ライフサイエンスコーパス: hydroxylation

1 m singular transformations (for example, C-H hydroxylation).

2 e that help bias substrate desaturation over hydroxylation.

3 e leucine isomers and catalyze regiospecific hydroxylation.

4 coordination of an additional ligand during hydroxylation.

5 ce, next-generation catalyst systems for C-H hydroxylation.

6 rects opposite stereoselectivity of Asp beta-hydroxylation.

7 using conditions supporting robust HIF-alpha hydroxylation.

8 (3-fold) in CYP46A1-mediated cholesterol 24-hydroxylation.

9 icient cells and accompanied by its enhanced hydroxylation.

10 y retained high preferences for octane omega-hydroxylation.

11 with the observed regio- and stereoselective hydroxylation.

12 isotope effect for 3-hydroxylation but not 4-hydroxylation.

13 urface termination and the extent of surface hydroxylation.

14 ed reducing equivalents to support substrate hydroxylation.

15 ning the terminal carbon of octane for omega-hydroxylation.

16 several peroxygenases that favor fatty acid hydroxylation.

17 te that contribute to a preference for omega-hydroxylation.

18 es chlorination effectively competitive with hydroxylation.

19 e generated ferryl species to catalyze l-Arg hydroxylation.

20 se component and an indication of HIF-1alpha hydroxylation.

21 th a unique tricopper cluster as the site of hydroxylation.

22 ic switching, with no observable effect on 4-hydroxylation.

23 D2 to the HSP90 pathway to promote HIF-alpha hydroxylation.

24 ttranslational modifications, such as lysine hydroxylation.

25 (HAA) of substrate C-H bonds and subsequent hydroxylation.

26 might be responsible for the observed arene hydroxylation.

27 ing of the pro-S C-H bond, thus preferring R hydroxylation.

28 d that this process is controlled by surface hydroxylation.

29 f constituent benzene rings, methylation and hydroxylation.

30 eaction starts with an Fe(IV) -oxo-catalyzed hydroxylation.

31 HIF1 (FIH1)- and oxygen-dependent asparagine hydroxylation.

32 tom and the highest chance to follow rebound hydroxylation.

33 r rs384467435 SNV showed a reduced TST 6beta-hydroxylation.

34 ylase and the NRPS-bound amino acid prior to hydroxylation.

35 el via a mechanism requiring ADSL proline 24 hydroxylation.

36 brafish P450 17A2 catalyzes only the 17alpha-hydroxylations.

37 JDBD specifically to J-DNA can facilitate T hydroxylation 12-14 bp downstream on the complementary s

38 on pathway metabolites, or in the ratio of 2-hydroxylation:16-hydroxylation pathway metabolites, were

39 nt include an enantioselective enolate alpha-hydroxylation, a diastereoselective hydroboration-oxidat

40 Mutation of the hydroxylation acceptor proline precludes tyrosine autoph

41 hol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation

42 romote mTORC1 activity is independent of its hydroxylation activity but is caused by decreased protei

43 rate to produce norwogonin, although minor 6-hydroxylation activity can also be detected.

44 We describe here a so far unknown Pro hydroxylation activity which occurs in active sites of p

45 These results indicating that Pio hydroxylation affects its potency and efficacy as a PPAR

46 Protein hydroxylation affects protein stability, activity, and i

47 BOA-Glc) by an uncommon reaction involving a hydroxylation and a likely ortho-rearrangement of a meth

48 The enzyme catalyzes both 17alpha-hydroxylation and a subsequent 17alpha,20-lyase reaction

49 o the discovery of enhanced flavonoid B-ring hydroxylation and an increased proportion of prodelphini

50 s effect is the result of an increase in the hydroxylation and degradation of the transcription facto

51 or alternariol monomethyl ether (AME)) while hydroxylation and glucuronidation had the opposite effec

52 nsights on the relative influence of surface hydroxylation and hydrate precipitation on the hydration

53 ivity in differentially blocking the 17alpha-hydroxylation and lyase activities of the enzyme.

54 ed in detail the processivity of the 17alpha-hydroxylation and lyase steps.

55 We quantified products of ring hydroxylation and oxidation of alkyl substituents as wel

56 Tyrosinases catalyze theo-hydroxylation and oxidation of phenolic compounds, where

57 SSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation, and thus enha

58 ion with two model compounds reconfirmed the hydroxylation and ring cleavage of DOM by HO(.) attack d

59 n internalization via O(2)-dependent proline hydroxylation and subsequent ubiquitination by an E3 ubi

60 Thus, hydroxylation and sulfation of LC-PCBs result in selecti

61 er, the proline residue of DYRK1 targeted by hydroxylation and the role of prolyl hydroxylation in ty

62 IP5 promotes HIF-1alpha prolyl hydroxylation and thus pVHL-dependent degradation of HIF

63 IP5 acts by enhancing HIF-1alpha hydroxylation and thus pVHL-dependent degradation of HIF

64 is increased in hypoxia via reduced proline hydroxylation and, hence, inefficient degradation by the

65 acid are directly employed in photocatalyzed hydroxylations and nitrohydroxylations of benzenes.

66 undant yet understudied PTMs such as proline hydroxylation, and its unexpected association with cance

67 m photodegradation and formed by hydrolysis, hydroxylation, and N-acylation as well as three new meta

68 100(Fe) convert propane via dehydrogenation, hydroxylation, and overoxidation pathways in reactions w

69 of recombinant AspH-catalyzed cyclic peptide hydroxylation appears to reflect levels of EGFD hydroxyl

70 -site residues constraining octane for omega-hydroxylation are conserved in family 4 P450s.

71 yer-Villiger rearrangement, epoxidation, and hydroxylation are included, and biological advancements

72 The effects of hydroxylation are stereospecific; replacement of ProB28

73 Here, we identify asparagine hydroxylation as a novel posttranslational modification

74 ctive bacterial enzyme capable of fatty acid hydroxylation at a >3,000 min(-1) turnover rate.

75 we report that ChREBP is modified by proline hydroxylation at several residues.

76 of these modifications are species-specific, hydroxylation at the C3(2) position is commonly found in

77 t iron-2OG enzymes perform a radical rebound hydroxylation at the site of the H-atom abstraction (HAA

78 ytochrome P450s play key roles in fatty acid hydroxylation at the terminal, or omega, carbon, but the

79 oduced a strong kinetic isotope effect for 3-hydroxylation but not 4-hydroxylation.

80 e investigated pathways for desaturation and hydroxylation by an iron(IV)-oxo active-site model.

81 binding protein 1 (OTUB1) is a substrate for hydroxylation by FIH on N22.

82 ir effect on CYP27A1-mediated cholesterol 27-hydroxylation by in vitro enzyme assay.

83 -protein interaction downstream of HIF-alpha hydroxylation by PHD enzymes.

84 A and 1B (DYRK1A and DYRK1B) requires prolyl hydroxylation by PHD1 prolyl hydroxylase.

85 bserved for inhibition of testosterone 6beta-hydroxylation by ritonavir and indinavir.

86 We monitored their hydroxylation by solid-phase extraction coupled to MS.

87 cid substrate and its enantio/regioselective hydroxylation by the active species of the enzyme, Compo

88 ta-OHAsp residues of alterobactin arise from hydroxylation by the beta-hydroxylase domain integrated

89 ies raised the question of whether substrate hydroxylation by these enzymes occurs via a hydroxyl reb

90 Observations that HIFalpha hydroxylation can be impaired even when oxygen is suffic

91 ional processing of collagen requires prolyl hydroxylation, catalyzed by collagen prolyl 3-hydroxylas

92 elation of atRA metabolism with testosterone hydroxylation, clearance of atRA in the fetal livers was

93 ut displays a 15-fold lower apparent rate of hydroxylation compared with JBP1.

94 For outcomes other than hydroxylation, coupling of the resultant carbon radical

95 Collagen prolyl hydroxylation (CPH), which is catalyzed by prolyl 4-hydr

96 tion of TBECH via cyctochrome P450-catalyzed hydroxylation, debromination, and alpha-oxidation.

97 ation at C-4 produced a 4-fold increase in 3-hydroxylation due to metabolic switching, with no observ

98 nock-out mice revealed a common lysine under-hydroxylation effect at helical domain cross-linking sit

99 CYP27A1 and had Ki values for cholesterol 27-hydroxylation either in the submicromolar (clevidipine,

100 echanism that synergized J recognition and T hydroxylation, ensuring inheritance of base J in specifi

101 s, and sulfoxides through bioelectrochemical hydroxylation, epoxidation, sulfoxidation, and demethyla

102 Biocatalysts that perform C-H hydroxylation exhibit exceptional substrate specificity

103 emoselective, remote, nondirected C(sp(3))-H hydroxylation followed by aminocyclization.

104 e to scopolamine via two separate reactions: hydroxylation followed by oxidative cyclization.

105 BbdD catalyzes a second hydroxylation, forming 2,6-dichloro-3,5-dihydroxybenzoic

106 The full extent of proline (Pro) hydroxylation has yet to be established, as it is largel

107 itional steps of modification, including Pro hydroxylation, Hyp glycosylation, and/or Tyr sulfation.

108 O(MeAN)-RPhO(-) species that leads to ortho-hydroxylation in a tyrosinase-like fashion and (ii) addi

109 Our findings highlight the role of ADSL hydroxylation in controlling cMYC and TNBC tumorigenesis

110 Our studies show that surface hydroxylation in CSP does not inhibit crystallization; i

111 s that favor decarboxylation over fatty acid hydroxylation in OleTJE could enable protein engineering

112 rt a three-enzyme cascade affording C7 alpha-hydroxylation in PTM and PTN biosynthesis.

113 rences in the role of prolyl and asparaginyl hydroxylation in regulating hypoxia-responsive genes in

114 le for posttranslational modification by Pro hydroxylation in the regulation of CLE40 formation and a

115 eted by hydroxylation and the role of prolyl hydroxylation in tyrosine autophosphorylation of DYRK1 a

116 In all three cases, substrate hydroxylation incorporates a greater fraction of solvent

117 on of a new catalytic protocol for sp(3) C-H hydroxylation is described.

118 e is shared by most CMGC kinases, and prolyl hydroxylation is essential for catalytic activation.

119 octane reveals that the propensity for omega-hydroxylation is orchestrated by active-site sterics, pa

120 EPOR hydroxylation is required for binding to the beta domain

121 Tertiary and benzylic C-H hydroxylation is strongly favored over N-oxidation for n

122 ain microsomal enzymes shows that estrogen 4-hydroxylation is the main metabolic pathway in the centr

123 Proline hydroxylation is the most prevalent post-translational m

124 From this ferric intermediate, hydroxylation is thermodynamically favored, but chlorina

125 racellular lipid supply inhibited HIF prolyl hydroxylation, leading to accumulation of the HIFalpha s

126 uccessive decarboxylation and intramolecular hydroxylation mechanism forming 2HG in a Fe(II)- and O(2

127 ed by a low-energy and competitive substrate hydroxylation mechanism hence, should give considerable

128 n this collaborative article, we studied the hydroxylation mechanism in great detail, resulting in th

129 dical rebound, as observed in the native C-H hydroxylation mechanism of the P450 enzyme.

130 the data fully support an electrophilic C-F hydroxylation mechanism.

131 The first two steps are typical hydroxylations, mediated by an electrophilic compound I

132 icals formed during these CYP101B1-catalyzed hydroxylations must have very short lifetimes, of just a

133 as well as three new metabolites formed by N-hydroxylation, N-methylation, and attachment of an amine

134 roxylation appears to reflect levels of EGFD hydroxylation observed in vivo, which vary considerably.

135 We cannot exclude PHD-catalysed prolyl hydroxylation occurring under conditions other than thos

136 Selective hydroxylation occurs for these cis-Fe(III)(OH)(X) (X = C

137 We demonstrate that this hydroxylation occurs in senescent chloroplasts of Arabid

138 r all six P450 21A2 variants examined for 21-hydroxylation of 21-d3-progesterone, indicating that C-H

139 e describe an enzyme catalyzing the direct 3-hydroxylation of 4-coumarate to caffeate in lignin biosy

140 ions involving visible light-induced aerobic hydroxylation of 4-nitrophenylboronic acid to 4-nitrophe

141 In this transformation, biocatalytic hydroxylation of a benzylic C-H bond affords a benzylic

142 lished by the late-stage, amide-directed C-H hydroxylation of a lycoricidine intermediate.

143 stitution severely impaired OGFOD1-dependent hydroxylation of a neighboring proline residue resulting

144 cherichia coli is capable of efficient ortho-hydroxylation of a wide range of phenolic compounds and

145 as an electrophilic oxidant in the initial N-hydroxylation of an arylamine and then becoming a nucleo

146 tions in red-light-induced aerobic oxidative hydroxylation of arylboronic acids and benzylic C(sp(3))

147 mediated via a noncanonical surface and that hydroxylation of Asn(35) inhibits ubiquitin binding.

148 genase that catalyzes the post-translational hydroxylation of Asp and Asn residues in epidermal growt

149 ragine-beta-hydroxylase (AspH) catalyses the hydroxylation of Asp/Asn-residues in epidermal growth fa

150 AspH catalyses hydroxylation of asparaginyl- and aspartyl-residues in e

151 rt here a practical method for the ortho C-H hydroxylation of benzamides with inexpensive copper(II)

152 for GA 2-oxidases, AtGA2ox9 performs 2alpha-hydroxylation of C(19)-GAs and harbors putative desatura

153 effective precatalyst for chemoselective C-H hydroxylation of C(sp(3))-H bonds and have noted a marke

154 The selective hydroxylation of C-H bonds is of great interest to the s

155 Hydroxylation of chiral tertiary centers is enantiospeci

156 terol 27-hydroxylase (CYP27A1) initiates the hydroxylation of cholesterol in the alternative pathway.

157 Thus, proline hydroxylation of ChREBP is a novel post-translational mo

158 F5H) of the monolignol pathway catalyzes the hydroxylation of coniferyl alcohol, coniferaldehyde and

159 tor is linked mainly to the oxygen-dependent hydroxylation of conserved proline residues in its alpha

160 as 9, the observation of rapid and catalytic hydroxylation of cyclohexane, and a million-fold acceler

161 s) capable of enantio- and regioselective C5 hydroxylation of decanoic acid 1 to (S)-5-hydroxydecanoi

162 henylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyro

163 enzyme catalyzing regio- and stereospecific hydroxylation of different sterols.

164 bis(pyridine)silver(I) permanganate promoted hydroxylation of diketopiperazines has served as a pivot

165 vely catalyse epimerization, methylation and hydroxylation of diverse amino acids.

166 Prolyl hydroxylation of DYRK1 initiates a cascade of events lea

167 reactions that are catalyzed by AOXs are the hydroxylation of heterocycles and the oxidation of aldeh

168 Hydroxylation of HIF at different sites promotes both it

169 dentification of the enzymes responsible for hydroxylation of JA reveals a missing step in JA metabol

170 e CO2 molecules while also catalyzing the C5 hydroxylation of l-arginine (l-Arg) driven by the oxidat

171 ase, are previously reported to catalyze the hydroxylation of l-isoleucine, l-leucine, and l-alpha-am

172 oxygenase that catalyzes the NADPH-dependent hydroxylation of l-ornithine through a multistep oxidati

173 Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA.

174 -dependent modification in immune evasion, 2-hydroxylation of lipid A limits the activation of the mi

175 ich encodes the enzyme responsible for the 2-hydroxylation of lipid A.

176 JMJD6 is reported to catalyze hydroxylation of lysine residue(s) of histones, the tumo

177 cytochrome P450 that catalyzes the C-16alpha hydroxylation of medicagenic acid toward zanhic acid, th

178 Oxidative C-H hydroxylation of methyl groups, followed by their remova

179 Tyrosinase is a metalloenzyme involved in o-hydroxylation of monophenols and oxidation of o-diphenol

180 d range of difficult chemical reactions e.g. hydroxylation of non-activated C-H Bonds and stereoselec

181 roxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues.

182 Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of

183 lfonation and/or denitrification, as well as hydroxylation of photo-oxidized heterocyclic rings, have

184 roid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the s

185 pregnenolone to DHEA than toward the 17alpha-hydroxylation of pregnenolone.

186 ia-sensing mechanism involves oxygen limited hydroxylation of prolyl residues in the N- and C-termina

187 oxylases (DdPhyA and TgPhyA) catalyze prolyl-hydroxylation of S-phase kinase-associated protein 1 (Sk

188 y basic conditions and enable the late-stage hydroxylation of several functionally-dense drug-like ar

189 lly clustered with SiTPS8, catalyzes the C19 hydroxylation of SiTPS8 products to generate the corresp

190 P450-BM3 mutants that catalyze the oxidative hydroxylation of six different steroids with pronounced

191 Prolyl hydroxylation of Skp1 contributes to O2-dependent Dictyo

192 substrate to catalyse the post-translational hydroxylation of specific prolyl and asparaginyl residue

193 ecker showed that copper and O2 promoted the hydroxylation of steroid-containing ligands.

194 for using O-rich ligand environments for the hydroxylation of strong C-H bonds in enzymatic reactions

195 eagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroar

196 Hydroxylation of substituted phenols by flavin-dependent

197 relations from initial hits, has enabled the hydroxylation of substituted tetrahydroquinolines, quino

198 n performing the thermodynamically favorable hydroxylation of substrate.

199 ponding cyclopropanone derivatives, by alpha-hydroxylation of sulfonylcyclopropanes using a bis(silyl

200 roxyl radicals (OH( *)) were detected by the hydroxylation of terephthalate.

201 This report examines the selective aerobic hydroxylation of tertiary alpha-C-H bonds in ketones wit

202 The side reactions-chlorination and hydroxylation of the 1,3-dicarbonyl partners-may be mini

203 The reactions follow a preferred order, with hydroxylation of the alpha-carbon preceding functionaliz

204 l (TP 166) and 4-(trifluoromethyl)phenol, by hydroxylation of the benzyl moiety, by CF(3) substitutio

205 reas acyclic amides are known to promote the hydroxylation of the C(sp(2))-H bond enabling five-membe

206 the cyclic imides studied herein enabled the hydroxylation of the C(sp(2))-H bond via larger six-memb

207 ug is well defined and oriented suitably for hydroxylation of the C1 atom, the major site of metaboli

208 alpha-ketoglutarate-dependent oxygenase for hydroxylation of the C3 of the glutamine, and a thioeste

209 eprotonation of multiple water molecules via hydroxylation of the cluster oxo bridges for all investi

210 t alter the binding properties, whereas hemi-hydroxylation of the equivalent cytosine in an mCG site

211 The enzymatic beta-C-H hydroxylation of the feedstock chemical isobutyric acid

212 ry, we demonstrate that LpxO catalyzes the 2-hydroxylation of the laurate transferred by A. baumannii

213 n to virulence is dependent on LpxO-mediated hydroxylation of the LpxL2-transferred myristate.

214 Hydroxylation of the ring and oxidation of the alkyl sub

215 y accepted transformation pathway-sequential hydroxylation of the ring followed by ring cleavage and

216 Furthermore, a base-mediated C-H hydroxylation of the synthesized 9H-fluorene derivatives

217 levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF.

218 <200 fs lifetime of radical pairs from DMDO hydroxylation of trans-1-phenyl-2-ethylcyclopropane meas

219 activity toward performing a radical rebound hydroxylation of triphenylmethylradical.

220 committed step in the pathway, namely the 3-hydroxylation of tyrosine to form l-3,4-dihydroxyphenyla

221 egulated splicing, and JMJD6-mediated lysine hydroxylation of U2AF65 could account for, at least part

222 Iterative rounds of nTET hydroxylations of ssDNA proceeded with high stereo speci

223 , which in turn increases proline and lysine hydroxylation on collagen.

224 /catalyst ratio of 200) affords targeted C-H hydroxylation on heterocyclic cores, while preserving el

225 hols, employing an oxyacetamide-directed C-H hydroxylation on phenols.

226 SFMBT1 hydroxylation on Proline residue 651 by EglN1 mediated i

227 tivity: three CYP3A28 SNVs reduced TST 6beta-hydroxylation; one CYP3A38 variant increased TST 16beta-

228 demonstrate that the selectivity toward fast hydroxylation or radical diffusion (known as the OH-rebo

229 ed C4a-hydroperoxyflavin formation and, upon hydroxylation, oxidation occurred with a rate constant s

230 ound that a relative increase in levels of 2-hydroxylation pathway metabolites, or in the ratio of 2-

231 lites, or in the ratio of 2-hydroxylation:16-hydroxylation pathway metabolites, were associated inver

232 in collagen-derived peptides with asymmetric hydroxylation patterns.

233 The dramatic hydroxylation phenotype of MYB115 overexpressors is like

234 en-translocation (TET) proteins catalyze DNA hydroxylation, playing an important role in demethylatio

235 catabolic pathway/modification included ring-hydroxylation preparing the substrate for subsequent rin

236 Hydroxylation proceeds by coupling of the resultant subs

237 t be responsible for the critical bifurcated hydroxylation process in the biosynthesis pathway.

238 Furthermore, 4-hydroxyphenylalanine, a hydroxylation product of phenylalanine, was identified a

239 facile overoxidation of the initially formed hydroxylation product.

240 Hydroxylation-proficient ADSL, by affecting adenosine le

241 LpxO-dependent lipid A 2-hydroxylation protects A. baumannii from polymyxin B, co

242 iary steps as well as direct, late stage C-7 hydroxylation provides both natural products in six and

243 Complex 2-O displayed a C-F hydroxylation rate similar to that of 1-O.

244 However, the transiency of the hydroxylation reaction hinders the identification of hyd

245 mong higher plants and features a critical 3-hydroxylation reaction involving phenolic esters.

246 s that carry out intramolecular aromatic C-F hydroxylation reactions is reported.

247 occurs by a mechanism involving consecutive hydroxylation reactions of the C-7 methyl group to form

248 (mu-O)2 Co(III) ](2+) core through aromatic hydroxylation reactions represent a new domain for high-

249 bonds, so only 3 engages in stereoretentive hydroxylation reactions.

250 nant oxidation is a desaturation and in that hydroxylation represents only a minor pathway.

251 arasite Toxoplasma gondii The full effect of hydroxylation requires modification of the hydroxyprolin

252 ecular level by a loss of telopeptide lysine hydroxylation, resulting in reduced collagen pyridinolin

253 The second cleavage is prevented by Pro hydroxylation, resulting in the formation of mature and

254 posed that involves epoxidation, hydrolysis, hydroxylation, ring contraction, or loss of the carbamoy

255 e, consistent with the level of lysine under-hydroxylation seen in individual chains at cross-linking

256 ution of the two FMOs to chlorination versus hydroxylation selectivity in SyrB2 is related to a react

257 Chlorination versus hydroxylation selectivity is then determined by the orie

258 This hydroxylation sets the stage for the subsequent A-ring c

259 sensing components of the HIF system: prolyl-hydroxylation signals for dioxgen availability-dependent

260 ng an atypical finger 3 and oxygen-dependent hydroxylation site.

261 However, species containing one or three hydroxylation sites can be detected frequently.

262 This variability in the number of hydroxylation sites on the sphingolipid long-chain base

263 c-3-OH-FAs are sensed in a chain length- and hydroxylation-specific manner, with free (R)-3-hydroxyde

264 ne, a degradation product of JA, in a single hydroxylation step catalyzed by jasmone hydroxylase (TcJ

265 The first hydroxylation step is typically catalyzed by monooxygena

266 substrate binding, and demonstrate that the hydroxylation step occurs prior to chloride elimination.

267 xidized benzene via pathways involving fewer hydroxylation steps compared to HO(*) or CO3(*-).

268 (III/III) complex is an intermediate in both hydroxylation steps, as shown by the concentration-depen

269 be modulated by oxygen-dependent asparagine hydroxylation, suggesting that Cezanne is regulated by o

270 rgo either oxidative rearrangement or simple hydroxylation, suggesting that the C1 carbocation is not

271 formation from pregnenolone and for 17alpha-hydroxylation, suggestive of processivity.

272 ol, which only differ in the position of the hydroxylation taking place in the benzylic and aromatic

273 Proline hydroxylation targets both ectopically expressed ChREBP

274 prehensive mechanism for diiron enzyme arene hydroxylation that accounts for many prior experimental

275 B1 exhibits structural adaptations for omega-hydroxylation that include changes in the conformation o

276 photoredox/enzymatic process for direct C-H hydroxylation that proceeds with broad reactivity, chemo

277 During hydroxylation, there is a roughly 85:1 preference for H

278 Specifically, instead of canonical hydroxylation, these enzymes can catalyze non-native nit

279 ptor) through copper-mediated C-H amination, hydroxylation, thiolation, arylation, and trifluoromethy

280 ; the latter's effects require intracellular hydroxylation to 1alpha,25(OH)(2)D(3).

281 im of investigating the initial step for C-F hydroxylation, two new ligands were synthesized, N4Py(2A

282 ses HIF-2alpha protein by post-translational hydroxylation under sufficient oxygen availability.

283 The regioselectivity of hydroxylation was broken when the reactive carbon was ad

284 iate in SyrB2 to perform chlorination versus hydroxylation was computationally evaluated for differen

285 The preference for omega-hydroxylation was decreased in an E310A mutant having a

286 No effect on prolyl 3-hydroxylation was evident on screening the spectrum of k

287 The rebound mechanism for alkane hydroxylation was invoked over 40 years ago to help expl

288 Finally, SNVs functional impact on TST hydroxylation was measured ex vivo in liver microsomes f

289 The lysine under-hydroxylation was shown to alter the divalent aldimine c

290 ompound oxidation that do not result in ring hydroxylation, we identified products formed after the i

291 ncluding glycosylation, phosphorylation, and hydroxylation, were identified and localized.

292 o directly suppresses PHD2-induced HIF1alpha hydroxylation, which has a mutually dependent interplay

293 HIF-1alpha prolyl hydroxylation, which is prerequisite for pVHL recognitio

294 , we identify a new pathway of nitrocatechol hydroxylation, which proceeds simply by oxidation and th

295 The extent of HIF-alpha substrate prolyl hydroxylation, which signals for subsequent HIF-alpha de

296 on; one CYP3A38 variant increased TST 16beta-hydroxylation, while a CYP3A48 SNV showed enhanced NIF o

297 highly site-selective and chemoselective C-H hydroxylation with a mild, functional-group-tolerant met

298 capable of effecting cyclohexane and benzene hydroxylation within seconds at -40 degrees C.

299 ) species, which are responsible for key C-H hydroxylation within the solvent cage.

300 ons including tyrosine sulfation and proline hydroxylation within, and proteolytic maturation after e