ライフサイエンスコーパス: hydroxyproline

1 of (DOG)10, (PKG)10, and (POG)10 chains (O = hydroxyproline).

2 ing Stickland acceptor (glycine, proline, or hydroxyproline).

3 -amino acids), and plant protein biomarkers (hydroxyproline).

4 arabinogalactan polysaccharides O-linked to hydroxyproline.

5 the racemization of free proline or trans-4-hydroxyproline.

6 pendent manner and without a requirement for hydroxyproline.

7 ins of type I, II, and III collagens to (3S)-hydroxyproline.

8 e two closely related molecules, proline and hydroxyproline.

9 rs of the pentasaccharide cap formed on Skp1 hydroxyproline.

10 lowing sufficient room for the 4-hydroxyl of hydroxyproline.

11 CAGLRGGCVLPONLROKFKE-NH2, where O is 4-trans-hydroxyproline.

12 st-translationally modified residue, 4-trans-hydroxyproline.

13 inhibition by sugars; and a requirement for hydroxyproline.

14 hydrogen-bonded hydration networks involving hydroxyproline.

15 nous domains of bacterial proteins that lack hydroxyproline.

16 ue for pathology, immunohistology, mRNA, and hydroxyproline.

17 1 is responsible for converting proline to 3-hydroxyproline.

18 bers of the proline racemase superfamily, 4R-hydroxyproline 2-epimerase (UniProt ID A0NXQ7 ; 4HypE) a

19 he Calpha atom of a Pro residue to produce 2-hydroxyproline (2-Hyp).

20 yr540 increases the catalytic efficiency for hydroxyproline 3-fold and decreases the specificity for

21 function is known for the much less common 3-hydroxyproline (3Hyp), although genetic defects inhibiti

22 and Yaa are typically proline and (2S,4R)-4-hydroxyproline (4(R)Hyp), respectively.

23 (2S,4R)-4-Hydroxyproline(4-nitrobenzoate) was synthesized.

24 -phase peptide synthesis to incorporate Fmoc-hydroxyproline (4R-Hyp).

25 n X is (2S)-proline (Pro) and Y is (2S,4R)-4-hydroxyproline (4R-Hyp).

26 All extracts contained hydroxyproline (61-73 residues/1000 residues) and hydrox

27 repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for the stabili

28 was to investigate the utility of monitoring hydroxyproline, a signature amino acid for gelatin and c

29 rastructural changes, as well as attenuating hydroxyproline accumulation and inhibiting myofibroblast

30 mice treated with CO had significantly lower hydroxyproline accumulation than controls.

31 ol1a1, Col3a1, Col5a1, and Tgfb1 expression, hydroxyproline accumulation, and vascular stiffening, wi

32 They share a glycine-phenylalanine-hydroxyproline/alanine (GFO/A) motif that is recognised

33 combinant Skp1 by recombinant (Skp1-protein)-hydroxyproline alpha-N-acetyl-d-glucosaminyltransferase.

34 A20FMDV2 peptide correlated positively with hydroxyproline, alphavbeta6 protein, and itgb6 messenger

35 aration of the cis- and trans- forms of both hydroxyproline and fluoroproline was achieved using TWIM

36 chiral imidazolium salt derived from trans-L-hydroxyproline and its applications as a catalyst for th

37 eplacement of the canonical amino acids (4R)-hydroxyproline and proline by cysteine or homocysteine,

38 dicate that fibril formation greatly affects hydroxyproline and proline prolyl pucker ring conformati

39 e chondrocytes was impaired, the amount of 4-hydroxyproline and the Tm of collagen II were reduced, a

40 ive, the calix[4]resorcinarenes with trans-4-hydroxyproline and trans-3-hydroxyproline moieties gener

41 The absence of 3-hydroxyproline and/or the increased glycosylation of hyd

42 KO mice, as measured by collagen deposition (hydroxyproline) and histopathological features.

43 XX'GER motifs (GROGER and GMOGER, where O is hydroxyproline) and one containing two adjacent GXX'GEN

44 tions in collagen density, collagen content, hydroxyproline, and collagen advanced glycation end prod

45 in early liver fibrosis markers (sirius red, hydroxyproline, and collagen-1) were normalized by both

46 None of the peptides contain hydroxyproline, and furthermore the zwitterionic peptide

47 atin increased circulating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h after the

48 quencing, immunoblots, immunohistochemistry, hydroxyproline, and mass cytometry time of flight assays

49 ridines from commercially available proline, hydroxyproline, and pipecolinate esters.

50 Hepatic TGF-beta1 mRNA, tissue hydroxyproline, and plasminogen activator inhibitor 1 (P

51 lationally modified to 3-hydroxyproline or 4-hydroxyproline, and the rate-limiting step in formation

52 Mass spectrometry and anti-hydroxyproline antibody assays demonstrate PKM2 hydroxyl

53 rella hpat mutants lack cell-wall associated hydroxyproline arabinosides and can be rescued with exog

54 irst steps in the degradation of proline and hydroxyproline are catalyzed by proline oxidase (POX) an

55 epeating sequence -G-X-Y-, where proline and hydroxyproline are major constituents in X and Y positio

56 Proline and hydroxyproline are metabolized by distinct pathways.

57 n collagen synthesis because the resulting 4-hydroxyprolines are necessary for the stability of all c

58 Herein, we introduce natural hydroxyproline as a convertible unit for the production

59 ysine, phenylalanine, arginine, alanine, and hydroxyproline as the sole carbon and nitrogen sources.

60 exhibited strong epimerization activity with hydroxyproline as the substrate.

61 gregata to utilize several isomeric 3- and 4-hydroxyprolines as sole carbon sources.

62 urine, pyruvate and octadecenoic acid with 4-hydroxyproline, aspartate, cysteine, glutamine, lysine,

63 veloped more severe fibrosis, as measured by hydroxyproline assay and histological scoring, than wild

64 n collagen content of CP muscles measured by hydroxyproline assay and observed using immunohistochemi

65 ed, and the degree of injury was measured by hydroxyproline assay and quantification of neutrophil ge

66 action, collagen composition was measured by hydroxyproline assay as soluble collagen (1 mol/L NaCl e

67 ty profile was examined using a colorimetric hydroxyproline assay to determine the amount of soluble

68 s measured by acetic acid extraction and the hydroxyproline assay, and correlated with the decreased

69 ) and were confirmed by hepatic morphometry, hydroxyproline assay, and IFM.

70 red, and alpha-smooth muscle actin staining, hydroxyproline assay, and soluble ELISAs.

71 ex vivo by means of histologic analysis and hydroxyproline assay.

72 and r = 0.8429 and rho = 0.7607 [P = .001 vs hydroxyproline assay]).

73 ron microscopy, fluorescence microscopy, and hydroxyproline assays demonstrated that the expression o

74 ron microscopy, fluorescence microscopy, and hydroxyproline assays were used to demonstrate that DDR

75 ere assessed with dimethylmethylene blue and hydroxyproline assays, respectively.

76 nt as measured by acetic acid extraction and hydroxyproline assays.

77 son's trichrome and Sirius red staining, and hydroxyproline assays.

78 e that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus.

79 controlled synthesis of novel oligomers from hydroxyproline-based building blocks and conjugated thes

80 luoro-phenoxy)-pyrrolidin-1-y l]-ethanone, a hydroxyproline-based H(3) receptor antagonist, on 100 g

81 Hydroxyproline-based monomers enable the incorporation o

82 tetramer of the beta-l-arabinofuranosylated hydroxyproline (beta-l-Araf-Hyp) glycocluster is describ

83 FO motif in fibrillar collagens (O denotes 4-hydroxyproline) binds 3 unrelated proteins: von Willebra

84 f hydroxylation requires modification of the hydroxyproline by a pentasaccharide that, in Dictyosteli

85 cturally, it serves as a negative filter for hydroxyproline by clashing with the 4-hydroxyl group of

86 erine residue participates in recognition of hydroxyproline by forming a hydrogen bond with the 4-hyd

87 olyl-4-hydroxylase (PhyA), and the resulting hydroxyproline can subsequently be modified by a five-su

88 fibroblasts was inhibited, and the levels of hydroxyproline, COL1A1, COL3A1, IL-1beta, IL-18, and alp

89 d a 3-point flexural test, quantification of hydroxyproline (collagen solubilization), static and dyn

90 ung collagen deposition (Masson's trichrome, hydroxyproline, collagen type I alpha 1 chain, and colla

91 ivity (marker for osteoblasts), collagen and hydroxyproline composition, and histological and quantit

92 parameters and quantitative fibrosis extent (hydroxyproline concentration) and portal pressure.

93 and FKBP65 showed increased activity toward hydroxyproline-containing peptide substrates.

94 Hydroxyproline-containing peptides exhibited an IgE-bind

95 0 +/- 368 vs. 842 +/- 342; P < 0.05) and low hydroxyproline content (0.79 +/- 0.17 microL/mL/g versus

96 HSCs vs control mice; P < .001), and hepatic hydroxyproline content (328 mg/g in mice given HSCs vs 4

97 0.001), histological hepatic fibrosis, liver hydroxyproline content (P = 0.006), collagen 1 messenger

98 e lungs of FAP-deficient mice decreases lung hydroxyproline content after intratracheal bleomycin to

99 s but a profound, 5-fold lower procollagen 4-hydroxyproline content and enhanced cysteinyl sulfenic a

100 CR) of fibrotic marker genes, measurement of hydroxyproline content and histological methods.

101 The latter was accompanied by elevated hydroxyproline content and mRNA levels of collagen-1 and

102 is as observed by Sirius red staining, liver hydroxyproline content and mRNA levels of TGF- beta and

103 Hydroxyproline content and Sirius red staining of VX-166

104 aining, and low collagen production based on hydroxyproline content and Sirius Red staining.

105 fibrillation (AF) exhibited 4-fold increased hydroxyproline content compared with patients in sinus r

106 At day 40 the hydroxyproline content had increased further (48.91 +/-

107 The presence of normal collagen decreased hydroxyproline content in bones, altered the apatite cry

108 ical measures of fibrosis revealed increased hydroxyproline content in DM adipose tissue, but no diff

109 r P4H mRNA levels were associated with lower hydroxyproline content in root and shoot tissues indicat

110 afts at day 28 showed a significantly higher hydroxyproline content than the isografts (33.21 +/- 1.8

111 treatment significantly decreased granuloma hydroxyproline content to a greater extent than the anti

112 protein content with 77.8% while the highest hydroxyproline content was found in chicken skin gelatin

113 uctions in the bile salt pool size and liver hydroxyproline content were also seen with treatment wit

114 hepatic fibrosis (collagen 1alpha1 mRNA and hydroxyproline content), as well as elevated inflammatio

115 Development of fibrosis was assessed by lung hydroxyproline content, and alphavbeta6 protein and itgb

116 Fibrosis was detected by IHC, hydroxyproline content, and by qPCR for fibrotic markers

117 osis, as indicated by histological analysis, hydroxyproline content, and immunoblot analysis.

118 ntilation was associated with increased lung hydroxyproline content, and increased expression of tran

119 rats versus EP1, CP1, and CP3 by histology, hydroxyproline content, and mRNA expression for collagen

120 es, histopathology of the liver, the hepatic hydroxyproline content, and the expression of various he

121 confirmed with immunohistochemistry, tissue hydroxyproline content, and tissue mRNA expression of fi

122 in doses, histologic score of fibrosis, lung hydroxyproline content, and weight loss.

123 trichrome blue staining and biochemically by hydroxyproline content, in wild-type but not in recombin

124 sgenic mice, as demonstrated by staining and hydroxyproline content, is preceded by activation and pr

125 improved NASH-related fibrosis markers (FR: hydroxyproline content, P < 0.01; EX: collagen 1alpha1 m

126 otrimers are further discouraged by reducing hydroxyproline content, which would otherwise lead to no

127 rosis, hepatic collagen gene expression, and hydroxyproline content.

128 ung injury as assessed by lung histology and hydroxyproline content.

129 -smooth muscle actin expression, and hepatic hydroxyproline content.

130 alysis of picrosirius red stained slides and hydroxyproline content.

131 Finally, MSC transplantation decreased bone hydroxyproline content.

132 and type III collagen, and normalized total hydroxyproline content.

133 sue was analyzed for Sirius Red staining and hydroxyproline content.

134 elatines had higher imino acids (proline and hydroxyproline) contents compared to those extracted aft

135 The absence of hydroxyprolines could then affect the accuracy of compon

136 An efficient conversion of hydroxyproline "customizable" units into new amino acids

137 e calix[4]resorcinarenes containing 3- and 4-hydroxyproline, d-nipecotic acid, (S)-2-(methoxymethyl)p

138 compared with female Spp1+/+ mice, and lung hydroxyproline decreased in male Spp1-/- mice compared w

139 rate specificity of the related enzyme human hydroxyproline dehydrogenase, which has serine in place

140 biologically relevant l-proline and l-trans-hydroxyproline, delivering unique 2,5-dialkylated amino

141 Moreover, FKBP22 showed a hydroxyproline-dependent effect by increasing the amount

142 activation of caspase-9 with adriamycin in a hydroxyproline-dependent manner.

143 ng the structure of the (2S,4S)-configured 4-hydroxyproline derivative 4, a selective picomolar inhib

144 cient route but also the shortest route to 3-hydroxyproline derivatives, which are not accessible by

145 demonstrated the validity and robustness of hydroxyproline determination according to ISO 17025.

146 ver tissues were analyzed by histochemistry, hydroxyproline determination, reverse-transcription poly

147 phenylacetylglutamine, hippurate, and prolyl-hydroxyproline did not reach statistical significance in

148 In contrast, corresponding peptides without hydroxyprolines displayed a very weak IgE-binding capaci

149 ite is mutated back into cysteine regained 3-hydroxyproline epimerase activity.

150 PR utilized only d-proline but not l-hydroxyproline, even in the presence of an expressed and

151 ncreased connective tissue growth factor and hydroxyproline expression in cardiac fibroblasts, which

152 Hydroxyproline expression was increased in cardiac fibro

153 positions 260 (alanine for isoleucine), 261 (hydroxyproline for alanine), and 263 (asparagine for phe

154 ntiation of osteoblasts, collagen synthesis, hydroxyproline formation, and biomineralization.

155 Here we describe a method to date hydroxyproline found in collagen (~10% of collagen carbo

156 Here we report a thermally stable hydroxyproline-free ABC heterotrimeric collagen mimetic

157 s of the secondary amino acids proline and 4-hydroxyproline from gelatin hydrolysates using anion-exc

158 Oxidation of proline to 5-hydroxyproline furnishes a versatile intermediate that c

159 modifications characteristic of conotoxins (hydroxyproline, gamma-carboxyglutamate) are present.

160 gamma-Aminobutyric acid, 4-hydroxyproline, glycine, leucine+isoleucine and putresci

161 e features collagen's characteristic proline-hydroxyproline-glycine repeating unit, complemented by d

162 ptides designed to include a glycine-proline-hydroxyproline (GPO) amino acid triad are biomimetic ana

163 hich the content of critical glycine-proline-hydroxyproline (GPO) triplets was varied in relation to

164 The derivatives with the hydroxyproline groups are especially effective at causin

165 xyphenylalanine, Arg > Val > Lys, Tyr, Pro > hydroxyproline > alpha-aminobutyric acid > Gln, Thr, Ser

166 tereospecific; replacement of ProB28 by (4R)-hydroxyproline (Hyp) causes little change in the rates o

167 The Hyp diastereomer (2S,4S)-4-hydroxyproline (hyp) has not been observed in a protein,

168 ncode activity for adding galactose (Gal) to hydroxyproline (Hyp) in AGP protein backbones.

169 this work, we investigated the function of 4-hydroxyproline (Hyp) in conotoxins from three distinct g

170 The resulting product trans-4-hydroxyproline (Hyp) is of critical importance for the s

171 The resulting (2 S,4 R)-4-hydroxyproline (Hyp) residues are essential for the fold

172 The resulting (2S,4R)-4-hydroxyproline (Hyp) residues are essential for the fold

173 ified systematically through substitution by hydroxyproline (Hyp), (S)-beta-homoproline (betaPro), 2-

174 ce in an invertebrate collagen has (2S,4R)-4-hydroxyproline (Hyp), a C(gamma)-exo-puckered Pro deriva

175 and Y are most commonly proline (Pro) and 4R-hydroxyproline (Hyp), respectively.

176 fusion glycoprotein yielded a population of hydroxyproline (Hyp)-arabinogalactan polysaccharides ran

177 Among them, hydroxyproline (Hyp)-rich glycoproteins constitute a com

178 ctan-proteins (AGPs) are highly glycosylated hydroxyproline (Hyp)-rich glycoproteins that are frequen

179 h included the collagen breakdown amino acid hydroxyproline (Hyp).

180 lastin, and other proteins to form (2S,4R)-4-hydroxyproline (Hyp).

181 elective detection and quantification of L-4-Hydroxyproline (Hyp).

182 ber of these peptides additionally contain 4-hydroxyproline (Hyp).

183 equence, where Xaa is often proline and Yaa, hydroxyproline (Hyp/O).

184 eat, Ser-Hyp4, serine and the consecutive C4-hydroxyprolines (Hyps) are substituted with an alpha-gal

185 n 28 of the insulin B-chain (ProB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin th

186 fibril swelling and evidence for excess cis-hydroxyproline in the 6.45-microm debris.

187 It is known that hydroxyproline in the Yaa position stabilises the triple

188 In studies of the distribution of 3-hydroxyproline in type I collagen of rat bone, skin, and

189 quence analysis, the presence of repeating 3-hydroxyprolines in consecutive GPP triplets adjacent to

190 als unexpectedly large numbers of X-position hydroxyprolines in Gly-X-Y amino acid triplets.

191 Hydroxyproline, in contrast, is not reutilized for prote

192 binding recombinant collagen did not contain hydroxyproline, indicating hydroxyproline is not essenti

193 xpression systems where the incorporation of hydroxyproline is challenging.

194 We show here that TgSkp1 hydroxyproline is modified by a similar pentasaccharide,

195 ated protist, Dictyostelium discoideum, Skp1 hydroxyproline is modified by five sugars via the action

196 n did not contain hydroxyproline, indicating hydroxyproline is not essential for binding.

197 ollagen, consisting of glycine, proline, and hydroxyproline, is a fibrous protein that can form a rop

198 tion of a vinylogous malonate derived from 4-hydroxyproline, is described.

199 r side chains amino acids that were proline, hydroxyproline, leucine, isoleucine and valine on the ne

200 D treatment group showed consistently lower hydroxyproline level but still higher than that of the c

201 epatic fibrosis, as evidenced by a decreased hydroxyproline level in the liver and a reduced incidenc

202 The bleomycin group had rising hydroxyproline level on days 14, 21 and 28, whereas the

203 iaphragm muscle fiber density, and decreased hydroxyproline levels (significant improvement for 1D11

204 osis in mdx mice, as determined by measuring hydroxyproline levels and collagen deposition in diaphra

205 diffuse interstitial fibrosis and increased hydroxyproline levels at both times, but injected normal

206 by changes in lung function, histology, and hydroxyproline levels in mice.

207 carring by Masson trichrome staining, kidney hydroxyproline levels, and collagen immunofluorescence d

208 Collagen content was measured by determining hydroxyproline levels, and collagen type I synthesis by

209 of the collagen proportional area and kidney hydroxyproline levels.

210 had increased Trichrome staining and tissue hydroxyproline levels.

211 t a high degree of proline hydroxylation and hydroxyproline-linked arabinosides, on a mucin (MUC1)-de

212 as characterized mainly by peaks assigned to hydroxyproline, lipids, and collagen.

213 Silica-induced lung collagen and hydroxyproline (markers of fibrosis), and SPP1 levels de

214 in reaction of fibrosis-related genes, liver hydroxyproline measurement, and Picro-Sirius red stainin

215 increased production of hepatic collagen by hydroxyproline measurement.

216 lagen ultrafiltration and single amino acid (hydroxyproline) methods, these specimens consistently da

217 betaine, creatine, acetylcholine, aspartate, hydroxyproline, methylhistidine, tryptophan, cystamine,

218 The observed hydroxyproline modifications, however, call for addition

219 Therefore, we propose that hydroxyproline modulates the rate of Ziploc-ing of the t

220 enes with trans-4-hydroxyproline and trans-3-hydroxyproline moieties generally produce the largest no

221 modified by a pentasaccharide attached to a hydroxyproline near its C terminus.

222 om readily available starting materials like hydroxyproline, nitrobenzaldehyde, pyrrolidine, and pipe

223 dification of CLE peptides by enzymes of the hydroxyproline O-arabinosyltransferase (HPAT/RDN) family

224 The most extreme mutant is disrupted in a hydroxyproline O-arabinosyltransferase and can be rescue

225 Hydroxyproline O-arabinosyltransferases (HPATs) are memb

226 HYDROXYPROLINE O-ARABINOSYLTRANSFERASEs (HPATs) initiate

227 , and the glycosyltransferases that cap Skp1 hydroxyproline occur also in the genomes of Toxoplasma a

228 jor amino acid with imino acids (proline and hydroxyproline) of 194-195 residues/1000 residues).

229 ptide fragment of collagen type II with five hydroxyprolines (OH) can be selectively produced by the

230 that are post-translationally modified to 3-hydroxyproline or 4-hydroxyproline, and the rate-limitin

231 e are catalyzed by proline oxidase (POX) and hydroxyproline oxidase (OH-POX), respectively.

232 tion of Sirius red staining (P = 0.0003) and hydroxyproline (P = 0.007) than wild-type mice after BDL

233 Hydroxyproline plays a major role in stabilizing collage

234 To determine the hydroxyproline profiles among animal- and plant-based sa

235 Crystal structures of Y540S complexed with hydroxyproline, proline, and the proline analogue l-tetr

236 erences, with (2S,4R)-perfluoro-tert-butyl 4-hydroxyproline promoting polyproline helix.

237 promotes pathology, immunohistochemical and hydroxyproline quantification studies on aged RAGE-null

238 rosis were analyzed by histology and hepatic hydroxyproline quantification.

239 for quantitative RT-PCR, and immunoblot and hydroxyproline release assays.

240 Hydroxyproline release by differentiating pre-adipocytes

241 dulus of elasticity and collagen solubility (hydroxyproline release).

242 A central hydroxyproline residue anchors IDA to the receptor.

243 s in each chain, which include no proline or hydroxyproline residues and contain a chymotrypsin cleav

244 Lacking hydroxyproline residues and telopeptides, two factors im

245 the precursor gene were synthesized but with hydroxyproline residues at positions found in the native

246 o be influenced by the number of proline and hydroxyproline residues in the triple helix structure.

247 ve related collagen-like molecules that have hydroxyproline residues occupying positions not observed

248 s of the peptide sequence indicated that the hydroxyproline residues play a significant role in suppo

249 H-II, and C-P4H-III) catalyze formation of 4-hydroxyproline residues required to form triple-helical

250 Notably, an unexpectedly large number of hydroxyproline residues were mapped to the X-positions o

251 has an abundance of 2S-proline and (2S,4R)-4-hydroxyproline residues, and can be stabilized by (2S,4R

252 Collagen triple helices are stabilized by 4-hydroxyproline residues.

253 ylases and subsequent O-glycosylation of the hydroxyproline residues.

254 which Xaa and Yaa frequently are proline and hydroxyproline, respectively.

255 phenylacetylglutamine, hippurate, and prolyl-hydroxyproline, respectively.

256 e tomato leaf polyprotein precursor of three hydroxyproline-rich glycopeptide defense signals (called

257 osttranslationally modified to produce three hydroxyproline-rich glycopeptide signals (HypSys peptide

258 Hydroxyproline-rich glycopeptides (HypSys peptides) are

259 Hydroxyproline-rich glycopeptides (HypSys peptides) have

260 A mixture of three homologous bioactive hydroxyproline-rich glycopeptides (HypSys peptides) of 1

261 ana arabinogalactan protein (AGP) encoded by hydroxyproline-rich glycoprotein family protein gene At3

262 genesis transcriptome are cell wall enzymes, hydroxyproline-rich glycoproteins (extensins) and arabin

263 Hydroxyproline-rich glycoproteins (HRGPs) are a superfam

264 Genes encoding hydroxyproline-rich glycoproteins (HRGPs) in green organ

265 is a major posttranslational modification of hydroxyproline-rich glycoproteins (HRGPs) that is cataly

266 A superfamily of cell wall proteins, the hydroxyproline-rich glycoproteins (HRGPs), have characte

267 accharides, plant cell walls are composed of hydroxyproline-rich glycoproteins (HRGPs), which include

268 amily of developmentally expressed cell wall hydroxyproline-rich glycoproteins (HRGPs).

269 nogalactan proteins (AGPs), a superfamily of hydroxyproline-rich glycoproteins present in the extrace

270 Extensins are hydroxyproline-rich glycoproteins that can be cross link

271 ctan proteins (AGPs), a superfamily of plant hydroxyproline-rich glycoproteins, are present at cell s

272 Arabinogalactan proteins (AGPs), a family of hydroxyproline-rich glycoproteins, occur throughout the

273 evident on screening the spectrum of known 3-hydroxyproline sites from all major tissue collagen type

274 e presence of a relatively large number of 3-hydroxyproline sites with less than 100% occupancy, sugg

275 cium diet with 5% trans-4-hydroxy-l-proline (hydroxyproline) so that the rats would exclusively form

276 The unexpected abundance of X-position hydroxyprolines suggests a mechanism for differential mo

277 Hydroxyproline-supplemented GHS rats were used to test t

278 n endo ring conformation, whilst when Yaa is hydroxyproline, the Xaa proline adopts a range of endo a

279 ntrast, even though bacterial collagens lack hydroxyproline, their thermal stability is comparable to

280 Skp1 hydroxyproline then becomes the target of five sequentia

281 ectra suggest that the carbohydrate links to hydroxyproline through the galactose (galactosylation).

282 l by compound-specific radiocarbon dating of hydroxyproline to 34,950-33,900 Cal.

283 f a common amino acid and oxalate precursor, hydroxyproline, to the diet of the GHS rats leads to for

284 Regarding the organic phase of bone, the hydroxyproline-to-proline ratio was increased by 18% in

285 bit a pronounced preference for proline over hydroxyproline (trans-4-hydroxy-l-proline) as the substr

286 translational modifications, namely, trans-4-hydroxyproline, trans-2,3-cis-3,4-dihydroxyproline, and

287 ch based on the extraction of the amino acid hydroxyproline, using preparative high-performance liqui

288 distribution pattern among 59 samples due to hydroxyproline variability.

289 es in consecutive GPP triplets adjacent to 4-hydroxyproline was confirmed as a unique feature of the

290 From this, 4-hydroxyproline was revealed as a regulating hub in low o

291 vitamin C, trytophan, taurine, histidine and hydroxyproline were below the reference range throughout

292 Morphometric features and levels of hydroxyproline were determined as measures of dermal fib

293 , patchy interstitial fibrosis and increased hydroxyproline were present in the lungs of immunodefici

294 (2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and fre

295 lant-specific O-glycosylation; unsubstituted hydroxyprolines were identified in our MUC1 construct.

296 phenylacetylglutamine, hippurate, and prolyl-hydroxyproline-were associated with impaired executive f

297 ase inhibition by Y-27632 prevented CTGF and hydroxyproline, whereas the RhoA activator CN03 increase

298 proline residues in a peptide chain into R-4-hydroxyproline, which is essential for collagen cross-li

299 double fluorination of N-protected (2S,4R)-4-hydroxyproline with 4-tert-butyl-2,6-dimethylphenylsulfu

300 Derivatives of 4-hydroxyproline with a series of hydrophobic groups in we