ライフサイエンスコーパス: hydroxylate

1 type IV collagen, these sites are normally 3-hydroxylated.

2 vel annulation reaction for the synthesis of hydroxylated 1,3-cyclohexadiones in a single step.

3 and regioselective synthesis of a series of hydroxylated 1-methylphenanthrenes 9 by a combined direc

4 (with catalytically competent kinetics) plus hydroxylated 17alpha-hydroxysteroids.

5 of the still-bioactive primary photoproduct hydroxylated 17alpha-TBOH, produced via phototransformat

6 f these cytochrome P450s had the capacity to hydroxylate 4-coumaroyl shikimate or 4-coumaroyl quinate

7 factor for Tet methylcytosine dioxygenase to hydroxylate 5-mC.

8 ished by esterification or etherification of hydroxylated 5alpha/beta-pregnane-3,20-dione or 5beta-ch

9 mediate a wide variety of cellular events by hydroxylating a growing list of protein substrates.

10 phosphoryl-1,4-dioxobutane) (DOB) and the C4-hydroxylated abasic site (C4-AP), are formed reversibly.

11 resent in carbohydrates, amino alcohols, and hydroxylated acyclic compounds in good to excellent yiel

12 we demonstrate that sphingolipids with alpha-hydroxylated acyl-chains of at least 24 carbon atoms are

13 Besides interconversion of hydroxylated acyl-CoA esters, wild-type HCM as well as H

14 o extract the information on unsaturated and hydroxylated acylcarnitine species, amines, and purine a

15 iopinines and pseudoargiopinines I and II, N-hydroxylated Agel-489 and Agel-505, as well as N-methyla

16 ppel-Lindau protein (pVHL) bound directly to hydroxylated Akt and inhibited Akt activity.

17 hat exhibits low swelling, attributed to the hydroxylated alkyl side-chain functionalization.

18 f the VHL E3 ubiquitin ligase, which targets hydroxylated alpha subunit of hypoxia inducible factors

19 termediate that, in the case of AlkB, slowly hydroxylates an alkylated nucleobase.

20 o the discovery of the biologically active 2-hydroxylated analogue and 3-hydroxylated metabolite, thu

21 measured postbioremediation is likely due to hydroxylated and carboxylated transformation products of

22 Finally, comparing the gas adsorption of hydroxylated and dehydroxylated UiO-66, we found that th

23 k-etched nanopores in polymer membranes, and hydroxylated and functionalized nanoporous silica.

24 phous water are found to coexist at adjacent hydroxylated and hydroxyl-free domains of the moire stru

25 xynitrite, however, decayed to radicals that hydroxylated and nitrated other active-site residues (Tr

26 19:0 metabolite was formed by CYP4F2 and one hydroxylated and one carboxylated C19:0 were tentatively

27 ther arginine residue in the PSST subunit is hydroxylated and probably lies near to the quinone.

28 Oxidation of PCBs, especially to di-hydroxylated and quinone metabolites, was associated wit

29 affinities for a group of LC-PCBs and their hydroxylated and sulfated derivatives by selective displ

30 he amounts of nonpolar, aliphatic, aromatic, hydroxylated and sulfur-rich amino acids were higher in

31 d (methylated, glycosylated, phosphorylated, hydroxylated), and labeled (fluorinated, isotopically la

32 nohydroxylated, dihydroxylated, methoxylated-hydroxylated, and methoxylated-dihydroxylated metabolite

33 emperature-programmed desorption on reduced, hydroxylated, and oxidized rutile TiO2(110) surfaces.

34 ain, medium-chain, long-chain, dicarboxylic, hydroxylated, and unsaturated acyl moieties) were used t

35 Several acetylated, hydroxylated, and/or sulfated metabolites were identifie

36 JBP1 then binds to J and hydroxylates another T 13 bp downstream (but not upstrea

37 primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their correspon

38 The corresponding quinones or hydroxylated arenes were obtained in moderate to good yi

39 -hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epi

40 of PLN, interacts with PHD2 and PHD3 and is hydroxylated at 2 proline residues.

41 We show that catechol estrogens, hydroxylated at positions C2 and C4 of the steroid A rin

42 12alpha-Hydroxylated BAs (12HBAs) are altered in multiple diseas

43 e (IR) was associated with increased 12alpha-hydroxylated BAs (cholic acid, deoxycholic acid, and the

44 , ratios of 12alpha-hydroxylated/non-12alpha-hydroxylated BAs were associated with key features of IR

45 bserve disproportionate increases in 12alpha-hydroxylated BAs.

46 ARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the

47 rons, where 6-OH-BDE-47 and another specific hydroxylated BDE metabolite similarly impaired phosphory

48 nt SB paired mainly with oleic acid (C18:1), hydroxylated behenic acid (C22:0;1) and hydroxylated lig

49 with the model compound catechol and further hydroxylated benzenes were performed to examine a common

50 es, benzonitriles, phenols, methoxylated, or hydroxylated benzoic acids, pyridines, thiophenes, furoi

51 Apart from 1,4-diketones and alpha-hydroxylated beta-oxoesters formed as byproducts, the yi

52 ul synthons for the synthesis of chiral beta-hydroxylated, beta-fluorinated, and beta-arylated carbox

53 VHL mutants fail to bind hydroxylated BIM-EL, regardless of whether they have the

54 mation, the regioselective oxidation of 8,8'-hydroxylated binaphthols to binaphtho-para-quinones, and

55 lly applied on several sensitive and complex hydroxylated bioactive compounds including 7-deacetylaza

56 e) was used to identify two novel isomers of hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-T

57 Highly hydroxylated block copolymer worms are shown to be a sui

58 se revises previous literature hypotheses of hydroxylated BN edges as the active component on h-BN.

59 PMO3s hydroxylate both C1 and C4.

60 ad of d-Val, l-Lys, and l-allo-Ile) and is a hydroxylated brunsvicamide.

61 for binding, and may explain why only 3beta-hydroxylated bufadienolides are present as a toxic chemi

62 counterparts, Skp1 from Toxoplasma gondii is hydroxylated by an O2-dependent prolyl-4-hydroxylase (Ph

63 The HIFalpha subunit is usually prolyl-hydroxylated by EglN family members under normoxic condi

64 BIM-EL, a proapoptotic BH3-only protein, is hydroxylated by EglN3 and subsequently bound by VHL.

65 A1 site in type I collagen is exclusively 3-hydroxylated by P3H1, and presumably, this enzyme is req

66 he CMGC insert of the DYRK1 kinase domain is hydroxylated by PHD1, and this event precedes tyrosine a

67 ver 50% of GalCer and sulfatide in myelin is hydroxylated by the integral membrane enzyme fatty acid

68 We found that Akt was prolyl-hydroxylated by the oxygen-dependent hydroxylase EglN1.

69 which are class III GA 2-oxidases that 2beta-hydroxylate C(20)-GAs.

70 Hydroxylated C(13)-apocarotenol substrates were produced

71 t two different carbon centers, and CYP76AK1 hydroxylates C-20 of two of the resulting intermediates.

72 A subgroup of PMO3s (PMO3*) hydroxylate C1.

73 iral glycosphingolipids, composed of unusual hydroxylated C17 sphingoid bases (t17:0) were highly enr

74 One hydroxylated C19:0 metabolite was formed by CYP4F2 and o

75 carrier protein but can either chlorinate or hydroxylate C4 and (ii) two bifunctional enzymes that no

76 appended to the carrier protein, SyrB1, but hydroxylates C5 of l-norvaline and, to a lesser extent,

77 (i) the halogenase SyrB2, which exclusively hydroxylates C5 of norvaline appended to its carrier pro

78 When the rate drops, the amount of hydroxylated Ca3SiO5 decreases, thus demonstrating the p

79 rome P450cam (CYP101Fe(3+)) regioselectively hydroxylates camphor.

80 H oxygenations to provide cyclic carbonates, hydroxylated carbamates, or 1,2-diols.

81 teps involve the successive oxidation of the hydroxylated carbon 1 to give a carboxylic group by TcAD

82 ormula: see text], leading to the specific 2-hydroxylated cationic products.

83 binoids and N-acyl ethanolamides, and 21 non-hydroxylated ceramides and sphingoid bases, several demo

84 therapeutically useful synthetic mimics) and hydroxylated cholesterol derivatives (oxysterols); Smo i

85 0 27A1 (CYP27A1) is a ubiquitous enzyme that hydroxylates cholesterol and other sterols.

86 e P450 reductase as a donor of electrons and hydroxylates cinnamic acid to form 4-coumaric acid in ph

87 n) mouse eye tissues was significantly under-hydroxylated compared with their wild-type littermates.

88 e b5 (CYB5), it catalyzes the reduction of N-hydroxylated compounds such as amidoximes.

89 Both molybdoenzymes reduce a variety of N-hydroxylated compounds.

90 For instance, the existence of hydroxylated CTTs (OH-CTTs) in authentic environmental a

91 ormation of a highly reactive OH radical and hydroxylated cysteine.

92 ral role of CYP735A1/2 in synthesizing trans-hydroxylated cytokinins, which specify shoot growth, vit

93 that it is an SaOhyA substrate and that its hydroxylated derivative is not antimicrobial.

94 bolize polychlorinated biphenyls (PCBs) into hydroxylated derivatives (OH-PCBs), which are sometimes

95 C-C activation of cyclobutanols resident in hydroxylated derivatives of pinene, which proceed in a c

96 associated with levels of 19 sterols and 25-hydroxylated derivatives of vitamin D (P < 10(-7)).

97 ar Mn(II) complex with ((H)O)L-L(OH) and its hydroxylated derivatives.

98 igated during the production of their 1alpha-hydroxylated derivatives.

99 onounsaturated fatty acids into mono- and di-hydroxylated derivatives.

100 peracid, and other directed epoxidations of hydroxylated dienes.

101 This study determined that hydroxylated docosahexaenoic acid metabolites (HDoHEs) a

102 pproach led to the structural elucidation of hydroxylated docosapentaenoic acid-containing diacyl-pho

103 lethality involves the interaction of non-3-hydroxylated embryonic type IV collagen with the materna

104 I) by a terminal histidine residue in copper hydroxylating enzymes activates dioxygen to form unknown

105 ha, showed a severe defect in binding prolyl hydroxylated EPOR peptides.

106 Nevertheless, branched hydroxylated esters, such as ethyl 2-hydroxy-3-methylbut

107 low extent, but also accepted an artificial hydroxylated fatty acid and low amounts of kaempferol.

108 ds were further esterified by long (omega-1)-hydroxylated fatty acids comprising 26-34 carbon atoms.

109 the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids

110 cture, the number of ester-linked long chain hydroxylated fatty acids, as well as the presence of a t

111 The oxidation of hydroxylated fatty acids, such as the conversion of pros

112 The so formed Cpd I subsequently hydroxylates fatty acids at their alpha-position with S-

113 h isopropyl 2-iodoxybenzoate to give the C-F hydroxylated Fe(III)-OAr products.

114 te- and iron(II)-dependent dioxygenases that hydroxylate four sp(3) carbons; one flavin-dependent deh

115 Here we report that EglN2 can hydroxylate FOXO3a on two specific prolyl residues in vi

116 Failure to hydroxylate FOXO3a promotes its accumulation in cells, w

117 Water-soluble, hydroxylated fullerene (fullerol) materials have recentl

118 ral product comprising a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 6'-amino-ps

119 Ov TAG estolides contain two non-hydroxylated, glycerol-bound fatty acids (FAs) and one d

120 PMO1s and PMO2s hydroxylate glycosidic positions C1 and C4, respectively

121 ough 12 O-H...O hydrogen bonds to the [L](-) hydroxylate groups.

122 es single-stranded target sequences using 5'-hydroxylated guide RNAs rather than the 5'-phosphorylate

123 class with noncanonical specificity for a 5'-hydroxylated guide.

124 l halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

125 f prolyl hydroxyl dioxygenase enzymes, which hydroxylate HIF-1alpha and HIF-2alpha to destabilize HIF

126 Furthermore, albumin reduced the level of hydroxylated HIF-1alpha, indicating an inhibition of the

127 ading to selective on-target accumulation of hydroxylated HIF-alpha in a concentration- and time-depe

128 a 2-oxoglutarate-dependent dioxygenase that hydroxylates HIF-1alpha and targets it for recognition b

129 ess of whether they have the ability to bind hydroxylated HIFalpha or not.

130 etoglutarate-dependent enzymes (IbetaH(His)) hydroxylates histidyl residues with l-threo stereospecif

131 reliable method for the synthesis of B-ring hydroxylated homoisoflavonoids and 3-hetarylmethyl chrom

132 ice deficient in prolyl hydroxylase 2, which hydroxylates hypoxia-inducible factor-1alpha, rescued th

133 unmodified OLs, a variety of OL derivatives hydroxylated in different structural positions has been

134 5-hydroxyvitamin D species, and then further hydroxylated in the kidney to various dihydroxyvitamin D

135 y calculations provide insights into why the hydroxylated intermediate undergoes an aldol-like phenox

136 biosynthesis can occur through the transient hydroxylated intermediate.

137 Metabolomic analysis identified two hydroxylated intermediates as well as a glucuronidated h

138 Thus, formation of prolyl-hydroxylated intermediates is a novel mechanism of kinas

139 whether they suppress hydroxylation or form hydroxylated intermediates on the pathways to other outc

140 rmore, abnormal MAs, likely generated from 3-hydroxylated intermediates, accumulated.

141 on that controls the configuration at C-5 of hydroxylated intermediates.

142 Possible hydroxylating intermediates in the catalytic cycle of th

143 The interplay between hydroxylated interphase on the surface and the unique bi

144 citor electrode material with a well-ordered hydroxylated interphase.

145 monolayer islands form on the bare film, the hydroxylated iron oxide film acts as a hydrophilic nanot

146 In particular, the enzyme that hydroxylates JA to 12-OH-JA, an inactive form of JA that

147 Human phenylalanine hydroxylase (hPAH) hydroxylates L-phenylalanine (L-Phe) to L-tyrosine, a pr

148 by solvent immersion, which deprotonates the hydroxylated LAO surface; interface conductivity is rest

149 :1), hydroxylated behenic acid (C22:0;1) and hydroxylated lignoceric acid (C24:0;1).

150 UVR produces vitamin D in skin, which is hydroxylated locally to 1alpha,25-dihydroxyvitamin D(3)

151 g more superoxide and hydrogen peroxide than hydroxylated Lys.

152 dependent oxygenase Jmjd6 has been shown to hydroxylate lysine residues in the essential splice fact

153 However, SidA is also able to hydroxylate lysine with lower efficiency.

154 antly diminished HLCCs and increased the non-hydroxylated lysine-aldehyde-derived collagen cross-link

155 agen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residues in collagen telopeptides an

156 l hydroxylase (LH) isoform that specifically hydroxylates lysine residues in collagen telopeptides, a

157 s formed is biologically important, as the 4-hydroxylated metabolite is carcinogenic, whereas the 2-h

158 ed metabolite is carcinogenic, whereas the 2-hydroxylated metabolite is not.

159 gically active 2-hydroxylated analogue and 3-hydroxylated metabolite, thus providing strategically pl

160 radation by Sphingobium sp. BiD32 detected a hydroxylated metabolite.

161 3',6,6'-hexachlorobiphenyl (PCB 136) and its hydroxylated metabolites (HO-PCBs) in mice with defectiv

162 Their hydroxylated metabolites (OH-PCBs) are also potentially

163 enyl ring is expected to form axially chiral hydroxylated metabolites (OH-PCBs); however, the formati

164 PBDEs and their hydroxylated metabolites appear to primarily target the

165 Some of these hydroxylated metabolites are chiral, and chiral compound

166 The primary hydroxylated metabolites formed from atRA by CYP26A1, an

167 Also detected were two polybrominated hydroxylated metabolites having polybenzofuran structure

168 d hydrazine drugs and the O-acetylation of N-hydroxylated metabolites of aromatic and heterocyclic am

169 nti-miR-23b also significantly increased the hydroxylated metabolites of BDE47 (3-OH-BDE47, 4-OH-BDE4

170 Synthetic analogs and hydroxylated metabolites of efavirenz enhance CYP46A1 ac

171 /z 353 and 355 are proposed to correspond to hydroxylated metabolites of glyceollins, wherein the lat

172 PCB3) has been proven to be transformed into hydroxylated metabolites of PCB3 (OH-PCB3s) in whole pop

173 However, hydroxylated metabolites of PCBs, including OH-PCB3s, as

174 Hydroxylated metabolites of polychlorinated biphenyls (O

175 Some POPs, i.e., hydroxylated metabolites of polychlorinated biphenyls (O

176 of function resulted in the accumulation of hydroxylated metabolites upon exposure to PCB-153, leadi

177 endazole and its sulphoxide, sulphone, and p-hydroxylated metabolites was carried out isocratically w

178 No hydroxylated metabolites were present in incubations wit

179 on of the exocyclic amine group to produce N-hydroxylated metabolites, which are critical intermediat

180 was highly selective for BDE-47 and selected hydroxylated metabolites.

181 nic activity contained hetero-PAHs and their hydroxylated metabolites.

182 bolism of PCB 95 and PCB 136 and formed meta-hydroxylated metabolites.

183 brominate or stereoisomerize, but formed two hydroxylated metabolites; ss- and gamma-HBCD were both e

184 his regard, having an outstanding ability to hydroxylate methane rapidly at room temperature to form

185 conversion to Q, the diiron(IV) oxidant that hydroxylates methane.

186 r and iron zeolites are remarkably reactive, hydroxylating methane and benzene selectively at low tem

187 136, and 153 and their relevant metabolites (hydroxylated, methoxylated, sulfated, and quinone)] in c

188 Peptidylglycine alpha-hydroxylating monooxygenase (PHM) and dopamine beta-mono

189 separation of soluble peptidylglycine alpha-hydroxylating monooxygenase from membrane-associated PAL

190 Peptidylglycine alpha-hydroxylating monooxygenase is a noninteracting bicopper

191 of its monooxygenase (peptidylglycine alpha-hydroxylating monooxygenase) and lyase (peptidyl-alpha-h

192 beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase.

193 N-Hydroxylating monooxygenases are involved in the biosynt

194 lic health through a novel poly(eosin Y, EY)/hydroxylated multi-walled carbon nanotubes composite mod

195 has been shown that JMJD6 interacts with and hydroxylates multiple serine/arginine-rich (SR) proteins

196 I chains, whereas P3h2 is responsible for 3-hydroxylating multiple proline sites in collagen types I

197 oxygenase-like (HO-like) domain sequentially hydroxylates N(delta) and N(omega)' of l-NMA.

198 Furthermore, ratios of 12alpha-hydroxylated/non-12alpha-hydroxylated BAs were associate

199 ifunctional cytochrome P450 monooxygenase, a hydroxylating nonheme-iron-dependent dioxygenase, and an

200 N-Hydroxylated nucleobases and nucleosides as N-hydroxylam

201 rential reactivity of 2'-O-methylated and 2'-hydroxylated nucleosides to periodate oxidation to devel

202 Hydroxylated (OH-) and methoxylated (MeO-) polybrominate

203 show that erythropoietin receptor (EPOR) is hydroxylated on proline 419 and 426 via prolyl hydroxyla

204 (ii) two bifunctional enzymes that normally hydroxylate one carbon before coupling that oxygen to a

205 rs to form different but overlapping sets of hydroxylated or epoxidized products.

206 been shown to regulate cellular processes by hydroxylating or demethylating histone and non-histone t

207 ip between the structure and fluctuations of hydroxylated organic surfaces and the temperature at whi

208 SidA selectively hydroxylates ornithine to produce N(5)-hydroxyornithine.

209 efective in pdoA2, encoding an aromatic ring-hydroxylating oxygenase (RHO).

210 about the functions and the biosynthesis of hydroxylated oxylipins remains scarce.

211 Biliary metabolites included the hydroxylated PAH metabolites (OH-PAHs) 1-naphthol, 2-nap

212 ucts (PAH-TPs) are nitrated, oxygenated, and hydroxylated PAHs (NPAHs, OPAHs, and OHPAHs, respectivel

213 ther, our results support that certain ortho-hydroxylated PBDE metabolites are promiscuous kinase inh

214 urrence of very low levels or the absence of hydroxylated PBDE metabolites in the cats.

215 re to 6-OH-BDE-47, one of the most prevalent hydroxylated PBDE metabolites, suppresses both spontaneo

216 09), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and 2,4,6-TBP in order to

217 Ps), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and perfluorinated compou

218 ase inhibitors, we hypothesized that certain hydroxylated PBDEs mediate neurotoxicity, at least in pa

219 ate, halogenated bisphenols and phenols, and hydroxylated PBDEs were found to be potent PPARgamma lig

220 in containing protein EGLN3 (or PHD3), which hydroxylates PC1.

221 ue to species-dependent oxidation of PCBs to hydroxylated PCB metabolites (OH-PCBs).

222 Traces of para-hydroxylated PCB metabolites were detected in incubation

223 sting the sequential transformation of these hydroxylated PCB3 metabolites into PCB3 sulfates in whol

224 summation operatorPCBs = 45 ng/g lw) and 12 hydroxylated PCBs (median summation operatorOH-PCBs = 0.

225 Sera were analyzed for all 209 PCBs and 4 hydroxylated PCBs (OH-PCBs).

226 recapitulated with an equimolar mixture of a hydroxylated peptide and the deletion variant.

227 Hydroxylated peptides of 15 and 27 amino acid residues w

228 ion of 1-methylpyrene generated the benzylic hydroxylated phase I product, 1-pyrenecarboxylic acid th

229 ynthetase (PheRS) proofreads the non-protein hydroxylated phenylalanine derivative m-Tyr after its at

230 nabled by the selective C-C bond cleavage of hydroxylated pinene derivatives obtained from carvone.

231 Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) a

232 active natural brominated compounds, such as hydroxylated polybrominated diphenyl ethers (OH-PBDEs),

233 this work, the aminated aptamer selected for hydroxylated polychlorinated biphenyl (OH-PCB) was coval

234 Hydroxylated polychlorinated biphenyls (OH-PCBs) were me

235 Concentrations of 12 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs)

236 asil (Ocimum basilicum L.) cultivars readily hydroxylate position 6 of 7-O-methylated apigenin but no

237 endent monooxygenase Coq6, which is known to hydroxylate position C5, also deaminates position C4 in

238 Here, we demonstrate that hydroxylated-PQ metabolites (OH-PQm) are responsible for

239 h Arthrobacter, suggesting that formation of hydroxylated PQS may be a common mechanism of inactivati

240 ated by a unique pentasaccharide attached to hydroxylated Pro-143 within its C-terminal F-box-binding

241 ficient oxidation of a range of C-H bonds to hydroxylated products in one reaction vessel with only w

242 LC-HRMS/MS analysis identified a range of hydroxylated products that were no longer photoactive, w

243 rm 16-hydroxylation reactions on its 17alpha-hydroxylated products to yield 16,17alpha-dihydroxypregn

244 oglutarate that, under normoxia, selectively hydroxylate proline residues of HIF, initiating proteoso

245 studies revealed that P3h1 preferentially 3-hydroxylates proline at a single site in collagen type I

246 droxylase that regio- and stereospecifically hydroxylates proline residues in a peptide chain into R-

247 y re-expressing WT but not ChREBP that lacks hydroxylated prolines in ChREBP-deleted hepatocytes.

248 Functionally, we found that specific hydroxylated prolines were dispensable for protein stabi

249 ded a waste-free method for the synthesis of hydroxylated propargylamines which are versatile precurs

250 results in the formation of polyphenols and hydroxylated quinones.

251 The C21-hydroxylated (rebound) product, which undergoes deprenyl

252 The silanols can be hydroxylated (regenerated) to their original state upon

253 oxygenases (group V) from the prototype ring-hydroxylating Rieske oxygenases involved in bioremediati

254 ty for, and forms a stable complex with, the hydroxylated RPS23 substrate.

255 As reported for other vegetables, a hydroxylated SB was observed whereby the N-acyl chains s

256 Ceres' dry exterior displays hydroxylated silicates, including ammoniated clays of en

257 hould be slower than to the adjacent, solely hydroxylated site.

258 sing performance originates from UVO-derived hydroxylated species on the dielectric surface and not f

259 ral packing relative to common saturated and hydroxylated species.

260 trong triplet excited state sensitizers from hydroxylating species such as hydroxyl radical ((*)OH) p

261 ence exists for hydroxyl radical ((*)OH) and hydroxylating species.

262 ins (PHDs), which use O(2) as a substrate to hydroxylate specific prolyl residues on hypoxia inducibl

263 Indeed, direct genetic perturbation of the hydroxylated sphingolipid metabolism modulated rhabdomer

264 a correlation between increased abundance of hydroxylated sphingolipids and abnormal rhabdomeric grow

265 In particular, altered biosynthesis of hydroxylated sphingolipids impaired apical trafficking v

266 pids and phospholipids are predominantly non-hydroxylated, sphingolipids are typically dihydroxylated

267 Prolyl hydroxylase domain proteins hydroxylate substrate proline residues and have been lin

268 metabolites of PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and glucuronidated PCMC) we

269 Four new metabolites of PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and

270 ures of the two compounds were identified as hydroxylated TBPH with a hydroxyl group on the aromatic

271 showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptidyl lysine residues on collagen, s

272 droxylase enzyme that was initially found to hydroxylate the HIF-alpha, preventing its transcriptiona

273 (II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFalpha subunit, facilitating its prote

274 gobium aromaticivorans DSM 12444 is found to hydroxylate the methyl group of a range of methylcubane

275 on encountering deuterium at the first site, hydroxylate the second site instead.

276 adical abstracts a hydrogen and subsequently hydroxylates the substrate via an oxygen-rebound mechani

277 ting bicopper enzyme that stereospecifically hydroxylates the terminal glycine of small peptides for

278 PHD site specifically prolyl hydroxylates the transcription factor HIF-alpha, thereby

279 ty and selectivity are also attained by meta hydroxylating the 3-pyridyl and the phenyl ethers of (S)

280 tion of the PHD2 isoform, preventing it from hydroxylating the transcription factor hypoxia inducible

281 ere previously underestimated, as they might hydroxylate their--so far unknown--natural substrates in

282 al mid- to long-chain fatty acids, typically hydroxylating these lipids at the omega-1, omega-2 and o

283 We report the SAR evolution of hydroxylated thienopyrimidinone ethers culminating in th

284 esis is initiated by the JBP1/2 enzymes that hydroxylate thymine, forming 5-hydroxymethyluracil (hmU)

285 A monolayer of water on the hydroxylated TiO(2) surface increased the H(2) dissociat

286 I) 2 O2 species, where the bonded phenolates hydroxylate to catecholates in high yields.

287 (i) HNA is omega-hydroxylated to 4,9-dihydroxynonanoic acid, which is sub

288 ato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different meta

289 A variety of compounds, namely TPHP, hydroxylated TPHP and RDP (meta-HO-TPHP and meta-HO-RDP)

290 TxtC was shown to hydroxylate two remote sites within the Phe residue of i

291 These results indicate that TxtC is able to hydroxylate two spatially remote sites by binding distin

292 that the interaction between GPVI and non-3-hydroxylated type IV collagen might also play a role in

293 BC enzyme complex of Escherichia coli, which hydroxylates tyrosol into HT.

294 This finding is of great importance because hydroxylated UiO-66 is the practically more relevant, no

295 O)(OAc)(PyNMe3)](2+) (2b) species capable of hydroxylating unactivated alkyl C-H bonds with stereoret

296 We further show that BaP4H can hydroxylate unique peptidyl proline sites in collagen-de

297 f DIMs with the PM showed an enrichment of 2-hydroxylated very-long-chain fatty acid-containing GIPCs

298 e hydroxylase, a cytochrome P450 enzyme that hydroxylates vinorine to form vomilenine, which was foun

299 e oxidations, the designed methylcubanes are hydroxylated with high efficiency and selectivity, givin

300 ted flavones except cirsimaritin, which is 8-hydroxylated with less than 0.2% relative activity.