ライフサイエンスコーパス: hydroxymethyl

1 oxidation that converted the C16 methyl to a hydroxymethyl.

2 1,1-dimethylethyl)-4-hydroxy-, 1,1'-[2,2-bis(hydroxymethyl)-1,3-propanediyl] ester (both class II tox

3 ic hydroxymethyl functions in 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-d-ribofuranose

4 hyl group at the ring junction, namely, C-8a-hydroxymethyl-1-deoxycastanospermine congeners 1a, 2a, 3

5 by [3+3] condensation of 10,10'-bis[(p-toly)hydroxymethyl]-1,3-bis(2-thienyl)benzenediol with variou

6 phan (ARP), Tryptophol (TRO), 2-(2-formyl-5-(hydroxymethyl-1H-pyrrole-1-yl)butanoic acid (PBA) and Tr

7 rom matched human samples showed that the 5-(hydroxymethyl)-2'-deoxycytidine level was 5-fold lower i

8 urement of the 5-methyl-2'-deoxycytidine, 5-(hydroxymethyl)-2'-deoxycytidine, 5-formyl-2'-deoxycytidi

9 hat the yield of Tg is similar as that of 5-(hydroxymethyl)-2'-deoxycytidine.

10 eoxycytidine, 5-carboxy-2'-deoxycytidine, 5-(hydroxymethyl)-2'-deoxyuridine, 2'-deoxyuridine, and 8-o

11 erences was found for 2'-deoxyuridine and 5-(hydroxymethyl)-2'-deoxyuridine.

12 e includes structures with Bis-Tris (2,2-bis(hydroxymethyl)-2,2',2''-nitrilotriethanol) and L-ribose

13 thyl-1-butanol and furan derivatives like 5-(hydroxymethyl)-2-furaldehyde and 2-furaldehyde has been

14 5-(Hydroxymethyl)-2-furaldehyde and 2-furaldehyde were dete

15 ation of the sucrose and the formation of 5-(hydroxymethyl)-2-furfural (HMF).

16 FAMP is then converted to 4-amino-5-(hydroxymethyl)-2-methylpyrimidine (HMP) and recycled int

17 responsible for the synthesis of 4-amino-5-(hydroxymethyl)-2-methylpyrimidine phosphate in the thiam

18 ous solution of a substrate conjugated to 3-(hydroxymethyl)-2-naphthol (NQMP).

19 eous solution of substrates conjugated to 3-(hydroxymethyl)-2-naphthol (NQMP).

20 ivatized with a vinyl ether moiety, while 3-(hydroxymethyl)-2-naphthol is attached to the other via a

21 y efficient photodehydration (Phi=0.2) of 3-(hydroxymethyl)-2-naphthol undergo facile hetero-Diels-Al

22 DM), sodium hydroxymethylglycinate (SMG), 2-(hydroxymethyl)-2-nitro-1,3-propanediol (NT = nitrotriol)

23 Analysis of 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-2',3'-endo-methylene-uridine by X-ray crys

24 t contains a carbohydrate-like 4'-hydroxy-5'-hydroxymethyl-2',7'-dioxane moiety attached to the aglyc

25 ns an extraordinary sugar-like 4'-hydroxy-5'-hydroxymethyl-2',7'-dioxane moiety attached via a carbon

26 athway to transform the 5hmC into glucosyl-5-hydroxymethyl-2'-deoxycytidine (5-gmC) and achieved 20%

27 replacement of 2'-deoxycytidine (dC) with 5-hydroxymethyl-2'-deoxycytidine (5hmC) in the E. coli gen

28 d quantitative methods to assess levels of 5-hydroxymethyl-2'-deoxycytidine (5hmdC) and 5-methyl-2'-d

29 ee new cytosine derived DNA modifications, 5-hydroxymethyl-2'-deoxycytidine (hmdC), 5-formyl-2'-deoxy

30 ctrometry, we identified the nucleotide as 5-hydroxymethyl-2'-deoxycytidine (hmdC).

31 , only 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine are predicted to be effic

32 pounds 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine were found to increase th

33 ounds, 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine, should be mutagenic.

34 A may be enzymatically deaminated to yield 5-hydroxymethyl-2'-deoxyuridine (5-HmdU).

35 replaced around 75% of thymidine (T) with 5'-hydroxymethyl-2'-deoxyuridine (5hmU) in the Escherichia

36 eaving reactions or deamination of hmdC to 5-hydroxymethyl-2'-deoxyuridine (hmdU).

37 Once again, only 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deo

38 y, we predicted that two of our compounds, 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deo

39 nds in cell culture because only compounds 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deo

40 This terminator is based on 5-hydroxymethyl-2'-deoxyuridine triphosphate (HOMedUTP), a

41 The benzylindazole derivative 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) is an a

42 YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an HIF-1 inh

43 a small molecule HIF-inhibitor, YC-1 (3-[5'-Hydroxymethyl-2'-furyl]-1-benzyl-indazole), or vehicle t

44 ecently identified oxidized forms of 5mdC: 5-hydroxymethyl-2'deoxycytidine (5hmdC), 5-formy-2'deoxycy

45 -glyceraldehyde and 2,3-dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranoses from d-i

46 For the first time 5-hydroxymethyl-2-furaldehyde (HMF) was separated from cru

47 The mean values of all IFs for potential 5-hydroxymethyl-2-furaldehyde (HMF)+2-furaldehyde (F) were

48 Y-12632 and its transcriptomic response to 5-hydroxymethyl-2-furaldehyde (HMF), a commonly encountere

49 e to promote a whiter color and a low free 5-hydroxymethyl-2-furaldehyde content (HMF).

50 be phenethyl alcohol, 2,3-butylene glycol, 5-hydroxymethyl-2-furaldehyde, ethyl hydrogen succinate, a

51 Carboxylic acids, 2-furaldehyde, 5-hydroxymethyl-2-furaldehyde, furfuryl alcohol, 2-furoic

52 orbance at 420nm (A420) and the content of 5-hydroxymethyl-2-furfural (5-HMF).

53 The heterocyclic aldehyde 5-hydroxymethyl-2-furfural (5HMF) interacts allosterically

54 5-Hydroxymethyl-2-furfural (5HMF), a component of natural

55 5-Hydroxymethyl-2-furfural (5HMF), a component of natural

56 a UHPLC-UV method for the determination of 5-hydroxymethyl-2-furfural (HMF), 5-hydroxymethyl-2-furoic

57 e industries, often contain high levels of 5-hydroxymethyl-2-furfural (HMF), a toxic contaminant.

58 ermal treatment result in the formation of 5-hydroxymethyl-2-furfural (HMF), and changes in the antio

59 vated temperatures with glucose (GLC), and 5-hydroxymethyl-2-furfural (HMF).

60 Formation of 5-hydroxymethyl-2-furfural from fructose was found to be a

61 e, 3-deoxyglucosone, 3,4-dideoxyglucosone, 5-hydroxymethyl-2-furfural, glyoxal, methylglyoxal and dia

62 dentified the hitherto unknown compound as 5-hydroxymethyl-2-furfuraldehyde (5-HMF).

63 and final stages, the measurement of free 5-hydroxymethyl-2-furfuraldehyde and color, proved not to

64 i compound from the determination of total 5-hydroxymethyl-2-furfuraldehyde would have correlate well

65 ation of 5-hydroxymethyl-2-furfural (HMF), 5-hydroxymethyl-2-furoic acid (HMFA), 2-furfural (F), 5-me

66 2-furoylglycine and 5-hydroxymethyl-2-furoic acid - potential biomarkers for c

67 )-2,3-butanediol (N7G-N1A-BD), and 1,N(6)-(1-hydroxymethyl-2-hydroxypropan-1,3-diyl)-2'-deoxyadenosin

68 e a defect in the synthesis of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamin

69 In bacteria, the 4-amino-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamin

70 tide (AIR) is the precursor of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) pyrophosphate moi

71 ormation of the pyrimidine moiety (4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synth

72 butenyl-4-diphosphate synthase and 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, res

73 ThiC (4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; EC

74 diate 5-aminoimidazole ribotide to 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate, an intermedi

75 ires the independently synthesized 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate (HMP-PP)

76 in that catalyzes the formation of 4-amino-5-hydroxymethyl-2-methylpyrimidine.

77 sm, T(s) shifts induced by the nitro-triol 2-hydroxymethyl-2-nitro-1,3-propanediol (HNPD) were superi

78 nduction of tumor cell apoptosis) [2,5-bis(5-hydroxymethyl-2-thienyl) furan] (NSC-652287) inhibits HI

79 substituted 3-hydroxymorphinans, including 2-hydroxymethyl-, 2-aminomethyl-, and N-substituted 2-amin

80 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-(2S,3S)-1,4-benzodiox in-6-propanol, thre

81 All 16 stereoisomeric N-methyl 5-(hydroxymethyl)-3,4-dihydroxyproline amides have been syn

82 66), and (2S,3R,11bR)-9-(3-fluoropropoxy)-2-(hydroxymethyl)-3-isobutyl-10-methoxy-2,3,4,6, 7,11b-hexa

83 biosynthetic precursor, (1E,3S,4R,5E)-1-(2-(hydroxymethyl)-3-methoxyphenyl)hepta-1,5-diene-3,4-diol,

84 s led to the identification of (S)-(-)-4-(4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1

85 The debate whether statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhi

86 ersion of the ceramide analog N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl) dodecanamide, was investig

87 n, whereas the CERT inhibitor N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (1R,3R isomer)

88 (5aS,6R,7R,8R,9aR)-2-amino-6,7-dihydroxy-8-(hydroxymethyl)-3H,4H,5H,5aH,6H,7H,8H, 9aH,10H-pyrano[3,2

89 by purine-rich TFOs on the processing of 4'-(hydroxymethyl)-4,5',8-trimethylpsoralen (HMT) ICLs by th

90 [4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta [g]quinazolin-6-yl]am

91 [(+/-)-1-[(3R*,4R*)-1-(cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl -1,3-dihydro-2H-be

92 -[1-(cyclooctylmethyl)-1,2,3,6-tetrahydro-5-(hydroxymethyl)-4-pyridinyl]-3-ethyl -1,3-dihydro-2H-benz

93 tivation mechanism of the related compound 2-hydroxymethyl-4-chloropyridine is probed here in more de

94 onist J-113397 [(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H benzim

95 erent FARs [diazolidinyl urea (DAU), 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione (DMDM

96 -deoxycytidine (5-mdC) in DNA to yield the 5-hydroxymethyl, 5-formyl and 5-carboxyl derivatives of 2'

97 ytosine (5mC) by Tet dioxygenases generate 5-hydroxymethyl (5hmC), 5-formyl (5fC), and 5-carboxyl (5c

98 n may undergo successive oxidations to the 5-hydroxymethyl (5hmC), 5-formyl (5fC), and 5-carboxyl (5c

99 C), or to undergo further oxidation to the 5-hydroxymethyl (5hmC), 5-formyl (5fC), or 5-carboxyl (5ca

100 namely, butyl-2-[(6aR,9R,10aR)-1-hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-h exahydro-6

101 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a nove

102 ioxygenase MhpB from Escherichia coli with 6-hydroxymethyl-6-methylcyclohexa-2,4-dienone led to the f

103 was isolated from incubation of CatA with 6-hydroxymethyl-6-methylcyclohexa-2,4-dienone, an analogue

104 es the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin and is a yet-to-be-drugg

105 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

106 cule intensity-time trajectories of enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

107 with the potent MAIT cell ligand, reduced 6-hydroxymethyl-8-D-ribityllumazine (rRL-6-CH(2)OH), speci

108 doperoxides that can be reduced to produce 1-hydroxymethyl-9,10-anthraquinones.

109 the synthetically more accessible C-terminus hydroxymethyl aglycon derivatives and full details of th

110 c acid and (S)-SEGPHOS delivers products of (hydroxymethyl)allylation 4a-4i in good isolated yields (

111 eneral method for enantioselective carbonyl (hydroxymethyl)allylation, a process that has no highly s

112 imitations of the ring expansion of cyclic 2-hydroxymethyl amines induced by diethylaminosulfur trifl

113 nanofiber membrane functionalized with tris(hydroxymethyl)aminomethane (P-Tris) was used in affinity

114 Buffers based on pyridine (py) and tris(hydroxymethyl)aminomethane (TRIS) are catalytically inac

115 ange of 0.1 mM to 1 mM, using the bases tris(hydroxymethyl)aminomethane, ammonia, carbonate, hydroxid

116 Structural analysis reveals that the methyl, hydroxymethyl, and formyl modifications are easily accom

117 uble HbS (aromatic aldehydes o-vanillin or 5-hydroxymethyl, and urea) reduced haemolysis, an effect n

118 ta-lactam intermediates, (5S,6S)-5-hydroxy-6-hydroxymethyl- and (5S,6S)-5-hydroxy-6-methylpiperidin-2

119 It is based on phenol derivatives with three hydroxymethyl arms at both ortho and para positions of t

120 Contrary to earlier studies with N-(hydroxymethyl)benzamide compounds, no evidence for mecha

121 reaction, between pH 10 and 14, of eight N-(hydroxymethyl)benzamide derivatives in water at 25 degre

122 Similar treatment of o- and p-(hydroxymethyl)benzoate derivatives results largely in lo

123 Birch reductive alkylation of methyl m-(hydroxymethyl)benzoate derivatives, using lithium in amm

124 des from resin beads whereby exposure of a 4-hydroxymethyl benzoic acid (HMBA)-linked peptide to high

125 duce the Diels-Alder dehydration product, 4-(hydroxymethyl)benzoic acid (HMBA), with 31% selectivity

126 Hydroxymethyl benzotriazole, which is an inexpensive and

127 nsferase by the gamma-folate ester of O6-[4-(hydroxymethyl)benzyl]guanine was similar to that of the

128 is quantitatively converted to two products, hydroxymethyl BHT (1) and 3-hydroxy- tert-butyl BHT (2).

129 dehyde in order to introduce selectively the hydroxymethyl branch, and second, a tandem beta-fragment

130 PET with (18)F-FEAU and (18)F-9-[4-fluoro-3-(hydroxymethyl)butyl]guanine ((18)F-FHBG) was performed i

131 acil (FEAU), penciclovir, and 9-[4-fluoro-3-(hydroxymethyl)butyl]guanine (FHBG) and clinically applie

132 beled PET reporters FHBG [9-(4-18F-fluoro-3-[hydroxymethyl] butyl) guanine] and FLT (18F-3'-deoxy-3-'

133 imaging reporter probe 9-(4-(18)F-fluoro-3-[hydroxymethyl]butyl)guanine ((18)F-FHBG), the herpes sim

134 cloguanosine derivative 9-(4-(18)F-fluoro-3-[hydroxymethyl]butyl)guanine ((18)F-FHBG).

135 PET/CT imaging with 9-(4-[(18)F]-fluoro-3-[hydroxymethyl]butyl)guanine ([(18)F]FHBG) of B7H3-sr39tk

136 scriptional activity by 9-(4-(18)F-fluoro-3-[hydroxymethyl]butyl)guanine PET, in both mouse and canin

137 roteins could convert 5-methyl C (5-mC) to 5-hydroxymethyl C (5-hmC).

138 with DNA containing methyl-CG, methyl-CA and hydroxymethyl-CA are all reduced in vivo.

139 In the cAMP assay, the 9-hydroxymethyl cannabinol analogue 24 (AM4089) had a part

140 ed alkenes to give terminal and internal 1,3-hydroxymethyl chirons.

141 l-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.

142 The pseudorotaxane complex of the new hydroxymethyl cryptand 3 with N,N'-dimethyl-4,4'-bipyrid

143 l (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate 2, an essential interm

144 ns, providing access to synthetically useful hydroxymethyl cyclopropanes.

145 identification of 3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)iso

146 e conversion of 5-methyl cytosine (5mC) to 5-hydroxymethyl cytosine (5hmC) and play important roles d

147 The recent discovery of 5-hydroxymethyl-cytosine (5 hmC) in embryonic stem cells a

148 sts (CAF), along with increased amounts of 5-hydroxymethyl-cytosine (5-HmC) in CAFs, in progression f

149 f 5mC in CpG dinucleotides is converted to 5-hydroxymethyl-cytosine (hmC) by the action of 2-oxogluta

150 hyl-cytosines (glc-5hmC) and T4gt DNA with 5-hydroxymethyl-cytosines (5hmC).

151 ted REase activity on T4 DNA with glucosyl-5-hydroxymethyl-cytosines (glc-5hmC) and T4gt DNA with 5-h

152 y map DNA epigenetic marks 5-methyl-dC and 5-hydroxymethyl-dC in genomic DNA isolated from lungs of A

153 -ethylenedioxythiophene) (PEDOT:TsO) and the hydroxymethyl derivative PEDOT-OH:TsO, which was covalen

154 nd that it is converted to adenine via its 6-hydroxymethyl derivative.

155 ted in the development of a new series of 4-(hydroxymethyl)diarylhydantoin analogues as potent, parti

156 Herein, we describe a C2-hydroxymethyl dihydropyrrole KSP inhibitor ( 11) that ci

157 identified as 4,4'-dihydroxy-3,5,3',5'-tetra(hydroxymethyl)diphenylmethane.

158 lectrocatalytic response in the presence of (hydroxymethyl)ferrocene as redox mediator.

159 To this end, (hydroxymethyl)-ferrocene (FcCH2OH) was employed to provi

160 ng ADC that use poly-1-hydroxymethylethylene hydroxymethyl-formal (PHF), also known as Fleximer.

161 the cytosine bases is replaced with methyl-, hydroxymethyl-, formyl-, or carboxylcytosine.

162 anslocated via its distal carbon atom to the hydroxymethyl functionality.

163 acetylation of one of the two diastereotopic hydroxymethyl functions in 3-O-benzyl-4-C-hydroxymethyl-

164 talytic studies explored the conversion of 5-hydroxymethyl furfural (5-HMF) to the fuel precursor 2,5

165 Biomass-derived commodity chemical 5-hydroxymethyl furfural is an underutilized C6-platform c

166 access 2,5-diaryl nonsymmetric furans from 5-hydroxymethyl furfural utilizing decarboxylative cross-c

167 The physicochemical parameters (moisture, hydroxymethyl furfural, colour, electrical conductivity,

168 ng a mixture of two furanic (furfural, FF; 5-hydroxymethyl furfural, HMF) and three phenolic (syringi

169 creasing of browning index and increasing of hydroxymethyl furfural.

170 5-(Hydroxymethyl)furfural (HMF) and levulinic acid producti

171 anuka honey, the kinetics of formation of 5-(hydroxymethyl)furfural (HMF) was studied at temperatures

172 nillin, the natural baked marker compound 5-(hydroxymethyl)furfural (HMF), specific markers of oxidat

173 ate, now characterized as a butenolide of 5-(hydroxymethyl)furfural (HMF).

174 entified: Acortatarins A, Acortatarins C, 5-(hydroxymethyl)furfural(HMF), 2,3-dihydro-3,5-dihydroxy-6

175 glycosides were identified together with 5-(hydroxymethyl)furfural.

176 5-(Hydroxymethyl)-furfural content emerged as a critical fa

177 -free heterogeneous selective oxidation of 5-hydroxymethyl-furfural (HMF) to 2,5-furandicarboxylic ac

178 The partially oxidized HMF, 5-(hydroxymethyl)furoic acid (HMFA), is reacted with high p

179 genase, 6-phosphogluconate dehydrogenase, 2-(hydroxymethyl)glutarate dehydrogenase, and phenylserine

180 Hydroxymethyl glutaryl-coenzyme A reductase degradation

181 1:01 and statins for the development of anti-hydroxymethyl glutaryl-coenzyme A reductase-positive sta

182 maldehyde detoxification by FrmA requires S-(hydroxymethyl)glutathione, yet glutathione inhibits form

183 [formaldehyde] than required to generate S-(hydroxymethyl)glutathione.

184 oupling, and the carbon in CO ends up in the hydroxymethyl group (-CH(2)OH) of the produced 1-propano

185 Lepadiformine A and B contain a hydroxymethyl group adjacent to the amine.

186 ack of coordination imparted mobility to the hydroxymethyl group and enabled a crucial hydrogen bond

187 eveloped that defined our use of a protected hydroxymethyl group as the substituent that controls the

188 vindoline and defined our use of a protected hydroxymethyl group as the substituent used to control t

189 Polyhydroxylated quinolizidines bearing a hydroxymethyl group at the ring junction were synthesize

190 ew quaternary indolizidine iminosugars, with hydroxymethyl group at the ring junction, namely, C-8a-h

191 However, introduction of the C2-hydroxymethyl group caused 11 to be a substrate for cell

192 ng earlier studies on the role played by the hydroxymethyl group conformation on glycoside reactivity

193 The hydroxymethyl group in Ser originated from formate, whic

194 The introduction of the hydroxymethyl group in the biologically relevant molecul

195 val of benzoyl protection, and conversion of hydroxymethyl group into mesyloxymethyl group.

196 ailable, deacetylation to access the free 3'-hydroxymethyl group is problematic when the carboxylic a

197 e towards the opposite direction because the hydroxymethyl group of 5hmC and formyl group of 5fC adop

198 re supposed to directly interact with the C6 hydroxymethyl group of D-glucose negatively affected tra

199 The hydroxymethyl group of serine is a primary source of tet

200 ture results in lack of coordination for the hydroxymethyl group of the substrate at the -1 subsite.

201 The oxidation of the 16-hydroxymethyl group present in the axial position was ac

202 etic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of

203 cations, such as the addition of a methyl or hydroxymethyl group to cytosine, can also play a role.

204 hate (PLP)-dependent enzyme that catalyzes a hydroxymethyl group transfer from L-serine to tetrahydro

205 The hydroxymethyl group was then oxidized and then decarbony

206 ning the desymmetrization of a prochiral bis-hydroxymethyl group with the epimerization of a chiral f

207 formaldehyde to introduce the requisite C16 hydroxymethyl group.

208 subsequently reduced in two stages to the 5'-hydroxymethyl group.

209 based on a chemical tagging strategy for the hydroxymethyl group.

210 , and reduction in an one-pot operation to a hydroxymethyl group.

211 combination with 5'-N-ethylcarboxamido or 5'-hydroxymethyl groups.

212 sphingoid bases lacking the 1-hydroxyl- or 1-hydroxymethyl- groups.

213 rmaldehyde gives easily crystallized menthyl hydroxymethyl-H-phosphinate (1).

214 A key finding was that the presence of the hydroxymethyl handle enhances the yields of the palladiu

215 Of these, 9-hydroxymethyl hexahydrocannabinol 11 (AM4054) exhibited

216 nitric acid (HNO3), hydrogen cyanide (HCN), hydroxymethyl hydroperoxide, peroxyacetic acid, organic

217 The method gives access to 1-alkynyl-2-(hydroxymethyl)imidazoles which undergo 6-endo-dig or 5-e

218 A series of bis(hydroxymethyl)indolizino[6,7-b]indoles and their bis(alk

219 o acids are reduced to iodomethyl groups via hydroxymethyl intermediates.

220 sophthalate derivative bis(1-ethylpentyl) 5-(hydroxymethyl)isophthalate induced parallel changes in p

221 Cyclic alpha-hydroxymethyl ketimines undergo highly diastereoselectiv

222 as a furfural-sensitive indicator monomer, 2-hydroxymethyl methacrylate as a comonomer, and ethylene

223 ion of a linear trisaccharide, modified with hydroxymethyl moiety at C4 of glucopyranose moiety.

224 ing N-acetoxymethyl-, N-alkoxymethyl-, and N-hydroxymethyl-N-arylimidazo[1,2-a]pyridine-3-amine deriv

225 d for the preparation of 3,5-disubstituted 4-hydroxymethyl-N-arylpyrazole derivatives from the beta-e

226 faces were derivatized with photoreactive 3-(hydroxymethyl)naphthalene-2-ol (NQMP) moieties.

227 on a one-pot reduction/condensation of tris(hydroxymethyl)nitromethane with a benzaldehyde derivativ

228 ally distorted the ion binding sites, 2) the hydroxymethyl of Thr(772) rotates to stabilize bound For

229 In the crystal, the hydroxymethyl (OH-CH2-) moiety of 5hmC points to the met

230 e study the effects of the epigenetic mark 5-hydroxymethyl on cytosine on the structure of the Dicker

231 age deoxofluorination of the corresponding 5-hydroxymethyl or 5-formyl derivatives, respectively, in

232 (3)/sp(2))-H functionalizations of a methyl, hydroxymethyl, or aldehyde group has been developed prov

233 This review focuses on 4'-hydroxymethyl- or nucleobase-transposed nucleosides, nuc

234 The biological activities of all known 4'-hydroxymethyl- or nucleobase-transposed nucleosides, nuc

235 ro-1H-cyclopenta[a]phenanthren-3-yl]o xy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5

236 3-yl]o xy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol], an alkaloid isolated f

237 sting of acetylene-functionalized 3-ethyl-3-(hydroxymethyl)oxetane (EAMO) repeat units (Patent No.: U

238 y-methoximes, vinyl-substituted oxiranes, or hydroxymethyl oxiranes.

239 C name: 2-{2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-oxolan-2-yl]-1-methylcarbamim idamido}ace

240 n be activated by an esterase to generate a "hydroxymethyl persulfide" intermediate, which rapidly co

241 Using diol, hydroxymethyl phenols or benzoyl methyl hydroxamates, an

242 by leveraging oxidative dearomatization of 2-hydroxymethyl phenols with concurrent N-hydroxycarbamate

243 e describes oxidative dearomatizations of 2-(hydroxymethyl)phenols via their derived bis(dichloroacet

244 The novel tracer molecule based on a 2-hydroxymethyl phenyl boronic acid derivative binds even

245 DIPYs containing functional groups such as p-hydroxymethyl phenyl, p-hydroxyphenyl, p-cyanophenyl, p-

246 4-(Hydroxymethyl)phenyl benzyl selenoxide (4) sequestered i

247 soleucine, and l-phenylalanine esters of [3-(hydroxymethyl)phenyl]guanidine (3-HPG) were synthesized

248 and identified together with 1-(2-hydroxy-4-hydroxymethyl)-phenyl-6-O-caffeoyl-beta-d-gluco-pyranosi

249 the process, a new phenolic glycoside (E)-4-hydroxymethyl-phenyl-6-O-caffeoyl-beta-d-glucopyranoside

250 )(-) salt; bpy = 2,2'-bipyridine, thp = tris(hydroxymethyl)phosphine] is both strongly luminescent an

251 complex, [Ni(DHMPE)2](2+) (DHMPE = 2-bis(di(hydroxymethyl)phosphino)ethane), for the hydrogen evolut

252 t that, by addition of ionic liquid tetrakis(hydroxymethyl)phosphonium chloride solution to the alpha

253 volves generation of and chemistry at the 3'-hydroxymethyl position.

254 on channel potentiation by (3alpha,5alpha)-3-hydroxymethyl-pregnan-20-one, but mutation of the neighb

255 -9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)pro pane-1,3-diol (DCAP), a potent broad-s

256 ield from the commercially available 2,2-bis(hydroxymethyl)propionic acid and used as the starting bu

257 2,2-Bis(hydroxymethyl)propionic acid hyperbranched poly(ethylene

258 c wedges (generations 0-4), based on 2,2-bis(hydroxymethyl)propionic acid, was designed to bind Au na

259 on 5-hydroxymethyl-pyrimidines and 7-deaza-7-hydroxymethyl-purines lay the foundation for development

260 mp)4(mu-OAc)2(mu2-OAc)2(H2O)2] (1) (hmp = 2-(hydroxymethyl)pyridine) as the first Co(II)-based cubane

261 H2O] ({Co(II)3Ln(OR)4}; Ln = Ho-Yb, hmp = 2-(hydroxymethyl)pyridine) cubane WOC series is introduced

262 tes only one equiv of pyridine, and forms N-(hydroxymethyl)pyridinium ion.

263 ng linkers between the alpha-carbon and a 2-(hydroxymethyl)pyridyl group were synthesized in enantioe

264 erivatives and those using TET/JBP-generated hydroxymethyl pyrimidines as biosynthetic starting point

265 Modified nucleotides based on 5-hydroxymethyl-pyrimidines and 7-deaza-7-hydroxymethyl-pu

266 ne (topoisomerase inhibition moiety) and bis(hydroxymethyl)pyrrole (DNA cross-linking moiety).

267 InCl(3)-catalyzed condensation of 4-bromo-2-(hydroxymethyl)pyrrole and pyrrole to give the 8-bromodip

268 ies (antiangiogenetic pharmacophore) and bis(hydroxymethyl)pyrrole moieties (DNA cross-linking agent)

269 L-IsoDMDP [(2S,3S,4R)-2,4-bis(hydroxymethyl)pyrrolidine-3,4-diol], prepared in 11 step

270 ADP-ribose (ADPR), adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol (ADP-HPD) and 8-n-octyl-am

271 cross-linking agent) to form a series of bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine hybrids.

272 the free energies of nitrone reactivity with hydroxymethyl radical as well as on the electron affinit

273 he present case) and takes place through the hydroxymethyl radical formed from methanol oxidation by

274 s intramolecular 1,4-conjugate addition of a hydroxymethyl radical generated from Ti (III) mediated r

275 Their ability to trap hydroxymethyl radical was evaluated by electron paramagn

276 cols are used in combination with Merrifield hydroxymethyl resin and TFA/TMSBr cleavage.

277 We previously developed gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a tool to d

278 new fluorescent method using gamma-glutamyl hydroxymethyl rhodamine green to diagnose metastatic lym

279 A paromomycin analog lacking the hydroxymethyl ring I side chain is considerably less act

280 iously undescribed rotamer transition of the hydroxymethyl side chain of the absolutely conserved Thr

281 e effect of this modification is to lock the hydroxymethyl side chain of the neomycin or paromomycin

282 tions, a variable amount of oxidation of the hydroxymethyl substituent into an aldehyde was observed

283 Obviously, the 3-hydroxymethyl substituent shows similar reactivity and a

284 In contrast, the matching of hydroxymethyl substituents in the aminocyclitols and the

285 The resulting hydroxymethyl substituted aminocyclitols were tested as

286 alkynes to 1-methyl-, propyl-, benzyl-, and hydroxymethyl-substituted 1,3,5-cycloheptatrienes in the

287 ough chemoselective allyl transfer between 2-hydroxymethyl-substituted allylic silanes and imines is

288 The hydroxymethyl substrate 4 (R(3) = CH(2)OH), however, was

289 study proposed that besides HMS, its isomer hydroxymethyl sulfite (HMSi), which has not been identif

290 he synthetic base 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-perimidin-2(3H )

291 implicit solvent model are carried out on 5-(hydroxymethyl)tetrahydropyran to investigate the effects

292 of different constitutions, namely 4,4'-bis(hydroxymethyl)tetrathiafulvalene (OTTFO) and 4,4'-bisthi

293 -restricted TCR that differ only in a buried hydroxymethyl that forms a common TCR beta-chain V regio

294 functional studies demonstrated that serine hydroxymethyl transferase 1 (SHMT1) was necessary for ov

295 ces of cysteine desulphurase, serine/glycine hydroxymethyl transferase, and components of the alpha-k

296 ligonucleotides containing nucleobase- or 4'-hydroxymethyl-transposed nucleotides are discussed.

297 ligonucleotides containing nucleobase- or 4'-hydroxymethyl-transposed nucleotides as small oligonucle

298 The betaine lipid diacylglyceryl-hydroxymethyl-trimethyl-beta-alanine and phosphatidyldim

299 ation of the degradation was observed at the hydroxymethyl uracil and tricyclic guanidine groups; ura

300 ssibility of replacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5hmU) in the genomic DNA of Esche