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1 of the 5-lipoxygenase metabolite, 5-HETE (5-hydroxyeicosatetraenoic acid).
2 m four other classes (e.g., hypoxanthine, 12-hydroxyeicosatetraenoic acid).
3 can be reduced to the eicosanoid 12-HETE (12-hydroxyeicosatetraenoic acid).
4 4 and prostaglandin J2; and a decrease in 20-hydroxyeicosatetraenoic acid.
5 r of omega-hydroxylase, which synthesizes 20-hydroxyeicosatetraenoic acid.
6 in so doing up-regulate the production of 15-hydroxyeicosatetraenoic acid.
7 15-lipoxygenase pathway, predominantly to 15-hydroxyeicosatetraenoic acid.
8 se, which converts arachidonic acid to 15(S)-hydroxyeicosatetraenoic acid.
9 roxyeicosatetraenoic acid, 15-oxo-ETE, and 5-hydroxyeicosatetraenoic acid.
10 oxylase products (+/-)-15-, (+/-)-19-, or 20-hydroxyeicosatetraenoic acid.
11 also catalyze the formation of a variety of hydroxyeicosatetraenoic acids.
12 ially inhibited by exogenous 12(S)- or 15(S)-hydroxyeicosatetraenoic acids.
13 glandins, plus smaller amounts of 11- and 15-hydroxyeicosatetraenoic acids.
14 hway producing epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids.
15 leukotrienes, epoxyeicosatrienoic acids, and hydroxyeicosatetraenoic acids.
16 cluding epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids.
17 xyeicosatetraenoic acid (15-HETE) and 11-(R)-hydroxyeicosatetraenoic acid (11-HETE), whereas acetylat
19 nd that the 12/15-lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) increased AT1R
21 ed whether thrombin or the eicosanoid, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), could activat
22 ic acid metabolite of 12-lipoxygenase, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), not only medi
26 r biolipids produced by platelets include 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-hydroxyeic
27 etabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an import
28 homogenates from disrupted cells produced 12-hydroxyeicosatetraenoic acid (12-HETE) and minor amounts
31 tauro-beta-muricholate, taurocholate and 12-hydroxyeicosatetraenoic acid (12-HETE) were detected in
32 xyoctadecadienoic acid (13-HODE) and 12-( S)-hydroxyeicosatetraenoic acid (12-HETE), also affect subs
33 tion of the allosteric effector molecule, 12-hydroxyeicosatetraenoic acid (12-HETE), indicating a tun
34 an arachidonate 12-lipoxygenase (ALOX12)-12-hydroxyeicosatetraenoic acid (12-HETE)-G-protein-coupled
37 se-derived arachidonate metabolite and 12(R)-hydroxyeicosatetraenoic acid (12[R]-HETE) is formed by a
38 NPD1, PEDF+DHA, lipoxin A4 (LXA4), 12- or 15-hydroxyeicosatetraenoic acid (12[S] or 15[S]-HETE), and
41 creased levels of the 12/15-LO product 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] and also 12/15
43 ceptor 31 (GPR31) as the high-affinity 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] receptor (12-H
44 d, other cP450 arachidonate metabolites (12R-hydroxyeicosatetraenoic acid (12R-HETE), 14,15-dihydroxy
45 the unusual arachidonic acid metabolite 12R-hydroxyeicosatetraenoic acid (12R-HETE), a product of th
47 s in levels of urinary 12/15LO products, 12S-hydroxyeicosatetraenoic acid (12S-HETE) and 13S-hydroxyo
48 lated IK, and the 12-LO metabolite of AA 12S-hydroxyeicosatetraenoic acid (12S-HETE) stimulated IK.
49 To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates Rac1
50 To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates sign
51 on of its arachidonic acid metabolites 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) and 12(S)-hydr
52 is able to blunt PDGF-induced ROS and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) production, in
53 rgeted lipidomics approach showed that 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) was the major
54 t with the 15-lipoxygenase metabolite, 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), followed by E
55 5-LOX1 metabolite of arachidonic acid, 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), on vascular s
59 of matrix metalloproteinases (MMPs) in 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE)-induced angiog
60 erstand the molecular basis underlying 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE)-induced angiog
63 rtly involves the 15-LOX-2 promoter and 15-S-hydroxyeicosatetraenoic acid (15-(S)-HETE), a product of
64 is essentially a lipoxygenase, making 15-(R)-hydroxyeicosatetraenoic acid (15-HETE) and 11-(R)-hydrox
65 12/15-Lipoxygenase (12/15-LO) produces 15-hydroxyeicosatetraenoic acid (15-HETE) and 13-hydroxyoct
66 tes two products in nearly equal amounts: 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-ketoeicosa
67 yclooxygenase-2-derived lipoxin precursor 15-hydroxyeicosatetraenoic acid (15-HETE) in esterified for
69 the ability of one of these metabolites, 15-hydroxyeicosatetraenoic acid (15-HETE), to regulate the
72 oxygenase (soybean lipoxidase), or [U-14C]15-hydroxyeicosatetraenoic acid (15-HPETE) and analyzed by
74 o understand the mechanisms underlying 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE]-induced angiog
75 ntrol, as well as higher levels of plasma 15-hydroxyeicosatetraenoic acid, 15-oxo-ETE, and 5-hydroxye
76 Epithelial 15LO1 generates intracellular 15-hydroxyeicosatetraenoic acid (15HETE) conjugated to phos
77 ock prostaglandin biosynthesis, and give 15R-hydroxyeicosatetraenoic acid (15R-HETE) as the only prod
78 etory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous a
79 bility of benign prostate tissue to form 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous a
81 e present in abundance in the CF lung, to 19-hydroxyeicosatetraenoic acid (19-HETE; K(m) = 41 muM, V(
82 upregulation of CYP4A and an increase in 20-hydroxyeicosatetraenoic acid (20-HETE) and Nox oxidases.
83 n of omega-hydroxylase, and the efflux of 20-hydroxyeicosatetraenoic acid (20-HETE) from the isolated
85 amily (CYP4A) convert arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) in blood vessels
86 ood pressure (BP)), and exhibit increased 20-hydroxyeicosatetraenoic acid (20-HETE) in kidney and uri
93 dizes endogenous arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite wit
94 a-hydroxylase catalyzing the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), a potent constri
95 me P450 4A enzymes (P450 4A) and produce 20- hydroxyeicosatetraenoic acid (20-HETE), a potent constri
96 roinflammatory hepatic prostaglandins and 20-hydroxyeicosatetraenoic acid (20-HETE), a potent vasocon
98 of endothelial cells in the metabolism of 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoactive med
99 (20-COOH-AA) is a bioactive metabolite of 20-hydroxyeicosatetraenoic acid (20-HETE), an eicosanoid th
100 CYP) 4A enzymes catalyze the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), an eicosanoid wh
103 450 enzyme to produce the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE), and that this me
105 a CYPomega-hydroxylase metabolite of AA, 20-hydroxyeicosatetraenoic acid (20-HETE), on the extent of
107 ons of the metabolic product of Cyp4a12a, 20-hydroxyeicosatetraenoic acid (20-HETE), were found to be
108 eater than 120-fold higher blood level of 20-hydroxyeicosatetraenoic acid (20-HETE), which correlates
109 e CYP4A enzymes catalyze the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which has potent
112 arachidonic acid to a mixture of 19- and 20-hydroxyeicosatetraenoic acids (20 and 80% of the total p
113 metabolites of arachidonic acid tested, 5(S)-hydroxyeicosatetraenoic acid (5(S)-HETE) induced DNA syn
114 rease in lipoxygenase (LOX) metabolites 5(S)-hydroxyeicosatetraenoic acid (5-HETE), 8-HETE, and 15-HE
115 with this hypothesis, Erk activation by 5(S)-hydroxyeicosatetraenoic acid (5-HETE; lipoxygenase-indep
116 pid body formation was not LTB4 but was 5(S)-hydroxyeicosatetraenoic acid [5(S)-HETE], which was acti
117 f arachidonic acid, 5(S)-, 12(S)-, and 15(S)-hydroxyeicosatetraenoic acids [5(S)-HETE, 12(S)-HETE, an
118 PV1 (12-hydroperoxyeicosatetraenoic acid, 15-hydroxyeicosatetraenoic acid, 5-hydroxyeicosatetraenoic
120 on and of its arachidonic acid metabolite, 8-hydroxyeicosatetraenoic acid (8-HETE), are highly elevat
122 CYP4F3B converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a potent activator of prot
123 e oxidizes endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid, a renal vasoconstrictor an
124 which is converted to the end product 12(S)-hydroxyeicosatetraenoic acid, an eicosanoid that promote
125 c acid to nearly enantiomerically pure 18(R)-hydroxyeicosatetraenoic acid and 14(S), 15(R)-epoxyeicos
126 oncentrations, and that the eicosanoids 8(S)-hydroxyeicosatetraenoic acid and 15-deoxy-Delta12,14-pro
127 ice had 2.5-fold elevations in levels of 12S-hydroxyeicosatetraenoic acid and a 2-fold increase in ex
129 ated with arachidonic acid generated less 12-hydroxyeicosatetraenoic acid and more polar products rel
130 ygenase and cytochrome P450 pathway, such as hydroxyeicosatetraenoic acids and epoxyeicosatrienoic ac
131 ochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and epoxyeicosatrienoic ac
132 , whereas CYP2C55 metabolizes AA to EETs and hydroxyeicosatetraenoic acids and linoleic acid to EOAs
133 erivatives such as lipoxins, prostaglandins, hydroxyeicosatetraenoic acids and, most importantly, leu
134 oxygenase metabolites of arachidonic acid, 5-hydroxyeicosatetraenoic acid, and leukotriene B4 in part
135 oic acid, 15-hydroxyeicosatetraenoic acid, 5-hydroxyeicosatetraenoic acid, and leukotriene B4), TRPV4
136 negligible amounts of NPD1, 12(S)- and 15(S)-hydroxyeicosatetraenoic acid, and lipoxin A4 were found
137 through fibronectin was stimulated by 12(S)-hydroxyeicosatetraenoic acid, and this stimulated invasi
138 -associated metabolites prostaglandin E2, 11-hydroxyeicosatetraenoic acid, and thromboxane B2 were id
139 ipid mediators, including leukotrienes, PGs, hydroxyeicosatetraenoic acids, and lipoxins, were produc
140 quence variants in the genes that produce 20-hydroxyeicosatetraenoic acid are associated with hyperte
141 hy, the product was identified as >98% 12(R)-hydroxyeicosatetraenoic acid as opposed to the S-stereoi
142 -, and 8, 9-epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic acid as the principal reaction p
143 press 12-LOX and synthesize 12(S)- and 15(S)-hydroxyeicosatetraenoic acids as their major LOX metabol
144 io- and stereospecific manner to 16(R)-HETE (hydroxyeicosatetraenoic acid) as the major product.
145 eration of prostaglandin D(2), LTB(4), and 5-hydroxyeicosatetraenoic acid by BMMC from LTC(4)S (-/-)
147 , 9-epoxyeicosatrienoic acids and 11- and 15-hydroxyeicosatetraenoic acids (catalytic turnover, 4.5 n
148 onverts arachidonic acid to 12(S)- and 15(S)-hydroxyeicosatetraenoic acids, causes impaired cell sign
149 g neuropeptide Y, and astrocytes, through 20-hydroxyeicosatetraenoic acid, contribute to this process
150 f selected lipoxygenases products: 5-,12-,15-hydroxyeicosatetraenoic acid, cysteinyl leukotrienes, le
151 d leukotriene B(4) (LTB(4)) and decreased 5S-hydroxyeicosatetraenoic acid; decreased docosahexaenoic
152 metabotropic glutamate receptors mediate 20-hydroxyeicosatetraenoic acid-dependent vasoconstriction.
153 including the prostaglandins, leukotrienes, hydroxyeicosatetraenoic acids, epoxyeicosatetraenoic aci
154 ases in vitro, forming the novel metabolites hydroxyeicosatetraenoic acid ethanolamides and epoxyeico
155 itors of tyrosine kinase each inhibited 5(S)-hydroxyeicosatetraenoic acid formation by HL-60 cells st
157 me from the HCU-mediated induction of the 20-hydroxyeicosatetraenoic acid generating cytochrome CYP4A
158 tissues may represent a site of localized 15-hydroxyeicosatetraenoic acid generation resulting from c
159 n-treated COX-2 oxygenates 2-AG to afford 15-hydroxyeicosatetraenoic acid glycerol ester in a reactio
160 cies and of the oxidized phospholipid (C18:0/hydroxyeicosatetraenoic acid)-glycerophosphoethanolamine
161 e production and extracellular release of 15-hydroxyeicosatetraenoic acid glyceryl ester (15-HETE-G),
162 nheme cofactor) and its major metabolite 12S-hydroxyeicosatetraenoic acid have been implicated in car
164 d a marked reduction in the production of 11-hydroxyeicosatetraenoic acid (HETE) and 15(S)-HETE, in a
165 B(4), LTE(4), prostaglandin (PG)E(2), and 15-hydroxyeicosatetraenoic acid (HETE) and the mast cell me
167 thrombin stimulates synthesis of 12- and 15-hydroxyeicosatetraenoic acid (HETE) from the released ar
170 cted cells metabolize arachidonic acid to 19-hydroxyeicosatetraenoic acid (HETE) thus CYP2J9 is enzym
171 se products in this regard, since LTD4 and 5-hydroxyeicosatetraenoic acid (HETE) were unable to ampli
173 -oxo-eicosatetraenoic acid, leukotriene B4 5-hydroxyeicosatetraenoic acid (HETE), 12-HETE, and 15-HET
174 was not affected by the LTB4 precursor 5(S)-hydroxyeicosatetraenoic acid (HETE), the omega-oxidation
175 lates the synthesis of the eicosanoid, 12(S)-hydroxyeicosatetraenoic acid (HETE), whereas Sema3A-indu
179 ncrease Ca(2+)-dependent production of toxic hydroxyeicosatetraenoic acids (HETEs) and attenuate the
180 series of signaling molecules, including the hydroxyeicosatetraenoic acids (HETEs) and hydroxyoctadec
181 nstrate that proinflammatory lipids, such as hydroxyeicosatetraenoic acids (HETEs) and leukotriene B4
182 pholipid hydrolysis is then metabolized into hydroxyeicosatetraenoic acids (HETEs) through lipoxygena
183 ienoic acids (EETs); 5-, 8-, 9-, 12-, and 15-hydroxyeicosatetraenoic acids (HETEs), and 5,6-, 8,15-,
184 hydroperoxyeicosatetraenoic acids (HPETEs), hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrieno
185 re to UFP significantly increased intestinal hydroxyeicosatetraenoic acids (HETEs), including 15-HETE
186 icosatrienoic acids (EETs) and to 19- and 20-hydroxyeicosatetraenoic acids (HETEs), respectively.
189 the generation of leukotrienes versus 15(S)-hydroxyeicosatetraenoic acid in cells that possess both
190 easing production of the vasoconstrictor, 20-hydroxyeicosatetraenoic acid in the kidney of the Ephx2-
192 pport a role for renal monooxygenases and 20-hydroxyeicosatetraenoic acid in the regulation of BP and
193 he 12/15-lipoxygenase (12/15-LO) product 12S-hydroxyeicosatetraenoic acid increases monocyte adhesion
194 es by cell lysates from prostaglandins to 15-hydroxyeicosatetraenoic acid, indicating the presence of
195 rgeting the lipid peroxidation product 12(S)-hydroxyeicosatetraenoic acid-induced [12(S)-HETE-induced
196 yeicosatrienoic, dihydroxyeicosatrienoic and hydroxyeicosatetraenoic acids influences the biological
197 the following: 1) the 15-LOX2 product, 15(S)-hydroxyeicosatetraenoic acid, inhibits prostate cancer c
198 have potent vasodilatory properties while 20-hydroxyeicosatetraenoic acid is a potent vasoconstrictor
200 landins, thromboxane B(2), leukotriene B(4), hydroxyeicosatetraenoic acid isomers, and arachidonic ac
201 on and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid, its major bioactive lipid
202 the development of hypertension and CKD; 20-hydroxyeicosatetraenoic acid levels are elevated after r
207 egulated (by approximately 60-fold), whereas hydroxyeicosatetraenoic acid metabolites were decreased,
211 e prevents their formation from exogenous 15-hydroxyeicosatetraenoic acid-PE in human monocytes.
213 rface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-phosphatidylethanolamines.
214 donic acid, oleic acid, linoleic acid, or 20-hydroxyeicosatetraenoic acid, presumably due to competit
216 ase (12-LO, gene ALOX12), which catalyzes 12-hydroxyeicosatetraenoic acid production from arachidonic
218 ression of CYP4A or exogenous addition of 20-hydroxyeicosatetraenoic acid promoted M2 polarization an
220 h LXA(4), but not its metabolic precursor 15-hydroxyeicosatetraenoic acid, reduced expression of VEGF
221 either 14,15-epoxyeicosatrienoic acid nor 19-hydroxyeicosatetraenoic acid significantly improved func
222 in the production of leukotriene B(4) and 5-hydroxyeicosatetraenoic acid, significantly higher than
223 demonstrated that the PPARalpha ligand 8(S)-hydroxyeicosatetraenoic acid strongly promotes the inter
225 Cyp1b1 generated retinoic acid as well as 20-hydroxyeicosatetraenoic acid that regulated P-glycoprote
226 osatrienoic acids and vasoconstrictive 19,20-hydroxyeicosatetraenoic acid, the aim of this study was
228 ne signaling by eicosanoids, including 12(S)-hydroxyeicosatetraenoic acid, to stimulate extracellular
229 Phorbol 12-myristate 13-acetate and 12(S)-hydroxyeicosatetraenoic acid, two activators of protein
230 d mediators [lipoxin A4 and 15(S)- and 12(S)-hydroxyeicosatetraenoic acids] under these conditions an
231 ate a 4-fold increase in the formation of 20-hydroxyeicosatetraenoic acid was measured along with a 3
232 a-1 hydroxylase activity (formation of 20/19-hydroxyeicosatetraenoic acid) was detected at 10 weeks a
234 , and 14,15-epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid when reconstituted with adr
235 lipoxygenase protein and biosynthesize 12(S)-hydroxyeicosatetraenoic acid, which correlates with thei
236 lved remain controversial, especially for 20-hydroxyeicosatetraenoic acid, which has both vasoconstri
237 ous eicosanoids that were tested, only 12(S)-hydroxyeicosatetraenoic acid, which signals through the
238 ites formed via LO, 5(S)-, 12(S)-, and 15(S)-hydroxyeicosatetraenoic acids, which activate p38 MAPK,