group and started with an exclusively endo selec

33 validated the initial hypothesis that the C7 hydroxy group and the C14 and C16 methyl groups of (+)-d

34 tramolecular hydrogen bonding between the C8 hydroxy group and the C7 oxygen functionality in (aR,7R)

35 Oxidation of the hydroxy group and the reduction of a phenylnitro group p

36 wed by protection of the resulting secondary hydroxy group and treatment of the product with Boc anhy

37 re modified by the repositioning of phenolic hydroxy groups and by the addition of alkyl substituents

38 The position of individual hydroxy groups and the location of the stabilizing intra

39 rol, including compounds that were devoid of hydroxy groups and were 100-fold more potent than resver

40 ing process, (2) flexible positioning of the hydroxy group, and (3) potential extension to other medi

41 Chlorophenylacetate, which lacks the ortho-hydroxy group, and hydroxyphenylacetate, lacking the chl

42 hat they interact electrostatically with the hydroxy group, and that the guanidinium group of Arg9 fo

43 astereomeric helicate form when bearing free hydroxy groups, and another in the case of its methylate

44 rect protection methods targeting a specific hydroxy group are demanded.

45 side chain containing either a 3-oxo or a 3-hydroxy group are optimal structures for immune suppress

46 The phosphoramidite and the hydroxy group are reacted in step (i), thus leading to a

47 otected form of kaempferol in which all four hydroxy groups are differentiated and the first bis-glyc

48 Interactions between methoxy and hydroxy groups are found to reduce membrane partitioning

49 Vicinal hydroxy groups around the chiral quaternary center were

50 Protection of the hydroxy group as a THP acetal and oxidative cleavage of

51 pyridine ring, implicating the oxazole alpha-hydroxy group as an active participant in the cycloadduc

52 cting groups, including enones, ketones, and hydroxy groups, as well as never reported before lactams

53 exist in two alternative anomers (in which a hydroxy group at C-1 takes different orientations) and e

54 Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-

55 a hydroxy group (to give TDP-quinovose), the hydroxy group at C3 is oxidized to a ketone with no C4-d

56 Asymmetric introduction of hydroxy group at C7 is achieved by the enantioselective

57 mmins acetate aldol reaction to generate the hydroxy group at the C-13 position, Horner-Wadsworth-Emm

58 here demonstrate that the introduction of a hydroxy group at the C11beta position affords high selec

59 the 4-chromanone scaffold together with the hydroxy groups at 5- and 7-positions enhanced antibacter

60 The results showed that phenols having two hydroxy groups at meta positions of the aromatic ring we

61 show the effects of protected or unprotected hydroxy groups at six different positions and their impa

62 nacene (TBTQ) derivatives bearing methoxy or hydroxy groups at the peripheral positions [(2,6-(OMe)2,

63 he synthesis of monosaccharides in which the hydroxy groups at their 4- and 6-positions are replaced

64 dendritic rods constructed by placing a tri(hydroxy) group at the apex of dendritic oligo-fluorenes

65 cis-diols, having an equatorial and an axial hydroxy group, benzoyl cyanide or acetyl cyanide as an a

66 These results indicate that the 6-hydroxy group can be modified to develop functional subs

67 acids to form reversible covalent bonds with hydroxy groups can be exploited to enable both electroph

68 A terminal hydroxy group cannot be reconciled with the spectroscopi

69 utated 36 evolutionarily conserved basic and hydroxy group containing residues within RAG2.

70 However, although the 3-hydroxy group could be removed without significantly red

71 ilis toward different flavonols, where the 5-hydroxy group determines metabolic priority.

72 the side chain, the sterol nucleus, or the 3-hydroxy group did not.

73 se that catalyzes the dehydration of the C17 hydroxy group during iso-MGS biosynthesis.

74 ster cofactors in reductive ring opening and hydroxy-group elimination.

75 ted dienes in chains having also hydroperoxy/hydroxy groups, epoxides and aldehydes); the formation o

76 -norvitamin D analogue 4 possessing a 1alpha-hydroxy group fixed in the axial orientation (beta-chair

77 7 catalyzes the dehydrogenation of the 3beta-hydroxy group followed by isomerization of the Delta(5)-

78 by contrast, recognizes few phosphate or 2'-hydroxy groups for aminoacylation.

79 nd stereochemistry of the C10-methyl and C11-hydroxy groups for potent PP2A inhibition.

80 d compounds (containing different numbers of hydroxy groups) for dansylation.

81 ly occurring analog of LPA in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phos

82 The primary hydroxy group from atROL is preserved in the metabolite.

83 receptor distinguishes estradiol's unique 3-hydroxy group from the 3-keto function of most other ste

84 proceeded by intramolecular transfer of the hydroxy group from the nitrogen to the C-2 position of t

85 he C-6 ester (H1 series), removal of the C-4 hydroxy group gave compounds with reduced potency, where

86 e N6-amino group with methylthio, chloro, or hydroxy groups greatly reduced the ability to interact w

87 The apparent specificity for the C(6)-hydroxy group in 1 suggests that an efficient hydrogen b

88 related analogues demonstrated that the C(6) hydroxy group in 1 was essential for activity.

89 We found that replacing the C(6)-hydroxy group in 1 with weaker hydrogen bond donors led

90 replacement of a single hydrogen atom with a hydroxy group in a Hp/Py pairing regulates affinity and

91 nol occurs with significant migration of the hydroxy group in cyclohexanol and the double bond in cyc

92 A one-carbon-away placed hydroxy group in RAP can only generate a monoamine-hydro

93 atalyst, the nucleophilicity of the phenolic hydroxy group in salicylaldehyde reduces further to make

94 e analogs but failed in delivering a crucial hydroxy group in the final step.

95 oth C-20 epimeric pairs containing the 24(R)-hydroxy group in the gemini and 19-norgemini series.

96 tionale in which proton abstraction from the hydroxy group in the initial cation radical does not cau

97 rent from the intermolecular transfer of the hydroxy group in the non-enzymatic Bamberger rearrangeme

98 Asp 145 in close proximity to the ligand's 4-hydroxy group in the structure of the product-enzyme com

99 In CAP, two adjacent hydroxy groups in a benzene ring facilitate selective di

100 p the benefits but minimize the drawbacks of hydroxy groups in drug discovery.

101 directing groups because of the ubiquity of hydroxy groups in organic small molecules.

102 Site-selective functionalization of hydroxy groups in sugar derivatives is a major challenge

103 rifies the molecular conformation of the two hydroxy groups in terrein established by X-ray data.

104 ound I species that reacts with nucleophilic hydroxy groups in the 20R,22R-dihydroxycholesterol inter

105 Addition of a 14-hydroxy (the 4a-hydroxy) group in the enantiomeric isoquinolinones, (+)-

106 substituents in both positions ortho to the hydroxy group inhibited BDA and Cl-BDA formation, but th

107 ed for wasteful stoichiometric activation of hydroxy groups into halides or sulfonates.

108 Reaction is completed only when the anomeric hydroxy group is cis to an adjacent hydroxy group.

109 of binding observed with the removal of the hydroxy group is decreased severalfold as compared to wh

110 ucture of an oxophlorin where the alpha-meso hydroxy group is deprotonated.

111 compound repository demonstrated that the 7-hydroxy group is essential for integrase inhibition.

112 introduced in which a stereocenter bearing a hydroxy group is given two different tags.

113 The 14-hydroxy group is known to increase the antagonist potenc

114 ply that the axial orientation of the 1alpha-hydroxy group is necessary for biological activity of vi

115 The product is unstable unless its 4-hydroxy group is protected, as it undergoes facile dimer

116 In the ferrous form, the alpha-hydroxy group is protonated and consequently the prosthe

117 itution at the C-2 position revealing that a hydroxy group is required for optimal activity.

118 Hydrogen-bonding via hydroxy groups is crucial for catalysis also.

119 nterion favors dual hydrogen bonding to both hydroxy groups leading to equatorial O-acylation.

120 ly removes methoxy groups in the presence of hydroxy groups leading to phenol products, while hydrode

121 nded to reduce the electron density on the N-hydroxy group, leading to higher redox potential and low

122 N-phenyl tended to increase the Km of the N-hydroxy group, leading to lower oxidation rate.

123 Subsequent optimization and removal of the 7-hydroxy group led to coumarin 59, which had increased po

124 array of representative reactions, including hydroxy group manipulation (acylation, protection/deprot

125 quine analogues and their Nomega-oxides with hydroxy group meta to the amino rather than in para posi

126 roup and that the nitrogen atom of the non-N-hydroxy group must contain at least a single hydrogen at

127 s the reduction of the carbonyl group to the hydroxy-group negates this difference to zero.

128 Replacement of the 4-hydroxy group of 1 with an ethyl group abolishes activit

129 Functionalization of the hydroxy group of 45 with a series of piperidinylalkyl gr

130 FosDH2 catalyzed the slow exchange of the 3-hydroxy group of 8 with [(18)O]-water.

131 tert-butyldimethylsilyl ether for the gamma-hydroxy group of Ahad.

132 involved in hydrogen bonding with a phenolic hydroxy group of cyperin.

133 stalled a photolabile structural cage on the hydroxy group of D-F07 to generate PC-D-F07.

134 ole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE).

135 catalyzes regiospecific methylation at the 7-hydroxy group of its native substrate, 2,7-dihydroxy-5-m

136 n atom or (ii) be attacked by a nucleophilic hydroxy group of its substrate, 20R,22R-dihydroxycholest

137 However, the role of the 6-hydroxy group of PIP(2) for interaction and hydrolysis b

138 the glycosyl donor but high affinity to the hydroxy group of the acceptor alcohol moiety, thus leadi

139 ay be similar and involves the attack of the hydroxy group of the alpha-hydroxyphosphonate or alpha-h

140 utyldimethylsilyl protecting group at the C3-hydroxy group of the beta-lactams provided optimum kinet

141 een catalytic aspartic acid residues and the hydroxy group of the bound clinical drug darunavir, loca

142 Replacement of the 4-hydroxy group of the high-affinity compound 2 with an am

143 the Gln217-Gly219 region caused by the ortho-hydroxy group of the inhibitor's aminobenzamidine moiety

144 The 7-hydroxy group of the isoquinoline skeleton of the aglyco

145 ue implicated in the binding of the phenolic hydroxy group of the keto and enol isomers of (p-hydroxy

146 xpected to occur upon the protonation of the hydroxy group of the N-hydroxysulfenamide intermediate.

147 the absolute configuration of the side chain hydroxy group of the natural product to be assigned as (

148 biosynthesis, the phosphorylation of the 3'-hydroxy group of the ribose sugar moiety.

149 equent hydrogen atom transfer (HAT) from the hydroxy group of the salicyl moiety to the vinyl radical

150 of the binding pocket for the N-acetyl or C2 hydroxy group of the substrate.

151 d O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids.

152 Ile12 forms the proline type I turn, and the hydroxy group of Tyr11 interacts with the two guanidiniu

153 and were covalently linked to the (omega-1)-hydroxy group of very long chain fatty acid in bradyrhiz

154 de the capsule and is hydrogen bonded to the hydroxy groups of 2a.

155 ioselectively differentiate the enantiotopic hydroxy groups of myo-inositol 1,3,5-orthoformate in the

156 al DHs that catalyze dehydration of the beta-hydroxy groups of the nascent polyketide intermediates,

157 tion; and (iv) the carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for

158 ted by the kinase hinge region with flanking hydroxy groups of the Y815 and D819 side chains.

159 Some hydroxy groups of these fatty acids were further esterif

160 dictate the spectral response of individual hydroxy group (OH) oscillators.

161 Upon photoactivation, the re-exposed hydroxy group on D-F07 triggered the aldehyde-protecting

162 The hydroxy group on the amine nucleophile was found to be c

163 It is observed that the presence of a hydroxy group on the benzene ring of PEAs resulted in de

164 ytic site and forms a hydrogen bond with the hydroxy group on the farnesyl side chain of the heme.

165 vide convincing evidence for the presence of hydroxy groups on surface Ru sites in the HOR potential

166 Derivatives having hydroxy groups on the aryl moieties (2c, 2j-l) demonstra

167 effectively shield one of the two prochiral hydroxy groups on the diol complex, whereas a strategica

168 ation and discrimination of the enantiotopic hydroxy groups on the diol substrate occurs via a define

169 rfaces stemming from the partitioning of the hydroxy groups on the hydrophilic molecules to the well-

170 hin a MOF that features open metal sites and hydroxy groups on the pore walls can serve as a highly e

171 ation of graphite, to produce both epoxy and hydroxy groups on the surface of fullerenes (C(60)) and

172 = 1.2 microM) are reduced by incorporating a hydroxy group onto the 4-position of the piperidine ring

173 ocking the C(2)-position of erlotinib with a hydroxy group or a methyl group decreased inactivation p

174 nds displaying amino groups, carboxy groups, hydroxy groups, or triazolo-pyridines, which should enab

175 us PQS but not PQS derivatives lacking the 3-hydroxy group overcame the cell density but not growth p

176 trating enhanced activity due to methoxy and hydroxy group patterns.

177 ic activities of 7 and 9 suggest that the 14-hydroxy group plays an important role in determining the

178 lexation directed by proximal alpha- or beta-hydroxy groups present in the phosphine oxide structures

179 does not require prefunctionalization of the hydroxy group prior to its removal.

180 ystem and either a keto group (probe 5) or a hydroxy group (probe 6) in the C3 position.

181 tetrahydropyran (THP) core incorporating a 6-hydroxy group proposed to be introduced by alpha-hydroxy

182 rivatives of N-hydroxyurea that contain an N-hydroxy group react with oxyhemoglobin to form methemogl

183 alogues were synthesized in which the 1alpha-hydroxy group, required for biological activity, is almo

184 proposed to proceed via transposition of the hydroxy group resulting from the initial annulation.

185 ese guanidinium groups are curled toward the hydroxy group so that they interact electrostatically wi

186 bonding of cyanide to the most acidic axial hydroxy group supported by hydrogen bonding of the equat

187 s a hydrogen-bonding network involving the 4-hydroxy group that anchors the aromatic ring and thereby

188 ity of the misassigned structures featured a hydroxy group that is proximal to the proposed anhydride

189 ubstrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the l

190 may share a D1 pharmacophore made up of two hydroxy groups, the nitrogen atom (ca. 7 A from the oxyg

191 such proteins discriminate between amino and hydroxy groups, the remodeled domains function in a path

192 i-facial intramolecular hydrogen bond from a hydroxy group to an arene is favored by approximately 1.

193 Here, use of a proximal hydroxy group to control regioselection in the functiona

194 Introduction of a hydroxy group to increase the flexibility afforded B whi

195 ydrogen bond donor interaction from the C(6)-hydroxy group to rho or the C(6) hemiaminal bond cleavag

196 ported by hydrogen bonding of the equatorial hydroxy group to the axial oxygen.

197 mental data suggest that coordination of the hydroxy group to the iron hydride intermediate plays an

198 ple, we demonstrate that the addition of two hydroxy groups to AQDS increases the open circuit potent

199 hatic polyols do not require a threo pair of hydroxy groups to form hypercoordinated Si complexes, al

200 iperidine and subsequent deprotection of the hydroxy groups to give novel dicarboxylic acid 11 or dia

201 goes a very exothermic coupling of alkyl and hydroxy groups to give the alcohol complex VI of Fe(III)

202 ited-state proton transfer from the catechol hydroxy groups to the solvent.

203 eavage of the aromatic bond with two vicinal hydroxy groups to yield substituted cis,cis-muconic acid

204 er, if the C4 amino group is replaced with a hydroxy group (to give TDP-quinovose), the hydroxy group

205 reaction-inspired strategy, and the tertiary hydroxy group was introduced by an NBS-mediated brominat

206 alogues in which either the sn-1 or the sn-2 hydroxy group was replaced by fluorine, or the bridging

207 e E (6) to N-acyliminium ion 7, from which a hydroxy group was selectively introduced to the C6, C7,

208 ly assigned, while the position of the other hydroxy group was tentatively assigned.

209 eries of substituted trans-stilbenes without hydroxy groups were compared with resveratrol for their

210 is due to dual hydrogen bonding of the axial hydroxy group which enhances the nucleophilicity of the

211 eugenol, and methyl vanillate all contain a hydroxy group which is apparently important for the stro

212 " has been modified by replacement of the 4'-hydroxy group with a hydrogen, fluorine, or chlorine ato

213 ip study of 1 showed that replacing the C(6)-hydroxy group with alkoxy and thioalkoxy substituents le

214 highly directed interaction of the ligands' hydroxy group with an asparagine (N508(6.52)) prevents r

215 to having the required pharmacophore (the 4-hydroxy group with hydrogen-bonding interaction with the

216 r the 3alpha-isomer, yet replacing the 3beta-hydroxy group with larger polar groups in the same confi

217 trates that the noncovalent interaction of a hydroxy group with pi-deficient pyrazine and quinoxaline

218 -30 were prepared from 16a by protecting all hydroxy groups with esters with an aim to facilitate dru

219 After protection of the hydroxy groups with iodomethane, diiodide 6 is subjected

220 )CHNR2), where Ar(1) is substituted with a 2-hydroxy group, with arylboroxines (Ar(3)BO)3 in the pres

221 upled electron transfer (PCET) activation of hydroxy groups within the polymer network to generate ke

222 cts, while hydrodehydroxylation only removes hydroxy groups without cleavage of methoxy groups giving