ライフサイエンスコーパス: hydroxymethyltransferase

1 t phenotype, which encodes a putative serine hydroxymethyltransferase.

2 -THF) is formed by a side reaction of serine hydroxymethyltransferase.

3 two tRNA synthetases, and a putative serine hydroxymethyltransferase.

4 al folate-dependent enzymes including serine hydroxymethyltransferase.

5 The 5'-untranslated region (UTR) of serine hydroxymethyltransferase 1 (SHMT1) contains an internal

6 Serine hydroxymethyltransferase 1 (SHMT1) expression limits rat

7 Mutation of the photorespiratory enzyme Ser-hydroxymethyltransferase 1 (SHMT1) in a PPSB-deficient b

8 Serine hydroxymethyltransferase 1 (SHMT1) is an essential scaff

9 de novo biosynthesis is regulated by serine hydroxymethyltransferase 1 (SHMT1).

10 nd repair and consists of the enzymes serine hydroxymethyltransferase 1 and 2alpha (SHMT1 and SHMT2al

11 Serine hydroxymethyltransferase 2 (SHMT2) regulates one-carbon

12 Among these genes, only serine hydroxymethyltransferase 2 (SHMT2) was overexpressed at

13 in turn promotes the succinylation of serine hydroxymethyltransferase 2 (SHMT2) within the mitochondr

14 PSPH)) and de novo glycine synthesis (serine hydroxymethyltransferase 2 (SHMT2)).

15 We focused on serine hydroxymethyltransferase 2 (SHMT2), a key enzyme in one-

16 e metabolism enzymes Psat1 and Shmt2 (serine hydroxymethyltransferase 2), as well as translation fact

17 High expression of serine hydroxymethyltransferase-2 (SHMT2) and methylenetetrahyd

18 ne to glycine conversion catalyzed by serine hydroxymethyltransferase-2 as well as ornithine aminotra

19 media can be explained by the loss of serine hydroxymethyltransferase-2-dependent production of one-c

20 ed by the pharmacologic inhibition of serine hydroxymethyltransferase, a key enzyme that feeds methyl

21 0 kDa chloroplast membrane protein, a serine hydroxymethyltransferase, a nuclease, and two proteins o

22 -stimulated (35%; P=0.004) lymphocyte serine hydroxymethyltransferase activities in vitro.

23 hat this assay can be used to measure serine hydroxymethyltransferase activity at 10(-8) to 10(-3)M (

24 hat 5-formyltetrahydrofolate inhibits serine hydroxymethyltransferase activity in vivo and that serin

25 , the 5,10-CH(2)-H(4)PteGlu formed by serine hydroxymethyltransferase activity is reduced to 5-CH(3)-

26 vel HPLC-based fluorometric assay for serine hydroxymethyltransferase activity.

27 was confirmed by the activation of aposerine hydroxymethyltransferase after release of the ligand by

28 ternary structure of liganded E. coli serine hydroxymethyltransferase also differs in symmetry and re

29 The gene encodes a serine hydroxymethyltransferase, an enzyme that is ubiquitous i

30 the other two enzymes in the cytosol, serine hydroxymethyltransferase and C1-tetrahydrofolate synthas

31 dylate synthesis, and suggesting that serine hydroxymethyltransferase and FTHFS compete for a limitin

32 are inhibited in the PPIP5K KO cells: serine hydroxymethyltransferase and phosphoribosyl pyrophosphat

33 e the folate cofactor binding site in serine hydroxymethyltransferase and the differences in orientat

34 We also observed downregulation of Serine Hydroxymethyltransferase and Thymidylate Synthase, two O

35 s encoding a glycine cleavage system, serine hydroxymethyltransferase, and serine dehydratase.

36 The active serine hydroxymethyltransferase, and two other enzymes that for

37 in vitro folding of Escherichia coli serine hydroxymethyltransferase at 4 degrees C, both monomer an

38 The maturation of serine hydroxymethyltransferase by ICP55 is unusual, as it invo

39 o be the viable in vivo substrate for serine hydroxymethyltransferase-catalyzed formation of 5-formyl

40 the rate of (i) tetrahydrofolate-independent hydroxymethyltransferase chemistry between formaldehyde

41 otent inhibitor of the Gly decarboxylase/Ser hydroxymethyltransferase complex.

42 Cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme levels are eleva

43 associated with decreased cytoplasmic serine hydroxymethyltransferase (cSHMT) expression in MCF-7 cel

44 The human cytoplasmic serine hydroxymethyltransferase (CSHMT) gene was isolated, sequ

45 Cytoplasmic serine hydroxymethyltransferase (cSHMT) is a tetrameric, pyrido

46 region (UTR) of the human cytoplasmic serine hydroxymethyltransferase (cSHMT) message is alternativel

47 The influence of cytoplasmic serine hydroxymethyltransferase (cSHMT) on this competition was

48 ferential partitioning of cytoplasmic serine hydroxymethyltransferase (cSHMT)-derived methylenetetrah

49 e folate-dependent enzyme cytoplasmic serine hydroxymethyltransferase (cSHMT).

50 uctase [MTHFR] and C1420T cytoplasmic serine hydroxymethyltransferase [cSHMT]).

51 Serine hydroxymethyltransferase (EC 2.1.2.1), a member of the a

52 arrier protein transacylase and ketopantoate hydroxymethyltransferase, enzymes that are required for

53 d by metal dependent 3-methyl-2-oxobutanoate hydroxymethyltransferase from E. coli (KPHMT) and varian

54 the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT1).

55 an indirect consequence of damage to serine hydroxymethyltransferase (GlyA; E.C. 2.1.2.1).

56 eans, eighteen members constitute the serine hydroxymethyltransferase (GmSHMT) gene family, of which

57 g4 gene encodes a predicted cytosolic serine hydroxymethyltransferase (GmSHMT08); however, the novel

58 The panB gene that encodes ketopantoate hydroxymethyltransferase has been cloned from Mycobacter

59 o folding pathway of Escherichia coli serine hydroxymethyltransferase has both monomer and dimer inte

60 hality of the yggS and glyA (encoding serine hydroxymethyltransferase) has been described, but the me

61 Human cytosolic serine hydroxymethyltransferase (hcSHMT) is a promising target

62 2.4 A resolution of Escherichia coli serine hydroxymethyltransferase in ternary complex with glycine

63 Ketopantoate hydroxymethyltransferase (KPHMT) and pantothenate synthe

64 enzymic reactions catalysed by ketopantoate hydroxymethyltransferase (KPHMT), L: -aspartate-alpha-de

65 The human mitochondrial serine hydroxymethyltransferase (mSHMT) gene was isolated, sequ

66 A cDNA clone for mitochondrial serine hydroxymethyltransferase (mSHMT) that was capable of par

67 to sequences in rabbit mitochondrial serine hydroxymethyltransferase (mSHMT).

68 enase reaction to an excess of either serine hydroxymethyltransferase or C1-tetrahydrofolate synthase

69 However, addition of either serine hydroxymethyltransferase or C1-tetrahydrofolate synthase

70 ys were viable and lacked cytoplasmic serine hydroxymethyltransferase protein, confirming that mimosi

71 a protein with sequence similarity to serine hydroxymethyltransferases, resulting in the proposal tha

72 characterized a family of Arabidopsis serine hydroxymethyltransferase (SHM) genes.

73 xpectedly, mutation of both cytosolic serine hydroxymethyltransferase (SHM2) and one-carbon tetrahydr

74 sed fluorometric method for measuring serine hydroxymethyltransferase (SHMT) activity toward formatio

75 several with defects in mitochondrial serine hydroxymethyltransferase (SHMT) activity.

76 ed via a second catalytic activity of serine hydroxymethyltransferase (SHMT) and strongly inhibits SH

77 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible

78 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible

79 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible

80 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible

81 Serine hydroxymethyltransferase (SHMT) from all sources tested

82 Serine hydroxymethyltransferase (SHMT) from plant mitochondria

83 rofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenet

84 Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5'-phosph

85 Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate

86 Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridox

87 Serine hydroxymethyltransferase (SHMT) is the major provider of

88 folding mechanism of Escherichia coli serine hydroxymethyltransferase (SHMT) showed that the final ra

89 amate forms to rabbit liver cytosolic serine hydroxymethyltransferase (SHMT) were determined by a com

90 netetrahydrofolate reductase (MTHFR), serine hydroxymethyltransferase (SHMT), and cystathionine beta-

91 Mitochondrial serine hydroxymethyltransferase (SHMT), combined with glycine d

92 based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve mic

93 Nevertheless for serine hydroxymethyltransferase (SHMT), one of the key enzymes

94 is, a pathway composed of the enzymes serine hydroxymethyltransferase (SHMT), thymidylate synthase (T

95 F, a slow, tight-binding inhibitor of serine hydroxymethyltransferase (SHMT), was enriched in nuclei,

96 y observed for reactions catalyzed by serine hydroxymethyltransferase (SHMT).

97 amide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).

98 -d]pyrimidine antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and

99 Serine is metabolized by serine hydroxymethyltransferase (SHMT)2 in the mitochondria and

100 Serine hydroxymethyltransferase (SHMT; EC 2.1.2.1) catalyzes th

101 res of the human and rabbit cytosolic serine hydroxymethyltransferases (SHMT) confirmed their close s

102 ted at the genes encoding one or both serine hydroxymethyltransferases (SHMT) or at the genes encodin

103 se-thymidylate synthase, dhfr-ts, and serine hydroxymethyltransferase, shmt) gave the most abundant t

104 onine synthase (MS A2756G), cytosolic serine hydroxymethyltransferase (SHMT1 C1420T), and a double (2

105 reductase (MTHFR 677C>T and 1298A>C); serine hydroxymethyltransferase (SHMT1 C1420T); reduced folate

106 tide transformylase (ATIC) 347GG, and serine hydroxymethyltransferase (SHMT1) 1420CC were measured an

107 Serine hydroxymethyltransferase (SHMT1) partitions folate-deriv

108 Cytoplasmic serine hydroxymethyltransferase (SHMT1) regulates the partition

109 lioblastoma multiforme, mitochondrial serine hydroxymethyltransferase (SHMT2) and glycine decarboxyla

110 rough the activities of mitochondrial serine hydroxymethyltransferase (SHMT2), thymidylate synthase (

111 Serine hydroxymethyltransferases (SHMTs) reversibly transform s

112 with the unliganded rabbit cytosolic serine hydroxymethyltransferase structure identifies changes in

113 Additionally, we find that the DNA hydroxymethyltransferase TET1 suppresses ILC1 but not IL

114 l 5'-phosphate is used to activate aposerine hydroxymethyltransferase to form the catalytically activ

115 o of specific proteins indicated that serine hydroxymethyltransferase was affected in icp55.

116 portional to the amount of active holoserine hydroxymethyltransferase, which is a measure of the amou