ライフサイエンスコーパス: hydroxysteroid

1 NADPH-dependent reduction of ketosteroids to hydroxysteroids.

2 abolism of androgenic and neuroactive 3alpha-hydroxysteroids.

3 ing pregnenolone and progesterone to 17alpha-hydroxysteroids.

4 atalyzes metabolism of retinoids and 3 alpha-hydroxysteroids.

5 characterized the functional effect of 3beta-hydroxysteroids.

6 ns of barbiturates was also reduced by 3beta-hydroxysteroids.

7 ation of synaptic currents induced by 3alpha-hydroxysteroids.

8 ompetent kinetics) plus hydroxylated 17alpha-hydroxysteroids.

9 ransport, and sulfonylation of bile acids or hydroxysteroids.

10 dipose tissue (WAT) genes but also represses hydroxysteroid 11-beta-dehydrogenase 1 (HSD11B1) indepen

11 On the other hand, LSD1 represses HSD11B1 (hydroxysteroid 11-beta-dehydrogenase isozyme 1), a key g

12 Recently, rs72613567:TA in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) was s

13 , superfamily member 2 [TM6SF2] p.E167K; and hydroxysteroid 17-beta dehydrogenase 13 [HSD17B13] rs726

14 ain containing 7, glucokinase regulator, and hydroxysteroid 17-beta dehydrogenase 13) to NAFLD and ex

15 another deceased case (SF) with undetectable hydroxysteroid (17beta) dehydrogenase 10 (HSD10) activit

16 of the neurological handicap associated with hydroxysteroid (17beta) dehydrogenase 10 deficiency.

17 Approximately half of the cases of hydroxysteroid (17beta) dehydrogenase X (HSD10) deficien

18 s reduced the potentiation induced by 3alpha-hydroxysteroids, 3beta-hydroxysteroids acted noncompetit

19 ion induced by 3alpha-hydroxysteroids, 3beta-hydroxysteroids acted noncompetitively with respect to p

20 encompassing 3-hydroxyacyl-CoA derivatives, hydroxysteroids, alcohols and beta-hydroxybutyrate, and

21 codes a sulfoconjugation enzyme that acts on hydroxysteroids and cholesterol-derived sterol bile acid

22 effect on GABAergic synaptic currents, 3beta-hydroxysteroids and low concentrations of sulfated stero

23 3beta-Hydroxysteroids are also direct, noncompetitive GABA(A)

24 3beta-Hydroxysteroids coapplied with GABA significantly inhibi

25 ne, indicating Delta4-ketosteroids to Delta5-hydroxysteroids conversion, provides strong evidence for

26 dology for the quantitative determination of hydroxysteroids dehydroepiandrosterone and pregnenolone

27 hat mediates sulfo-conjugation of endogenous hydroxysteroids (dehydroepiandrosterone, testosterone, b

28 Two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) interconvert

29 Isozymes of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) act at a prere

30 The 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes contro

31 ly of systemic levels, by isozymes of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) that interconv

32 verting cortisone to cortisol via the 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 pathway

33 ,12(2)H3] cortisol (D3-cortisol) via 11-beta hydroxysteroid dehydrogenase (11beta-HSD) type 1, D3-cor

34 ra with a luminal signaling sequence (11beta-hydroxysteroid dehydrogenase (11beta-HSD1)(1-41)/Rdh1(23

35 ery of potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1).

36 The kidney also expresses both of the 11beta-hydroxysteroid dehydrogenase (11betaHSD) enzymes.

37 11beta-Hydroxysteroid dehydrogenase (11betaHSD) isozymes cataly

38 s study, we have examined the role of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 2 in the

39 tive metabolizing enzyme, the type II 17beta-hydroxysteroid dehydrogenase (17beta-HSD), in the ZR-75-

40 ls in HEK293 cells expressing type 10 17beta-hydroxysteroid dehydrogenase (17beta-HSD10), but not its

41 steroid-5alpha-reductase (SRD5A) and 17beta-hydroxysteroid dehydrogenase (17betaHSD) isoenzymes.

42 ssor of the P(4)-metabolizing enzyme 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD).

43 he progesterone inactivating enzyme 20-alpha-hydroxysteroid dehydrogenase (20alpha-HSD; median, 2.5 a

44 Bacterial 20beta-hydroxysteroid dehydrogenase (20beta-HSDH) regulates cor

45 Human PGFS is 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) type II and h

46 DH-4 from a related enzyme, RoDH-like 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), which is 3-fo

47 lpha-reductase type I (5alpha-RI) and 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD).

48 alpha-reductase (5alpha-R) type I and 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD).

49 these enzymes were analyzed using rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD, AKR1C9) as the

50 he source of NADPH-dependent cytosolic 3beta-hydroxysteroid dehydrogenase (3beta-HSD) activity is unk

51 The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play

52 of differentiated function, including 3beta-hydroxysteroid dehydrogenase (3betaHSD) activity.

53 We identified the 3-beta-hydroxysteroid dehydrogenase (3betaHSD) family member HS

54 mmonly requires enzymatic reactions by 3beta-hydroxysteroid dehydrogenase (3betaHSD), steroid-5alpha-

55 50, aldehyde dehydrogenase (ALDH3A2), and 21-hydroxysteroid dehydrogenase (AKR1C18) were found to be

56 Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significan

57 The enzyme 11beta-hydroxysteroid dehydrogenase (HSD) type 1 converts inact

58 Flux through the 11beta hydroxysteroid dehydrogenase (HSD) type 1 pathway can be

59 e crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding pro

60 rogenase 4 (RoDH4, SDR9C8), RoDH-like 3alpha-hydroxysteroid dehydrogenase (RL-HSD, SDR9C6), and RDH-l

61 We tested this by expressing 11-beta-hydroxysteroid dehydrogenase (type II) in dentate gyrus

62 Expression of 11-beta-hydroxysteroid dehydrogenase (type II), mostly in mature

63 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) has been a

64 Several tissues express 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1), including

65 e metabolism through its induction of 11beta-hydroxysteroid dehydrogenase 1 (HSD1) and glucocorticoid

66 Regulation of 11 beta-hydroxysteroid dehydrogenase 1 expression is important s

67 The 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17

68 8[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta-hydroxysteroid dehydrogenase 1 gene HSD17B1 (Ser312Gly)

69 Lower relative abundance of 11-beta-hydroxysteroid dehydrogenase 1 mRNA in HG explants sugge

70 loid A3, stearoyl-CoA desaturase, and 11beta-hydroxysteroid dehydrogenase 1 were induced while actin

71 lucose elimination, and inhibitors of 11beta-hydroxysteroid dehydrogenase 1, which reduce the glucoco

72 hich was induced by both agents, and 11 beta-hydroxysteroid dehydrogenase 1, which was decreased by t

73 gous and are most closely related to 17-beta-hydroxysteroid dehydrogenase 1.

74 converted to active corticosterone by 11beta-hydroxysteroid dehydrogenase 1.

75 died rs6834314 and its nearest gene, 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13), to identify

76 controls negative feedback mechanism, 11beta-hydroxysteroid dehydrogenase 2 (11betaHSD2).

77 17beta-Hydroxysteroid dehydrogenase 2 (17beta-HSD2) catalyzes t

78 e inner mitochondrial membrane protein 3beta-hydroxysteroid dehydrogenase 2 (3betaHSD2) synthesizes p

79 ated by the inner mitochondrial enzyme 3beta-hydroxysteroid dehydrogenase 2 (3betaHSD2).

80 the glucocorticoid receptor and the 11-beta hydroxysteroid dehydrogenase 2 isozyme were significantl

81 f the glucocorticoid receptor or the 11-beta hydroxysteroid dehydrogenase 2 isozyme.

82 dipose tissue compared to SC, whereas 17beta-hydroxysteroid dehydrogenase 5 (AKR1C3) showed predomina

83 ainly with mRNA and protein levels of 17beta-hydroxysteroid dehydrogenase 6 (17beta-HSD6), one of sev

84 tive loss of AKR1C1, which encodes a 20alpha-hydroxysteroid dehydrogenase [20alpha-HSD (EC 1.1.1.149)

85 .1.149)], and AKR1C2, which encodes a 3alpha-hydroxysteroid dehydrogenase [3alpha-HSD (EC 1.1.1.52)],

86 %), but does not have the retinol and 3alpha-hydroxysteroid dehydrogenase activity of either, nor is

87 ens with high positional selectivity (17beta-hydroxysteroid dehydrogenase activity) as well as 3-keto

88 oblasts express significant oxidative 3alpha-hydroxysteroid dehydrogenase activity, which can convert

89 by reduced progesterone secretion and 3beta-hydroxysteroid dehydrogenase activity.

90 ts identified estrogen receptors and 17-beta-hydroxysteroid dehydrogenase as potential targets.

91 with inhibitors of type 1- and type 2-17beta hydroxysteroid dehydrogenase did not affect the previous

92 s derived from DHT by 3-keto reductase/3beta-hydroxysteroid dehydrogenase enzymes.

93 Disruption of the 3beta-hydroxysteroid dehydrogenase gene in Mtb abrogates mycob

94 ted levels of P4-metabolizing enzyme 20alpha-hydroxysteroid dehydrogenase in corpora lutea (CL) inact

95 he Rv1106c gene that is annotated as a 3beta-hydroxysteroid dehydrogenase in Mtb has been cloned and

96 The expression of the 3beta-hydroxysteroid dehydrogenase in Mtb is intracellular.

97 te expression of 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase mRNAs in the NTS, and this

98 CE) by depositing NADH and the enzyme 3alpha-hydroxysteroid dehydrogenase onto the MB-SPCE surface; s

99 GR and NF1 binding on the endogenous 11beta-hydroxysteroid dehydrogenase promoter, also regulated by

100 dihydrotestosterone (DHT) and/or its 3alpha-hydroxysteroid dehydrogenase reduced metabolite 3alpha-a

101 romentin, the proposed inhibition of 17-beta-hydroxysteroid dehydrogenase should be considered as a s

102 r glucocorticoid reamplifying enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) foun

103 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catal

104 tive 11-keto forms through the enzyme 11beta hydroxysteroid dehydrogenase type 1 (11beta HSD-1).

105 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catal

106 In adipocytes, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) conve

107 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) intra

108 ion of D4 cortisol to D3 cortisol via 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) occur

109 11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) amplif

110 The cortisol-regenerating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) amplif

111 11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) cataly

112 In vivo, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) cataly

113 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) conver

114 heses of AMG 221 (2), an inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) discov

115 The 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme

116 The 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme

117 novel, potent inhibitor against human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme

118 urs through increased activity of the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme

119 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) has be

120 the glucocorticoid-generating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in adi

121 xpression of the GC-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in cul

122 tion of glucocorticoids by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in fat

123 neration of active glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in met

124 from a rapidly metabolized adamantane 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibi

125 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the

126 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the

127 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the

128 ve glucocorticoid by NADPH-dependent, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) oxored

129 ification of glucocorticoids (GCs) by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) plays

130 glucocorticoids in vivo by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) plays

131 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regene

132 The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regene

133 a defect in the gene HSD11B1 encoding 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), a pri

134 cocorticoid (GC) regenerating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), in ad

135 nd that tissue regeneration of GCs by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), rathe

136 glucocorticoid metabolism, including 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which

137 acid (CA) is a selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which

138 ) in Src-1/-2 dKO fetal lungs encodes 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which

139 to be potent inhibitors of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

140 sulin resistance and are regulated by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

141 racellular cortisone-cortisol shuttle 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

142 regulated by the GC-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

143 We investigated whether inhibition of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, also k

144 ular glucocorticoid-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1(-/-)) ha

145 CP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (

146 culum by an enzyme complex containing 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and hex

147 11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) catalyz

148 11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a th

149 P2), glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) mRNA in

150 11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) perform

151 tion of glucocorticoids by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1).

152 17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is tho

153 nt estrogen in human, is catalyzed by 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).

154 on that leads to a gain-of-function in 3beta-hydroxysteroid dehydrogenase type 1 (3betaHSD1), which c

155 I-MS/MS) was used to observe in vitro 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) enzyme-cataly

156 family 11, subfamily A1 (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) also down-r

157 oid secretion and metabolism (notably 11beta-hydroxysteroid dehydrogenase type 1 and 5alpha-reductase

158 er reviews the functional role(s) of 11 beta-hydroxysteroid dehydrogenase type 1 and examines factors

159 polymorphisms in the genes encoding 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phospha

160 trate that the reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 depends on reduced n

161 In mice, overexpression of 11 beta-hydroxysteroid dehydrogenase type 1 in adipose or liver

162 Thus, 11 beta-hydroxysteroid dehydrogenase type 1 is a promising drug

163 In obese humans, 11 beta-hydroxysteroid dehydrogenase type 1 is relatively highly

164 Hexose-6-phosphate dehydrogenase and 11 beta-hydroxysteroid dehydrogenase type 1 may play important r

165 d activity because global deletion of 11beta-hydroxysteroid dehydrogenase type 1 normalized Ca(2+) an

166 , respectively, whereas mice lacking 11 beta-hydroxysteroid dehydrogenase type 1 resist diet-induced

167 ortisol by the reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1, which can thus incr

168 d for the 11-oxoreductase activity of 11beta-hydroxysteroid dehydrogenase type 1, which converts inac

169 17beta-Hydroxysteroid dehydrogenase type 10 (HSD10) is multifun

170 The enzyme 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), also known

171 ion, and metabolic functions of human 17beta-hydroxysteroid dehydrogenase type 10/short chain L-3-hyd

172 e HCV interactome, we identified the 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) as a hum

173 cental glucocorticoid inactivation by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) plays

174 The expression of 11beta hydroxysteroid dehydrogenase type 2 (11beta-HSD2) was ag

175 centa) or inhibitors of fetoplacental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), the p

176 Expression of MR was similar, as was 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which

177 th >10000-fold selectivity over human 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2).

178 11b2(-/-) mice, which lack the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) and thu

179 The reduced activity of 11beta hydroxysteroid dehydrogenase type 2 (11betaHSD2) contrib

180 nction mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), allowi

181 fects of GCs, in part by induction of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2).

182 ribe the design of a nanomolar potent 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD2) inhibi

183 on, such as potentially inhibitors of 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD2), may b

184 In the adrenals, testes, and ovaries, 3beta-hydroxysteroid dehydrogenase type 2 (3betaHSD2) catalyze

185 c acute regulatory protein (StAR), and 3beta-hydroxysteroid dehydrogenase type 2 (3betaHSD2) via its

186 zyme with sequence homology to CD13), 11beta-hydroxysteroid dehydrogenase type 2 (a steroid pathway e

187 These neurons express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) and are activ

188 terone-sensitive neurons that express 11beta-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleu

189 e glucocorticoid-inactivating enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a signature

190 abel neurons in the NTS that express 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), an enzyme th

191 locorticoid receptors and the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), which makes

192 n of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), which makes

193 ive neurons which contain the enzyme 11 beta-hydroxysteroid dehydrogenase type 2 (HSD2).

194 TS neurons, which express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

195 of the NTS, which express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

196 n of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

197 ue to their expression of the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

198 3beta-Hydroxysteroid dehydrogenase type 2 (HSD3B2) is a steroi

199 mangiomas were identified, including 17-beta hydroxysteroid dehydrogenase type 2 and tissue factor pa

200 Mutations in 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) cause

201 ptors, transgenic mice overexpressing 11beta-hydroxysteroid dehydrogenase type 2 in cardiomyocytes we

202 t the ability of the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 to inactivate cortis

203 izin (a potent inhibitor of placental 11beta-hydroxysteroid dehydrogenase type 2, the "barrier" to ma

204 ctus solitarius expresses the enzyme 11-beta-hydroxysteroid dehydrogenase type 2, which makes them se

205 The HSD2 (11-beta-hydroxysteroid dehydrogenase type 2-expressing) neurons

206 lasts via transgenic (tg) expression of 11ss-hydroxysteroid dehydrogenase type 2.

207 biosynthesis by using an inhibitor of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is a s

208 onal variants: HSD17B4, which encodes 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4), also know

209 response element-luciferase reporter, 17beta-hydroxysteroid dehydrogenase type 6 (17betaHSD6) convert

210 Human 11beta-hydroxysteroid dehydrogenase type I (11beta-HSD1) is an

211 lucocorticoid receptor (GR)-alpha and 11beta-hydroxysteroid dehydrogenase type I (11beta-HSD1)-mediat

212 cortisone to cortisol is catalyzed by 11beta-hydroxysteroid dehydrogenase type I (11beta-HSD1).

213 We found that expression of 11beta-hydroxysteroid dehydrogenase type II (11betaHSD2), which

214 Androgen biosynthesis requires 3beta-hydroxysteroid dehydrogenase type II (3betaHSDII) and th

215 to show that inhibition of the enzyme 11beta-hydroxysteroid dehydrogenase type II(11betaHSD2) reduces

216 to as the human bile acid binder and 3alpha-hydroxysteroid dehydrogenase type III, is a multifunctio

217 ffects of exogenous estradiol (E2) on 17beta-hydroxysteroid dehydrogenase type IV (HSD17B4) and the c

218 We focused on a Z-linked gene, 17beta-hydroxysteroid dehydrogenase type IV (HSD17B4), coding f

219 11beta-Hydroxysteroid dehydrogenase type-1 (11beta-HSD1) conver

220 11beta-hydroxysteroid dehydrogenase type-1 (HSD1) regulates con

221 roteins including cytochrome b(5) and 11beta-hydroxysteroid dehydrogenase were degraded slowly or not

222 l type of microsomal NAD(+)-dependent 3alpha-hydroxysteroid dehydrogenase with unique catalytic prope

223 do-keto reductase 1C3 (AKR1C3; type 5 17beta-hydroxysteroid dehydrogenase) is overexpressed in castra

224 Rv1106c (hsd; 3beta-hydroxysteroid dehydrogenase) is required by Mycobacteri

225 esizing enzymes (5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase) was increased in the hypot

226 Type 5 17beta-hydroxysteroid dehydrogenase, aldo-keto reductase 1C3 (A

227 teroidogenic acute regulatory protein, 3beta-hydroxysteroid dehydrogenase, and P450c17) was impaired.

228 a-reductase, 6alpha-hydroxylase, 3alpha/beta-hydroxysteroid dehydrogenase, and reverse Delta4minus si

229 The enzyme is most efficient as a 3alpha-hydroxysteroid dehydrogenase, converting 3alpha-tetrahyd

230 in expression of 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase, especially in cerebellum.

231 chain cleavage enzyme, P450 aromatase, 3beta-hydroxysteroid dehydrogenase, luteinization hormone rece

232 Human type 3 3alpha-hydroxysteroid dehydrogenase, or aldo-keto reductase (AK

233 In summary, in addition to 3alpha-hydroxysteroid dehydrogenase, rat osteoblasts express si

234 ocorticoid binding by the absence of 11-beta hydroxysteroid dehydrogenase, salt-mineralocorticoid-ind

235 enveloped virus host range protein, dUTPase, hydroxysteroid dehydrogenase, superoxide dismutase, serp

236 than reported for 3alpha-reduction by 3alpha-hydroxysteroid dehydrogenase, the major enzyme known to

237 17-beta-Hydroxysteroid dehydrogenase, type 7, was identified onl

238 cocorticoid (GC) metabolising enzyme, 11beta-hydroxysteroid dehydrogenase-1 (11beta-HSD1) converts in

239 d compounds, acting by inhibition of 11-beta-hydroxysteroid dehydrogenase-1 (11beta-HSD1), gave rise

240 HSD3B1 encodes for 3beta-hydroxysteroid dehydrogenase-1 (3beta-HSD1), which catal

241 Deficiency of placental 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2), which inac

242 in E3-ligase, AMFR, mediating loss of 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2), which othe

243 Human ECs also express the enzyme 11-beta-hydroxysteroid dehydrogenase-2 (11betaHSD2), and inhibit

244 for the O-GlcNAc mark identified the 17 beta hydroxysteroid dehydrogenase-3 (Hsd17b3) locus in male E

245 We identified hydroxysteroid dehydrogenase-3beta isotype 4 and osteopo

246 The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing n

247 her, nor is it active as a 17beta- or 11beta-hydroxysteroid dehydrogenase.

248 rt chain dehydrogenase, DHS-16, as a novel 3-hydroxysteroid dehydrogenase.

249 HSD-1 is orthologous to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase

250 As skin expresses 3alpha/beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerases, c

251 or P450 side chain cleavage and Delta5-3beta-hydroxysteroid dehydrogenase/Delta5-Delta4- isomerase en

252 The enzyme 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD) is e

253 Human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD/isome

254 tissues) and type 2 (adrenals, gonads) 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD/isomer

255 pe 2 (adrenals and gonads) isoforms of 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1 and 3

256 es of unknown function (e.g., D127 in 3 beta-hydroxysteroid dehydrogenase/isomerase-1).

257 opment of a fluorogenic substrate for 17beta-hydroxysteroid-dehydrogenase type 10 (17beta-HSD10), whi

258 pathway is controlled by the activity of the hydroxysteroid-dehydrogenase-17-beta-3 (HSD17B3).

259 ess the cortisol-inactivating enzyme 11-beta-hydroxysteroid-dehydrogenase-2 (11betaHSD2).

260 cholestan-3beta,5alpha-diol (OCDO) by 11beta-hydroxysteroid-dehydrogenase-type-2 (11betaHSD2).

261 11beta-hydroxysteroid dehydrogenases (11beta-HSD) perform prere

262 11beta-hydroxysteroid dehydrogenases (11beta-HSDs) catalyse the

263 ptor metabolism of glucocorticoids by 11beta-hydroxysteroid dehydrogenases (11beta-HSDs) modulates ce

264 R), glucocorticoid receptor (GR), and 11beta-hydroxysteroid dehydrogenases (11beta-HSDs).

265 The 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyze the

266 3Alpha-hydroxysteroid dehydrogenases (3alpha-HSDs) catalyze the

267 anolone biosynthesis, is catalyzed by 3alpha-hydroxysteroid dehydrogenases (3alpha-HSDs).

268 3beta-hydroxysteroid dehydrogenases (HSD3Bs), encoded by the H

269 Hydroxysteroid dehydrogenases (HSDs) are essential for t

270 s high selectivity in living cells for human hydroxysteroid dehydrogenases (HSDs) of the aldo-keto re

271 forms have been shown to act as 3alpha/3beta-hydroxysteroid dehydrogenases (HSDs) on 5alpha-dihydrote

272 4)-3-ketosteroids, whereas AKR1C enzymes are hydroxysteroid dehydrogenases (HSDs).

273 GR), mineralocorticoid receptor (MR), 11beta-hydroxysteroid dehydrogenases 1 and 2 (11beta-HSD1 and 1

274 ature distinguishes it from all known 17beta-hydroxysteroid dehydrogenases, and endows mitochondria w

275 and access to nuclear receptors by acting as hydroxysteroid dehydrogenases.

276 a conversion catalyzed by one or more 17beta-hydroxysteroid dehydrogenases.

277 3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase, known as Em

278 ar interest, we identify EBP (encoding 3beta-hydroxysteroid-Delta8,Delta7-isomerase), a key enzyme in

279 ensitive to both the direct effects of 3beta-hydroxysteroids on GABA(A) responses and the reduction o

280 oid reductase activity of the enzymes, their hydroxysteroid oxidase activity was potently inhibited b

281 Cs also expressed substantial 3alpha[17beta]-hydroxysteroid oxidase activity with 3alpha-Diol as the

282 progesterone (P4)'s 5 alpha-reduced, 3 alpha-hydroxysteroid oxidoreduced product, facilitates lordosi

283 uctase inhibitor, or indomethacin, a 3 alpha-hydroxysteroid oxidoreductase inhibitor, either systemic

284 wer than in group-housed mice whereas 3alpha-hydroxysteroid oxidoreductase mRNA expression was equal

285 lic reduction by 5alpha-reductase and 3alpha-hydroxysteroid oxidoreductase to form 5alpha-dihydrodeox

286 methacin (100 mg/kg), an inhibitor of 3alpha-hydroxysteroid oxidoreductase.

287 Although 3beta-hydroxysteroids reduced the potentiation induced by 3alp

288 near (typical R2 is superior to 0.98 for all hydroxysteroids studied) over the concentration range of

289 oepiandrosterone sulfotransferase (STD) is a hydroxysteroid sulfo-conjugating enzyme with preferentia

290 te from a previously determined structure of hydroxysteroid sulfotransferase (SULT2A1) binding dehydr

291 The gene for human hydroxysteroid sulfotransferase (SULT2B1) encodes two pe

292 of an alternative exon 1, the gene for human hydroxysteroid sulfotransferase (SULTB1) encodes for two

293 -glucuronosyltransferase 1A1, 1A3, 1A4, 1A6, hydroxysteroid sulfotransferase enzyme 2A1, multidrug re

294 SNPs in the hydroxysteroid sulfotransferase, SULT2A1, have been iden

295 e 5'-phosphosulfate, and either rat or human hydroxysteroid sulfotransferase, the formation of DNA ad

296 ifene was a poor substrate for rat and human hydroxysteroid sulfotransferases.

297 This direct, noncompetitive effect of 3beta-hydroxysteroids was sufficient to account for the appare

298 Hydroxysteroids were extracted using methanol and steroi

299 d external neurosteroid antagonist site, and hydroxysteroids, which bind an independent site, are eff

300 e exhibits an oxidoreductase activity toward hydroxysteroids with NAD(+) and NADH as the preferred co